Emerging Treatments for Insomnia, Sleep Apnea, and Restless Leg Syndrome Among Dialysis Patients
Sleep disturbances are highly prevalent in patients with predialysis chronic kidney disease, end-stage kidney disease, and after a kidney transplant. They contribute to impairment in daily function and are associated with a high burden of physical and psychiatric symptoms, decreased quality of life, and increased morbidity and mortality. Sleep disturbances also may precipitate and accelerate kidney disease progression. They often evolve across the spectrum of kidney dysfunction and may persist or re-emerge in kidney transplant recipients. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - November 1, 2021 Category: Urology & Nephrology Authors: Shanna Diaz, Kashif Abad, Sanjay R. Patel, Mark L. Unruh Source Type: research
Sexual Dysfunction Among Patients With Chronic Kidney Disease
Summary: Sexual dysfunction (SD) in patients with chronic kidney disease is common and negatively impacts quality of life. SD is often under-appreciated because of overall low awareness. Diagnosis of SD is subjective, and manifestations can be different among men and women. Causes of SD are multifactorial, including psychological disorders, hormonal imbalances, vascular disorders, neurological disorders, and medication side effects. Non-specific approaches to improving sexual function include addressing underlying psychological disorders, promoting lifestyle modifications, optimizing dialysis care, and facilitating success...
Source: Seminars in Nephrology - November 1, 2021 Category: Urology & Nephrology Authors: Connie J. Wang, Daniel Cukor, Kirsten L. Johansen Source Type: research
Emerging Patient-Centered Concepts in Pain Among Adults With Chronic Kidney Disease, Maintenance Dialysis, and Kidney Transplant
Patient reports of moderate to severe pain are common across the spectrum of chronic kidney disease. The synergistic effects of comorbid depression and anxiety can lead to maladaptive coping responses to pain, namely pain catastrophizing and illness-related post-traumatic stress disorder. If underlying depression and anxiety and associated maladaptive coping responses are not treated, patients can experience an increased perception of pain, worsened disability, decreased quality of life, withdrawal from social activities, and increased morbidity and mortality. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - November 1, 2021 Category: Urology & Nephrology Authors: Mark B. Lockwood, Jennifer L. Steel, Ardith Z Doorenbos, Blanca N. Contreras, Michael J. Fischer Source Type: research
Disparities in Mental Health and Well-Being Among Black and Latinx Patients With Kidney Disease
Black and Latinx individuals in the United States are afflicted disproportionately with kidney disease. Because of structural racism, social risk factors drive disparities in disease prevalence and result in worse outcomes among these patient groups. The impact of social and economic oppression is pervasive in physical and emotional aspects of health. In this review, we describe the history of race and ethnicity among black and Latinx individuals in the United States and discuss how these politicosocial constructs impact disparities in well-being and mental health. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - November 1, 2021 Category: Urology & Nephrology Authors: Nwamaka D. Eneanya, Max Jordan Nguemeni Tiako, Tessa K. Novick, Jenna M. Norton, Lilia Cervantes Source Type: research
Social Support, Caregivers, and Chronic Kidney Disease
The morbidity and mortality associated with chronic kidney disease remains unacceptably high. Psychosocial issues in CKD patients are frequently overlooked yet are often modifiable risk factors for mortality. Addressing patient perception of social support can potentially improve patient outcomes. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - November 1, 2021 Category: Urology & Nephrology Authors: Jairo Fuertes, Sofia Rubinstein, Niloufarsadat Yarandi, Scott D. Cohen Source Type: research
The Role of Kidney Supportive Care and Active Medical Management Without Dialysis in Supporting Well-Being in Kidney Care
People living with kidney failure often experience a higher symptom burden (including anxiety and depression) and lower quality of life than patients with other serious chronic diseases. The end of life for these patients is characterized by high intensity of treatment (such as intensive care unit stays) and lack of support for family. Kidney supportive care, which emphasizes quality of life, person-centered care, and holistic care for the person and their family, is an approach that improves well-being by aligning care with the patient's preferences and goals. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - November 1, 2021 Category: Urology & Nephrology Authors: Dale Lupu, Alvin H. Moss Source Type: research
Masthead
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Source: Seminars in Nephrology - November 1, 2021 Category: Urology & Nephrology Source Type: research
Editorial Board
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Source: Seminars in Nephrology - November 1, 2021 Category: Urology & Nephrology Source Type: research
Table of Contents
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Source: Seminars in Nephrology - November 1, 2021 Category: Urology & Nephrology Source Type: research
Biomarkers, Imaging and Patient Reported Outcomes in The Chronic Kidney Disease in Children Study
The Chronic Kidney Disease in Children (CKiD) cohort study, initiated in 2003, was designed to fill critical gaps in our knowledge of kidney disease in children. The primary aims of the study since its inception have been as follows: (1) to identify novel risk factors for chronic kidney disease (CKD) progression; (2) to measure the impact of kidney function decrease on growth, cognition, and behavior; and (3) to characterize the evolution of cardiovascular disease risk factors. The CKiD study is a large observational cohort study of children with kidney diseases and is a network spanning 56 sites in the United States and C...
Source: Seminars in Nephrology - September 1, 2021 Category: Urology & Nephrology Authors: Susan Furth, Bradley A. Warady Source Type: research
Kidney Disease Progression in Children and Young Adults With Pediatric CKD: Epidemiologic Perspectives and Clinical Applications
Chronic kidney disease (CKD) progression is typically characterized as either time to a clinically meaningful event (such as dialysis or transplant), or longitudinal changes in kidney function. This review describes pediatric kidney disease progression using these two distinct frameworks by reviewing and discussing data from the Chronic Kidney Disease in Children study. We first describe new equations to estimate glomerular filtration rate (GFR) for patients younger than age 25 years, and how the average of serum creatinine-based and cystatin C –based GFR equations yield valid estimates than either alone. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - September 1, 2021 Category: Urology & Nephrology Authors: Derek K. Ng, Christopher B. Pierce Source Type: research
Plasma and Urine Biomarkers of CKD: A Review of Findings in the CKiD Study
Summary: Serum creatinine and level of proteinuria, as biomarkers of chronic kidney disease (CKD) progression, inadequately explain the variability of glomerular filtration rate decline, and are late markers of glomerular filtration rate decline. Recent studies have identified plasma and urine biomarkers at higher levels in children with CKD and also associate independently with CKD progression, even after adjustment for serum creatinine and proteinuria. These novel biomarkers represent diverse biologic pathways of tubular injury, tubular dysfunction, inflammation, and tubular health, and can be used as a liquid biopsy to ...
Source: Seminars in Nephrology - September 1, 2021 Category: Urology & Nephrology Authors: Ibrahim Sandokji, Jason H. Greenberg Source Type: research
Ultrasound-Based Renal Parenchymal Area and Kidney Function Decline in Infants With Congenital Anomalies of the Kidney and Urinary Tract
Congenital anomalies of the kidney and urinary tract are the leading cause of chronic kidney disease in children. Noninvasive imaging biomarkers that predict chronic kidney disease progression in early infancy are needed. We performed a pilot study nested in the prospective Chronic Kidney Disease in Children cohort study to determine the association between renal parenchymal area (RPA) on first post-natal renal ultrasound and change in estimated glomerular filtration rate (eGFR) in children with congenital anomalies of the kidney and urinary tract. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - September 1, 2021 Category: Urology & Nephrology Authors: Bernarda Viteri, Mohamed Elsingergy, Jennifer Roem, Derek Ng, Bradley Warady, Susan Furth, Gregory Tasian Source Type: research
Cardiovascular Disease Risk Factors in Chronic Kidney Disease in Children
Summary: Over the past 2 decades, cardiovascular (CV) disease has been recognized as one of the most important complications of chronic kidney disease (CKD) and one of the leading causes of death in children with advanced CKD and in young adults who developed CKD during childhood. CV abnormalities develop early and progress during the course of CKD in children. Characterization of the prevalence and evolution of CV disease risk factors in progressive CKD is one of the primary aims of the Chronic Kidney Disease in Children study. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - September 1, 2021 Category: Urology & Nephrology Authors: Mark M. Mitsnefes Source Type: research
Adverse Consequences of Chronic Kidney Disease on Bone Health in Children
Chronic kidney disease (CKD) mineral bone disorder has long-term effects on skeletal integrity and growth. Abnormalities in serum markers of mineral metabolism are evident early in pediatric CKD. Bone deformities, poor linear growth, and high rates of fractures are common in children with CKD. Newer imaging modalities such as high-resolution peripheral quantitative computed tomography shows promise in assessing bone mineral density more comprehensively and predicting incident fractures. A lack of large-scale studies that provide a comprehensive assessment of bone histology and correlations with serum biomarkers has contrib...
Source: Seminars in Nephrology - September 1, 2021 Category: Urology & Nephrology Authors: Juhi Kumar, Farzana Perwad Source Type: research
