A Significance Score for Protein ‐Protein Interaction Models Through Random Docking
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 11, 2023 Category: Biochemistry Authors: Katherine Maia McCoy,
Margaret E. Ackerman,
Gevorg Grigoryan Tags: RESEARCH ARTICLE Source Type: research
Evaluation of AlphaFold Antibody ‐Antigen Modeling with Implications for Improving Predictive Accuracy
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 11, 2023 Category: Biochemistry Authors: Rui Yin,
Brian G. Pierce Tags: RESEARCH ARTICLE Source Type: research
The intrinsically disordered transcriptional activation domain of CIITA is functionally tuneable by single substitutions: An exception or a new paradigm?
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 11, 2023 Category: Biochemistry Authors: Shwetha Sreenivasan,
Paul Heffren,
Kyung ‐Shin Suh,
Mykola V. Rodnin,
Edina Kosa,
Aron W. Fenton,
Alexey S. Ladokhin,
Paul E. Smith,
Joseph D. Fontes,
Liskin Swint‐Kruse Tags: RESEARCH ARTICLE Source Type: research
Escherichia coli strains with precise domain deletions in the ribonuclease RNase E can achieve greatly enhanced levels of membrane protein production
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 11, 2023 Category: Biochemistry Authors: Eleni Vasilopoulou,
Tania Chroumpi,
Georgios Skretas Tags: RESEARCH ARTICLE Source Type: research
Direct evidence of lipid transport by the Drs2 ‐Cdc50 flippase upon truncation of its terminal regions
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 9, 2023 Category: Biochemistry Authors: Sara Abad Herrera,
Bo H øjen Justesen,
Thibaud Dieudonné,
Cédric Montigny,
Poul Nissen,
Guillaume Lenoir,
Thomas Günther Pomorski Tags: RESEARCH ARTICLE Source Type: research
MLOsMetaDB, a meta ‐database to centralize the information on liquid‐liquid phase separation proteins and membraneless organelles
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 8, 2023 Category: Biochemistry Authors: Fernando Orti,
Mar ía Laura Fernández,
Cristina Marino‐Buslje Tags: TOOLS FOR PROTEIN SCIENCE Source Type: research
Human islet amyloid polypeptide ‐induced β‐cell cytotoxicity is linked to formation of α‐sheet structure
AbstractType 2 diabetes (T2D) results from insulin secretory dysfunction arising in part from the loss of pancreatic islet β-cells. Several factors contribute to β-cell loss, including islet amyloid formation, which is observed in over 90% of individuals with T2D. The amyloid is comprised of human islet amyloid polypeptide (hIAPP). Here we provide evidence that early in aggregation, hIAPP forms toxic oligomers prior t o formation of amyloid fibrils. The toxic oligomers contain α-sheet secondary structure, a nonstandard secondary structure associated with toxic oligomers in other amyloid diseases.De novo, synthetic α-sh...
Source: Protein Science - December 8, 2023 Category: Biochemistry Authors: Cheng ‐Chieh Hsu,
Andrew T. Templin,
Tatum Prosswimmer,
Dylan Shea,
Jinzheng Li,
Barbara Brooks‐Worrell,
Steven E. Kahn,
Valerie Daggett Tags: RESEARCH ARTICLE Source Type: research
Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N ‐terminal domain
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 8, 2023 Category: Biochemistry Authors: Rob Geens,
Jessica Stanisich,
Olivier Beyens,
Stijn D'Hondt,
Jean ‐Michel Thiberge,
Amber Ryckebosch,
Anke De Groot,
Stefan Magez,
Didier Vertommen,
Rogerio Amino,
Hans De Winter,
Alexander N. Volkov,
Peter Tompa,
Yann G.‐J. Sterckx Tags: RESEARCH ARTICLE Source Type: research
Structural and time ‐resolved mechanistic investigations of protein hydrolysis by the acidic proline‐specific endoprotease from Aspergillus niger
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 7, 2023 Category: Biochemistry Authors: Tjaard Pijning,
Andreja Vuji čić‐Žagar,
Jan‐Metske van der Laan,
René M. de Jong,
Carlos Ramirez‐Palacios,
Andre Vente,
Luppo Edens,
Bauke W. Dijkstra Tags: RESEARCH ARTICLE Source Type: research
A naturally occurring G11S mutation in the 3C ‐like protease from the SARS‐CoV‐2 virus dramatically weakens the dimer interface
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 7, 2023 Category: Biochemistry Authors: Guanyu Wang,
Felipe Venegas,
Andres Rueda,
Nuwani Weerasinghe,
Kevin A. Uggowitzer,
Christopher J. Thibodeaux,
Nicolas Moitessier,
Anthony K. Mittermaier Tags: RESEARCH NOTE Source Type: research
KMT2D preferentially binds mRNAs of the genes it regulates, suggesting a role in RNA processing
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 7, 2023 Category: Biochemistry Authors: Harem Muhamad Amin,
Rawan Abukhairan,
Beata Szabo,
Mevan Jacksi,
Gyorgy Varady,
Rita Lozsa,
Eva Schad,
Agnes Tantos Tags: RESEARCH ARTICLE Source Type: research
A Conserved Electrostatic Membrane ‐Binding Surface in Synaptotagmin‐Like Proteins Revealed Using Molecular Phylogenetic Analysis and Homology Modeling
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 2, 2023 Category: Biochemistry Authors: Nara L. Chon,
Sherleen Tran,
Christopher S. Miller,
Hai Lin,
Jefferson D. Knight Tags: RESEARCH ARTICLE Source Type: research
Two distinct mechanisms of flavoprotein spectral tuning revealed by low ‐temperature and time‐dependent spectroscopy
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 1, 2023 Category: Biochemistry Authors: Andrey Nikolaev,
Elena V. Tropina,
Kirill N. Boldyrev,
Eugene G. Maksimov,
Valentin Borshchevskiy,
Alexey Mishin,
Anna Yudenko,
Alexander Kuzmin,
Elizaveta Kuznetsova,
Oleg Semenov,
Alina Remeeva,
Ivan Gushchin Tags: RESEARCH ARTICLE Source Type: research
NMR ‐identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc‐associated factor X
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 1, 2023 Category: Biochemistry Authors: Ludovica Martina Epasto,
Christopher P ötzl,
Herwig Peterlik,
Mahdi Khalil,
Christine Saint‐Pierre,
Didier Gasparutto,
Giuseppe Sicoli,
Dennis Kurzbach Tags: RESEARCH NOTE Source Type: research
Probing binding and occlusion of substrate in the human creatine transporter ‐1 by computation and mutagenesis
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 1, 2023 Category: Biochemistry Authors: Amy Clarke,
Clemens V. Farr,
Ali El ‐Kasaby,
Daniel Szöllősi,
Michael Freissmuth,
Sonja Sucic,
Thomas Stockner Tags: RESEARCH ARTICLE Source Type: research
