Self ‐assembly of temperature‐responsive di‐block polypeptides functionalized with unnatural amino acids
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 26, 2023 Category: Biochemistry Authors: Rotem Azulay,
Daniela S. Strugach,
Miriam Amiram Tags: RESEARCH ARTICLE Source Type: research
Dynamic proximity interaction profiling suggests that YPEL2 is involved in cellular stress surveillance
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 26, 2023 Category: Biochemistry Authors: Gizem Turan, Çağla Ece Olgun,
Hazal Ayten,
Pelin Toker,
Annageldi Ashyralyyev,
Büşra Savaş,
Ezgi Karaca,
Mesut Muyan Tags: RESEARCH ARTICLE Source Type: research
Molecular Mechanisms of Chaperone Directed Protein Folding: Insights from Atomistic Simulations
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 25, 2023 Category: Biochemistry Authors: Matteo Castelli,
Andrea Magni,
Giorgio Bonollo,
Silvia Pavoni,
Francesco Frigerio,
A. Sofia F. Oliveira,
Fabrizio Cinquini,
Stefano A. Serapian,
Giorgio Colombo Tags: RESEARCH ARTICLE Source Type: research
Structural determination and kinetic analysis of the Transketolase from Vibrio vulnificus reveal unexpected cooperative behavior
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 25, 2023 Category: Biochemistry Authors: Rainier ‐Numa Georges,
Lionel Ballut,
Guillaume Octobre,
Arnaud Comte,
Laurence Hecquet,
Franck Charmantray,
Bastien Doumèche Tags: RESEARCH ARTICLE Source Type: research
Molecular Mechanism of Fe3+ Binding Inhibition to Vibrio metschnikovii Ferric Ion ‐Binding Protein, FbpA, by Rosmarinic Acid and its Hydrolysate, Danshensu
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 25, 2023 Category: Biochemistry Authors: Peng Lu,
Jinyan Jiang,
Chang Liu,
Suguru Okuda,
Hideaki Itoh,
Ken Okamoto,
Michio Suzuki,
Koji Nagata Tags: RESEARCH ARTICLE Source Type: research
Probing Effects of Site ‐Specific Aspartic Acid Isomerization on Structure and Stability of GB1 through Chemical Protein Synthesis
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 25, 2023 Category: Biochemistry Authors: Shelby L. Heath,
Alex J. Guseman,
Angela M. Gronenborn,
W. Seth Horne Tags: RESEARCH ARTICLE Source Type: research
Residues within the LptC transmembrane helix are critical for Escherichia coli LptB2FG ATPase regulation
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 23, 2023 Category: Biochemistry Authors: Nicholas P. Cina,
Dara W. Frank,
Candice S. Klug Tags: RESEARCH ARTICLE Source Type: research
Exploring protein –protein interactions and oligomerization state of pulmonary surfactant protein C (SP‐C) through FRET and fluorescence self‐quenching
AbstractPulmonary surfactant (PS) is a lipid –protein complex that forms films reducing surface tension at the alveolar air–liquid interface. Surfactant protein C (SP-C) plays a key role in rearranging the lipids at the PS surface layers during breathing. The N-terminal segment of SP-C, a lipopeptide of 35 amino acids, contains two palmito ylated cysteines, which affect the stability and structure of the molecule. The C-terminal region comprises a transmembrane α-helix that contains a ALLMG motif, supposedly analogous to a well-studied dimerization motif in glycophorin A. Previous studies have demonstrated the potenti...
Source: Protein Science - December 20, 2023 Category: Biochemistry Authors: Mishelle Mor án‐Lalangui,
Ana Coutinho,
Manuel Prieto,
Alexander Fedorov,
Jesús Pérez‐Gil,
Luís M. S. Loura,
Begoña García‐Álvarez Tags: RESEARCH ARTICLE Source Type: research
Molecular interactions between perlecan LG3 and the SARS ‐CoV‐2 spike protein receptor binding domain
In this study, we investigated the binding interactions between the SARS-CoV-2 spike protein RBD and perlecan LG3 through molecular modeling simulations and surface plasmon resonance (SPR) experiments. Our results indicate stable binding between LG3 and SARS-CoV-2 spike protein RBD, which may potentially enhance RBD-ACE2 interactions. These findings shed light on the role of perlecan LG3 in SARS-CoV-2 infection and provide insight into SARS-CoV-2 pathophysiology and potential therapeutic strategy for COVID-19. (Source: Protein Science)
Source: Protein Science - December 20, 2023 Category: Biochemistry Authors: Timothy E. Gressett,
Md Lokman Hossen,
Grant Talkington,
Milla Volic,
Hugo Perez,
Purushottam B. Tiwari,
Prem Chapagain,
Gregory Bix Tags: RESEARCH ARTICLE Source Type: research
TEPCAM: Prediction of T ‐cell receptor–epitope binding specificity via interpretable deep learning
AbstractThe recognition of T-cell receptor (TCR) on the surface of T cell to specific epitope presented by the major histocompatibility complex is the key to trigger the immune response. Identifying the binding rules of TCR –epitope pair is crucial for developing immunotherapies, including neoantigen vaccine and drugs. Accurate prediction of TCR–epitope binding specificity via deep learning remains challenging, especially in test cases which are unseen in the training set. Here, we propose TEPCAM (TCR–EPitope ide ntification based on Cross-Attention and Multi-channel convolution), a deep learning model that incorpora...
Source: Protein Science - December 20, 2023 Category: Biochemistry Authors: Junwei Chen,
Bowen Zhao,
Shenggeng Lin,
Heqi Sun,
Xueying Mao,
Meng Wang,
Yanyi Chu,
Liang Hong,
Dong ‐Qing Wei,
Min Li,
Yi Xiong Tags: TOOLS FOR PROTEIN SCIENCE Source Type: research
4 ‐Thiaproline accelerates the slow folding phase of proteins containing cis prolines in the native state by two orders of magnitude
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 20, 2023 Category: Biochemistry Authors: Jennie O ’. Loughlin,
Kirill Zinovjev,
Silvia Napolitano,
Marc van der Kamp,
Marina Rubini Tags: RESEARCH ARTICLE Source Type: research
Helicity of a tardigrade disordered protein contributes to its protective function during desiccation
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 20, 2023 Category: Biochemistry Authors: Sourav Biswas,
Edith Gollub,
Feng Yu,
Garrett Ginell,
Alex Holehouse,
Shahar Sukenik,
Thomas C. Boothby Tags: RESEARCH ARTICLE Source Type: research
Structure ‐Based Development of a Canine TNF‐α‐Specific Antibody Using Adalimumab as a Template
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 19, 2023 Category: Biochemistry Authors: Cheng ‐Chung Lee,
Wen‐Chih Kuo,
Ya‐Wen Chang,
Shu‐Fang Hsu,
Chia‐Hung Wu,
Ya‐Wen Chen,
Jui‐Jen Chang,
Andrew H.‐J. Wang Tags: RESEARCH ARTICLE Source Type: research
Exploring the conformational changes of the Munc18 ‐1/syntaxin 1a complex
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 18, 2023 Category: Biochemistry Authors: Ioanna Stefani,
Justyna Iwaszkiewicz,
Dirk Fasshauer Tags: RESEARCH ARTICLE Source Type: research
A functional and structural comparative analysis of Large Tumor Antigens reveals evolution of different importin α‐dependent nuclear localization signals
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - December 18, 2023 Category: Biochemistry Authors: Emily M. Cross,
Nasim Akbari,
Hanieh Ghassabian,
Mikayla Hoad,
Silvia Pavan,
Daryl Ariawan,
Camilla M. Donnelly,
Enrico Lavezzo,
Gayle F. Petersen,
Jade K. Forwood,
Gualtiero Alvisi Tags: RESEARCH ARTICLE Source Type: research
