Engineering gain ‐of‐function mutants of a WW domain by dynamics and structural analysis
This study validates the use of dynamic profiles as guiding principles for affecting the binding affinity of small protei ns.This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 14, 2023 Category: Biochemistry Authors: Jin Lu,
Mohammad Imtiazur Rahman,
I. Can Kazan,
Nicholas R. Halloran,
Andrey A. Bobkov,
S. Banu Ozkan,
Giovanna Ghirlanda Tags: RESEARCH ARTICLE Source Type: research
Engineering the catalytic activity of an Antarctic PET ‐degrading enzyme by loop exchange
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 14, 2023 Category: Biochemistry Authors: Paula Bl ázquez‐Sánchez,
Jhon A. Vargas,
Adriano A. Furtado,
Aransa Griñen,
Diego A. Leonardo,
Susana A. Sculaccio,
Humberto D'Muniz Pereira,
Christian Sonnendecker,
Wolfgang Zimmermann,
Beatriz Díez,
Richard C. Garratt,
César A. Ramíre Tags: RESEARCH ARTICLE Source Type: research
Reevaluation of bromodomain ligands targeting BAZ2A
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 14, 2023 Category: Biochemistry Authors: Giulia Cazzanelli,
Andrea Dalle Vedove,
Eleonora Parolin,
Vito Giuseppe D'Agostino,
Andrea Unzue,
Cristina Nevado,
Amedeo Caflisch,
Graziano Lolli Tags: RESEARCH ARTICLE Source Type: research
Multimeric structure of a subfamily III haloalkane dehalogenase ‐like enzyme solved by combination of cryo‐EM and X‐ray crystallography
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 14, 2023 Category: Biochemistry Authors: Klaudia Chmelova,
Tadeja Gao,
Martin Polak,
Andrea Schenkmayerova,
Tristan I. Croll,
Tanvir R. Shaikh,
Jana Skarupova,
Radka Chaloupkova,
Kay Diederichs,
Randy J. Read,
Jiri Damborsky,
Jiri Novacek,
Martin Marek Tags: RESEARCH ARTICLE Source Type: research
ParSe 2.0: A web application that enables proteome ‐scale searches for sequences that drive protein‐mediated phase separation
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 14, 2023 Category: Biochemistry Authors: Colorado Wilson,
Karen A. Lewis,
Nicholas C. Fitzkee,
Loren E. Hough,
Steven T. Whitten Tags: TOOLS FOR PROTEIN SCIENCE Source Type: research
The structural principles underlying molybdenum insertase complex assembly
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 13, 2023 Category: Biochemistry Authors: Ahmed H. Hassan,
Christian Ihling,
Claudio Iacobucci,
Panagiotis L. Kastritis,
Andrea Sinz,
Tobias Kruse Tags: RESEARCH ARTICLE Source Type: research
The nuclear receptor LRH ‐1 discriminates between ligands using distinct allosteric signaling circuits
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 12, 2023 Category: Biochemistry Authors: Suzanne G. Mays,
David Hercules,
Eric A. Ortlund,
C. Denise Okafor Tags: RESEARCH ARTICLE Source Type: research
Pathogenic mutation hotspots in protein kinase domain structure
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 12, 2023 Category: Biochemistry Authors: Kirill E. Medvedev,
R. Dustin Schaeffer,
Jimin Pei,
Nick V. Grishin Tags: RESEARCH NOTE Source Type: research
Salmonella YqiC exerts its function through an oligomeric state
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 9, 2023 Category: Biochemistry Authors: Wei ‐Chun Huang,
Wai‐Ting Chen,
Yueh‐Chen Chen,
Shiuh‐Bin Fang,
Tzu‐Wen Huang,
Pei‐Ru Chang,
Yu‐Chu Chang Tags: RESEARCH ARTICLE Source Type: research
A critical inter ‐subunit interaction for the transmission of the allosteric signal in the Agrobacterium tumefaciens ADP‐glucose pyrophosphorylase
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 9, 2023 Category: Biochemistry Authors: Hiral P. Patel,
Gabriela Martinez ‐Ramirez,
Emily Dobrzynski,
Alberto A. Iglesias,
Dali Liu,
Miguel A. Ballicora Tags: RESEARCH ARTICLE Source Type: research
A cellular selection identifies elongated flavodoxins that support electron transfer to sulfite reductase
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 8, 2023 Category: Biochemistry Authors: Albert Truong,
Dru Myerscough,
Ian Campbell,
Joshua Atkinson,
Jonathan J. Silberg Tags: RESEARCH ARTICLE Source Type: research
Arginine cluster introduction on framework region in anti ‐Lysozyme antibody improved association rate constant by changing conformational diversity of CDR loops
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 8, 2023 Category: Biochemistry Authors: Shingo Maeta,
Makoto Nakakido,
Hiroaki Matsuura,
Naoki Sakai,
Kunio Hirata,
Daisuke Kuroda,
Atsushi Fukunaga,
Kouhei Tsumoto Tags: RESEARCH ARTICLE Source Type: research
Modulation of a conformational ensemble by a small molecule that inhibits key protein –protein interactions involved in cell adhesion
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 3, 2023 Category: Biochemistry Authors: Akinobu Senoo,
Satoru Nagatoishi,
Daisuke Kuroda,
Sho Ito,
Go Ueno,
Jose M. M. Caaveiro,
Kouhei Tsumoto Tags: RESEARCH ARTICLE Source Type: research
Redesigning methionyl ‐tRNA synthetase for β‐methionine activity with adaptive landscape flattening and experiments
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - July 31, 2023 Category: Biochemistry Authors: Vaitea Opuu,
Giuliano Nigro,
Christine Lazennec ‐Schurdevin,
Yves Mechulam,
Emmanuelle Schmitt,
Thomas Simonson Tags: RESEARCH ARTICLE Source Type: research
Diphtheria toxin ‐derived, anti‐PD‐1 immunotoxin, a potent and practical tool to selectively deplete PD‐1+ cells
ConclusionWith its remarkable selective and potent cytotoxicity towards PD-1+ cells, coupled with its high production yield, PD-1 DIT emerges as a powerful biotechnological tool for elucidating the physiological roles of PD-1+ cells. Furthermore, the potential of PD-1 DIT to be developed into a novel therapeutic agent becomes evident.This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - July 30, 2023 Category: Biochemistry Authors: Tianxiao Zhang,
Shuyun Dong,
Yujia Zhai,
Lauren Naatz,
Zemin Zhou,
Mingnan Chen Tags: RESEARCH ARTICLE Source Type: research
