Site ‐specific relaxation of peptide bond planarity induced by electrically attracted proton/deuteron observed by neutron crystallography
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 25, 2023 Category: Biochemistry Authors: Kaori Chiba,
Takuro Matsui,
Toshiyuki Chatake,
Takashi Ohhara,
Ichiro Tanaka,
Katsuhide Yutani,
Nobuo Niimura Tags: RESEARCH ARTICLE Source Type: research
Artificial RING finger reveals unique auto ‐ubiquitination with E2 specificity
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 25, 2023 Category: Biochemistry Authors: Kazuhide Miyamoto,
Atsushi Matsumoto Tags: RESEARCH NOTE Source Type: research
Molecular mechanism of the common and opposing co ‐solvent effects of fluorinated alcohol and urea on a coiled coil protein
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 25, 2023 Category: Biochemistry Authors: Noa Nakata,
Ryuichi Okamoto,
Tomonari Sumi,
Kenichiro Koga,
Takeshi Morita,
Hiroshi Imamura Tags: RESEARCH ARTICLE Source Type: research
Allosteric site variants affect GTP hydrolysis on Ras
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 25, 2023 Category: Biochemistry Authors: Christian W. Johnson,
Susan K. Fetics,
Kathleen P. Davis,
Jose A. Rodrigues,
Carla Mattos Tags: RESEARCH ARTICLE Source Type: research
Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin ‐ligase Dma1 in vitro
AbstractIntrinsically disordered proteins (IDPs) are often multifunctional and frequently posttranslationally modified. Deleted in split hand/split foot 1 (Dss1 —Sem1 in budding yeast) is a highly multifunctional IDP associated with a range of protein complexes. However, it remains unknown if the different functions relate to different modified states. In this work, we show thatSchizosaccharomyces pombe Dss1 is a substrate for casein kinase 2 in vitro, and we identify three phosphorylated threonines in its linker region separating two known disordered ubiquitin-binding motifs. Phosphorylations of the threonines had no ef...
Source: Protein Science - August 22, 2023 Category: Biochemistry Authors: Nina L. Jacobsen,
Magnus Bloch,
Peter S. Millard,
Sarah F. Ruidiaz,
Jonas D. Elsborg,
Wouter Boomsma,
Ruth Hendus ‐Altenburger,
Rasmus Hartmann‐Petersen,
Birthe B. Kragelund Tags: RESEARCH ARTICLE Source Type: research
Identification and expression of small multidrug resistance transporters in early ‐branching anaerobic fungi
In this study, we show that SMR transporters from anaerobic fungi can be produced heterologously in the model yeastSaccharomyces cerevisiae, demonstrating the potential of these proteins as targets for further characterization. The discovery of these novel anaerobic fungal SMR transporters offers a promising path forward to enhance bioproduction from engineered microbial strains. (Source: Protein Science)
Source: Protein Science - August 22, 2023 Category: Biochemistry Authors: Susanna Sepp älä,
Taylor Gierke,
Elizabeth E. Schauer,
Jennifer L. Brown,
Michelle A. O'Malley Tags: RESEARCH NOTE Source Type: research
Cover Image
Metastable conformational states of the phosphodiesterase 5 (PDE5) enzyme are shown in the apo state (leftmost panels) and two inhibitor-bound states, the allosteric inhibitor evodiamine-bound PDE5 (middle panels), and the competitive inhibitor avanafil-bound PDE5 (rightmost panels). The conformational states correspond to minima in the free energy surfaces (top panels) labeled with blue, orange, and red dots. For details, see: Shubhandra Tripathi et al.,Protein Science, 2023.https://doi.org/10.1002/pro.4720 (Source: Protein Science)
Source: Protein Science - August 22, 2023 Category: Biochemistry Tags: Cover Image Source Type: research
Issue information
(Source: Protein Science)
Source: Protein Science - August 21, 2023 Category: Biochemistry Tags: Issue Information Source Type: research
AQcalc: A Web Server that Identifies Weak Molecular Interactions in Protein Structures
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 19, 2023 Category: Biochemistry Authors: Maral Afshinpour,
Logan A. Smith,
Suvobrata Chakravarty Tags: TOOLS FOR PROTEIN SCIENCE Source Type: research
DeepAFP: an effective computational framework for identifying antifungal peptides based on deep learning
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 18, 2023 Category: Biochemistry Authors: Lantian Yao,
Yuntian Zhang,
Wenshuo Li,
Chia ‐Ru Chung,
Jiahui Guan,
Wenyang Zhang,
Ying‐Chih Chiang,
Tzong‐Yi Lee Tags: TOOLS FOR PROTEIN SCIENCE Source Type: research
Refined read ‐out: The hUHRF1 Tandem‐Tudor domain prefers binding to histone H3 tails containing K4me1 in the context of H3K9me2/3
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 18, 2023 Category: Biochemistry Authors: Michel Choudalakis,
Goran Kungulovski,
Rebekka Mauser,
Pavel Bashtrykov,
Albert Jeltsch Tags: RESEARCH ARTICLE Source Type: research
Structural and functional characterization of Aedes aegypti pupal cuticle protein that controls dengue virus infection
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 18, 2023 Category: Biochemistry Authors: Qingqing Huang,
Edem Gavor,
Nikhil Kumar Tulsian,
Jingsong Fan,
Qingsong Lin,
Yu Keung Mok,
R. Manjunatha Kini,
Sivaraman J Tags: RESEARCH ARTICLE Source Type: research
Engineering gain ‐of‐function mutants of a WW domain by dynamics and structural analysis
This study validates the use of dynamic profiles as guiding principles for affecting the binding affinity of small protei ns.This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 14, 2023 Category: Biochemistry Authors: Jin Lu,
Mohammad Imtiazur Rahman,
I. Can Kazan,
Nicholas R. Halloran,
Andrey A. Bobkov,
S. Banu Ozkan,
Giovanna Ghirlanda Tags: RESEARCH ARTICLE Source Type: research
Engineering the catalytic activity of an Antarctic PET ‐degrading enzyme by loop exchange
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 14, 2023 Category: Biochemistry Authors: Paula Bl ázquez‐Sánchez,
Jhon A. Vargas,
Adriano A. Furtado,
Aransa Griñen,
Diego A. Leonardo,
Susana A. Sculaccio,
Humberto D'Muniz Pereira,
Christian Sonnendecker,
Wolfgang Zimmermann,
Beatriz Díez,
Richard C. Garratt,
César A. Ramíre Tags: RESEARCH ARTICLE Source Type: research
Reevaluation of bromodomain ligands targeting BAZ2A
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - August 14, 2023 Category: Biochemistry Authors: Giulia Cazzanelli,
Andrea Dalle Vedove,
Eleonora Parolin,
Vito Giuseppe D'Agostino,
Andrea Unzue,
Cristina Nevado,
Amedeo Caflisch,
Graziano Lolli Tags: RESEARCH ARTICLE Source Type: research
