Photosensitizer ‐Mesoporous Silica Nanoparticles Combination for Enhanced Photodynamic Therapy (PDT)
The objective of this review is to collect and compare different nanosystems based on PS-MSNs pointing out their advantages in PDT against diverse types of cancers. (Source: Photochemistry and Photobiology)
Source: Photochemistry and Photobiology - March 14, 2023 Category: Science Authors: Ruth Prieto ‐Montero,
Teresa Arbeloa,
Virginia Martínez‐Martínez Tags: Special Issue Invited Review Source Type: research
New Hybrid Compound Candidate as Photothermal Agent Based on DPP Derivatives and Toluidine Blue: A Theoretical Perspective
AbstractIn this article the synthesis of a new hybrid compound, candidate as photothermal agent, is proposed, based on TDPP (3,6-di(thiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione) and toluidine blue. Electronic structure calculations at the DFT, TD-DFT and CCSD level of theories were performed to obtain ground and excited states molecular structures, photophysical properties and absorption spectrum of the hybrid and the starting compounds. Additionally, ADMET calculations were performed to predict the pharmacokinetic, metabolic and toxicity properties of the proposed compound. The results showed that the propos...
Source: Photochemistry and Photobiology - March 9, 2023 Category: Science Authors: Mariana Yoshinaga,
Willian R. Rocha Tags: Research Article Source Type: research
Adventures in Photodynamic Therapy: Location, Location, Location.
(Source: Photochemistry and Photobiology)
Source: Photochemistry and Photobiology - March 9, 2023 Category: Science Authors: David Kessel Tags: Correspondence Source Type: research
Viricidal Efficacy of a 405 ‐nm Environmental Decontamination System for Inactivation of Bacteriophage Phi6: Surrogate for SARS‐CoV‐2
This study investigates the efficacy of a low irradiance 405-nm light environmental decontamination system for the inactivation of bacteriophage phi6 as a surrogate for SARS-CoV-2. Bacteriophage phi6 was exposed to increasing doses of low irradiance (~0.5 mW cm-2) 405-nm light whilst suspended in SM buffer and artificial human saliva at low (~103-4 PFU mL-1) and high (~107-8 PFU mL-1) seeding densities, to determine system efficacy for SARS-CoV-2 inactivation and establish the influence of biologically-relevant suspension media on viral susceptibility. Complete/near-complete ( ≥99.4%) inactivation was demonstrated in all...
Source: Photochemistry and Photobiology - March 6, 2023 Category: Science Authors: Lucy G. Sinclair,
Zornitsa Ilieva,
Georgina Morris,
John G. Anderson,
Scott J. MacGregor,
Michelle Maclean Tags: Research Note Source Type: research
Critical PDT Theory VI: Preclinical Translation
AbstractThe translation of photodynamic effects into clinical practice is a complex process that involves the pharmacokinetics of photosensitizing agents, light dosimetry and oxygenation levels. But even the ‘translation’ of basic photobiology into meaningful pre-clinical information can be challenging. Some thoughts on directions for progress in clinical trials are suggested. (Source: Photochemistry and Photobiology)
Source: Photochemistry and Photobiology - March 3, 2023 Category: Science Authors: David Kessel Tags: Correspondence Source Type: research
Sun Light Responsive 2D Covalent ‐Organic Frameworks Platform as a Catalysts Boost C–H Bond Arylation and Dopamine Regeneration
Here, we synthesized a sunlight-responsive 2D covalent-organic frameworks platform for boosting up C –H bond arylation and dopamine regeneration. 2D covalent-organic frameworks have been more effective due to their excellent band gap, photo-stability reusability and efficient electron transfer capability. The products with a C–H bond aryl group and generation of leucodopaminechrome have numerou s pharmaceutical uses. AbstractPhotocatalysis is one of the most promising methods for producing organic compounds with a renewable source of energy. Two-dimensional covalent organic frameworks (2D COFs) are a type of polymer th...
Source: Photochemistry and Photobiology - February 27, 2023 Category: Science Authors: Rajnish K. Singh,
Rajesh K. Yadav,
Poran P. Pande,
Satyam Singh,
Pooja Singh,
Sarvesh K. Gupta,
Shivani Gupta,
Prateek Khare,
Santosh K. Tripathi,
Dhanesh Tiwary Tags: Research Article Source Type: research
Modulating Photochemical Properties to Enhance the Stability of Electronically Dimmable Eye Protection Devices
AbstractThe study evaluates compatibility of stabilizers with dye dopped liquid crystal (LC) scaffolds that are used in electronically dimmable materials. The photodegradation of the materials were investigated and suitable stabilizers were evaluated to slow the degradation process. Various types of benzotriazole based stabilizers were evaluated for stabilizing the liquid crystals Based on spin trapping experiments radical generated upon UV exposure is likely responsible for the degradation of the system. The radical generation is competitively inhibited by the addition of stabilizers. (Source: Photochemistry and Photobiology)
Source: Photochemistry and Photobiology - February 25, 2023 Category: Science Authors: Sruthy Baburaj,
Jayachandran Parthiban,
Sarvar Aminovich Rakhimov,
Rasheedah Johnson,
Ludmila Sukhomlinova,
Paul Luchette,
Steffen Jockusch,
Malcolm D. E. Forbes,
Jayaraman Sivaguru Tags: Special Issue Research Article Source Type: research
A New Method to Easily Assess Bacteriostatic and Bactericidal Activity of Ultraviolet Radiation Using Quantitative Image Analysis
AbstractUltraviolet (UV) radiation can elicit both bactericidal and bacteriostatic activity depending on light parameters and targeted bacteria. Current methods based on bacterial growth on solid medium allow measurement of only bactericidal but not bacteriostatic activity, while liquid cultures exhibit low light penetration.Here, we propose a method to quantify both bactericidal and bacteriostatic activity of radiation based on (a) bacterial cultures on solid medium, (b) acquisition and quantitative analysis of photographic images of plates containing bacterial colonies, (c) application of two mathematical equations to ev...
Source: Photochemistry and Photobiology - February 24, 2023 Category: Science Authors: Angela Sandri,
Maria M. Lle ò,
Pietro Bontempi,
Federico Boschi Tags: Research Article Source Type: research
Light ‐Emitting Diode Can Enhance the Metabolism and Paracrine Action of Mesenchymal Stem Cells
This study investigated the influence of red light-emitting diodes (LED, 630 nm) on different irradiation parameters and the number of applications on mesenchymal stem cells derived from adipose tissue (AdMSCs) metabolism and paracrine factors. The AdMSCs were irradiated with a LEDbox device (output power: 2452.5 mW; laser beam: 163.5 cm2; irradiance: 15 mW/cm2) using radiant exposures of 0.5, 2, and 4 J/cm2, respectively. AdMSCs were irradiated once or every 48 h up to three irradiations. All molecular analyses were performed 24 hours after the last irradiation. LED did not induce changes in cell count, DNA damage, and ox...
Source: Photochemistry and Photobiology - February 20, 2023 Category: Science Authors: Barbara Sampaio Dias Martins Mansano,
Vitor Pocani da Rocha,
Ighor Luiz Azevedo Teixeira,
Helenita Antonia de Oliveira,
Stella Souza Vieira,
Ednei Luiz Antonio,
Paulo Jose Ferreira Tucci,
Andrey Jorge Serra Tags: Research Article Source Type: research
In Vitro Effect of Photobiomodulation Therapy with 980 nm Diode Laser on Gene Expression of Key Regulators of Bone Remodeling by Human Periodontal Ligament Cells under Mild Orthodontic Forces
In conclusion, these findings suggest that this PBM protocol may be effective in enhancement of the gene expression in favor of bone remodeling acceleration that should be confirmed in future animal and human studies. (Source: Photochemistry and Photobiology)
Source: Photochemistry and Photobiology - February 20, 2023 Category: Science Authors: Seyyedeh Niloufar Tabatabaei,
Mahshid Hodjat,
Neda Hakimiha,
Mohammad Sadegh Ahmad Akhoundi,
Mohammad Javad Kharazifard Tags: Research Article Source Type: research
Sun Light Responsive 2D Covalent ‐Organic Frameworks Platform as a Catalysts Boost C‐H Bond Arylation and Dopamine Regeneration
AbstractPhotocatalysis is one of the most promising methods for producing organic compounds with a renewable source of energy. Two-dimensional covalent organic frameworks (2D COFs) are a type of polymer that has developed as a potential light-harvesting catalyst for artificial photosynthesis with a design-controllable platform that might be developed into a new type of cost-effective and metal-free photocatalyst. Here, we present a two-dimensional covalent organic framework synthesis technique as a low-cost and highly efficient visible light active flexible photocatalyst for C-H bond activation and dopamine regeneration. 2...
Source: Photochemistry and Photobiology - February 16, 2023 Category: Science Authors: Rajnish Kumar Singh,
Rajesh K. Yadav,
P.P. Pande,
Satyam Singh,
Pooja Singh,
Sarvesh Kumar Gupta,
Shivani Gupta,
Prateek Khare,
Santosh Kumar Tripathi,
Dhanesh Tiwary Tags: Research Article Source Type: research
Optimizing the Seasonal Shade and Ultraviolet Protection of a Suburban Playground by Utilization of the Playground Shade Index
AbstractThe Playground Shade Index (PSI) is introduced as a design metric for assessing the shade and solar ultraviolet (UV) protection provided by eight different cloth weave shade structures currently utilized in public playgrounds across a regional city located in southern Queensland, Australia. The PSI, expressing the ratio of available ambient solar UV exposure relative to the UV exposure received by a shaded 184 m2 playground surface over a whole day in mid-summer and mid-winter is used to determine the best design and aspect of all eight existing structures. Unlike subjective shade audits, that may only consider the...
Source: Photochemistry and Photobiology - February 15, 2023 Category: Science Authors: Nathan Downs,
Harry Butler,
Alfio Parisi,
Melanie Beckman ‐Downs,
Damien Igoe Tags: Research Article Source Type: research
Elimination of Human Papillomavirus and Cervical Pathological Microbiota with Photodynamic Therapy in Women from Mexico City with Cervical Intraepithelial Neoplasia I
AbstractCervical carcinoma is the second cause of cancer death in Mexican women. It starts with premalignant lesions known as Intraepithelial Cervical Neoplasia (CIN) that can develop due to infection by Human Papillomavirus (HPV) and other microorganisms. Current CIN therapy involves invasive methods that affect cervix integrity and fertility; we propose the use of photodynamic therapy (PDT) as a strategy with few side effects. In this work, the effectiveness of PDT for CIN I, HPV, and pathogenic vaginal microbiota elimination in 29 women of Mexico City with CIN I, CIN I+HPV, and HPV diagnosis was determined. After 6 mont...
Source: Photochemistry and Photobiology - February 12, 2023 Category: Science Authors: Mar ía Teresa López‐Cárdenas,
Adriana Jiménez,
Araceli Espinosa‐Montesinos,
Elizabeth Maldonado‐Alvarado,
Martha Olivia Osorio‐Peralta,
Alejandro Martínez‐Escobar,
Alejandra Moreno‐Vázquez,
María Guadalupe Aguilera‐Arreola,
Ev Tags: Research Article Source Type: research
A Novel Molecule 3 ‐(1′‐Methyltetrahydropyridinyl)‐2,4‐6‐Trihydroxy Acetophenone Alleviates Ultraviolet‐B‐Induced Photoaging in Human Dermal Fibroblasts and BALB/c Mice
In this study, we investigated the role of 3- (1′-methyltetrahydropyridinyl)-2,4-6-trihydroxy acetophenone (IIIM-8) in thwarting the UV-B-induced photoaging. We observed that IIIM-8 ameliorates UV-B-induced oxidative stress, ER stress, Loss of Mitochondrial membrane potential, MAPK activation and Inflammation in irradiated skin cells. Ultravi olet radiation-related damage to fibroblasts within the dermis leads to collagen degradation-the hallmark of photoaging. IIIM-8 substantially restored the synthesis of collagen and prevented its degradationvia the downregulation of matrix metalloproteinases. Topical application of I...
Source: Photochemistry and Photobiology - February 8, 2023 Category: Science Authors: Shahid H. Naikoo,
Haroon Rashid,
Ragni Gupta,
Raghu Rai Sharma,
Sanjay Kumar,
Riyaz Ahmad,
Satish Gudup,
Parvinder P. Singh,
Sheikh Tasduq Abdullah Tags: Research Article Source Type: research
Chemiexcitation: Mammalian Photochemistry in the Dark †
A 1,2-dioxetane, which thermally decomposes between the two oxygens and two carbons to yield two carbonyls, one of which is excited to a high-energy triplet state in a process termed “chemiexcitation”. Chemiexcited molecules underlie invertebrate bioluminescence but recently have been found to occur in mammalian cells, sometimes causing pathogenic effects. AbstractLight is one way to excite an electron in biology. Another is chemiexcitation, birthing a reaction product in an electronically excited state rather than exciting from the ground state. Chemiexcited molecules, as in bioluminescence, can release more energy th...
Source: Photochemistry and Photobiology - February 8, 2023 Category: Science Authors: Douglas E. Brash,
Leticia C. P. Goncalves Tags: Special Issue Invited Review Source Type: research
