Elimination of Human Papillomavirus and Cervical Pathological Microbiota with Photodynamic Therapy in Women from Mexico City with Cervical Intraepithelial Neoplasia I

AbstractCervical carcinoma is the second cause of cancer death in Mexican women. It starts with premalignant lesions known as Intraepithelial Cervical Neoplasia (CIN) that can develop due to infection by Human Papillomavirus (HPV) and other microorganisms. Current CIN therapy involves invasive methods that affect cervix integrity and fertility; we propose the use of photodynamic therapy (PDT) as a strategy with few side effects. In this work, the effectiveness of PDT for CIN I, HPV, and pathogenic vaginal microbiota elimination in 29 women of Mexico City with CIN I, CIN I+HPV, and HPV diagnosis was determined. After 6 months of PDT application, HPV infection was eliminated in 100% of the patients (p<0.01), CIN I+HPV in 64.3% (p<0.01), and CIN I in 57.2 % (p>0.05). PDT also eliminated pathogenic microorganisms:Chlamydia trachomatis in 81% of the women (p<0.001) andCandida albicans in 80% (p<0.05), without affecting normal microbiota sinceLactobacillus iners was eliminated only in 5.8% of patients and the opportunisticGardnerella vaginalis in 20%. These results show that PDT was highly effective in eradicating HPV and pathogenic microorganisms, suggesting that PDT is a promising therapy for cervical infections.

Source: Photochemistry and Photobiology - February 12, 2023 Category: Science Authors: Mar ía Teresa López‐Cárdenas, Adriana Jiménez, Araceli Espinosa‐Montesinos, Elizabeth Maldonado‐Alvarado, Martha Olivia Osorio‐Peralta, Alejandro Martínez‐Escobar, Alejandra Moreno‐Vázquez, María Guadalupe Aguilera‐Arreola, Ev Tags: Research Article Source Type: research