A Novel Molecule 3 ‐(1′‐Methyltetrahydropyridinyl)‐2,4‐6‐Trihydroxy Acetophenone Alleviates Ultraviolet‐B‐Induced Photoaging in Human Dermal Fibroblasts and BALB/c Mice

In this study, we investigated the role of 3- (1′-methyltetrahydropyridinyl)-2,4-6-trihydroxy acetophenone (IIIM-8) in thwarting the UV-B-induced photoaging. We observed that IIIM-8 ameliorates UV-B-induced oxidative stress, ER stress, Loss of Mitochondrial membrane potential, MAPK activation and Inflammation in irradiated skin cells. Ultravi olet radiation-related damage to fibroblasts within the dermis leads to collagen degradation-the hallmark of photoaging. IIIM-8 substantially restored the synthesis of collagen and prevented its degradationvia the downregulation of matrix metalloproteinases. Topical application of IIIM-8 prevented BALB/c mice skin from UV-B-induced leukocyte infiltration, epidermal thickening and disruption of Extracellular  matrix components. Implying that IIIM-8 has a strong photoprotective property and has potential to be developed as a topical therapeutic/cosmeceutical agent against UV-B-induced photoaging.
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: Research Article Source Type: research