Prevalence of Rhinorrhea in Parkinson Disease: A Systematic Review and Meta-analysis
Purpose of Review To perform a systematic review and determine the prevalence of rhinorrhea in Parkinson disease (PD). Recent Findings Of 451 patients with PD and 233 controls, the pooled prevalence of rhinorrhea in patients with PD was 45.0% (95% confidence interval 33.94–56.40), which was significantly greater than that in controls (p < 0.001). The prevalence of self-reported olfactory dysfunction was greater in patients with PD; however, a pooled analysis of studies using objective scores showed no difference. The mean age of patients with PD was greater than that of controls (p = 0.002). The mean age of patie...
Source: Neurology Clinical Practice - August 9, 2022 Category: Neurology Authors: Chen, T., Edwards, T. S., Hinson, V. K., Soler, Z. M. Tags: All Clinical Neurology, All Movement Disorders, Parkinson's disease/Parkinsonism, Clinical trials Systematic review/meta analysis, Clinical trials Prisma Source Type: research

Risk Factors for New Neurologic Diagnoses in Hospitalized Patients With COVID-19: A Case-Control Study in New York City
Discussion Hospitalized patients with SARS-CoV-2 and new neurologic diagnoses have significant morbidity and mortality postdischarge. Further research is needed to define the effect of neurologic diagnoses during acute hospitalization on longitudinal post-COVID-19–related symptoms including neurocognitive impairment. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - August 9, 2022 Category: Neurology Authors: Thakur, K. T., Chu, V. T., Hughes, C., Kim, C. Y., Fleck-Derderian, S., Barrett, C. E., Matthews, E., Balbi, A., Bilski, A., Chomba, M., Lieberman, O., Jacobson, S. D., Agarwal, S., Roh, D., Park, S., Ssonko, V., Silver, W. G., Vargas, W. D., Geneslaw, A. Tags: Research Article Source Type: research

Predictors of Disease Activity and Worsening in Relapsing-Remitting Multiple Sclerosis
Discussion Prospective data from a large clinical trial cohort show that younger MS patients with high BL relapses and MRI lesion burden have the highest risk of subsequent disease activity. Trial Registration Information Clinical trial registration number NCT00211887. CombiRx was registered at ClinicalTrials.gov (NCT00211887) on September 21, 2005. Study enrollment began in January 2005. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - August 9, 2022 Category: Neurology Authors: Zhang, Y., Cofield, S., Cutter, G., Krieger, S., Wolinsky, J. S., Lublin, F. Tags: MRI, Prognosis, All Clinical trials, Multiple sclerosis Research Article Source Type: research

Severity of Epilepsy and Response to Antiseizure Medications in Individuals With Multiple Sclerosis: Analysis of a Real-World Dataset
This study supports the notion that individuals with MS + E can have more severe epilepsy than those with E – MS. Seizure severity among individuals with MS + E treated with sodium channel blockers/modulators vs other ASM classes shows no significant differences. Classification of Evidence This study provides Class III evidence that individuals with MS + E can have more severe epilepsy than those with E – MS. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - August 9, 2022 Category: Neurology Authors: Villamar, M. F., Sarkis, R. A., Pennell, P., Kohane, I., Beaulieu-Jones, B. K. Tags: All Health Services Research, Multiple sclerosis, All epidemiology, All Epilepsy/Seizures, Antiepileptic drugs Research Article Source Type: research

Transient Global Amnesia Recurrence: Prevalence and Risk Factor Meta-analysis
Discussion The analysis showed that approximately 1 of 8 participants may experience recurrence, with an increased risk in the case of a history or current state of migraine, depression, or sexual intercourse before the event. A personal history of migraine and depression was associated with 2 and 4 times risk, respectively. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - August 9, 2022 Category: Neurology Authors: Hernandez, M. A., Arena, J. E., Alessandro, L., Allegri, R. F., Calandri, I. L. Tags: Migraine, Memory, Depression, Prevalence studies, Risk factors in epidemiology Research Article Source Type: research

Picking Brains on a Global Scale: Practice Current and Practice Buzz
When faced with challenging clinical situations, we often ask our colleagues: Can I pick your brain? As clinicians, we aim to provide evidence-based care, often presented as standardized protocols and guidelines. However, practice differences are frequently encountered when discussing challenging cases with peers. These may be more frequent among clinicians of different institutions and/or countries. The reasons for these variations are endless: lack of enough evidence, disparities in access to resources, local population characteristics, among others. Understanding these variations is important for a few key reasons. It c...
Source: Neurology Clinical Practice - August 9, 2022 Category: Neurology Authors: Zea Vera, A., Bartolini, L., Ganesh, A. Tags: Special Editorial Source Type: research

Intracranial Hypertension in a Transgender Man
Discussion Several reports have been published of IIH development in patients receiving testosterone therapy. Hormone prescribers for gender affirmation may wish to screen for visual loss and optic nerve edema in patients undergoing testosterone therapy, which may also stimulate appetite weight gain. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - June 7, 2022 Category: Neurology Authors: Qureshi, K., Qureshi, S., Hassan, A., Antonio, A. Tags: Idiopathic intracranial hypertension, Endocrine, All Neuro-ophthalmology Clinical/Scientific Note Source Type: research

Role of the Neurologist in the Care of Athletes With Head Injuries
Some American neurologists seem uncertain about their role in caring for head-injured athletes. My long neurologic career focusing on brain injury has taught me that neurologists have a unique clinical skill set and expertise that is invaluable to the medical care of patients with MTBI related to sports. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - June 7, 2022 Category: Neurology Authors: Casson, I. Tags: All Clinical Neurology, Brain trauma Commentary Source Type: research

Tackling Quality--It's Never a Level Playing Field: Companion Piece to the Neurology Outcome Measure Set
The American Academy of Neurology (AAN) has recently proposed 3 outcome metrics crafted to be both broadly applicable across neurologic diseases and to function as potential tools to facilitate quality improvement. These measures should be of interest to physicians and payers due to the increasing linkage of reimbursement to quality care. However, the use of quality measures cannot exist in a vacuum as external factors outside of physician control can negatively affect these metrics. The original Centers for Medicare and Medicaid (CMS) value-based programs illustrate the necessity for iterative review and revision of outco...
Source: Neurology Clinical Practice - June 7, 2022 Category: Neurology Authors: Cabaniss, B., Williams, K., Ward, M., Cremeen, D., Nair, K. Tags: Billing, Insurance, Other Education Commentary Source Type: research

Confirming a Historical Diagnosis of Multiple Sclerosis: Challenges and Recommendations
This article provides recommendations for a clinical approach to the evaluation of patients with a historical diagnosis of MS to aid diagnostic confirmation, avoid misdiagnosis, and inform therapeutic decision making. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - June 7, 2022 Category: Neurology Authors: Solomon, A. J., Arrambide, G., Brownlee, W., Cross, A. H., Gaitan, M. I., Lublin, F. D., Makhani, N., Mowry, E. M., Reich, D. S., Rovira, A., Weinshenker, B. G., Cohen, J. A. Tags: All Clinical Neurology, All Demyelinating disease (CNS), Multiple sclerosis Commentary Source Type: research

Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Five New Things
Purpose of Review The purpose of this review is to give an update on chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Recent findings There are several recent developments in CIDP, the major one being the 2021 second revision of the European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy. Other updates address therapy in CIDP, antibodies, serum neurofilament light chain, chronic immune sensory polyradiculopathy (CISP) and CIDP mimics. Summary CIDP criteria continue to be refined and some disorders are now exc...
Source: Neurology Clinical Practice - June 7, 2022 Category: Neurology Authors: Karam, C. Tags: Chronic inflammatory demyelinating polyneuropathy Five New Things Source Type: research

Cognitive-Motor Dissociation Following Pediatric Brain Injury: What About the Children?
Discussion These converging lines of evidence lead us to conclude that both participants had preserved cognitive function dissociated from their motor output. Throughout the 5+ years since injury, communication attempts and therapy had remained uninformed by such objective evidence of their cognitive abilities. Proper diagnosis of CMD is an ethical imperative. Children with covert cognition reflect a vulnerable and isolated population; the methods outlined here provide a first step in identifying such persons to advance efforts to alleviate their condition. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - June 7, 2022 Category: Neurology Authors: Kim, N., O'Sullivan, J., Olafson, E., Caliendo, E., Nowak, S., Voss, H. U., Lowder, R., Watson, W. D., Ivanidze, J., Fins, J. J., Schiff, N. D., Hill, N. J., Shah, S. A. Tags: fMRI, PET, EEG; see Epilepsy/Seizures, Evoked Potentials/Auditory Research Source Type: research

Using Semiology to Classify Epileptic Seizures vs Psychogenic Nonepileptic Seizures: A Meta-analysis
Discussion While all signs require an interpretation in the overall clinical context, the presence of ictal eye closure and asynchronous limb movements are reliable discriminative signs for PNES. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - June 7, 2022 Category: Neurology Authors: Muthusamy, S., Seneviratne, U., Ding, C., Phan, T. G. Tags: All Epilepsy/Seizures, Epilepsy semiology, Video/ EEG use in epilepsy, Nonepileptic seizures Research Source Type: research

Disparities in Telehealth Care in Multiple Sclerosis
Discussion Older age, lower socioeconomic status, and disease-related impairments are associated with less access to and use of telehealth services in people with MS. Barriers to telehealth should be addressed to avoid aggravating health care disparities when using digital medicine. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - June 7, 2022 Category: Neurology Authors: Marrie, R. A., Kosowan, L., Cutter, G., Fox, R., Salter, A. Tags: Inclusion, Diversity, Equity, Anti-racism, and Social Justice (IDEAS), Health disparities, Multiple sclerosis Research Source Type: research

Two-Year Profile of Preventable Errors in Hospital-Based Neurology
Discussion Systems-based interventions may reduce both clinical and systems-based errors, and protocol changes are effective when feasible. Given the important goal of optimizing care for every patient, quality leaders should conduct continuous audits of preventable errors and quality improvement systems in their clinical areas. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - June 7, 2022 Category: Neurology Authors: Marks, A., Takahashi, C., Anand, P., Lau, K. H. V. Tags: Outcome research, Harm/ risk (analysis), Medical care, Patient safety, Methods of education Source Type: research