Total Tau Level in Cerebrospinal Fluid as a Predictor of Survival in Creutzfeldt-Jakob Disease: A Retrospective Analysis

This study aims to fill this gap by examining the relationship between CSF total tau (t-tau) levels and time to death in patients with CJD. Methods We use cases with CJD recorded in the electronic health record of a tertiary academic medical center from 2010 to 2022. Results We identified 29 cases with diagnosis of CJD. Using a Cox proportional hazards model, we find that elevated t-tau levels (>4,000 pg/mL) are associated with 9.62 (95% confidence interval: 1.93–47.92) times the hazard of death compared with CJD patients with t-tau less than 4,000 pg/mL. Discussion This finding supports the use of CSF t-tau as a prognostic biomarker for CJD.
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Prion, Prognosis Research Article Source Type: research