Pembrolizumab-Induced Parsonage-Turner Syndrome
Parsonage-Turner syndrome is a rare and new immune-mediated adverse event resulting from the increasing use of immune checkpoint inhibitors (ICPIs). Patients who describe motor weakness or neuropathy while on treatment with ICPIs should be evaluated for nerve conduction deficits. Early diagnosis with an optimal clinical evaluation with the use of electrodiagnostics such as EMG and nerve conduction studies and imaging can allow for improved care and recovery in affected patients. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Keerty, D., Peguero, E. Tags: Clinical neurology history, Clinical neurology examination, All Oncology, Neuropathic pain, EMG Case Source Type: research
Wernicke Encephalopathy in Children
Frequency of pediatric WE is estimated to be similar to WE in adults, although it is an underdiagnosed condition. In our reports, the nutritional deficit (caused by persistent vomiting and prolonged partial parenteral feeding) triggered signs and symptoms of WE. Therefore, pediatric WE should be considered as a differential diagnosis in all patients at risk for nutritional deficiency, increasing clinical suspicion and early treatment. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Forno, A., Cunha, B., Luis, C., Castro, A., Moniz, M., Escobar, C., Lamy, S., Pereira, A., Martins, A., Conceicao, C. Tags: MRI, All Pediatric Case Source Type: research
Strychnine Poisoning Causing Generalized Tetanic Spasm
Strychnine poisoning should be considered in the differential of generalized tetanic-like muscle contractions with normal mental status—a sine qua non condition of this rare intoxication. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Winzer, S., Barlinn, K. Tags: All Clinical Neurology, Other toxicology, EEG; see Epilepsy/Seizures Case Source Type: research
New Daily Persistent Headache-like Presentation Triggered by a Sudden Head Drop in a Patient With Myasthenia Gravis
Head drop in myasthenia gravis may be a triggering factor for new daily persistent headache-like presentation. Possibility of cervicogenic basis should be considered for the persistence of headache. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Dhand, U. K. Tags: Case Source Type: research
Multiple Streptococcal Brain Abscesses in a Patient Taking Secukinumab
The approval of the interleukin (IL)-17A inhibitor secukinumab (Cosentyx; Novartis International, King of Prussia, PA) was a major advance in psoriasis treatment, with most patients experiencing a 75% reduction in severity.1 Known side effects include an increase in minor infections, but no major infectious adverse events and no nervous system involvement,1-4 leading to broad use and an increase in clinical trials targeting the IL-17 pathway. Here, we describe a patient administered with secukinumab who presented with severe neurologic deficits due to multifocal brain lesions. These were found to be disseminated streptococ...
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Bhatla, A., Asmar, M., Amado, D. A. Tags: Abscess, Bacterial infections Case Source Type: research
Isolated Hypoglossal Mononeuropathy Associated With Preeclampsia
Cranial mononeuropathies are unusual manifestations of preeclampsia. Facial and oculomotor nerves are the most affected. Brain MRI is necessary to exclude alternative diagnoses. There are no specific treatments except the management of preeclampsia. The prognosis is usually good. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Siso-Garcia, P., Fernandez Menendez, S. Tags: Cranial neuropathy Case Source Type: research
Central Diabetes Insipidus Associated With Thymoma in the Context of Myasthenia Gravis
Clinicians should be aware of the presence of symptoms suggestive of diabetes insipidus such as polyuria, polydipsia, or hypernatremia in patients with thymoma. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Lopez-Montoya, V., Llamas Otero, R., Roman-Gonzalez, A. Tags: All Immunology, Autoimmune diseases, Endocrine, Clinical neurology examination, Myasthenia Case Source Type: research
Giant Lumbar Pseudomeningocele Compression Mimicking Stroke and Seizure
Acute awareness impairment, confusion, or other neurologic symptoms occurring in supine position should raise the possibility of transient intracranial hypertension, notably through the compression of a possible pseudomeningocele. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: d'Esneval, M., Zegarek, G., Pugin, D., Vargas, M. I., Tessitore, E., Vulliemoz, S. Tags: EEG; see Epilepsy/Seizures, Syncope Case Source Type: research
A Neurostimulation-Triggered Trigeminal Neuralgia-like Pain: Risk Factors and Management
Consider TNP in a differential diagnosis of a sudden onset of dental or mandibular pain ipsilateral to the VNS insertion site, especially if it follows a recent stimulation therapy adjustment. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Torrealba-Acosta, G., Butt, H., Edmondson, E. A., Willaert, R., Viswanathan, A., Goldman, A. M. Tags: Trigeminal neuralgia, Vagus nerve stimulation, All Epilepsy/Seizures, All Genetics Case Source Type: research
Early-Onset Leptomeningeal Manifestation of G47R Hereditary Transthyretin Amyloidosis
Hereditary transthyretin amyloidosis in both endemic and nonendemic areas can have heterogeneous clinical presentations within the same family and may be difficult to diagnose. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Cechin, L., Gasmelseed, J., Bashford, J., Rowczenio, D., Reilly, M. M., Gillmore, J. D., Coutinho, E. Tags: Clinical neurology history, All Epilepsy/Seizures, Subarachnoid hemorrhage, All Genetics Case Source Type: research
Human Herpesvirus 6 in the CSF of a Woman With New-Onset Seizures: Encephalitis or Genomic Integration?
Human herpesvirus 6 (HHV-6) can successfully integrate itself into the human genome, which may complicate the diagnosis of HHV-6 encephalitis. Headache and visual symptoms can rarely be caused by epileptic seizure (ictal headache and hemicrania epileptica). (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Wenner, A. M., Weitz, L., Ostertag, K., Hubmer, S., Springer, E., Stoiser, B., Baumgartner, C., Riederer, F. Tags: Encephalitis, All Cerebrovascular disease/Stroke, EEG; see Epilepsy/Seizures Case Source Type: research
Enhanced MR Conspicuity of Type IIb Focal Cortical Dysplasia by T1WI With CHESS: Two Case Reports
T1-weighted imaging using a CHESS pulse is a useful MR sequence for diagnosing FCD. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Kusama, M., Sato, N., Tanei, Z.-i., Kimura, Y., Iwasaki, M., Sasaki, M., Miyagi, K., Saito, Y. Tags: MRI, PET, Partial seizures, Cortical dysplasia Case Source Type: research
Postictal Atrial Fibrillation: A Potential Biomarker for Severe Autonomic Dysfunction and SUDEP?
In patients in whom postictal AF is detected, efforts should be made to maximise their seizure control, ultimately to reduce their risk of SUDEP. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Nightscales, R., Sparks, P. B., O'Brien, T. J., Perucca, P., Sivathamboo, S. Tags: All Epilepsy/Seizures, Epilepsy monitoring Case Source Type: research
Occipital Epilepsy With Subcortical Atrophy in Celiac Disease: A Case Report
This report emphasizes the importance of recognizing gluten-associated neurologic manifestations and usefulness of thegluten-free diet. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Bostan, A., Mabiglia, C., Nouini, A., Visee, H., Dan, B., Dachy, B. Tags: Visual processing, EEG, Epilepsy semiology Case Source Type: research
Propofol-Related Infusion Syndrome in a Pediatric Patient With Intracerebral Hemorrhage
Propofol is a commonly used anesthetic, particularly in neurocritical care settings, but it can also be associated with an infusion syndrome. Careful assessment of risk factors for propofol-related infusion syndrome in children can help in early recognition and conversion to alternate anesthetic medications. Although muscle biopsy is traditionally used to confirm the diagnosis, MRI of the head may be helpful based on the characteristic white matter findings. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 11, 2021 Category: Neurology Authors: Sokola, M. S., O'Connor, K. F., Sokola, B. S., Miller, B., Neltner, J. H., Lukins, D., Khan, G. Tags: MRI, Intracerebral hemorrhage Case Source Type: research
