Pharmacokinetics of XEN496, a Novel Pediatric Formulation of Ezogabine, Under Fed and Fasted Conditions: A Phase 1 Trial
ConclusionThe biopharmaceutical performance of XEN496 in this study was as expected for an immediate-release, granular dosage formulation, and generally comparable to that reported for ezogabine tablets. Future studies are needed to characterize the efficacy, safety, and PK of XEN496 in a pediatric population. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 5, 2022 Category: Neurology Source Type: research
Clinical Characteristics and Prognostic Significance of Subclinical Seizures in Focal Epilepsy: A Retrospective Study
ConclusionThe rate of SCSs captured on IEEG monitoring was higher than that on VEEG monitoring during presurgical evaluation. SCSs detected on VEEG monitoring were associated with younger seizure onset. SCSs detected on IEEG monitoring were associated with temporal lobe epilepsy and also predicted surgical outcomes in focal epilepsy. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 4, 2022 Category: Neurology Source Type: research
Cladribine Tablets for Relapsing –Remitting Multiple Sclerosis: A Clinician’s Review
AbstractMultiple sclerosis (MS) is a chronic neurodegenerative disease characterized by inflammation and demyelination for which there is currently no cure; therefore, the aim of therapy is to reduce the risk of relapse and disability progression. The treatment options for MS have increased greatly in recent years with the development of several disease-modifying therapies (DMTs) and the advent of immune reconstitution therapy (IRT). IRTs are administered in short-dosing periods to produce long-term effects on the immune system. Treatment with an IRT is based on the 3Rs: reduction, repopulation, and reconstitution of lymph...
Source: Neurology and Therapy - March 23, 2022 Category: Neurology Source Type: research
Correction to: Staging Disease Severity Using the Alzheimer ’s Disease Composite Score (ADCOMS): A Retrospective Data Analysis
(Source: Neurology and Therapy)
Source: Neurology and Therapy - March 18, 2022 Category: Neurology Source Type: research
Alzheimer ’s Disease: Epidemiology and Clinical Progression
AbstractAlzheimer ’s disease (AD) is prevalent throughout the world and is the leading cause of dementia in older individuals (aged ≥ 65 years). To gain a deeper understanding of the recent literature on the epidemiology of AD and its progression, we conducted a review of the PubMed-indexed literature (2014– 2021) in North America, Europe, and Asia. The worldwide toll of AD is evidenced by rising prevalence, incidence, and mortality due to AD—estimates which are low because of underdiagnosis of AD. Mild cognitive impairment (MCI) due to AD can ultimately progress to AD dementia; estimates of AD dement ia etiol...
Source: Neurology and Therapy - March 14, 2022 Category: Neurology Source Type: research
COVID-19 Outcomes and Vaccination in People with Relapsing Multiple Sclerosis Treated with Ofatumumab
ConclusionCOVID-19 in RMS patients on ofatumumab was primarily of mild/moderate severity and non-serious in these observational data. Most recovered from COVID-19 without treatment interruption. Two people died with COVID-19. Breakthrough COVID-19 despite being fully/partially vaccinated was uncommon. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 13, 2022 Category: Neurology Source Type: research
Results from Patient Interviews on Fatigue in Progressive Multiple Sclerosis and Evaluation of Fatigue Patient-Reported Outcome (PRO) Instruments
ConclusionsThis qualitative study identified meaningful physical and mental fatigue concepts in patients with progressive MS and preliminarily supports the use of the FSIQ-RMS for this population. More research is needed to fully validate this instrument for progressive MS. (Source: Neurology and Therapy)
Source: Neurology and Therapy - March 9, 2022 Category: Neurology Source Type: research
Endovascular Treatment in Acute Ischemic Stroke with Large Vessel Occlusion According to Different Stroke Subtypes: Data from ANGEL-ACT Registry
ConclusionsFunctional outcomes were similar among different stroke subtypes. Despite a higher rate of complete recanalization, there is an increased risk of parenchymal hemorrhage in CE-LVO.Trial RegistrationClinical trial registration number: NCT03370939. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 19, 2022 Category: Neurology Source Type: research
Caregiver Involvement in MS: Duty or Disruption?
AbstractMultiple sclerosis (MS) is a complex condition with numerous physical, cognitive and emotional symptoms. These may necessitate significant, permanent lifestyle changes for people with multiple sclerosis (PwMS) and their caregivers and families, meaning it is important in contemporary neurological practice to consider including families and/or caregivers in the management of MS. However, existing evidence suggests that family involvement is not always beneficial; for example, it can exert either a strong positive or negative influence on the ability of PwMS to achieve optimal outcomes from their treatment and diseas...
Source: Neurology and Therapy - February 19, 2022 Category: Neurology Source Type: research
Effects of Training with a Brain –Computer Interface-Controlled Robot on Rehabilitation Outcome in Patients with Subacute Stroke: A Randomized Controlled Trial
ConclusionTraining with a BCI-controlled robot combined with traditional physiotherapy promotes cognitive function recovery, and enhances motor functions of the lower extremity in patients with subacute stroke. These patients also showed increased secretion of BDNF.Trial RegistrationChinese clinical trial registry: ChiCTR-INR-17012874. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 16, 2022 Category: Neurology Source Type: research
Mapping Motor Pathways in Parkinson ’s Disease Patients with Subthalamic Deep Brain Stimulator: A Diffusion MRI Tractography Study
ConclusionsDTI scanning is safe and delineation of white matter pathway is feasible for PD patients implanted with the DBS device. Postoperative DTI is a useful technique to strengthen our current understanding of the therapeutic effect of DBS for PD and has the potential to refine target selection strategies for brain stimulation. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 14, 2022 Category: Neurology Source Type: research
Long-Term Effectiveness, Safety and Tolerability of Fingolimod in Patients with Multiple Sclerosis in Real-World Treatment Settings in France: The VIRGILE Study
ConclusionsThe effectiveness and tolerability of fingolimod in everyday clinical practice are consistent with findings of previous phase III studies. Our study highlights the utility of fingolimod for the long-term management of patients with multiple sclerosis. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 11, 2022 Category: Neurology Source Type: research
Bioavailability and Safety of a New Highly Concentrated Midazolam Nasal Spray Compared to Buccal and Intravenous Midazolam Treatment in Chinese Healthy Volunteers
ConclusionIntranasal administration of midazolam may be a preferable alternative to the currently approve buccal midazolam treatment for prolonged acute convulsive seizures in children and adolescents.Trial RegistrationThis study is registered at the Chinese Clinical Trial [http://www.chictr.org.cn] (ChiCTR2000032595) on 3 May, 2020. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 7, 2022 Category: Neurology Source Type: research
Low Recruitment in a Double-Blind, Placebo-Controlled Trial of Ocrelizumab for Autoimmune Encephalitis: A Case Series and Review of Lessons Learned
ConclusionClinical trial recruitment for autoimmune encephalitis is challenging, and our trial did not meet recruitment goals. Large, multicenter clinical trials are still needed, and careful attention must be given to study design, endpoints, and patient selection. Instrumented functional rating scales will be valuable outcome measures for future studies.Trial RegistrationClinicalTrials.gov identifier: NCT03835728. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 7, 2022 Category: Neurology Source Type: research
Intrathecally Expanding B Cell Clones in Herpes Simplex Encephalitis: A Case Report
ConclusionIn our patient, HSE resulted in an intrathecal B cell response with expanding CSF clones. We report the B cell receptor sequences of several expanding and dominating clones; these sequences can be used to create recombinant antibodies. Even though the antigen specificity of these expanding clones is unknown, our findings suggest that an adaptive immune response in the central nervous system contributes to repelling herpes simplex virus infection in the brain. (Source: Neurology and Therapy)
Source: Neurology and Therapy - February 6, 2022 Category: Neurology Source Type: research
