Correction to: Measuring Overall Severity of Myasthenia Gravis (MG): Evidence for the Added Value of the MG Symptoms PRO
(Source: Neurology and Therapy)
Source: Neurology and Therapy - June 27, 2023 Category: Neurology Source Type: research
How I Treat Chronic Inflammatory Demyelinating Polyneuropathy Podcast
AbstractChronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated neuropathy that typically presents with progressive or relapsing, symmetric, proximal, and distal weakness of upper and lower limbs, sensory involvement of at least two limbs, and decreased or absent deep tendon reflexes. The symptoms of CIDP can be similar to those of other neuropathies, making diagnosis difficult, which can often lead to delays in correct diagnosis and treatment. The updated European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) 2021 guideline outlines a set of diagnostic criteria that help to identi...
Source: Neurology and Therapy - June 26, 2023 Category: Neurology Source Type: research
Real-World Safety and Effectiveness After 5 Years of Dimethyl Fumarate Treatment in Black and Hispanic Patients with Multiple Sclerosis in ESTEEM
ConclusionThe safety profile of DMF in these subgroups was consistent with the overall ESTEEM population. Relapse rates remained low in Black and Hispanic patients, and consistent with non-Black and non-Hispanic patients. These data demonstrate a comparable real-world treatment benefit of DMF in Black and Hispanic patients.Trial RegistrationClinicalTrials.gov identifier NCT02047097. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 24, 2023 Category: Neurology Source Type: research
Measuring Fatigue in Multiple Sclerosis: There may be Trouble Ahead
ConclusionMost existing fatigue PROs do not meet COSMIN content validity requirements. Although two PROs scored well on aggregate (NFI-MS and FSIQ-RMS), our subsequent evaluation of the item sets that generated their scores implied that both PROs have weaker content validity than COSMIN suggests. This indicates that COSMIN criteria require further development, and raises significant concerns about how we have measured one of the most common and burdensome MS symptoms. A detailed head-to-head psychometric evaluation is needed to determine the impact of different PRO development qualities and the implications of the problems...
Source: Neurology and Therapy - June 23, 2023 Category: Neurology Source Type: research
Podcast on the Challenges and Recommendations to Address Unmet Needs in MS for LGBTQ+ Populations in the United States
AbstractIn general, individuals who are lesbian, gay, bisexual, transgender, queer or questioning, plus other identities (LGBTQ+) living with multiple sclerosis (MS) have less favorable healthcare experiences and poorer overall health than cisgendered heterosexual individuals. They may experience further challenges in addition to managing their MS, including psychological or emotional problems, and an increased risk of comorbid diseases and substance abuse. Transgender individuals specifically face additional unique challenges, including high rates of mental health distress and effects from long-term exogenous hormone use ...
Source: Neurology and Therapy - June 23, 2023 Category: Neurology Source Type: research
Summary of Research: Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis
This article provides a summary of a previously published paper: Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis. The paper reported the results of the CHAMPION-MG trial which investigated the drug ravulizumab in the rare disease, myasthenia gravis.Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis (MP4 594600 KB) (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 23, 2023 Category: Neurology Source Type: research
Effects of the COVID-19 Pandemic on SMA Screening and Care: Physician and Community Insights
ConclusionsThis research evaluates the pandemic ’s interruption of SMA care and research. These insights can help mitigate and increase preparedness for future disruptive events. Expanded use of virtual tools including telehealth and remote monitoring may enhance continuity and access. However, additional research is required to evaluate their effectiveness. While this research was specific to SMA, its findings may have relevance for other patient communities. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 22, 2023 Category: Neurology Source Type: research
Treatment of Seizure Clusters in Epilepsy: A Narrative Review on Rescue Therapies
AbstractEpilepsy is a common neurological disorder in the United States, affecting approximately 1.2% of the population. Some people with epilepsy may experience seizure clusters, which are acute repetitive seizures that differ from the person ’s usual seizure pattern. Seizure clusters are unpredictable, are emotionally burdensome to patients and caregivers (including care partners), and require prompt treatment to prevent progression to serious outcomes, including status epilepticus and associated morbidity (e.g., lacerations, fracture s due to falls) and mortality. Rescue medications for community use can be administer...
Source: Neurology and Therapy - June 21, 2023 Category: Neurology Source Type: research
Summary of Research: Caregiver Involvement in MS: Duty or Disruption?
AbstractThis Summary of Research summarizes a previously published discussion between people with multiple sclerosis (PwMS) and their caregivers and healthcare professionals (HCPs) about how to include caregivers in consultations and decisions about multiple sclerosis (MS) care. The aim of the discussion was to help HCPs to understand differences in these relationships so they can adapt the style of consultations to support everyone. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 21, 2023 Category: Neurology Source Type: research
Systematic Comparison of Muscle Ultrasound Thickness in Polyneuropathies and Other Neuromuscular Diseases
ConclusionThe current study shows that muscle ultrasound thickness is not specific in NM disorders, but shows a global reduction in thickness compared with healthy controls after corrections for age and BMI. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 20, 2023 Category: Neurology Source Type: research
Shunt-Dependent Post-Traumatic Hydrocephalus: Predictors and Long-Term Functional Outcomes
ConclusionWe should emphasize the practices that can minimize the risks of shunt complications. Additionally, the rigorous radiographic and clinical surveillance will benefit those patients at high risk of developing PTH.Trial registrationClinicalTrials.gov identifier, ChiCTR2300070016. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 18, 2023 Category: Neurology Source Type: research
Istradefylline Improves Impaired Smooth Pursuit Eye Movements in Parkinson ’s Disease
ConclusionsIstradefylline ameliorated the oculomotor deficit in SPEM of patients with PD, although differences in somatomotor performance before and after istradefylline treatment were not significant during ON periods. The discrepancy observed between the oculomotor and somatomotor responses to istradefylline supports previous findings that SPEM is at least partially under nondopaminergic control. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 17, 2023 Category: Neurology Source Type: research
Pacemaker Implants and Their Influence on the Daily Life of Patients with Dementia with Lewy Bodies: A Qualitative Case Study
ConclusionIdentifying and managing concurrent bradyarrhythmia through a pacemaker implant could improve well-being for people with DLB. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 16, 2023 Category: Neurology Source Type: research
Determining the Relationship Between Seizure-Free Days and Other Predictors of Quality of Life in Patients with Dravet Syndrome and Their Carers from FFA Registration Studies
ConclusionThis regression framework highlights that SFDs are significantly correlated with both patients ’ and carers’ QoL. Treatment with effective antiseizure medications that increase SFDs directly improves QoL for patients and their carers. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 16, 2023 Category: Neurology Source Type: research
Dietary Patterns and Their Associations with Symptom Levels Among People with Multiple Sclerosis: A Real-World Digital Study
ConclusionsThree dietary clusters were identified. Compared to levels of self-assessed MS-related symptoms, and adjusted for potential confounders, the results suggested less symptom burden with increased intake of vegetables. Although the research design limits the possibilities of establishing causal inference, the results indicate that general guidelines for healthy diet may be relevant as a tool in coping with MS symptoms. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 13, 2023 Category: Neurology Source Type: research
