Correction to: Off-time Treatment Options for Parkinson ’s Disease
(Source: Neurology and Therapy)
Source: Neurology and Therapy - February 2, 2023 Category: Neurology Source Type: research
Treatment Preference for Alzheimer ’s Disease: A Multicriteria Decision Analysis with Caregivers, Neurologists, and Payors
ConclusionAll groups placed the highest value on drug efficacy and types of benefit derived by patients. In contrast, cost implications were among the least important aspects in their decision-making. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Non-drug Therapies for Alzheimer ’s Disease: A Review
AbstractAlzheimer ’s disease (AD) is a debilitating disease leading to great social and economic burdens worldwide. During the past decades, increasing understanding of this disease enables dynamic trials for disease interventions. Unfortunately, at present, AD still remains uncurable, and therefore, developing int ervention strategies for improving symptoms and slowing down the disease process becomes a practical focus in parallel with searching for a disease-modifying medication. The aim of this review is to summarize the outcomes of AD clinical trials of non-drug therapies published in the past decade, incl uding cogn...
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: Onset Following Acute COVID-19 Infection, a Case Series
ConclusionCOVID-19 infection has been linked to several neurological and immune-driven conditions. This study suggests that in susceptible individuals, acute COVID-19 infection may act as a trigger for developing MS and NMOSD. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
The Lived Experiences of People with Progressive Supranuclear Palsy and Their Caregivers
ConclusionThis work represents a major collaborative effort to understand the lived experience of PSP. The research illustrates that a coordinated effort from all stakeholders is required to address ongoing needs and challenges within PSP. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Real-World Analysis Affirms the High Persistence and Adherence Observed with Diroximel Fumarate in Patients with Multiple Sclerosis
ConclusionIn this analysis of > 1000 patients treated with DRF in real-world clinical practice, overall persistence at 16 months was high, treatment discontinuation due to GI AEs was low, and patients were highly adherent to therapy. Of 433 patients who switched from DMF to DRF, most (> 90%) were able to tolerate and persist on DRF after switching.Graphical abstract available for this article.Graphical Abstract (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Treatment with Cladribine Tablets Beyond Year 4: A Position Statement by Southeast European Multiple Sclerosis Centers
This study reviews th e practical aspects of using cladribine tablets, summarizes the evidence from clinical trials and real-world studies on the safety and efficacy of cladribine, and proposes a treatment algorithm developed by expert consensus for pwMS previously treated with cladribine. In brief, we propose that addit ional courses of cladribine tablets should be considered in patients with minimal (no relapses, 1–2 new lesions) or moderate (1 relapse, 3–4 new lesions) disease activity, while significant disease activity (> 1 relapse, > 3 new lesions) or progression should warrant a switch to another h...
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Association between Serum Amyloid A Level and White Matter Hyperintensity Burden: a Cross-Sectional Analysis in Patients with Acute Ischemic Stroke
ConclusionSAA level ranging from 2.12 to 19.89 mg/L is dose-dependently associated with periventricular WMH development. These findings point the way forward for future research into the pathophysiology of WMH. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Understanding the Symptom Burden and Impact of Myasthenia Gravis from the Patient ’s Perspective: A Qualitative Study
ConclusionsThe fluctuating and unpredictable nature of gMG symptoms was found to have a substantial impact on patients ’ emotional, social, and economic well-being. Participants’ goals for symptom management suggest that greater focus is needed to help them quickly resume a normal lifestyle by achieving symptom stability. Impacts of fluctuating and unpredictable symptoms are difficult to measure, but it is impor tant to consider symptom fluctuation as well as ongoing symptomatology when making treatment decisions, and to recognize the impact of uncontrolled symptoms on patients, their partners/caregivers, and family/fr...
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Disease Progression and Longitudinal Clinical Outcomes of Lewy Body Dementia in the NACC Database
ConclusionParticipants with LBD experienced decline across all outcomes over time, and impairment increased with disease severity. Findings highlight the substantial clinical burden associated with LBD and the importance of earlier diagnosis and effective treatment. Further research is needed to understand the predictors of cognitive and functional decline in LBD which may help inform clinical trials. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Brain Complexity Predicts Response to Adrenocorticotropic Hormone in Infantile Epileptic Spasms Syndrome: A Retrospective Study
ConclusionWe suggest that optimizing frequency-specific complexities over critical brain regions may be a promising strategy to facilitate predicting treatment response in IESS. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Effect of ANKK1 Polymorphisms on Serum Valproic Acid Concentration in Chinese Han Adult Patients in the Early Postoperative Period
ConclusionA PPK model of VPA in Chinese Han patients was successfully established; this can be helpful for model-informed precision-dosing approaches in clinical patient care, and for exploring the mechanism of VPA-induced weight gain. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Multiple Sclerosis in Pregnancy: A Commentary on Disease Modification and Symptomatic Drug Therapies
AbstractMultiple sclerosis (MS) frequently affects women of childbearing age, and an increasing number of disease-modifying therapies are available. However, a consequence of this is that women and clinicians face complex shared decisions surrounding disease-modifying therapy use in pregnancy and postpartum. It has been suggested that there are both knowledge and communication gaps that need to be addressed in order to improve outcomes for women with MS desiring a pregnancy. E xisting pregnancy studies are subject to limitations including selection bias and missing data; however, when these are combined with clinical exp...
Source: Neurology and Therapy - January 12, 2023 Category: Neurology Source Type: research
Optic Nerve Sheath Fenestration for Progressive Visual Loss in Cerebral Venous Sinus Thrombosis: A Long-Term Retrospective Observational Study
ConclusionThis was the largest study to describe ONSF ’s role in CVST based on a long-term follow-up. Considering its efficacy and favorable safety, ONSF can be considered an important adjunctive approach to resolving progressive visual loss of CVST patients, on the basis of anticoagulation and ICP-lowering therapy. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 7, 2023 Category: Neurology Source Type: research
Clinical Burden of Angiographic Vasospasm and Its Complications After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review
ConclusionPatients with angiographic VSP and its related complications often had poor functional, neurological, and cognitive outcomes and reduced odds of survival both in hospital and at follow-up. We estimate that angiographic VSP and its related complications, DCI and cerebral infarction, lead to an approximately threefold higher odds of poor functional and cognitive outcomes, and about a twofold increase in the odds of death. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 7, 2023 Category: Neurology Source Type: research
