Impact of Istradefylline on Levodopa Dose Escalation in Parkinson ’s Disease: ISTRA ADJUST PD Study, a Multicenter, Open-Label, Randomized, Parallel-Group Controlled Study
ConclusionIST treatment reduced levodopa dose escalation in PD patients, resulting in less cumulative levodopa use. Adjunctive IST may improve motor function more objectively than increased levodopa dose in patients with PD.Trial RegistrationJapan Registry of Clinical Trials: jRCTs031180248. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 16, 2024 Category: Neurology Source Type: research
Comparing the Efficacy and Safety of Galcanezumab Versus Rimegepant for Prevention of Episodic Migraine: Results from a Randomized, Controlled Clinical Trial
ConclusionsGalcanezumab was not superior to rimegepant for the primary endpoint; however, both interventions demonstrated efficacy as preventive treatments in participants with episodic migraine. The efficacy and safety profiles observed in galcanezumab-treated participants were consistent with previous studies.Trial registrationClinTrials.gov —NCT05127486 (I5Q-MC-CGBD). (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 14, 2024 Category: Neurology Source Type: research
An Integrative Nomogram for Identifying Cognitive Impairment Using Seizure Type and Cerebral Small Vessel Disease Neuroimaging Markers in Patients with Late-Onset Epilepsy of Unknown Origin
ConclusionOur nomogram provides a convenient tool for identifying patients with LOEU who are at risk of CI. Moreover, our findings demonstrate the importance of education for these patients. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 14, 2024 Category: Neurology Source Type: research
Paroxysmal Sympathetic Hyperactivity After Acquired Brain Injury: An Integrative Review of Diagnostic and Management Challenges
AbstractParoxysmal sympathetic hyperactivity (PSH) mainly occurs after acquired brain injury (ABI) and often presents with high fever, hypertension, tachycardia, tachypnea, sweating, and dystonia (increased muscle tone or spasticity). The pathophysiological mechanisms of PSH are not fully understood. Currently, there are several views: (1) disconnection theory, (2) excitatory/inhibitory ratio, (3) neuroendocrine function, and (4) neutrophil extracellular traps. Early diagnosis of PSH remains difficult, given the low specificity of its diagnostic tools and unclear pathogenesis. According to updated case analyses in recent y...
Source: Neurology and Therapy - January 14, 2024 Category: Neurology Source Type: research
Podcast on Identifying and Understanding Barriers to Care in Underserved Populations With MS in the United States
AbstractMultiple sclerosis (MS) can affect people from all racial and ethnic backgrounds, but, historically, the incidence of MS in the United States was thought to be highest in White individuals. More recent data suggest that the incidence of MS in Black or African American individuals is comparable to that in White individuals. In Hispanic or Latino individuals, incidence of MS is lower, but age of onset may be earlier compared with White individuals. Additionally, there are important differences in MS disease severity, disease progression, and mortality in Black or African American and Hispanic or Latino populations. C...
Source: Neurology and Therapy - January 14, 2024 Category: Neurology Source Type: research
Association of Atrial Fibrillation with Remote Intracerebral Hemorrhage After Intravenous Thrombolysis: Results from a Multicenter Study in China
ConclusionsThis study suggests that AF, regardless of whether it is newly diagnosed or previously known, may be associated with the occurrence of rICH following intravenous thrombolysis. Interestingly, our findings suggest that newly diagnosed AF may have a stronger impact on rICH than previously known AF, although confirmation from more studies is needed. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 14, 2024 Category: Neurology Source Type: research
Correction: Expert Narrative Review of the Safety of Cladribine Tablets for the Management of Relapsing Multiple Sclerosis
(Source: Neurology and Therapy)
Source: Neurology and Therapy - January 14, 2024 Category: Neurology Source Type: research
Twenty Years of Subcutaneous Interferon-Beta-1a for Multiple Sclerosis: Contemporary Perspectives
AbstractMultiple sclerosis (MS) is a chronic, progressive, inflammatory disorder of the central nervous system. Relapsing –remitting MS (RRMS), the most common form of the disease, is characterized by transient neurological dysfunction with concurrent accumulation of disability. Over the past three decades, disease-modifying therapies (DMTs) capable of reducing the frequency of relapses and slowing disability worseni ng have been studied and approved for use in patients with RRMS. The first DMTs were interferon-betas (IFN-βs), which were approved in the 1990s. Among them was IFN-β-1a for subcutaneous (sc) injection (Re...
Source: Neurology and Therapy - January 11, 2024 Category: Neurology Source Type: research
The Clinical Development of Taldefgrobep Alfa: An Anti-Myostatin Adnectin for the Treatment of Duchenne Muscular Dystrophy
ConclusionsThe futility analysis demonstrated that taldefgrobep alfa did not result in functional change for boys with DMD. The program was subsequently terminated in 2019. Overall, there were no safety concerns, and no patients were withdrawn from treatment as a result of treatment-related adverse events or serious adverse events.Trial RegistrationNCT02145234, NCT02515669, NCT03039686. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 8, 2024 Category: Neurology Source Type: research
Design and Validation of a Clinical Outcome Measure for Adolescents and Adult Patients with Spinal Muscular Atrophy: SMA Life Study Protocol
ConclusionsThe validation of this tool will facilitate the clinical evaluation of adult and adolescent patients with SMA and the quantification of their response to new treatments in both clinical practice and research. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 5, 2024 Category: Neurology Source Type: research
Insights for Healthcare Providers on Shared Decision-Making in Multiple Sclerosis: A Narrative Review
AbstractShared decision-making (SDM) between the patient and their healthcare provider (HCP) in developing treatment plans is increasingly recognized as central to improving treatment adherence and, ultimately, patient outcomes. In multiple sclerosis (MS), SDM is particularly crucial for optimizing treatment in a landscape that has grown more complex with the availability of newer, high-efficacy MS therapies. However, little direct evidence on the effectiveness of SDM is available to guide practice. Multiple factors, including patient age, ethnic background, perceptions, invisible MS symptoms, and psychological comorbiditi...
Source: Neurology and Therapy - January 5, 2024 Category: Neurology Source Type: research
Impact of Migraine on Daily Life: Results of the Observational survey of the Epidemiology, Treatment, and Care of Migraine (OVERCOME [Japan]) Study
ConclusionThe burden of migraine on daily activities, sleep, and mental health is substantial for people with migraine in Japan. In clinical practice, it is important to evaluate the impact of migraine on daily life in addition to migraine symptoms. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 4, 2024 Category: Neurology Source Type: research
Rapid Rescue Treatment with Diazepam Nasal Spray Leads to Faster Seizure Cluster Termination in Epilepsy: An Exploratory Post Hoc Cohort Analysis
ConclusionEchoing the importance of early use of benzodiazepines in status epilepticus, the findings from this exploratory analysis of patients with refractory epilepsy and frequent seizure clusters identify a potential benefit of early diazepam nasal spray treatment leading to faster seizure resolution within the seizure cluster.Trial Registration Information: ClinicalTrials.gov identifier NCT02721069 (https://clinicaltrials.gov/ct2/show/NCT02721069). (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 4, 2024 Category: Neurology Source Type: research
Humoral Response to SARS-COV-2 Vaccination in Patients with Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Real-World Study
ConclusionsTreatment with aCD20 or SP1-M therapies appears to be associated with a lower humoral response to vaccines against SARS-CoV-2. Vaccination prior to initiation of these DMTs should be recommended whenever possible. (Source: Neurology and Therapy)
Source: Neurology and Therapy - December 14, 2023 Category: Neurology Source Type: research
Bioequivalence Study of Two Tablet Formulations of Clonazepam 2 mg: A Randomized, Open-Label, Crossover Study in Healthy Mexican Volunteers Under Fasting Conditions
ConclusionThe test and reference formulations of clonazepam 2 mg were bioequivalent and well tolerated in healthy Mexican volunteers under fasting conditions.Protocol Authorization Number213301410B0051 (Approved on April 13, 2021). (Source: Neurology and Therapy)
Source: Neurology and Therapy - December 2, 2023 Category: Neurology Source Type: research
