Construction of an Assisted Model Based on Natural Language Processing for Automatic Early Diagnosis of Autoimmune Encephalitis
ConclusionsThe assisted diagnostic model could effectively increase the early diagnostic sensitivity for AE compared to previous diagnostic criteria, assist physicians in establishing the diagnosis of AE automatically after inputting the HPI and the results of standard paraclinical tests according to their narrative habits for describing symptoms, avoiding misdiagnosis and allowing for prompt initiation of specific treatment. (Source: Neurology and Therapy)
Source: Neurology and Therapy - May 11, 2022 Category: Neurology Source Type: research
Impact of Neuromyelitis Optica Spectrum Disorder on Quality of Life from the Patients ’ Perspective: An Observational Cross-Sectional Study
ConclusionFatigue, pain, and depressive symptoms are frequent problems among patients with NMOSD, impacting on their quality of life. Assessment of patient-oriented outcomes may be useful to achieve a holistic approach, allowing early specific interventions. (Source: Neurology and Therapy)
Source: Neurology and Therapy - May 6, 2022 Category: Neurology Source Type: research
Assessing the Clinical Meaningfulness of the Alzheimer ’s Disease Composite Score (ADCOMS) Tool
ConclusionsThe ADCOMS was previously established as a valid and reliable tool for use in clinical trials for MCI due to AD and dementia populations. By defining thresholds for clinically meaningful change of ADCOMS, this work is an important step in interpreting clinical findings and estimates of treatment effects in early stage AD trials. (Source: Neurology and Therapy)
Source: Neurology and Therapy - May 5, 2022 Category: Neurology Source Type: research
The European Lambert –Eaton Myasthenic Syndrome Registry: Long-Term Outcomes Following Symptomatic Treatment
ConclusionNo new safety signals were observed following long-term management of LEMS with 3,4-DAPP. (Source: Neurology and Therapy)
Source: Neurology and Therapy - May 5, 2022 Category: Neurology Source Type: research
Correction to: Comparative All-Cause Mortality Among a Large Population of Patients with Spinal Muscular Atrophy Versus Matched Controls
(Source: Neurology and Therapy)
Source: Neurology and Therapy - May 4, 2022 Category: Neurology Source Type: research
White Matter and Alzheimer ’s Disease: A Bidirectional Mendelian Randomization Study
ConclusionsIn this bidirectional MR study, we did not observe that WM injuries were associated with a higher risk of AD. Likewise, genetically predicted AD did not result in a causal effect on white matter damage. However, our research revealed that underlying mechanisms linking AD and white matter lesions might be related to the SNPs nearAPOE regions. (Source: Neurology and Therapy)
Source: Neurology and Therapy - May 3, 2022 Category: Neurology Source Type: research
Correction to: COVID-19 Outcomes and Vaccination in People with Relapsing Multiple Sclerosis Treated with Ofatumumab
(Source: Neurology and Therapy)
Source: Neurology and Therapy - May 3, 2022 Category: Neurology Source Type: research
Long-Term Health Outcomes of Lecanemab in Patients with Early Alzheimer ’s Disease Using Simulation Modeling
ConclusionThe model results demonstrate the potential clinical value of lecanemab for patients with early AD and how it can slow the rate of disease progression and reduce the lifetime probability for institutionalized care. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 25, 2022 Category: Neurology Source Type: research
Economic and Humanistic Burden of Cerebral Vasospasm and Its Related Complications after Aneurysmal Subarachnoid Hemorrhage: A Systematic Literature Review
ConclusionA substantial direct and indirect economic burden is linked to VSP and its related complications after aSAH. Although limited evidence was identified for humanistic burden, these patients seem to suffer from poor HRQoL with long-lasting burden. Overall, there is an urgent need to understand better the concept of “burden of illness” of VSP and its related complications after aSAH. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 20, 2022 Category: Neurology Source Type: research
Comparative Effectiveness of Carbidopa –Levodopa Enteral Suspension and Deep Brain Stimulation on Parkinson’s Disease-Related Pill Burden Reduction in Advanced Parkinson’s Disease: A Retrospective Real-World Cohort Study
ConclusionsDevice-aided therapies such as CLES and DBS are effective in significantly reducing PD-related pill burden. Patients treated with CLES were more likely to achieve pill-free status than patients receiving DBS. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 20, 2022 Category: Neurology Source Type: research
Assessing Risk for Relapse among Children with Infantile Spasms Using the Based Score after ACTH Treatment: A Retrospective Study
ConclusionThis study suggests the BASED score after ACTH treatment has potential value as a predictor for relapse after initial response. Children with IS who have a BASED score greater than or equal to 3 after the initial response of ACTH carry a high risk of relapse within 1 year. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 15, 2022 Category: Neurology Source Type: research
Therapeutic Effects of Batoclimab in Chinese Patients with Generalized Myasthenia Gravis: A Double-Blinded, Randomized, Placebo-Controlled Phase II Study
ConclusionBatoclimab is effective and safe in Chinese patients with gMG.Trial RegistrationThis study was registered at ClinicalTrials.gov (NCT04346888) on 15 April 2020, with the first patient enrolled on 23 July 2020. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 12, 2022 Category: Neurology Source Type: research
Efficacy of Plasma Exchange Treatment for Demyelinating Optic Neuritis Associated with Various Serum Antibodies: A Prospective Cohort Study
ConclusionPE therapy effectively improves visual outcomes for AQP4-ON patients, but offers limited value for D-ON patients. Early initiation greatly increases likelihood of achieving VA improvement. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 9, 2022 Category: Neurology Source Type: research
Pharmacokinetics of XEN496, a Novel Pediatric Formulation of Ezogabine, Under Fed and Fasted Conditions: A Phase 1 Trial
ConclusionThe biopharmaceutical performance of XEN496 in this study was as expected for an immediate-release, granular dosage formulation, and generally comparable to that reported for ezogabine tablets. Future studies are needed to characterize the efficacy, safety, and PK of XEN496 in a pediatric population. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 5, 2022 Category: Neurology Source Type: research
Clinical Characteristics and Prognostic Significance of Subclinical Seizures in Focal Epilepsy: A Retrospective Study
ConclusionThe rate of SCSs captured on IEEG monitoring was higher than that on VEEG monitoring during presurgical evaluation. SCSs detected on VEEG monitoring were associated with younger seizure onset. SCSs detected on IEEG monitoring were associated with temporal lobe epilepsy and also predicted surgical outcomes in focal epilepsy. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 4, 2022 Category: Neurology Source Type: research
