The Early Diagnosis of Alzheimer ’s Disease: A Patient-Centred Conversation with the Care Team
AbstractAlzheimer ’s disease (AD) is a neurodegenerative disorder which accounts for 60–80% of dementia cases, affecting approximately 10 million people in Europe. Neuroimaging techniques and cerebrospinal fluid biomarkers used in combination with cognitive assessment tools open the door to early diagnosis of AD. However, these tools present some challenges that need to be overcome, such as low sensitivity or specificity, high cost, limited availability or invasiveness. Thus, low-cost and non-invasive alternatives, such as plasma biomarkers, have the potential to drive changes in AD screening and diagnosis. In addition...
Source: Neurology and Therapy - December 18, 2022 Category: Neurology Source Type: research
Sphingosine-1 Phosphate Receptor Modulators Increase In Vitro Melanoma Cell Line Proliferation at Therapeutic Doses Used in Patients with Multiple Sclerosis
ConclusionThese data suggest an increased proliferation of various melanoma cell lines with S1P1-RM treatments used at therapeutic concentrations for patients with MS and should raise the question of increased dermatologic surveillance. (Source: Neurology and Therapy)
Source: Neurology and Therapy - December 16, 2022 Category: Neurology Source Type: research
Characteristics of Patients with Hereditary Transthyretin Amyloidosis-Polyneuropathy (ATTRv-PN) in NEURO-TTRansform, an Open-label Phase 3 Study of Eplontersen
ConclusionThe recruited population in the ongoing NEURO-TTRansform study has global representation characteristic of contemporary clinical practice.Trial RegistrationClinicalTrials.gov identifier NCT04136184. (Source: Neurology and Therapy)
Source: Neurology and Therapy - December 16, 2022 Category: Neurology Source Type: research
Response Letter to Vink et al. ‘Neurological Study Does Not Provide Any Evidence that Long COVID is Psychosomatic’
(Source: Neurology and Therapy)
Source: Neurology and Therapy - December 12, 2022 Category: Neurology Source Type: research
Letter to the Editor Regarding Fleischer et al. Neurological Study Does Not Provide Any Evidence that Long COVID is Psychosomatic
(Source: Neurology and Therapy)
Source: Neurology and Therapy - December 12, 2022 Category: Neurology Source Type: research
Psychomotor Vigilance Performance in Participants with Excessive Daytime Sleepiness in Obstructive Sleep Apnea or Narcolepsy Compared with SAFTE-FAST Model Predictions
ConclusionThis study represents a novel application of the SAFTE biomathematical model to approximate healthy controls in sleep disorder research and provides valuable lessons that may optimize future research. Future studies should perform a priori power analyses for model-tested outcomes and use sleep measures that capture sleep fragmentation characteristic of sleep disorders for sleep input (e.g., total sleep time rather than time in bed).Trial RegistrationNCT02806895, EudraCT 2015-003930-28: A Randomized, Double-Blind, Placebo-Controlled, Crossover On-Road Driving Study Assessing the Effect of JZP-110 on Driving Perfor...
Source: Neurology and Therapy - December 10, 2022 Category: Neurology Source Type: research
Neuroanatomy and Functional Connectivity in Patients with Parkinson ’s Disease with or without Restless Legs Syndrome
ConclusionOur study provides the first evidence that in patients with PD, RLS is associated with significantly larger gray matter volume in the posterior cingulate cortex and lower resting-state functional connectivity within the sensorimotor network. Our results may help clarify the pathophysiology of RLS in PD and identify possible therapeutic targets. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review
AbstractAttention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset neurodevelopmental disorder characterised by persistent inattention, hyperactivity and impulsivity. Moreover, ADHD is commonly associated with other comorbid diseases (depression, anxiety, bipolar disorder, etc.). The ADHD symptomatology interferes with subject function and development. The treatment of ADHD requires a multidisciplinary approach based on a combination of non-pharmacological and pharmacological treatments with the aim of ameliorating the symptomatology; among first-line pharmacological treatments are stimulants [such as meth...
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
Effectiveness of Training Programs for Reducing Adverse Psychological Outcomes in Parents of Children with Acquired Brain Injury: A Systematic Review and Meta-Analysis
ConclusionsCompared with usual care or an active comparator, parent training was associated with short-term reduction in stress, depression, and anxiety in parents of children with ABI. Future clinical trials of parent interventions are needed as there may be some short-term beneficial effects. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
Three Newly Recognized Likely Pathogenic Gene Variants Associated with Hereditary Transthyretin Amyloidosis
ConclusionsBased on several lines of evidence, threeTTR VUS were reclassified as VLP, resulting in a high likelihood of disease diagnosis for those and subsequent patients as well as at-risk family members. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
Unmet Needs and Treatment of Relapsing-Remitting Multiple Sclerosis in Saudi Arabia: Focus on the Role of Ofatumumab
AbstractTreatment-pattern data suggest that some patients with multiple sclerosis (MS) in the Kingdom of Saudi Arabia (KSA) may not be receiving optimal treatment. A virtual meeting of ten expert Saudi neurologists, held on October 23, 2020, discussed unmet needs in relapsing –remitting MS (RRMS), and the role of ofatumumab as a suitable treatment in the KSA. Multiple unmet needs were identified: poor quality of life, with high rates of depression and anxiety; a negative impact of MS on work ability; treatment choices that may compromise efficacy for safety or vice ver sa; inconvenient or complex dosage regimens; and lim...
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
Risk of Major Cardiovascular and Cerebrovascular Events in Users of Lisdexamfetamine and Other Medications for Attention-Deficit/Hyperactivity Disorder in Denmark and Sweden: A Population-Based Cohort Study
ConclusionOur findings suggest little to no increased risk of cardiovascular and cerebrovascular events in patients treated with LDX compared with patients previously treated with other ADHD medications. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
A Simulation Model to Evaluate the Potential Impact of Disease-Modifying Treatments on Burden of Illness in Alzheimer ’s Disease
ConclusionThis analysis demonstrated that DMTs that provide even small delays in the onset of AD can lead to an increase in disease-free years and sizable savings in the cost of care, providing significant benefits to patients, caregivers, and society. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
Post-COVID-19 Syndrome is Rarely Associated with Damage of the Nervous System: Findings from a Prospective Observational Cohort Study in 171 Patients
ConclusionsAlbeit frequently reported by patients, objectifiable affection of the nervous system is rare in post-COVID-19 syndrome. Instead, elevated levels of somatization point towards a pathogenesis potentially involving psychosomatic factors. However, thorough neurological assessment is important in this patient group in order to not miss neurological diseases other than post-COVID-19. (Source: Neurology and Therapy)
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
Correction to: Outcomes of Endovascular Therapy in Young Patients with Acute Basilar Artery Occlusion: A Substudy of BASILAR Registry Study
(Source: Neurology and Therapy)
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
