Estimated Prevalence and Incidence of Amyotrophic Lateral Sclerosis and SOD1 and C9orf72 Genetic Variants
Discussion: The estimated number of patients with SOD1 and C9orf72 ALS suggests that although the proportions of SOD1 and C9orf72 are higher among those with fALS, the majority of SOD1 and C9orf72 ALS cases may be found among those with sALS (about 53 and 74%, respectively). These results suggest that classification of fALS based on reported family history does not capture the full picture of ALS of genetic origin.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 9, 2021 Category: Epidemiology Source Type: research
Reduction in Acute Stroke Admissions during the COVID-19 Pandemic: Data from a National Stroke Registry
Conclusion: The marked decrease in admissions for acute stroke and TIA, occurring at a time of a relatively low burden of COVID-19, is of great concern. Public awareness campaigns are needed as patients reluctant to seek urgent stroke care are deprived of lifesaving procedures and secondary prevention treatments.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 8, 2021 Category: Epidemiology Source Type: research
Reproductive History and Age of Onset for Women Diagnosed with Amyotrophic Lateral Sclerosis: Data from the National ALS Registry: 2010 –2018
Conclusion: Women who reported completing menopause before age 50 were significantly more likely to be diagnosed with ALS before age 60 compared with those who reported entering menopause after age 50. More research is needed to determine the relationship between female reproductive history, especially regarding endogenous estrogen exposure and early-onset ALS.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 2, 2021 Category: Epidemiology Source Type: research
Characteristics Associated with Olfactory and Taste Disorders in COVID-19
Conclusion: This study confirms the higher frequency of OTDs in females than males and adults than children. Their high predictive value for the diagnosis of COVID-19 suggests that they should be systematically searched for in patients with respiratory symptoms, fever, or headache. The association of OTDs with headache, not previously reported, suggests that they share a common mechanism, which deserves further investigation.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - July 1, 2021 Category: Epidemiology Source Type: research
The Burden of Dementia due to Down Syndrome, Parkinson ’s Disease, Stroke, and Traumatic Brain Injury: A Systematic Analysis for the Global Burden of Disease Study 2019
Background: In light of the increasing trend in the global number of individuals affected by dementia and the lack of any available disease-modifying therapies, it is necessary to fully understand and quantify the global burden of dementia. This work aimed to estimate the proportion of dementia due to Down syndrome, Parkinson ’s disease, clinical stroke, and traumatic brain injury (TBI), globally and by world region, in order to better understand the contribution of clinical diseases to dementia prevalence.Methods: Through literature review, we obtained data on the relative risk of dementia with each condition and estima...
Source: Neuroepidemiology - June 28, 2021 Category: Epidemiology Source Type: research
Characteristics, Management, and Case-Fatality of Patients Hospitalized for Stroke with a Diagnosis of COVID-19 in France
Conclusion: Patients hospitalized for stroke with a concomitant COVID-19 diagnosis had a higher inhospital and 3 months case-fatality rates compared to patients hospitalized for stroke without a COVID-19 diagnosis. Further research is needed to better understand the excess of mortality related to these cases.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 24, 2021 Category: Epidemiology Source Type: research
Current and Future Projections of Amyotrophic Lateral Sclerosis in the United States Using Administrative Claims Data
Conclusions: This study provides incidence and prevalence estimates as well as geographical distribution for what the authors believe to be the largest ALS population studied to date. By using 2 separate administrative claims data sets, confidence in our estimates is increased. Future projections based on either database demonstrate an increase in ALS cases, which has also been seen in other large-scale ALS studies. These results can be used to help improve the allocation of healthcare resources in the future.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 21, 2021 Category: Epidemiology Source Type: research
Cerebral Small-Vessel Disease in Individuals with a Family History of Coronary Heart Disease: The Atherosclerosis Risk in Communities Study
Conclusion: Markers of cSVD, specifically lacunar infarcts and microhemorrhages, appear to be associated with FHCHD, potentially representing shared mechanisms in different vascular beds, and perhaps a genetic propensity for vascular disease.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 17, 2021 Category: Epidemiology Source Type: research
Alcohol Consumption and Stroke Risk in Men: A Population-Based Cohort Study in Rural Tianjin, China
Conclusions: These findings suggest that low-dose alcohol consumption may decrease the risk of ischemic strokes among men. Even so, the adverse effects of alcohol on the liver and pancreas cannot be ignored. Additionally, the effects of alcohol consumption on stroke risk vary with age, protecting against ischemic and total strokes among males ≥55 years old. Nevertheless, recommending light drinking and its potential health benefits should not be generalized to men of all ages.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 15, 2021 Category: Epidemiology Source Type: research
Association between Circulating Protein C Levels and Incident Dementia: The Atherosclerosis Risk in Communities Study
Conclusion: Circulating protein C has an inverse association with incident dementia independent of established risk factors, including stroke. Our results suggest studying anticoagulants in addition to coagulants can increase our understanding on the relationship between hemostasis and dementia.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 2, 2021 Category: Epidemiology Source Type: research
Putting Fine Particulate Matter and Dementia in the Wider Context of Noncommunicable Disease: Where are We Now and What Should We Do Next: A Systematic Review
Conclusion: The evidence base for PM2.5 as a risk factor for dementia is growing. It is not yet as strong as that for other NCDs. However, varied measurement/methodology hampers clarity across the field. We propose next steps.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - June 1, 2021 Category: Epidemiology Source Type: research
Temporal Trends in the Incidence of Ischemic Stroke in Young Adults: Dijon Stroke Registry
Conclusions: The incidence of ischemic stroke in young adults increased during the early 2000s and remained stable thereafter. These results highlight the priority need for dedicated prevention strategies for the young to reduce the burden of stroke.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 27, 2021 Category: Epidemiology Source Type: research
Stroke and Heart Attack Symptom Recognition in Older US Adults by Cognitive Impairment Status
Conclusions: Additional work is needed to address the challenge of improving recognition levels for specific stroke and heart attack symptoms in older US adults with cognitive impairment and especially for members of this group who live alone.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 19, 2021 Category: Epidemiology Source Type: research
The Association between Substance Use Disorders and Long-Term Outcome of Stroke: Results from a Population-Based Study of Stroke among 450,229 Urban Citizens
Conclusion: SUD increased the hazard ratio of stroke mortality with no effect on the disability rate. The public should be advised about the potential harm of substance abuse.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 11, 2021 Category: Epidemiology Source Type: research
Antibiotic Use and Risk of Multiple Sclerosis: A Nested Case-Control Study in Emilia-Romagna Region, Italy
Conclusions: Our results suggest an association between the use of antibiotics and MS risk in RER population. However, further epidemiological studies should be done with information on early life and lifestyle factors.Neuroepidemiology (Source: Neuroepidemiology)
Source: Neuroepidemiology - May 7, 2021 Category: Epidemiology Source Type: research
