CAR T-Cell therapy for the management of mantle cell lymphoma
Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, which is typically due to excess expression of Cyclin D1. Although with the progress in o... (Source: Molecular Cancer)
Source: Molecular Cancer - March 31, 2023 Category: Cancer & Oncology Authors: Zoufang Huang, Vivek P. Chavda, Rajashri Bezbaruah, Hemant Dhamne, Dong-Hua Yang and Hong-Bing Zhao Tags: Review Source Type: research
PROTAC ’ing oncoproteins: targeted protein degradation for cancer therapy
Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes i... (Source: Molecular Cancer)
Source: Molecular Cancer - March 30, 2023 Category: Cancer & Oncology Authors: Jeremy M. Kelm, Deepti S. Pandey, Evan Malin, Hussein Kansou, Sahil Arora, Raj Kumar and Navnath S. Gavande Tags: Review Source Type: research
Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination
Although metastasis is the foremost cause of cancer-related death, a specialized mechanism that reprograms anchorage dependency of solid tumor cells into circulating tumor cells (CTCs) during metastatic dissem... (Source: Molecular Cancer)
Source: Molecular Cancer - March 30, 2023 Category: Cancer & Oncology Authors: Hyunbin D. Huh, Yujin Sub, Jongwook Oh, Ye Eun Kim, Ju Young Lee, Hwa-Ryeon Kim, Soyeon Lee, Hannah Lee, Sehyung Pak, Sebastian E. Amos, Danielle Vahala, Jae Hyung Park, Ji Eun Shin, So Yeon Park, Han Sang Kim, Young Hoon Roh & hellip; Tags: Research Source Type: research
CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma
Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which contributes to drug resistance, necessitating development of novel therapeutic approaches. Pharmacological inhibitors of c... (Source: Molecular Cancer)
Source: Molecular Cancer - March 30, 2023 Category: Cancer & Oncology Authors: Elana Thieme, Nur Bruss, Duanchen Sun, Edward C. Dominguez, Daniel Coleman, Tingting Liu, Carly Roleder, Melissa Martinez, Krystine Garcia-Mansfield, Brian Ball, Patrick Pirrotte, Lili Wang, Zheng Xia and Alexey V. Danilov Tags: Research Source Type: research
HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC... (Source: Molecular Cancer)
Source: Molecular Cancer - March 30, 2023 Category: Cancer & Oncology Authors: Ganji Seeta Rama Raju, Eluri Pavitra, Sai Samyuktha Bandaru, Ganji Lakshmi Varaprasad, Ganji Purnachandra Nagaraju, Rama Rao Malla, Yun Suk Huh and Young-Kyu Han Tags: Review Source Type: research
Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment
Fibroblast growth factors (FGFs) and their receptors (FGFRs) play a crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving tumorigenesis. Therefore, many studies have targ... (Source: Molecular Cancer)
Source: Molecular Cancer - March 25, 2023 Category: Cancer & Oncology Authors: Ruiwen Ruan, Li Li, Xuan Li, Chunye Huang, Zhanmin Zhang, Hongguang Zhong, Shaocheng Zeng, Qianqian Shi, Yang Xia, Qinru Zeng, Qin Wen, Jingyi Chen, Xiaofeng Dai, Jianping Xiong, Xiaojun Xiang, Wan Lei & hellip; Tags: Review Source Type: research
The function and mechanisms of action of circular RNAs in Urologic Cancer
Kidney, bladder, and prostate cancer are the three major tumor types of the urologic system that seriously threaten human health. Circular RNAs (CircRNAs), special non-coding RNAs with a stabile structure and ... (Source: Molecular Cancer)
Source: Molecular Cancer - March 25, 2023 Category: Cancer & Oncology Authors: Zi-hao Zhang, Yue Wang, Ya Zhang, Sheng-Feng Zheng, Tao Feng, Xi Tian, Mierxiati Abudurexiti, Zhen-Da Wang, Wen-Kai Zhu, Jia-Qi Su, Hai-Liang Zhang, Guo-Hai Shi, Zi-Liang Wang, Da-Long Cao and Ding-Wei Ye Tags: Review Source Type: research
Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis
Recent studies suggest that cuproptosis, a novel mode of cell death, may be associated with the development of cancer. However, no studies are showing its role in tumorigenesis, progression, and prognosis. In ... (Source: Molecular Cancer)
Source: Molecular Cancer - March 24, 2023 Category: Cancer & Oncology Authors: Yan Qin, Yanling Liu, Xiaoyun Xiang, Xingqing Long, Zuyuan Chen, Xiaoliang Huang, Jianrong Yang and Wei Li Tags: Correspondence Source Type: research
Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
In recent years, tumor immunotherapy has made significant progress. However, tumor immunotherapy, particularly immune checkpoint inhibitors (e.g., PD-1/PD-L1 inhibitors), benefits only a tiny proportion of pat... (Source: Molecular Cancer)
Source: Molecular Cancer - March 21, 2023 Category: Cancer & Oncology Authors: Hao Zhang, Lin Liu, Jinbo Liu, Pengyuan Dang, Shengyun Hu, Weitang Yuan, Zhenqiang Sun, Yang Liu and Chengzeng Wang Tags: Review Source Type: research
Retraction Note: MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-017-0615-x. (Source: Molecular Cancer)
Source: Molecular Cancer - March 20, 2023 Category: Cancer & Oncology Authors: Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong and Chin-Lee Wu Tags: Retraction Note Source Type: research
Retraction Note: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-020-01225-2. (Source: Molecular Cancer)
Source: Molecular Cancer - March 20, 2023 Category: Cancer & Oncology Authors: Jianfa Li, Chenchen Huang, Yifan Zou, Jing Ye, Jing Yu and Yaoting Gui Tags: Retraction Note Source Type: research
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
Circular RNAs (circRNAs) can be encapsulated into exosomes to participate in intercellular communication, affecting the malignant progression of a variety of tumors. Dysfunction of CD8 + T cells is the main fa... (Source: Molecular Cancer)
Source: Molecular Cancer - March 18, 2023 Category: Cancer & Oncology Authors: Zongqiang Hu, Gang Chen, Yingpeng Zhao, Hongqiang Gao, Laibang Li, Yanfeng Yin, Jie Jiang, Li Wang, Yuanyi Mang, Yang Gao, Shengning Zhang, Jianghua Ran and Li Li Tags: Research Source Type: research
SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2/IL6 axis
Inflammation is undoubtedly a hallmark of cancer development. Its maintenance within tumors and the consequences on disease aggressiveness are insufficiently understood. (Source: Molecular Cancer)
Source: Molecular Cancer - March 17, 2023 Category: Cancer & Oncology Authors: Abdel Jelil Njouendou, Tibor Szarvas, Arnol Auvaker Zebaze Tiofack, Rovaldo Nguims Kenfack, Pamela Derliche Tonouo, Sidonie Noa Ananga, Esther H. M. Dina Bell, Gustave Simo, J örg D. Hoheisel, Jens T. Siveke and Smiths S. Lueong Tags: Correspondence Source Type: research
Minimally invasive approaches for the early detection of endometrial cancer
Endometrial cancer (EC) is one of the most common gynecologic cancers and its incidence is rising globally. Although advanced EC has a poor prognosis; diagnosing EC at an earlier stage could improve long-term ... (Source: Molecular Cancer)
Source: Molecular Cancer - March 17, 2023 Category: Cancer & Oncology Authors: Yufei Shen, Wenqing Yang, Jiacheng Liu and Yu Zhang Tags: Review Source Type: research
Correction: Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy
(Source: Molecular Cancer)
Source: Molecular Cancer - March 17, 2023 Category: Cancer & Oncology Authors: Qiang Cai, Shouhua Wang, Longyang Jin, Mingzhe Weng, Di Zhou, Jiandong Wang, Zhaohui Tang and Zhiwei Quan Tags: Correction Source Type: research
