METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome d... (Source: Molecular Cancer)
Source: Molecular Cancer - July 29, 2023 Category: Cancer & Oncology Authors: Raquel Garc ía-Vílchez, Ana M. Añazco-Guenkova, Sabine Dietmann, Judith López, Virginia Morón-Calvente, Silvia D’Ambrosi, Paz Nombela, Kepa Zamacola, Isabel Mendizabal, Saioa García-Longarte, Amaia Zabala-Letona, Ianire Astobiza, Sonia Fernández, Tags: Research Source Type: research
Durable response of lung carcinoma patients to EGFR tyrosine kinase inhibitors is determined by germline polymorphisms in some immune-related genes
Non-small cell lung cancer is a very poor prognosis disease. Molecular analyses have highlighted several genetic alterations which may be targeted by specific therapies. In clinical practice, progression-free ... (Source: Molecular Cancer)
Source: Molecular Cancer - July 29, 2023 Category: Cancer & Oncology Authors: Lorraine Dalens, Julie Niogret, Corentin Richard, Sandy Chevrier, Pascal Foucher, Bruno Coudert, Aur élie Lagrange, Laure Favier, Virginie Westeel, Stefano Kim, Olivier Adotevi, Caroline Chapusot, Laurent Martin, Laurent Arnould, Courèche-Guillaume Kade Tags: Correspondence Source Type: research
Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune responses. Their function and expression in the tumor microenvironment make them attractive targets for immunotherapy, leadin... (Source: Molecular Cancer)
Source: Molecular Cancer - July 29, 2023 Category: Cancer & Oncology Authors: Shan Muhammad, Tao Fan, Yang Hai, Yibo Gao and Jie He Tags: Review Source Type: research
Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma
Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC), contributing to early metastasis and poor patient survival. Compared to the localized tumors, current standard-of-care therapies have... (Source: Molecular Cancer)
Source: Molecular Cancer - July 24, 2023 Category: Cancer & Oncology Authors: Shailendra K. Gautam, Surinder K. Batra and Maneesh Jain Tags: Review Source Type: research
Extracellular vesicle-circEHD2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts
The encapsulation of circular RNAs (circRNAs) into extracellular vesicles (EVs) enables their involvement in intercellular communication and exerts an influence on the malignant advancement of various tumors. ... (Source: Molecular Cancer)
Source: Molecular Cancer - July 22, 2023 Category: Cancer & Oncology Authors: Tao He, Qiansheng Zhang, Peng Xu, Wen Tao, Fuyang Lin, Renfei Liu, Mingzhao Li, Xiaolu Duan, Chao Cai, Di Gu, Guohua Zeng and Yongda Liu Tags: Research Source Type: research
Correction: MIR22HG acts as a tumor suppressor via TGF β/SMAD signaling and facilitates immunotherapy in colorectal cancer
(Source: Molecular Cancer)
Source: Molecular Cancer - July 20, 2023 Category: Cancer & Oncology Authors: Juan Xu, Tingting Shao, Mingxu Song, Yunjin Xie, Jialiang Zhou, Jiaqi Yin, Na Ding, Haozhe Zou, Yongsheng Li and Jiwei Zhang Tags: Correction Source Type: research
Correction: Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2
(Source: Molecular Cancer)
Source: Molecular Cancer - July 18, 2023 Category: Cancer & Oncology Authors: Yonghao Zhan, Zhicong Chen, Shiming He, Yanqing Gong, Anbang He, Yifan Li, Lianghao Zhang, Xuepei Zhang, Dong Fang, Xuesong Li and Liqun Zhou Tags: Correction Source Type: research
Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1
Osteosarcoma (OS) is the most prevalent orthopedic malignancy with a dismal prognosis. The high iron absorption rate in OS cells of patients suggests that ferroptosis may be related to the progression of OS, b... (Source: Molecular Cancer)
Source: Molecular Cancer - July 17, 2023 Category: Cancer & Oncology Authors: Mingyang Jiang, Yiji Jike, Kaicheng Liu, Fu Gan, Ke Zhang, Mingjing Xie, Junlei Zhang, Chuanliang Chen, Xiaochong Zou, Xiaohong Jiang, Yongheng Dai, Weikui Chen, Yue Qiu and Zhandong Bo Tags: Research Source Type: research
Spatially resolved, high-dimensional transcriptomics sorts out the evolution of biphasic malignant pleural mesothelioma: new paradigms for immunotherapy
Malignant Pleural Mesothelioma (MPM) is a dreadful disease escaping the classical genetic model of cancer evolution and characterized by wide heterogeneity and transcriptional plasticity. Clinical evolution of... (Source: Molecular Cancer)
Source: Molecular Cancer - July 17, 2023 Category: Cancer & Oncology Authors: F Torricelli, B Donati, F Reggiani, V Manicardi, S Piana, R Valli, F Lococo and Alessia Ciarrocchi Tags: Research Source Type: research
Immunotherapy: an emerging modality to checkmate brain metastasis
The diagnosis of brain metastasis (BrM) has historically been a dooming diagnosis that is nothing less than a death sentence, with few treatment options for palliation or prolonging life. Among the few treatme... (Source: Molecular Cancer)
Source: Molecular Cancer - July 15, 2023 Category: Cancer & Oncology Authors: Aatiya Ahmad, Parvez Khan, Asad Ur Rehman, Surinder Kumar Batra and Mohd Wasim Nasser Tags: Review Source Type: research
Expression of mTOR in normal and pathological conditions
The mechanistic/mammalian target of rapamycin (mTOR), a protein discovered in 1991, integrates a complex pathway with a key role in maintaining cellular homeostasis. By comprising two functionally distinct com... (Source: Molecular Cancer)
Source: Molecular Cancer - July 15, 2023 Category: Cancer & Oncology Authors: A Marques-Ramos and R Cervantes Tags: Review Source Type: research
BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors
Drugs targeting the spindle assembly checkpoint (SAC), such as inhibitors of Aurora kinase B (AURKB) and dual specific protein kinase TTK, are in different stages of clinical development. However, cell respons... (Source: Molecular Cancer)
Source: Molecular Cancer - July 13, 2023 Category: Cancer & Oncology Authors: Jordi Bertran-Alamillo, Ana Gim énez-Capitán, Ruth Román, Sara Talbot, Rebecca Whiteley, Nicolas Floc’h, Elizabeth Martínez-Pérez, Matthew J. Martin, Paul D. Smith, Ivana Sullivan, Mikkel G. Terp, Jamal Saeh, Cristina Marino-Buslje, Giulia Fabbri, Tags: Research Source Type: research
Correction: Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/ PBX3 axis
(Source: Molecular Cancer)
Source: Molecular Cancer - July 12, 2023 Category: Cancer & Oncology Authors: Yongyan Wu, Yuliang Zhang, Xiwang Zheng, Fengsheng Dai, Yan Lu, Li Dai, Min Niu, Huina Guo, Wenqi Li, Xuting Xue, Yunfeng Bo, Yujia Guo, Jiangbo Qin, Yixiao Qin, Hongliang Liu, Yu Zhang & hellip; Tags: Correction Source Type: research
TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2
The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human lymphoid cancers. However, such molecular events have not be... (Source: Molecular Cancer)
Source: Molecular Cancer - July 10, 2023 Category: Cancer & Oncology Authors: Estelle Balducci, Thomas Steiml é, Charlotte Smith, Patrick Villarese, Mélanie Feroul, Dominique Payet-Bornet, Sophie Kaltenbach, Lucile Couronné, Ludovic Lhermitte, Aurore Touzart, Marie-Emilie Dourthe, Mathieu Simonin, André Baruchel, Hervé Dombret Tags: Correspondence Source Type: research
Combined proteomics and CRISPR ‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo
Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. (Source: Molecular Cancer)
Source: Molecular Cancer - July 8, 2023 Category: Cancer & Oncology Authors: Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Zie Tags: Research Source Type: research
