Gamma delta T-cell-based immune checkpoint therapy: attractive candidate for antitumor treatment
As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of immunotherapy in recent years. They have extraordinary antitumor potential and prospects for clinical application. Immune c... (Source: Molecular Cancer)
Source: Molecular Cancer - February 15, 2023 Category: Cancer & Oncology Authors: Zhifei Gao, Yifeng Bai, Anqi Lin, Aimin Jiang, Chaozheng Zhou, Quan Cheng, Zaoqu Liu, Xin Chen, Jian Zhang and Peng Luo Tags: Review Source Type: research
Emerging roles of tRNA-derived fragments in cancer
tRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to... (Source: Molecular Cancer)
Source: Molecular Cancer - February 13, 2023 Category: Cancer & Oncology Authors: Min Fu, Jianmei Gu, Maoye Wang, Jiahui Zhang, Yanke Chen, Pengcheng Jiang, Taofeng Zhu and Xu Zhang Tags: Review Source Type: research
Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers
In recent years, breakthroughs have been made in tumor immunotherapy. However, tumor immunotherapy, particularly anti-PD-1/PD-L1 immune checkpoint inhibitors, is effective in only a small percentage of patient... (Source: Molecular Cancer)
Source: Molecular Cancer - February 10, 2023 Category: Cancer & Oncology Authors: Liping Pei, Yang Liu, Lin Liu, Shuochen Gao, Xueyan Gao, Yudi Feng, Zhenqiang Sun, Yan Zhang and Chengzeng Wang Tags: Review Source Type: research
The chromatin-associated RNAs in gene regulation and cancer
Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly or indirectly and are calle... (Source: Molecular Cancer)
Source: Molecular Cancer - February 7, 2023 Category: Cancer & Oncology Authors: Jun Tang, Xiang Wang, Desheng Xiao, Shuang Liu and Yongguang Tao Tags: Review Source Type: research
Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T
In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy are two milestone achievements in clinical immunotherapy. However, both show limited efficacies in most solid ... (Source: Molecular Cancer)
Source: Molecular Cancer - February 7, 2023 Category: Cancer & Oncology Authors: Qiaofei Liu, Jiayi Li, Huaijin Zheng, Sen Yang, Yuze Hua, Nan Huang, Jorg Kleeff, Quan Liao and Wenming Wu Tags: Review Source Type: research
Letter to the Editor: clinical utility of urine DNA for noninvasive detection and minimal residual disease monitoring in urothelial carcinoma
Current methods for the early detection and minimal residual disease (MRD) monitoring of urothelial carcinoma (UC) are invasive and/or possess suboptimal sensitivity. We developed an efficient workflow named u... (Source: Molecular Cancer)
Source: Molecular Cancer - February 4, 2023 Category: Cancer & Oncology Authors: Kaiwei Yang, Hailong Hu, Junlong Wu, Huina Wang, Zhaoxia Guo, Wei Yu, Lin Yao, Feng Ding, Tao Zhou, Wang Wang, Yunkai Wang, Lei Liu, Jing Guo, Shuaipeng Zhu, Xinhao Zhang, Shanbo Cao & hellip; Tags: Correspondence Source Type: research
Regulatory cells and the effect of cancer immunotherapy
Several mechanisms and cell types are involved in the regulation of the immune response. These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid suppressor cells (MDSCs) and ot... (Source: Molecular Cancer)
Source: Molecular Cancer - February 4, 2023 Category: Cancer & Oncology Authors: Mar ía Iglesias-Escudero, Noelia Arias-González and Eva Martínez-Cáceres Tags: Review Source Type: research
Immunotherapies in rare cancers
Cancer remains a leading cause of death worldwide, placing a significant burden on healthcare systems as well as the global economy. Rare cancers comprise a group of about 200 cancers that individually occur a... (Source: Molecular Cancer)
Source: Molecular Cancer - February 1, 2023 Category: Cancer & Oncology Authors: Sneha Vivekanandhan, Deborah Bahr, Ashish Kothari, Mohammed Ali Ashary, Mizba Baksh and Emmanuel Gabriel Tags: Review Source Type: research
Retraction Note: Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0899-5. (Source: Molecular Cancer)
Source: Molecular Cancer - February 1, 2023 Category: Cancer & Oncology Authors: Qi Wu, Si Sun, Zhiyu Li, Qian Yang, Bei Li, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Changhua Yang, Juanjuan Li and Shengrong Sun Tags: Retraction Note Source Type: research
Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network
Excessive extracellular matrix deposition and increased stiffness are typical features of solid tumors such as hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC). These conditions creat... (Source: Molecular Cancer)
Source: Molecular Cancer - January 31, 2023 Category: Cancer & Oncology Authors: Zihan Yang, Li Zhou, Tongxu Si, Siyuan Chen, Chengxi Liu, Kelvin Kaki Ng, Zesheng Wang, Zhiji Chen, Chan Qiu, Guopan Liu, Qingliang Wang, Xiaoyu Zhou, Liang Zhang, Zhongping Yao, Song He, Mengsu Yang & hellip; Tags: Research Source Type: research
CAR T cells: engineered immune cells to treat brain cancers and beyond
Malignant brain tumors rank among the most challenging type of malignancies to manage. The current treatment protocol commonly entails surgery followed by radiotherapy and/or chemotherapy, however, the median ... (Source: Molecular Cancer)
Source: Molecular Cancer - January 31, 2023 Category: Cancer & Oncology Authors: Zoufang Huang, Saikat Dewanjee, Pratik Chakraborty, Niraj Kumar Jha, Abhijit Dey, Moumita Gangopadhyay, Xuan-Yu Chen, Jian Wang and Saurabh Kumar Jha Tags: Review Source Type: research
CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach to fight cancers. This approach consists of genetically engineered immune cells expressi... (Source: Molecular Cancer)
Source: Molecular Cancer - January 30, 2023 Category: Cancer & Oncology Authors: Karama Makni Maalej, Maysaloun Merhi, Varghese P. Inchakalody, Sarra Mestiri, Majid Alam, Cristina Maccalli, Honar Cherif, Shahab Uddin, Martin Steinhoff, Francesco M. Marincola and Said Dermime Tags: Review Source Type: research
Correction: circCYP24A1 facilitates esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF- κB-induced CCL5 secretion
(Source: Molecular Cancer)
Source: Molecular Cancer - January 26, 2023 Category: Cancer & Oncology Authors: Lina Gu, Yang Sang, Xixi Nan, Yang Zheng, Fei Liu, Lingjiao Meng, Meixiang Sang and Baoen Shan Tags: Correction Source Type: research
Targeting Pim kinases in hematological cancers: molecular and clinical review
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell prolife... (Source: Molecular Cancer)
Source: Molecular Cancer - January 25, 2023 Category: Cancer & Oncology Authors: Marcia Bellon and Christophe Nicot Tags: Review Source Type: research
Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution
Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the l... (Source: Molecular Cancer)
Source: Molecular Cancer - January 24, 2023 Category: Cancer & Oncology Authors: Johannes Robert Fleischer, Alexandra Maria Schmitt, Gwendolyn Haas, Xingbo Xu, Elisabeth Maria Zeisberg, Hanibal Bohnenberger, Stefan K üffer, Laure-Anne Teuwen, Philipp Johannes Karras, Tim Beißbarth, Annalen Bleckmann, Mélanie Planque, Sarah-Maria Fe Tags: Research Source Type: research
