Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis
The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic adenocarcinoma (PDAC) stems from their extremely low concentration in the whole circulating blood, necessitating enhanced detecti... (Source: Molecular Cancer)
Source: Molecular Cancer - November 13, 2023 Category: Cancer & Oncology Authors: Nikolas H. Stoecklein, Georg Fluegen, Rosa Guglielmi, Rui P.L. Neves, Thilo Hackert, Emrullah Birgin, Stefan A. Cieslik, Monica Sudarsanam, Christiane Driemel, Guus van Dalum, Andr é Franken, Dieter Niederacher, Hans Neubauer, Tanja Fehm, Jutta M. Rox, P Tags: Correspondence Source Type: research
Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: immune escape mechanisms and current implications for therapy
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the expansion of immature myeloid cells in the bone marrow (BM) and peripheral blood (PB) resulting in failure of normal hematopoiesis a... (Source: Molecular Cancer)
Source: Molecular Cancer - November 11, 2023 Category: Cancer & Oncology Authors: Tatjana Sauerer, Giuliano Filippini Vel ázquez and Christoph Schmid Tags: Review Source Type: research
Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia
Although the development of BCR::ABL1 tyrosine kinase inhibitors (TKIs) rendered chronic myeloid leukemia (CML) a manageable condition, acquisition of drug resistance during blast phase (BP) progression remain... (Source: Molecular Cancer)
Source: Molecular Cancer - November 6, 2023 Category: Cancer & Oncology Authors: Ji Eun Shin, Soo-Hyun Kim, Mingyu Kong, Hwa-Ryeon Kim, Sungmin Yoon, Kyung-Mi Kee, Jung Ah Kim, Dong Hyeon Kim, So Yeon Park, Jae Hyung Park, Hongtae Kim, Kyoung Tai No, Han-Woong Lee, Heon Yung Gee, Seunghee Hong, Kun-Liang Guan & hellip; Tags: Research Source Type: research
Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid
Knowing the homologous recombination deficiency (HRD) status in advanced epithelial ovarian cancer (EOC) is vital for patient management. HRD is determined by BRCA1/BRCA2 pathogenic variants or genomic instabi... (Source: Molecular Cancer)
Source: Molecular Cancer - November 6, 2023 Category: Cancer & Oncology Authors: Cyril Roussel-Simonin, Felix Blanc-Durand, Roseline Tang, Damien Vasseur, Audrey Le Formal, Laure Chardin, Elisa Yaniz, S ébastien Gouy, Amandine Maulard, Stéphanie Scherier, Claire Sanson, Ludovic Lacroix, Sophie Cotteret, Lea Mauny, François Zaccarin Tags: Research Source Type: research
CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Noncoding RNAs such as circular RNAs (circRNAs) are abundant in the human body and influence the occurrence and development of various diseases. Non-small cell lung cancer (NSCLC) is one of the most common mal... (Source: Molecular Cancer)
Source: Molecular Cancer - November 6, 2023 Category: Cancer & Oncology Authors: Yumeng Cui, Xiaojie Wu, Jie Jin, Weiling Man, Jie Li, Xiang Li, Yanghua Li, He Yao, Rongbin Zhong, Shiyun Chen, Jiahui Wu, Tianhao Zhu, Yanli Lin, Junjie Xu and Youliang Wang Tags: Research Source Type: research
Circulating tumor DNA landscape and prognostic impact of acquired resistance to targeted therapies in cancer patients: a national center for precision medicine (PRISM) study
Despite the effectiveness of the various targeted therapies currently approved for solid tumors, acquired resistance remains a persistent problem that limits the ultimate effectiveness of these treatments. Pol... (Source: Molecular Cancer)
Source: Molecular Cancer - November 4, 2023 Category: Cancer & Oncology Authors: Arnaud Bayle, Laila Belcaid, Lola-Jade Palmieri, Diego Teysonneau, Sophie Cousin, Mariella Spalato-Ceruso, Mihaela Aldea, Damien Vasseur, Melissa Alame, Laura Blouin, Isabelle Soubeyran, Claudio Nicotra, Maud Ngocamus, Antoine Hollebecque, Yohann Loriot, Tags: Correspondence Source Type: research
Correction: PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
(Source: Molecular Cancer)
Source: Molecular Cancer - October 30, 2023 Category: Cancer & Oncology Authors: Martina S. J. McDermott, Brigid C. Browne, Neil T. Conlon, Neil A. O ’Brien, Dennis J. Slamon, Michael Henry, Paula Meleady, Martin Clynes, Paul Dowling, John Crown and Norma O’Donovan Tags: Correction Source Type: research
circPSD3 is a promising inhibitor of uPA system to inhibit vascular invasion and metastasis in hepatocellular carcinoma
Vascular invasion is a major route for intrahepatic and distant metastasis in hepatocellular carcinoma (HCC) and is a strong negative prognostic factor. Circular RNAs (circRNAs) play important roles in tumorig... (Source: Molecular Cancer)
Source: Molecular Cancer - October 26, 2023 Category: Cancer & Oncology Authors: Liangliang Xu, Peng Wang, Li Li, Lian Li, Yang Huang, Yanfang Zhang, Xiaobo Zheng, Pengsheng Yi, Ming Zhang and Mingqing Xu Tags: Research Source Type: research
Correction: CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling
(Source: Molecular Cancer)
Source: Molecular Cancer - October 23, 2023 Category: Cancer & Oncology Authors: Tao Xie, Du-jiang Fu, Zhi-min Li, Dao-jun Lv, Xian-Lu Song, Yu-zhong Yu, Chong Wang, Kang-jin Li, Baoqian Zhai, Jiacheng Wu, Ning-Han Feng and Shan-Chao Zhao Tags: Correction Source Type: research
The strategies to cure cancer patients by eradicating cancer stem-like cells
Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a crucial factor contributing ... (Source: Molecular Cancer)
Source: Molecular Cancer - October 18, 2023 Category: Cancer & Oncology Authors: Yansui Mai, Jiyan Su, Chuan Yang, Chenglai Xia and Liwu Fu Tags: Review Source Type: research
Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their behavior is regulated throu... (Source: Molecular Cancer)
Source: Molecular Cancer - October 18, 2023 Category: Cancer & Oncology Authors: Zhen Zeng, Minyang Fu, Yuan Hu, Yuquan Wei, Xiawei Wei and Min Luo Tags: Review Source Type: research
Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated analysis of spatial and single-ce... (Source: Molecular Cancer)
Source: Molecular Cancer - October 13, 2023 Category: Cancer & Oncology Authors: Chenxi Ma, Chengzhe Yang, Ai Peng, Tianyong Sun, Xiaoli Ji, Jun Mi, Li Wei, Song Shen and Qiang Feng Tags: Research Source Type: research
Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation
The use of nanotechnology has the potential to revolutionize the detection and treatment of cancer. Developments in protein engineering and materials science have led to the emergence of new nanoscale targetin... (Source: Molecular Cancer)
Source: Molecular Cancer - October 9, 2023 Category: Cancer & Oncology Authors: Mohammad Chehelgerdi, Matin Chehelgerdi, Omer Qutaiba B. Allela, Renzon Daniel Cosme Pecho, Narayanan Jayasankar, Devendra Pratap Rao, Tamilanban Thamaraikani, Manimaran Vasanthan, Patrik Viktor, Natrayan Lakshmaiya, Mohamed J. Saadh, Ayesha Amajd, Mabrou Tags: Review Source Type: research
A circulating cell-free DNA methylation signature for the detection of hepatocellular carcinoma
To address the shortcomings of current hepatocellular carcinoma (HCC) surveillance tests, we set out to find HCC-specific methylation markers and develop a highly sensitive polymerase chain reaction (PCR)-base... (Source: Molecular Cancer)
Source: Molecular Cancer - October 6, 2023 Category: Cancer & Oncology Authors: Si-Cho Kim, Da-Won Kim, Eun Ju Cho, Jin-Young Lee, Jiwon Kim, Chaesun Kwon, Jeongsil Kim-Ha, Suk Kyun Hong, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Won Kim, Woojin Kim, Hyunsoo Kim, Yoon Jun Kim & hellip; Tags: Correspondence Source Type: research
ERK mediates interferon gamma-induced melanoma cell death
Interferon-gamma (IFN γ) exerts potent growth inhibitory effects on a wide range of cancer cells through unknown signaling pathways. We pursued complementary screening approaches to characterize the growth inhi... (Source: Molecular Cancer)
Source: Molecular Cancer - October 6, 2023 Category: Cancer & Oncology Authors: Ameya Champhekar, Rachel Heymans, Justin Saco, Guillem Turon Font, Cynthia Gonzalez, Anne Gao, John Pham, June Lee, Ryan Maryoung, Egmidio Medina, Katie M. Campbell, Daniel Karin, David Austin, Robert Damioseaux and Antoni Ribas Tags: Research Source Type: research
