CAR T cells: engineered immune cells to treat brain cancers and beyond
Malignant brain tumors rank among the most challenging type of malignancies to manage. The current treatment protocol commonly entails surgery followed by radiotherapy and/or chemotherapy, however, the median ... (Source: Molecular Cancer)
Source: Molecular Cancer - January 31, 2023 Category: Cancer & Oncology Authors: Zoufang Huang, Saikat Dewanjee, Pratik Chakraborty, Niraj Kumar Jha, Abhijit Dey, Moumita Gangopadhyay, Xuan-Yu Chen, Jian Wang and Saurabh Kumar Jha Tags: Review Source Type: research
CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach to fight cancers. This approach consists of genetically engineered immune cells expressi... (Source: Molecular Cancer)
Source: Molecular Cancer - January 30, 2023 Category: Cancer & Oncology Authors: Karama Makni Maalej, Maysaloun Merhi, Varghese P. Inchakalody, Sarra Mestiri, Majid Alam, Cristina Maccalli, Honar Cherif, Shahab Uddin, Martin Steinhoff, Francesco M. Marincola and Said Dermime Tags: Review Source Type: research
Correction: circCYP24A1 facilitates esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF- κB-induced CCL5 secretion
(Source: Molecular Cancer)
Source: Molecular Cancer - January 26, 2023 Category: Cancer & Oncology Authors: Lina Gu, Yang Sang, Xixi Nan, Yang Zheng, Fei Liu, Lingjiao Meng, Meixiang Sang and Baoen Shan Tags: Correction Source Type: research
Targeting Pim kinases in hematological cancers: molecular and clinical review
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell prolife... (Source: Molecular Cancer)
Source: Molecular Cancer - January 25, 2023 Category: Cancer & Oncology Authors: Marcia Bellon and Christophe Nicot Tags: Review Source Type: research
Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution
Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the l... (Source: Molecular Cancer)
Source: Molecular Cancer - January 24, 2023 Category: Cancer & Oncology Authors: Johannes Robert Fleischer, Alexandra Maria Schmitt, Gwendolyn Haas, Xingbo Xu, Elisabeth Maria Zeisberg, Hanibal Bohnenberger, Stefan K üffer, Laure-Anne Teuwen, Philipp Johannes Karras, Tim Beißbarth, Annalen Bleckmann, Mélanie Planque, Sarah-Maria Fe Tags: Research Source Type: research
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR
hsa_circ_0001727 (circZKSCAN1) has been reported to be a tumor-associated circRNA by sponging microRNAs. Intriguingly, we found that circZKSCAN1 encoded a secretory peptide (circZKSaa) in the liver. The presen... (Source: Molecular Cancer)
Source: Molecular Cancer - January 23, 2023 Category: Cancer & Oncology Authors: Runjie Song, Shuoqian Ma, Jiajia Xu, Xin Ren, Peilan Guo, Huijiao Liu, Peng Li, Fan Yin, Mei Liu, Qiang Wang, Lei Yu, Jiali Liu, Binwei Duan, Nafis A. Rahman, S ławomir Wołczyński, Guangming Li & hellip; Tags: Research Source Type: research
Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance
Despite advances in early detection and therapies, cancer is still one of the most common causes of death worldwide. Since each tumor is unique, there is a need to implement personalized care and develop robus... (Source: Molecular Cancer)
Source: Molecular Cancer - January 21, 2023 Category: Cancer & Oncology Authors: Pavel Stejskal, Hani Goodarzi, Josef Srovnal, Mari án Hajdúch, Laura J. van ’t Veer and Mark Jesus M. Magbanua Tags: Review Source Type: research
A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer
(Source: Molecular Cancer)
Source: Molecular Cancer - January 20, 2023 Category: Cancer & Oncology Authors: Keisuke Okuno, Raju Kandimalla, Marta Mendiola, Francesc Balaguer, Luis Bujanda, Carlos Fernandez-Martos, Jorge Aparicio, Jaime Feliu, Masanori Tokunaga, Yusuke Kinugasa, Joan Maurel and Ajay Goel Tags: Correspondence Source Type: research
Correction: CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug
(Source: Molecular Cancer)
Source: Molecular Cancer - January 20, 2023 Category: Cancer & Oncology Authors: Yanping Liang, Junjie Cen, Yong Huang, Yong Fang, Yunfei Wang, Guannan Shu, Yihui Pan, Kangbo Huang, Jiaqi Dong, Mi Zhou, Yi Xu, Junhang Luo, Min Liu and Jiaxing Zhang Tags: Correction Source Type: research
Harnessing the MYB-dependent TAL1 5 ’super-enhancer for targeted therapy in T-ALL
The acquisition of genetic abnormalities engendering oncogene dysregulation underpins cancer development. Certain proto-oncogenes possess several dysregulation mechanisms, yet how each mechanism impacts clinic... (Source: Molecular Cancer)
Source: Molecular Cancer - January 18, 2023 Category: Cancer & Oncology Authors: Charlotte Smith, Aurore Touzart, Mathieu Simonin, Christine Tran-Quang, Guillaume Hypolite, Mehdi Latiri, Guillaume P. Andrieu, Estelle Balducci, Marie- Émilie Dourthe, Ashish Goyal, Françoise Huguet, Arnaud Petit, Norbert Ifrah, André Baruchel, Hervé Tags: Correspondence Source Type: research
Retraction Note: CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-019-0958-6. (Source: Molecular Cancer)
Source: Molecular Cancer - January 16, 2023 Category: Cancer & Oncology Authors: Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang and Hongyong Cao Tags: Retraction Note Source Type: research
Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer
Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor prognosis can be attributed to both troublesome detections at the initial stage, which makes the majority of the treatme... (Source: Molecular Cancer)
Source: Molecular Cancer - January 12, 2023 Category: Cancer & Oncology Authors: Zhe Liu, Neha Parveen, Urushi Rehman, Aisha Aziz, Afsana Sheikh, Mohammed A. S. Abourehab, Wei Guo, Junhao Huang, Zhenning Wang and Prashant Kesharwani Tags: Review Source Type: research
Correction: Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6 - methyladenosine of Notch1
(Source: Molecular Cancer)
Source: Molecular Cancer - January 12, 2023 Category: Cancer & Oncology Authors: Chaohui Gu, Zhiyu Wang, Naichun Zhou, Guanru Li, Yiping Kou, Yang Luo, Yidi Wang, Jinjian Yang and Fengyan Tian Tags: Correction Source Type: research
Advancements in nanoparticle-based treatment approaches for skin cancer therapy
Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously rising environmental changes, industrialization, and genetic m... (Source: Molecular Cancer)
Source: Molecular Cancer - January 12, 2023 Category: Cancer & Oncology Authors: Leli Zeng, B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Mohammed A. S. Abourehab, Zhe-Sheng Chen, Changhua Zhang, Jia Li and Prashant Kesharwani Tags: Review Source Type: research
Clinical application and detection techniques of liquid biopsy in gastric cancer
Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of tumor-related mortality. Endoscopy and serological tumor marker testing are currently the main methods of GC screening, a... (Source: Molecular Cancer)
Source: Molecular Cancer - January 11, 2023 Category: Cancer & Oncology Authors: Shuo Ma, Meiling Zhou, Yanhua Xu, Xinliang Gu, Mingyuan Zou, Gulinaizhaer Abudushalamu, Yuming Yao, Xiaobo Fan and Guoqiu Wu Tags: Review Source Type: research
