Antimicrobial Potential of Polyphenols: An Update on Alternative for Combating Antimicrobial Resistance
Med Chem. 2024 Apr 5. doi: 10.2174/0115734064277579240328142639. Online ahead of print.ABSTRACTThe last decade has encountered an increasing demand for plant-based natural antibiotics. This demand has led to more research-based investigations for natural sources of antimicrobial agents and published reports demonstrating that plant extracts are widely applied in modern medicine, reporting potential activity that may be due to polyphenol compounds. Interestingly, the effects of polyphenols on the sensitivity of bacteria to antibiotics have not been well-studied. Hence, the current review encompasses the prospective applicat...
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Alok Sharma None Anurag Jasleen Kaur Anuradh Kesharwani Vipan Parihar Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery
Med Chem. 2024 Apr 2. doi: 10.2174/0115734064277371240325105016. Online ahead of print.ABSTRACTViruses are acellular, microscopic, and mobile particles containing genetic particles, either DNA/RNA strands as nucleoproteins, responsible for 69,53,743 deaths till the year 2023. Curcumin and related compounds are among the areas of pivotal interest for researchers because of their versatile pharmacological profile. Chemically known as diferuloylmethane, which is a main constituent of turmeric along with demethoxycurcumin and bisdemethoxycurcumin, they have a broad spectrum of antiviral activity against viruses such as human i...
Source: Medicinal Chemistry - April 4, 2024 Category: Chemistry Authors: Archana Sharma Twinkle Sharma Rajveer Bhaskar Monika Ola Alok Sharma Vijay Kumar Thakur Prabodh Chander Sharma Source Type: research
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaym é (GBB) Reactions
CONCLUSION: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.PMID:38523542 | DOI:10.2174/0115734064282699240315042428 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Kaushal Naithani Subhendu Bhowmik Source Type: research
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaym é (GBB) Reactions
CONCLUSION: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.PMID:38523542 | DOI:10.2174/0115734064282699240315042428 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Kaushal Naithani Subhendu Bhowmik Source Type: research
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaym é (GBB) Reactions
CONCLUSION: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.PMID:38523542 | DOI:10.2174/0115734064282699240315042428 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Kaushal Naithani Subhendu Bhowmik Source Type: research
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaym é (GBB) Reactions
CONCLUSION: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.PMID:38523542 | DOI:10.2174/0115734064282699240315042428 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Kaushal Naithani Subhendu Bhowmik Source Type: research
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaym é (GBB) Reactions
CONCLUSION: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.PMID:38523542 | DOI:10.2174/0115734064282699240315042428 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Kaushal Naithani Subhendu Bhowmik Source Type: research
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaym é (GBB) Reactions
CONCLUSION: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.PMID:38523542 | DOI:10.2174/0115734064282699240315042428 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Kaushal Naithani Subhendu Bhowmik Source Type: research
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaym é (GBB) Reactions
CONCLUSION: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.PMID:38523542 | DOI:10.2174/0115734064282699240315042428 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Kaushal Naithani Subhendu Bhowmik Source Type: research
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaym é (GBB) Reactions
CONCLUSION: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.PMID:38523542 | DOI:10.2174/0115734064282699240315042428 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Kaushal Naithani Subhendu Bhowmik Source Type: research
Predicting the Efficacy of Novel Synthetic Compounds in the Treatment of Osteosarcoma via Anti-Receptor Activator of Nuclear Factor- κB Ligand (RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) Targets
CONCLUSION: The analytic scrutiny of both algorithms underscores their commendable reliability in forecasting the efficacy of nascent compounds. A juxtaposition based on correlation coefficients elucidates that the GEP algorithm exhibits superior predictive prowess relative to the HM algorithm for novel synthetic compounds.PMID:38468522 | DOI:10.2174/0115734064287922240222115200 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Wenhua Zhang Siping Xu Peng Liu Xusheng Li Xinyuan Yu Bing Kang Source Type: research
