Ligand-Based and Structure-Based Virtual Screening of New Sodium Glucose Cotransporter Type 2 Inhibitors
CONCLUSION: These compounds are proposed as potential SGLT2 inhibitors.PMID:37534786 | DOI:10.2174/1573406419666230803122020 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - August 3, 2023 Category: Chemistry Authors: Ana Karen Estrada Domingo Mendez-Alvarez Alfredo Juarez-Saldivar Edgar E Lara-Ramirez Ana Veronica Martinez-Vazquez Juan Carlos Villalobos-Rocha Isidro Palos Eyra Ortiz-Perez Gildardo Rivera Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
