An Overview of Various Rifampicin Analogs against Mycobacterium tuberculosis and their Drug Interactions
Med Chem. 2023 Oct 5. doi: 10.2174/0115734064260853230926080134. Online ahead of print.ABSTRACTThe success of the TB control program is hampered by the major issue of drug-resistant tuberculosis (DR-TB). The situation has undoubtedly been made more difficult by the widespread and multidrug-resistant (XDR) strains of TB. The modification of existing anti-TB medications to produce derivatives that can function on resistant TB bacilli is one of the potential techniques to overcome drug resistance affordably and straightforwardly. In comparison to novel pharmaceuticals for drug research and progress, these may have a better ha...
Source: Medicinal Chemistry - October 19, 2023 Category: Chemistry Authors: Mohammad Asif Naeem F Qusty Saad Alghamdi Source Type: research
Synthetic Methods for Various Chromeno-fused Heterocycles and their Potential as Antimicrobial Agents
Med Chem. 2023 Oct 6. doi: 10.2174/0115734064274748231005074100. Online ahead of print.ABSTRACTChromenes are a significant family of heterocyclic chemicals that have a wide range of biological applications, a simple chemical structure, and only mildly undesirable side effects. The synthesis of a wide range of chromene analogs that displayed unexpected behaviors via numerous mechanisms was investigated by a number of different research teams, which led to the discovery of multiple pathways for their synthesis. In addition, different chromene-fused heterocycles exhibit a wide variety of fascinating biological actions, includ...
Source: Medicinal Chemistry - October 19, 2023 Category: Chemistry Authors: Neetu Agrawal Radhika Goswami Shilpi Pathak Source Type: research
An Overview of Various Rifampicin Analogs against Mycobacterium tuberculosis and their Drug Interactions
Med Chem. 2023 Oct 5. doi: 10.2174/0115734064260853230926080134. Online ahead of print.ABSTRACTThe success of the TB control program is hampered by the major issue of drug-resistant tuberculosis (DR-TB). The situation has undoubtedly been made more difficult by the widespread and multidrug-resistant (XDR) strains of TB. The modification of existing anti-TB medications to produce derivatives that can function on resistant TB bacilli is one of the potential techniques to overcome drug resistance affordably and straightforwardly. In comparison to novel pharmaceuticals for drug research and progress, these may have a better ha...
Source: Medicinal Chemistry - October 19, 2023 Category: Chemistry Authors: Mohammad Asif Naeem F Qusty Saad Alghamdi Source Type: research
Synthetic Methods for Various Chromeno-fused Heterocycles and their Potential as Antimicrobial Agents
Med Chem. 2023 Oct 6. doi: 10.2174/0115734064274748231005074100. Online ahead of print.ABSTRACTChromenes are a significant family of heterocyclic chemicals that have a wide range of biological applications, a simple chemical structure, and only mildly undesirable side effects. The synthesis of a wide range of chromene analogs that displayed unexpected behaviors via numerous mechanisms was investigated by a number of different research teams, which led to the discovery of multiple pathways for their synthesis. In addition, different chromene-fused heterocycles exhibit a wide variety of fascinating biological actions, includ...
Source: Medicinal Chemistry - October 19, 2023 Category: Chemistry Authors: Neetu Agrawal Radhika Goswami Shilpi Pathak Source Type: research
An Overview of Various Rifampicin Analogs against Mycobacterium tuberculosis and their Drug Interactions
Med Chem. 2023 Oct 5. doi: 10.2174/0115734064260853230926080134. Online ahead of print.ABSTRACTThe success of the TB control program is hampered by the major issue of drug-resistant tuberculosis (DR-TB). The situation has undoubtedly been made more difficult by the widespread and multidrug-resistant (XDR) strains of TB. The modification of existing anti-TB medications to produce derivatives that can function on resistant TB bacilli is one of the potential techniques to overcome drug resistance affordably and straightforwardly. In comparison to novel pharmaceuticals for drug research and progress, these may have a better ha...
Source: Medicinal Chemistry - October 19, 2023 Category: Chemistry Authors: Mohammad Asif Naeem F Qusty Saad Alghamdi Source Type: research
Synthetic Methods for Various Chromeno-fused Heterocycles and their Potential as Antimicrobial Agents
Med Chem. 2023 Oct 6. doi: 10.2174/0115734064274748231005074100. Online ahead of print.ABSTRACTChromenes are a significant family of heterocyclic chemicals that have a wide range of biological applications, a simple chemical structure, and only mildly undesirable side effects. The synthesis of a wide range of chromene analogs that displayed unexpected behaviors via numerous mechanisms was investigated by a number of different research teams, which led to the discovery of multiple pathways for their synthesis. In addition, different chromene-fused heterocycles exhibit a wide variety of fascinating biological actions, includ...
Source: Medicinal Chemistry - October 19, 2023 Category: Chemistry Authors: Neetu Agrawal Radhika Goswami Shilpi Pathak Source Type: research
Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
A Profound Insight into the Structure-activity Relationship of Ubiquitous Scaffold Piperazine: An Explicative Review
Med Chem. 2023 Oct 5. doi: 10.2174/0115734064244117230923172611. Online ahead of print.ABSTRACTDespite extensive research in the field of drug discovery and development, still there is a need to develop novel molecular entities. Literature reveals a substantial heterocyclic nucleus named, piperazine, which shows an immense therapeutic voyage. For several decades, molecules having the piperazine nucleus have entered the market as a drug exhibiting biological potential. It was known to possess antipsychotic, antihistamine, antianginal, antidepressant, anticancer, antiviral, cardioprotective, and anti-inflammatory activity wi...
Source: Medicinal Chemistry - October 10, 2023 Category: Chemistry Authors: Jasmine Chaudhary Vishal Sharma Akash Jain Diksha Sharma Bhawna Chopra Ashwani K Dhingra Source Type: research
In-silico Investigations for the Identification of Novel Inhibitors Targeting Hepatitis C Virus RNA-dependent RNA Polymerase
CONCLUSION: Data from exhaustive computational studies proposed eight molecules as potential anti-viral candidates, targeting Hepatitis C viral RNA Dependent RNA polymerases, which can be further evaluated for their biological potential.PMID:37815178 | DOI:10.2174/0115734064255683230919071808 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - October 10, 2023 Category: Chemistry Authors: Shailaja Mallya Raghuvir R S Pissurlenkar Source Type: research
