Exploring the Therapeutic Marvels: A Comprehensive Review on the Biological Potential of Quinoline-5,8-Dione
Med Chem. 2024 Jan 3. doi: 10.2174/0115734064287677231215070816. Online ahead of print.ABSTRACTQuinoline-5,8-diones, also referred to as 5,8-quinolinediones or quinolinequinones, have been researched extensively for their antiproliferative effects, where they displayed great results. Other than anticancer, they exhibit multiple activities such as antimalarial, antiviral, antibacterial, and antifungal activities. Natural quinolinequinones have also been known for their significant activities. The review highlights the diverse biological activities exhibited by synthetic quinoline- 5,8-diones over the past two decades. Conti...
Source: Medicinal Chemistry - January 4, 2024 Category: Chemistry Authors: Neetu Agrawal Dimple Bansal Shilpi Pathak Source Type: research
Exploring the Therapeutic Marvels: A Comprehensive Review on the Biological Potential of Quinoline-5,8-Dione
Med Chem. 2024 Jan 3. doi: 10.2174/0115734064287677231215070816. Online ahead of print.ABSTRACTQuinoline-5,8-diones, also referred to as 5,8-quinolinediones or quinolinequinones, have been researched extensively for their antiproliferative effects, where they displayed great results. Other than anticancer, they exhibit multiple activities such as antimalarial, antiviral, antibacterial, and antifungal activities. Natural quinolinequinones have also been known for their significant activities. The review highlights the diverse biological activities exhibited by synthetic quinoline- 5,8-diones over the past two decades. Conti...
Source: Medicinal Chemistry - January 4, 2024 Category: Chemistry Authors: Neetu Agrawal Dimple Bansal Shilpi Pathak Source Type: research
Exploring the Therapeutic Marvels: A Comprehensive Review on the Biological Potential of Quinoline-5,8-Dione
Med Chem. 2024 Jan 3. doi: 10.2174/0115734064287677231215070816. Online ahead of print.ABSTRACTQuinoline-5,8-diones, also referred to as 5,8-quinolinediones or quinolinequinones, have been researched extensively for their antiproliferative effects, where they displayed great results. Other than anticancer, they exhibit multiple activities such as antimalarial, antiviral, antibacterial, and antifungal activities. Natural quinolinequinones have also been known for their significant activities. The review highlights the diverse biological activities exhibited by synthetic quinoline- 5,8-diones over the past two decades. Conti...
Source: Medicinal Chemistry - January 4, 2024 Category: Chemistry Authors: Neetu Agrawal Dimple Bansal Shilpi Pathak Source Type: research
Exploring the Therapeutic Marvels: A Comprehensive Review on the Biological Potential of Quinoline-5,8-Dione
Med Chem. 2024 Jan 3. doi: 10.2174/0115734064287677231215070816. Online ahead of print.ABSTRACTQuinoline-5,8-diones, also referred to as 5,8-quinolinediones or quinolinequinones, have been researched extensively for their antiproliferative effects, where they displayed great results. Other than anticancer, they exhibit multiple activities such as antimalarial, antiviral, antibacterial, and antifungal activities. Natural quinolinequinones have also been known for their significant activities. The review highlights the diverse biological activities exhibited by synthetic quinoline- 5,8-diones over the past two decades. Conti...
Source: Medicinal Chemistry - January 4, 2024 Category: Chemistry Authors: Neetu Agrawal Dimple Bansal Shilpi Pathak Source Type: research
4D-QSAR and MIA-QSAR Studies of Aminobenzimidazole Derivatives as Fourth-generation EGFR Inhibitors
CONCLUSION: These results will provide theoretical guidance for the research and development of aminobenzimidazole derivatives as new EGFRdel19 T790M C797S inhibitors.PMID:37957859 | DOI:10.2174/0115734064258994231106052633 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xuegong Jia Chaochun Wei Nana Tian Hong Yan Hongjun Wang Source Type: research
Determination of Novel SARS-CoV-2 Inhibitors by Combination of Machine Learning and Molecular Modeling Methods
CONCLUSION: The results confirmed that the ChEMBL ID:1193133 compound showed good Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), hydrogen bonding, and remaining time in the active site; therefore, it was considered that it could be active against the virus. This compound was also tested for antiviral activity, and it was determined that it did not delay viral infection, although it was cytotoxic between 5mg/mL-1.25mg/mL concentrations. However, if other compounds could be tested, it might provide a chance to obtain activity, and compounds should also be tested against the enzymes as well as the oth...
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Ersin G üner Özgür Özkan G özde Yalcin Ozkat S üreyya Ölgen Source Type: research
4D-QSAR and MIA-QSAR Studies of Aminobenzimidazole Derivatives as Fourth-generation EGFR Inhibitors
CONCLUSION: These results will provide theoretical guidance for the research and development of aminobenzimidazole derivatives as new EGFRdel19 T790M C797S inhibitors.PMID:37957859 | DOI:10.2174/0115734064258994231106052633 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xuegong Jia Chaochun Wei Nana Tian Hong Yan Hongjun Wang Source Type: research
Determination of Novel SARS-CoV-2 Inhibitors by Combination of Machine Learning and Molecular Modeling Methods
CONCLUSION: The results confirmed that the ChEMBL ID:1193133 compound showed good Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), hydrogen bonding, and remaining time in the active site; therefore, it was considered that it could be active against the virus. This compound was also tested for antiviral activity, and it was determined that it did not delay viral infection, although it was cytotoxic between 5mg/mL-1.25mg/mL concentrations. However, if other compounds could be tested, it might provide a chance to obtain activity, and compounds should also be tested against the enzymes as well as the oth...
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Ersin G üner Özgür Özkan G özde Yalcin Ozkat S üreyya Ölgen Source Type: research
4D-QSAR and MIA-QSAR Studies of Aminobenzimidazole Derivatives as Fourth-generation EGFR Inhibitors
CONCLUSION: These results will provide theoretical guidance for the research and development of aminobenzimidazole derivatives as new EGFRdel19 T790M C797S inhibitors.PMID:37957859 | DOI:10.2174/0115734064258994231106052633 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xuegong Jia Chaochun Wei Nana Tian Hong Yan Hongjun Wang Source Type: research
Determination of Novel SARS-CoV-2 Inhibitors by Combination of Machine Learning and Molecular Modeling Methods
CONCLUSION: The results confirmed that the ChEMBL ID:1193133 compound showed good Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), hydrogen bonding, and remaining time in the active site; therefore, it was considered that it could be active against the virus. This compound was also tested for antiviral activity, and it was determined that it did not delay viral infection, although it was cytotoxic between 5mg/mL-1.25mg/mL concentrations. However, if other compounds could be tested, it might provide a chance to obtain activity, and compounds should also be tested against the enzymes as well as the oth...
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Ersin G üner Özgür Özkan G özde Yalcin Ozkat S üreyya Ölgen Source Type: research
4D-QSAR and MIA-QSAR Studies of Aminobenzimidazole Derivatives as Fourth-generation EGFR Inhibitors
CONCLUSION: These results will provide theoretical guidance for the research and development of aminobenzimidazole derivatives as new EGFRdel19 T790M C797S inhibitors.PMID:37957859 | DOI:10.2174/0115734064258994231106052633 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xuegong Jia Chaochun Wei Nana Tian Hong Yan Hongjun Wang Source Type: research
Determination of Novel SARS-CoV-2 Inhibitors by Combination of Machine Learning and Molecular Modeling Methods
CONCLUSION: The results confirmed that the ChEMBL ID:1193133 compound showed good Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), hydrogen bonding, and remaining time in the active site; therefore, it was considered that it could be active against the virus. This compound was also tested for antiviral activity, and it was determined that it did not delay viral infection, although it was cytotoxic between 5mg/mL-1.25mg/mL concentrations. However, if other compounds could be tested, it might provide a chance to obtain activity, and compounds should also be tested against the enzymes as well as the oth...
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Ersin G üner Özgür Özkan G özde Yalcin Ozkat S üreyya Ölgen Source Type: research
4D-QSAR and MIA-QSAR Studies of Aminobenzimidazole Derivatives as Fourth-generation EGFR Inhibitors
CONCLUSION: These results will provide theoretical guidance for the research and development of aminobenzimidazole derivatives as new EGFRdel19 T790M C797S inhibitors.PMID:37957859 | DOI:10.2174/0115734064258994231106052633 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xuegong Jia Chaochun Wei Nana Tian Hong Yan Hongjun Wang Source Type: research
Determination of Novel SARS-CoV-2 Inhibitors by Combination of Machine Learning and Molecular Modeling Methods
CONCLUSION: The results confirmed that the ChEMBL ID:1193133 compound showed good Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), hydrogen bonding, and remaining time in the active site; therefore, it was considered that it could be active against the virus. This compound was also tested for antiviral activity, and it was determined that it did not delay viral infection, although it was cytotoxic between 5mg/mL-1.25mg/mL concentrations. However, if other compounds could be tested, it might provide a chance to obtain activity, and compounds should also be tested against the enzymes as well as the oth...
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Ersin G üner Özgür Özkan G özde Yalcin Ozkat S üreyya Ölgen Source Type: research
4D-QSAR and MIA-QSAR Studies of Aminobenzimidazole Derivatives as Fourth-generation EGFR Inhibitors
CONCLUSION: These results will provide theoretical guidance for the research and development of aminobenzimidazole derivatives as new EGFRdel19 T790M C797S inhibitors.PMID:37957859 | DOI:10.2174/0115734064258994231106052633 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Xuegong Jia Chaochun Wei Nana Tian Hong Yan Hongjun Wang Source Type: research
