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Synthesis, Antimicrobial Evaluation, and Interaction of Emodin Alkyl Azoles with DNA and HSA
CONCLUSION: This work may supply useful directions for the exploration of novel antimicrobial agents.PMID:38351695 | DOI:10.2174/0115734064283049240124115544 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - February 14, 2024 Category: Chemistry Authors: Yu-Hang Zhou Ying Wang Hui-Zhen Zhang Source Type: research

Pharmacochemical Study of Multitarget Amino Acids' Hybrids. Design, Synthesis, In vitro, and In silico Studies
Med Chem. 2024 Feb 9. doi: 10.2174/0115734064279653240125081042. Online ahead of print.ABSTRACTNeuro-inflammation is a complex phenomenon resulting in several disorders. ALOX-5, COX-2, pro-inflammatory enzymes, and amino acid neurotransmitters are tightly correlated to neuro- inflammatory pathologies. Developing drugs that interfere with these targets will offer treatment for various diseases. Herein, we extend our previous research by synthesizing a series of multitarget hybrids of cinnamic acids with amino acids recognized as neurotransmitters. The synthesis was based on an in silico study of a library of cinnamic amide ...
Source: Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Dimitra Hadjipavlou-Litina Ioannis Fotopoulos Eleni Pontiki Source Type: research

New Analogues of the Nicotinamide Phosphoribosyltransferase Inhibitor FK866 as Potential Anti-Pancreatic Cancer Agents
CONCLUSION: The positive results observed for some newly synthesized molecules, particularly those carrying a thiophene unit as a tail group, indicate that they could act as in vivo anti-pancreatic cancer agents.PMID:38333979 | DOI:10.2174/0115734064289584240121142405 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Irene Conforti Andrea Benzi Irene Caffa Santina Bruzzone Alessio Nencioni Alberto Marra Source Type: research

Heterocyclic-Based Analogues against Sarcine-Ricin Loop RNA from Escherichia coli: In Silico Molecular Docking Study and Machine Learning Classifiers
CONCLUSION: The dataset from the molecular docking study was used for additional optimum analysis, and the molecular descriptors were classified using a variety of machine learning classifiers, including the GB Classifier, CB Classifier, RF Classifier, SV Classifier, KNN Classifier, and Voting Classifier. The research presented here showed that heterocyclic derivatives may operate as potent antibacterial agents when combined with other compounds to produce highly efficient antibacterial agents.PMID:38333980 | DOI:10.2174/0115734064266329231228050535 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - February 9, 2024 Category: Chemistry Authors: Shivangi Sharma Rahul Choubey Manish Gupta Shivendra Singh Source Type: research

Systematic Review On Major Antiviral Phytocompounds from Common Medicinal Plants Against SARS-CoV-2
CONCLUSION: The best advantage is that these phytocompounds being derived from nature in most of the cases, come with minimum or no side effects compared to that of chemically synthesized conventional bioactive compounds and are indigenously available hence are the source of cost effective drug formulations with strong therapeutic potentials.PMID:38317467 | DOI:10.2174/0115734064262843231120051452 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - February 6, 2024 Category: Chemistry Authors: Suvendu Ghosh Partha Singha Lakshmi Kanta Das Debosree Ghosh Source Type: research