Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents
CONCLUSION: These results indicate that compound 13e is excellent candicate for further study as a potential antibacterial agent.PMID:37767798 | DOI:10.2174/0115734064248204230919074743 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 28, 2023 Category: Chemistry Authors: Wen-Bo Xu Siqi Li Chang-Ji Zheng Yu-Xuan Yang Changhao Zhang Cheng-Hua Jin Source Type: research
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research
Design and Synthesis of New bis-oxindole and Spiro(triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
CONCLUSION: According to all of the findings, bis-oxindole 3c shows promise as a cancer treatment targeting CDK4.PMID:37723960 | DOI:10.2174/1573406419666230810124855 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Thoraya A Farghaly Rami Adel Pashameah Abrar Bayazeed Amerah M Al-Soliemy Amani M R Alsaedi Marwa F Harras Source Type: research
Diverse pharmacological potential of pyridazine analogs against various diseases
Med Chem. 2023 Sep 13. doi: 10.2174/1573406419666230913102835. Online ahead of print.ABSTRACTPyridazinone analogs possess diverse types of pharmacological activities, such as anticancer, antimicrobial, anticonvulsant, analgesic, anti-inflammatory, antioxidant, antihypertensive, antisecretory, antiulcer, and other useful pharmacological activities. They also possess cyclooxygenase (COX) inhibitors, dipeptidyl peptidase inhibitors, phosphodiesterase inhibitors, glutamate transporter activators, adenosine receptor antagonists, serotonin receptors antagonists, lipooxygenase, cholinesterase, vasodilator, and anesthetics. Pyrida...
Source: Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Mohammad Asif Mazen M Almehmadi Ahad Amer Alsaiari Source Type: research
Diverse pharmacological potential of pyridazine analogs against various diseases
Med Chem. 2023 Sep 13. doi: 10.2174/1573406419666230913102835. Online ahead of print.ABSTRACTPyridazinone analogs possess diverse types of pharmacological activities, such as anticancer, antimicrobial, anticonvulsant, analgesic, anti-inflammatory, antioxidant, antihypertensive, antisecretory, antiulcer, and other useful pharmacological activities. They also possess cyclooxygenase (COX) inhibitors, dipeptidyl peptidase inhibitors, phosphodiesterase inhibitors, glutamate transporter activators, adenosine receptor antagonists, serotonin receptors antagonists, lipooxygenase, cholinesterase, vasodilator, and anesthetics. Pyrida...
Source: Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Mohammad Asif Mazen M Almehmadi Ahad Amer Alsaiari Source Type: research
Diverse pharmacological potential of pyridazine analogs against various diseases
Med Chem. 2023 Sep 13. doi: 10.2174/1573406419666230913102835. Online ahead of print.ABSTRACTPyridazinone analogs possess diverse types of pharmacological activities, such as anticancer, antimicrobial, anticonvulsant, analgesic, anti-inflammatory, antioxidant, antihypertensive, antisecretory, antiulcer, and other useful pharmacological activities. They also possess cyclooxygenase (COX) inhibitors, dipeptidyl peptidase inhibitors, phosphodiesterase inhibitors, glutamate transporter activators, adenosine receptor antagonists, serotonin receptors antagonists, lipooxygenase, cholinesterase, vasodilator, and anesthetics. Pyrida...
Source: Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Mohammad Asif Mazen M Almehmadi Ahad Amer Alsaiari Source Type: research
Design, Synthesis And Anticonvulsant Activity Of Cinnamoyl Derivatives Of 3,4,6,7,8,9 Hexahydrodibenzo[B,D]Furan-1-(2h)-One Oxime
CONCLUSION: Molecular and pharmacophore modelling methods allowed us to create a new group of substituted cinnamoyl derivatives of 3,4,6,7,8,9 hexahydrodibenzo[b,d]furan-1-(2H)-one oxime with anticonvulsant activity.PMID:37694795 | DOI:10.2174/1573406419666230908121759 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Grigory V Mokrov Valentina E Birukova Tatiana Yu Vorobieva Andry S Pantileev Oksana S Grigorkevich Ludmila A Zhmurenko Alexey G Rebeko Felix S Bayburtskiy Svetlana A Litvinova Tatiana A Voronina Tatiana A Gudasheva Sergei B Seredenin Source Type: research
Design, Synthesis And Anticonvulsant Activity Of Cinnamoyl Derivatives Of 3,4,6,7,8,9 Hexahydrodibenzo[B,D]Furan-1-(2h)-One Oxime
CONCLUSION: Molecular and pharmacophore modelling methods allowed us to create a new group of substituted cinnamoyl derivatives of 3,4,6,7,8,9 hexahydrodibenzo[b,d]furan-1-(2H)-one oxime with anticonvulsant activity.PMID:37694795 | DOI:10.2174/1573406419666230908121759 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Grigory V Mokrov Valentina E Birukova Tatiana Yu Vorobieva Andry S Pantileev Oksana S Grigorkevich Ludmila A Zhmurenko Alexey G Rebeko Felix S Bayburtskiy Svetlana A Litvinova Tatiana A Voronina Tatiana A Gudasheva Sergei B Seredenin Source Type: research
Design, Synthesis And Anticonvulsant Activity Of Cinnamoyl Derivatives Of 3,4,6,7,8,9 Hexahydrodibenzo[B,D]Furan-1-(2h)-One Oxime
CONCLUSION: Molecular and pharmacophore modelling methods allowed us to create a new group of substituted cinnamoyl derivatives of 3,4,6,7,8,9 hexahydrodibenzo[b,d]furan-1-(2H)-one oxime with anticonvulsant activity.PMID:37694795 | DOI:10.2174/1573406419666230908121759 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Grigory V Mokrov Valentina E Birukova Tatiana Yu Vorobieva Andry S Pantileev Oksana S Grigorkevich Ludmila A Zhmurenko Alexey G Rebeko Felix S Bayburtskiy Svetlana A Litvinova Tatiana A Voronina Tatiana A Gudasheva Sergei B Seredenin Source Type: research
