A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
Med Chem. 2023 Jul 18. doi: 10.2174/1573406419666230718121644. Online ahead of print.ABSTRACTDementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-Synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of dementia after Alzheimer's disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation. Treatment of this disorder is generally symptomatic. This ...
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Menaka S Amuthalakshmi Sivaperuman Ramalakshmi Natarajan Keerthana Dhinakaran Source Type: research
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase with Tetrazole Core
CONCLUSION: These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.PMID:37464836 | DOI:10.2174/1573406419666230718152453 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Sara Mehrandish Elham Rezaee Anna Sedaghat Elmira Heidarli Nima Naderi Sayyed Abbas Tabatabai Source Type: research
In Silico Evaluation of Ferulic Acid Based Multifunctional Conjugates as Potential Drug Candidates
CONCLUSION: Cis FA, FA conjugates 3,5,and 6 act as good drug candidates that can be used to modify new hits.PMID:37448367 | DOI:10.2174/1573406419666230713161434 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 14, 2023 Category: Chemistry Authors: Hayat A Al-Btoush Mahmoud A Al-Sha'er Source Type: research
In Silico Evaluation of Ferulic Acid Based Multifunctional Conjugates as Potential Drug Candidates
CONCLUSION: Cis FA, FA conjugates 3,5,and 6 act as good drug candidates that can be used to modify new hits.PMID:37448367 | DOI:10.2174/1573406419666230713161434 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 14, 2023 Category: Chemistry Authors: Hayat A Al-Btoush Mahmoud A Al-Sha'er Source Type: research
In Silico Evaluation of Ferulic Acid Based Multifunctional Conjugates as Potential Drug Candidates
CONCLUSION: Cis FA, FA conjugates 3,5,and 6 act as good drug candidates that can be used to modify new hits.PMID:37448367 | DOI:10.2174/1573406419666230713161434 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 14, 2023 Category: Chemistry Authors: Hayat A Al-Btoush Mahmoud A Al-Sha'er Source Type: research
In Silico Evaluation of Ferulic Acid Based Multifunctional Conjugates as Potential Drug Candidates
CONCLUSION: Cis FA, FA conjugates 3,5,and 6 act as good drug candidates that can be used to modify new hits.PMID:37448367 | DOI:10.2174/1573406419666230713161434 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - July 14, 2023 Category: Chemistry Authors: Hayat A Al-Btoush Mahmoud A Al-Sha'er Source Type: research
An Explicative Review on The Current Advancement in Schiff Base-Metal Complexes as Anticancer Agents Evolved in The Past Decade: Medicinal chemistry aspects
Med Chem. 2023 Jul 7. doi: 10.2174/1573406419666230707105221. Online ahead of print.ABSTRACTIn the recent era, developments in the field of bio-inorganic chemistry have improved interest in Schiff base complexes (imine scaffolds) for their pharmacological excellence in different areas. Schiff bases are a kind of synthetic molecule that is synthesized by the condensation reaction between a 1o amine and a carbonyl compound. Imine derivatives are also acknowledged for their ability to form complexes with several metals. Due to their wide range of biological activities, they have acquired prominence in the therapeutic and phar...
Source: Medicinal Chemistry - July 10, 2023 Category: Chemistry Authors: Dipanjan Karati Swarupananda Mukherjee Souvik Roy Source Type: research
