Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
Breaking New Ground: The Dawn of Nanopharmaceutics as Antimicrobials
Med Chem. 2023 Oct 4. doi: 10.2174/0115734064267561230925060019. Online ahead of print.ABSTRACTIn the microscopic realm of pharmacology, we are witnessing a revolutionary era marked by the rapid evolution of nanopharmaceutics - a field converging the intricacies of nanotechnology with drug development. Emerging as a veritable force in the war against infectious diseases, nanopharmaceutics, coupled with antimicrobial applications, is pushing the boundaries of our fight against bacterial and viral pathogens. Drawing upon my experience in nanobioengineering, I'm excited to delve into recent advancements in this domain, demons...
Source: Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Jose Ruben Morones-Ramirez Source Type: research
A Profound Insight into the Structure-activity Relationship of Ubiquitous Scaffold Piperazine: An Explicative Review
Med Chem. 2023 Oct 5. doi: 10.2174/0115734064244117230923172611. Online ahead of print.ABSTRACTDespite extensive research in the field of drug discovery and development, still there is a need to develop novel molecular entities. Literature reveals a substantial heterocyclic nucleus named, piperazine, which shows an immense therapeutic voyage. For several decades, molecules having the piperazine nucleus have entered the market as a drug exhibiting biological potential. It was known to possess antipsychotic, antihistamine, antianginal, antidepressant, anticancer, antiviral, cardioprotective, and anti-inflammatory activity wi...
Source: Medicinal Chemistry - October 10, 2023 Category: Chemistry Authors: Jasmine Chaudhary Vishal Sharma Akash Jain Diksha Sharma Bhawna Chopra Ashwani K Dhingra Source Type: research
In-silico Investigations for the Identification of Novel Inhibitors Targeting Hepatitis C Virus RNA-dependent RNA Polymerase
CONCLUSION: Data from exhaustive computational studies proposed eight molecules as potential anti-viral candidates, targeting Hepatitis C viral RNA Dependent RNA polymerases, which can be further evaluated for their biological potential.PMID:37815178 | DOI:10.2174/0115734064255683230919071808 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - October 10, 2023 Category: Chemistry Authors: Shailaja Mallya Raghuvir R S Pissurlenkar Source Type: research
A Profound Insight into the Structure-activity Relationship of Ubiquitous Scaffold Piperazine: An Explicative Review
Med Chem. 2023 Oct 5. doi: 10.2174/0115734064244117230923172611. Online ahead of print.ABSTRACTDespite extensive research in the field of drug discovery and development, still there is a need to develop novel molecular entities. Literature reveals a substantial heterocyclic nucleus named, piperazine, which shows an immense therapeutic voyage. For several decades, molecules having the piperazine nucleus have entered the market as a drug exhibiting biological potential. It was known to possess antipsychotic, antihistamine, antianginal, antidepressant, anticancer, antiviral, cardioprotective, and anti-inflammatory activity wi...
Source: Medicinal Chemistry - October 10, 2023 Category: Chemistry Authors: Jasmine Chaudhary Vishal Sharma Akash Jain Diksha Sharma Bhawna Chopra Ashwani K Dhingra Source Type: research
In-silico Investigations for the Identification of Novel Inhibitors Targeting Hepatitis C Virus RNA-dependent RNA Polymerase
CONCLUSION: Data from exhaustive computational studies proposed eight molecules as potential anti-viral candidates, targeting Hepatitis C viral RNA Dependent RNA polymerases, which can be further evaluated for their biological potential.PMID:37815178 | DOI:10.2174/0115734064255683230919071808 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - October 10, 2023 Category: Chemistry Authors: Shailaja Mallya Raghuvir R S Pissurlenkar Source Type: research
Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents
CONCLUSION: These results indicate that compound 13e is excellent candicate for further study as a potential antibacterial agent.PMID:37767798 | DOI:10.2174/0115734064248204230919074743 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 28, 2023 Category: Chemistry Authors: Wen-Bo Xu Siqi Li Chang-Ji Zheng Yu-Xuan Yang Changhao Zhang Cheng-Hua Jin Source Type: research
Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents
CONCLUSION: These results indicate that compound 13e is excellent candicate for further study as a potential antibacterial agent.PMID:37767798 | DOI:10.2174/0115734064248204230919074743 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 28, 2023 Category: Chemistry Authors: Wen-Bo Xu Siqi Li Chang-Ji Zheng Yu-Xuan Yang Changhao Zhang Cheng-Hua Jin Source Type: research
Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents
CONCLUSION: These results indicate that compound 13e is excellent candicate for further study as a potential antibacterial agent.PMID:37767798 | DOI:10.2174/0115734064248204230919074743 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 28, 2023 Category: Chemistry Authors: Wen-Bo Xu Siqi Li Chang-Ji Zheng Yu-Xuan Yang Changhao Zhang Cheng-Hua Jin Source Type: research
Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents
CONCLUSION: These results indicate that compound 13e is excellent candicate for further study as a potential antibacterial agent.PMID:37767798 | DOI:10.2174/0115734064248204230919074743 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 28, 2023 Category: Chemistry Authors: Wen-Bo Xu Siqi Li Chang-Ji Zheng Yu-Xuan Yang Changhao Zhang Cheng-Hua Jin Source Type: research
Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents
CONCLUSION: These results indicate that compound 13e is excellent candicate for further study as a potential antibacterial agent.PMID:37767798 | DOI:10.2174/0115734064248204230919074743 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 28, 2023 Category: Chemistry Authors: Wen-Bo Xu Siqi Li Chang-Ji Zheng Yu-Xuan Yang Changhao Zhang Cheng-Hua Jin Source Type: research
Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents
CONCLUSION: These results indicate that compound 13e is excellent candicate for further study as a potential antibacterial agent.PMID:37767798 | DOI:10.2174/0115734064248204230919074743 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 28, 2023 Category: Chemistry Authors: Wen-Bo Xu Siqi Li Chang-Ji Zheng Yu-Xuan Yang Changhao Zhang Cheng-Hua Jin Source Type: research
Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents
CONCLUSION: These results indicate that compound 13e is excellent candicate for further study as a potential antibacterial agent.PMID:37767798 | DOI:10.2174/0115734064248204230919074743 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 28, 2023 Category: Chemistry Authors: Wen-Bo Xu Siqi Li Chang-Ji Zheng Yu-Xuan Yang Changhao Zhang Cheng-Hua Jin Source Type: research
Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents
CONCLUSION: These results indicate that compound 13e is excellent candicate for further study as a potential antibacterial agent.PMID:37767798 | DOI:10.2174/0115734064248204230919074743 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 28, 2023 Category: Chemistry Authors: Wen-Bo Xu Siqi Li Chang-Ji Zheng Yu-Xuan Yang Changhao Zhang Cheng-Hua Jin Source Type: research
