EGFR-specific single-chain variable fragment antibody-conjugated Fe3O4/Au nanoparticles as an active MRI contrast agent for NSCLC
AbstractOverexpression of epidermal growth factor receptor (EGFR) is closely associated with a poor prognosis in non-small cell lung cancer (NSCLC), thus making it a promising biomarker for NSCLC diagnosis. Here, we conjugated a single-chain antibody (scFv) targeting EGFR with Fe3O4/Au nanoparticles to form an EGFR-specific molecular MRI bioprobe (scFv@Fe3O4/Au) to better detect EGFR-positive NSCLC tumors in vivo. In vitro, we demonstrated that the EGFR-specific scFv could specifically deliver Fe3O4/Au to EGFR-positive NSCLC cells. In vivo experiments showed that the accumulation of scFv@Fe3O4/Au in tumor tissue was detect...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - August 1, 2021 Category: Materials Science Source Type: research

3T MEGA-PRESS study of N-acetyl aspartyl glutamate and N-acetyl aspartate in activated visual cortex
ConclusionThe MEGA-PRESS pulse sequence together with the spectral preprocessing techniques allowed to demonstrate that the concentrations of NAAG and NAA in the visual cortex remain constant during continuous visual stimulation within the margin of error. An increase in the lactate signal intensity signifies the activation of the anaerobic glycolysis in activated visual cortex. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - August 1, 2021 Category: Materials Science Source Type: research

Image distortion correction for MRI in low field permanent magnet systems with strong B0 inhomogeneity and gradient field nonlinearities
DiscussionIn case of\({B}_{0}\) inhomogeneities in the order of kHz, iterative MB reconstructions can help to improve both image quality and\(\Delta {B}_{0}\) map estimation. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - August 1, 2021 Category: Materials Science Source Type: research

ESMRMB annual meeting roundtable discussion: “Challenges and solutions in data sharing—an MRI perspective”
(Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - July 31, 2021 Category: Materials Science Source Type: research

Deuterium double quantum-filtered NMR studies of peripheral and optic nerves
Conclusions2H DQF-MT NMR characterizes the different components of nerves, the water exchange between them and their changes during processes such as nerve maturation and Wallerian degeneration. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - July 30, 2021 Category: Materials Science Source Type: research

Correction to: An MRI ‑compatible varus–valgus loading device for whole‑knee joint functionality assessment based on compartmental compression: a proof‑of‑concept study
(Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - July 23, 2021 Category: Materials Science Source Type: research

Effects of low-dose oxygen administration on renal blood oxygenation level-dependent MRI in children with glomerulonephritis
DiscussionLow-dose oxygen administration affects the results of BOLD MRI. We suggest that understanding  the fluctuations due to oxygen administration is useful in monitoring the disease activity of glomerulonephritis. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - July 18, 2021 Category: Materials Science Source Type: research

ESMRMB annual meeting roundtable discussion: “when less is more: the view of MRI vendors on low-field MRI”
(Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - July 14, 2021 Category: Materials Science Source Type: research

This house proposes that low field and high field MRI are by destiny worst enemies, and can never be the best of friends!
(Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - July 14, 2021 Category: Materials Science Source Type: research

Multicontrast MRI-based radiomics for the prediction of pathological complete response to neoadjuvant chemotherapy in patients with early triple negative breast cancer
ConclusionMRI-based radiomics may be relevant to predict NAC response in TN cancer. Our results promote the use of multi-contrast MRI sources for radiomics, providing enrich source of information to enhance model generalization. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - July 13, 2021 Category: Materials Science Source Type: research

Operator dependency of arterial input function in dynamic contrast-enhanced MRI
DiscussionAUC-normalized AIFs can reduce the variation in kinetic parameter results originating from operator input. The pop-AIF presented in this work may be applied in absence of a satisfactory measurement. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - July 2, 2021 Category: Materials Science Source Type: research

Comparative analysis of SINC-shaped and SLR pulses performance for contiguous multi-slice fast spin-echo imaging using metamaterial-based MRI
Discussion and conclusionSLR-based FSE together with the metadevice allowed to increase the slice selectivity while still being within the safe SAR limits. The “slice cross-talk” effects were conditioned by the number of echoes in the echo train, the repetition time, and T1 relaxation times. The approach was more beneficial for T1-weighted SLR-based FSE as compared to PD-weighted. The combination of the metadevice and SLR-based FSE offers a promising a lternative for MR investigations that require scanning in a “Low-SAR” regime such as those for children, pregnant women, and patients with implanted devices. (Source...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - June 28, 2021 Category: Materials Science Source Type: research

Feasibility of accelerated 3D T1-weighted MRI using compressed sensing: application to quantitative volume measurements of human brain structures
ConclusionCS-4 provided sufficient quality of 3D-TFE-T1W images for 1.5  T MRI equipped with a 12-channel receiver coil. Subcortical volumes obtained from the CS-4 images are consistent among different post-processing packages. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - June 28, 2021 Category: Materials Science Source Type: research

Evaluation of accelerated motion-compensated 3d water/fat late gadolinium enhanced MR for atrial wall imaging
DiscussionThe motion-compensated water/fat LGE method enables atrial wall imaging with diagnostic quality comparable to the current conventional approach with a significantly shorter scan of about 5  min. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - June 24, 2021 Category: Materials Science Source Type: research

Motion correction of free-breathing magnetic resonance renography using model-driven registration
In this study, we investigate whether MDR can effectively correct the motion in free-breathing MR renography (MRR).Materials and methodsMDR was generalised to linear tracer-kinetic models and implemented using 2D or 3D free-form deformations (FFD) with multi-resolution and gradient descent optimization. MDR was evaluated using a kidney-mimicking digital reference object (DRO) and free-breathing patient data acquired at high temporal resolution in multi-slice 2D (5 patients) and 3D acquisitions (8 patients). Registration accuracy was assessed using comparison to ground truth DRO, calculating the Hausdorff distance (HD) betw...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - June 23, 2021 Category: Materials Science Source Type: research