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Diagnostic performance of edited 2HG MR spectroscopy of central glioma in the clinical environment
ConclusionMultiple factors compromising spectral quality in the clinical adoption of edited 2HG MRS resulted in diminished sensitivity but clinically acceptable specificity. Furthermore, the 2HG/Cr ratio performs better than the sole 2HG concentration estimate in the pre-operative setting. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - January 5, 2022 Category: Materials Science Source Type: research

Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery
DiscussionWe have demonstrated feasibility of systolic FAIR in rest and exercise stress. 2RR delay systolic FAIR enables non-contrast perfusion assessment during stress with relatively high TSNR. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 27, 2021 Category: Materials Science Source Type: research

Evaluation of normal-appearing white matter with perfusion and diffusion MRI in patients with treated glioblastoma
DiscussionWe showed that both DSC and ASL perfusion values decreased correlatively in the first 3 months and showed a plateau after 1 year in patients with glioblastoma treated with CRT, unlike the literature. Although it was not as evident as perfusion MRI, it was observed that the ADC values also showed a plateau pattern following the increase in the first 3 months. Further studies are needed to explain late pathophysiological changes. Because of the high correlation, our results support ASL perfusion instead of contrast enhanced perfusion methods. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 24, 2021 Category: Materials Science Source Type: research

Automatic segmentation and volumetric assessment of internal organs and fatty tissue: what are the benefits?
(Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 17, 2021 Category: Materials Science Source Type: research

Metabolite interactions in prostatic fluid mimics assessed by 1H NMR
AbstractIntroductionMolecular interactions in prostatic fluid are of biological interest and may affect MRI and MRS of the prostate. We investigated the existence of interactions between the major components of this fluid: spermine, citrate and myoinositol, metal ions, including zinc, and proteins.Materials and methodsSolutions of 90 mM citrate, 18 mM spermine and 6 mM myo-inositol, mimicking expressed prostatic fluid, were investigated by 1H NMR using changes in T2 relaxation and chemical shift as markers for interactions.Results and discussionAdding to this metabolite mixture the ions Na+ , K+, Ca++, Mg++ and Zn...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 17, 2021 Category: Materials Science Source Type: research

A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue
AbstractCancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as ‘chemo fog’. This therapy-related damage to otherwise normal-appearing brain tissue is reported using post-mortem neuropathological analysis. Although the literature on monitoring therapy effects on structural magnetic resonance imaging (MRI) is well established, such macroscopic structural chan ges appear relatively late and irreversible. Early quantitative MRI biomarkers of therapy-induced damage would potentially permit taking the...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 17, 2021 Category: Materials Science Source Type: research

Feasibility of intravoxel incoherent motion in the assessment of tumor microvasculature and blood –brain barrier integrity: a case-based evaluation of gliomas
ConclusionThe results suggest IVIM may be a promising approach to delineate tumor extension and progression in size, and to predict histological grade, which are clinically relevant information that characterize tumors and guide therapeutic decisions in patients with glioma. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 15, 2021 Category: Materials Science Source Type: research

Gradient nonlinearity correction in liver DWI using motion-compensated diffusion encoding waveforms
ConclusionThe investigated gradient nonlinearity correction method can be used effectively with various motion-compensated diffusion encoding waveforms. In coronal liver DWI, ADC errors caused by motion and residual vessel signal can be increased even further by the gradient nonlinearity correction. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 11, 2021 Category: Materials Science Source Type: research

Automatic prostate segmentation of magnetic resonance imaging using Res-Net
ConclusionsOur experimental results show that the segmentation accuracy can be improved significantly using two stage neural networks. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 10, 2021 Category: Materials Science Source Type: research

GLINT: GlucoCEST in neoplastic tumors at 3  T—clinical results of GlucoCEST in gliomas
ConclusionFirst application of DGE ⍴ in a patient cohort shows an association between BBB leakage and DGE signal irrespective of the tumor grade. This indicates that glucoCEST corresponds more to the disruptions of BBB with Gd uptake than to the molecular tumor profile or tumor grading. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 10, 2021 Category: Materials Science Source Type: research

Detection of glioblastoma multiforme using quantitative molecular magnetic resonance imaging based on 5-aminolevulinic acid: in vitro and in vivo studies
DiscussionSequential administration of ALA and iron supplements increases the iron deposition in glioblastoma cells, enabling clinical 3  T MRI to detect GBM using R2’ or QSM. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 8, 2021 Category: Materials Science Source Type: research

Feasibility of glioblastoma tissue response mapping with physiologic BOLD imaging using precise oxygen and carbon dioxide challenge
ConclusionsOur preliminary investigation shows good feasibility of BOLD with standardized and precise CO2 and O2 modulation as an emerging physiologic imaging technique to detail specific glioblastoma characteristics. The unique tissue response patterns generated can be further investigated to better detail glioblastoma lesions and gauge treatment response. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 7, 2021 Category: Materials Science Source Type: research

Combined acquisition of diffusion and T2*-weighted measurements using simultaneous multi-contrast magnetic resonance imaging
DiscussionThe simultaneous acquisition of multiple contrasts reduces the overall examination time and there is an inherent registration between contrasts. By using the results of this study to control saturation effects in SMC, the method enables rapid acquisition of distortion-matched and well-registered diffusion-weighted and T2*-weighted imaging, which could support rapid diagnosis and treatment of acute stroke. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - December 2, 2021 Category: Materials Science Source Type: research

Repeatability of perfusion measurements in adult gliomas using pulsed and pseudo-continuous arterial spin labelling MRI
DiscussionPASL and PCASL showed similar repeatability for the assessment of perfusion parameters in patients with primary brain tumours as previous studies based on volunteers. Both methods displayed reasonable WCoV in the tumour area and CNAH. PCASL ’s more stable SNR in small areas (caudate) is likely to be due to the longer post-labelling delays. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - November 24, 2021 Category: Materials Science Source Type: research

Correction to: Report on the hot topic debate at ESMRMB 2021
(Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - November 24, 2021 Category: Materials Science Source Type: research