Bioinformatics analysis of potential common pathogenic mechanisms for systemic lupus erythematosus and acute myocardial infarction
CONCLUSIONS: This study reveals a common pathogenesis of SLE and AMI and provides new perspectives for further mechanism research. The identified common pathways and hub genes may have important clinical implications for the prevention and treatment of AMI in SLE patients.PMID:37800460 | DOI:10.1177/09612033231202659 (Source: Lupus)
Source: Lupus - October 6, 2023 Category: Rheumatology Authors: Yang Gao Yunxia Wang Muwei Li Chuanyu Gao Source Type: research
Bioinformatics analysis of potential common pathogenic mechanisms for systemic lupus erythematosus and acute myocardial infarction
CONCLUSIONS: This study reveals a common pathogenesis of SLE and AMI and provides new perspectives for further mechanism research. The identified common pathways and hub genes may have important clinical implications for the prevention and treatment of AMI in SLE patients.PMID:37800460 | DOI:10.1177/09612033231202659 (Source: Lupus)
Source: Lupus - October 6, 2023 Category: Rheumatology Authors: Yang Gao Yunxia Wang Muwei Li Chuanyu Gao Source Type: research
Maternal and fetal health outcomes in systemic lupus erythematosus pregnancies in the Emirati population: A comparative study
CONCLUSION: Pregnant women with SLE were at a higher risk for adverse maternal and fetal outcomes than age-matched pregnant women without SLE. These findings can guide clinical management and emphasize the need for close monitoring of SLE pregnancies.PMID:37786253 | DOI:10.1177/09612033231204650 (Source: Lupus)
Source: Lupus - October 3, 2023 Category: Rheumatology Authors: Hiba I Khogali Ghada S M Al-Bluwi Virgie Guy Pedo Ali M Al Dhanhani Source Type: research
Maternal and fetal health outcomes in systemic lupus erythematosus pregnancies in the Emirati population: A comparative study
CONCLUSION: Pregnant women with SLE were at a higher risk for adverse maternal and fetal outcomes than age-matched pregnant women without SLE. These findings can guide clinical management and emphasize the need for close monitoring of SLE pregnancies.PMID:37786253 | DOI:10.1177/09612033231204650 (Source: Lupus)
Source: Lupus - October 3, 2023 Category: Rheumatology Authors: Hiba I Khogali Ghada S M Al-Bluwi Virgie Guy Pedo Ali M Al Dhanhani Source Type: research
Maternal and fetal health outcomes in systemic lupus erythematosus pregnancies in the Emirati population: A comparative study
CONCLUSION: Pregnant women with SLE were at a higher risk for adverse maternal and fetal outcomes than age-matched pregnant women without SLE. These findings can guide clinical management and emphasize the need for close monitoring of SLE pregnancies.PMID:37786253 | DOI:10.1177/09612033231204650 (Source: Lupus)
Source: Lupus - October 3, 2023 Category: Rheumatology Authors: Hiba I Khogali Ghada S M Al-Bluwi Virgie Guy Pedo Ali M Al Dhanhani Source Type: research
Maternal and fetal health outcomes in systemic lupus erythematosus pregnancies in the Emirati population: A comparative study
CONCLUSION: Pregnant women with SLE were at a higher risk for adverse maternal and fetal outcomes than age-matched pregnant women without SLE. These findings can guide clinical management and emphasize the need for close monitoring of SLE pregnancies.PMID:37786253 | DOI:10.1177/09612033231204650 (Source: Lupus)
Source: Lupus - October 3, 2023 Category: Rheumatology Authors: Hiba I Khogali Ghada S M Al-Bluwi Virgie Guy Pedo Ali M Al Dhanhani Source Type: research
Identification of monocyte-associated biomarkers in systemic lupus erythematosus and their pan-cancer analysis
We examined the expression of hub genes in cancer and their interaction with monocytes using the GEPIA and TIMER databases to understand the significance of essential genes in tumorigenesis. In addition, we performed transcription factor identification. We discovered three biomarkers (IFI30, BLVRA, and RIN2) that are mostly involved in interferon-related signaling pathways and are associated with monocyte-mediated immune responses in SLE. The three important genes are also strongly expressed in a number of malignancies and have a relationship with monocytes. As a result, IFI30, BLVRA, and RIN2 may act as SLE-associated bio...
Source: Lupus - September 28, 2023 Category: Rheumatology Authors: Huiting Chen Jinxuan He Linwei Wang Yanbin Lin Zhixiang Mou Xiaoxuan Huang Lan Chen Source Type: research
Outcome of critically ill patients with systemic lupus erythematosus from a medical intensive care unit in Southern India
CONCLUSION: The mortality of SLE patients admitted to the ICU in this study is high, and infections were the principal reason for death. Baseline low HDL and higher procalcitonin are potential biomarkers to identify critically ill SLE patients.PMID:37769791 | DOI:10.1177/09612033231204074 (Source: Lupus)
Source: Lupus - September 28, 2023 Category: Rheumatology Authors: Arvind Bhargav Venkateswaran Ramanathan Ramu Ramadoss Chengappa Kavadichanda Christina M Mariaselvam Vir S Negi Molly M Thabah Source Type: research
Identification of monocyte-associated biomarkers in systemic lupus erythematosus and their pan-cancer analysis
We examined the expression of hub genes in cancer and their interaction with monocytes using the GEPIA and TIMER databases to understand the significance of essential genes in tumorigenesis. In addition, we performed transcription factor identification. We discovered three biomarkers (IFI30, BLVRA, and RIN2) that are mostly involved in interferon-related signaling pathways and are associated with monocyte-mediated immune responses in SLE. The three important genes are also strongly expressed in a number of malignancies and have a relationship with monocytes. As a result, IFI30, BLVRA, and RIN2 may act as SLE-associated bio...
Source: Lupus - September 28, 2023 Category: Rheumatology Authors: Huiting Chen Jinxuan He Linwei Wang Yanbin Lin Zhixiang Mou Xiaoxuan Huang Lan Chen Source Type: research
Outcome of critically ill patients with systemic lupus erythematosus from a medical intensive care unit in Southern India
CONCLUSION: The mortality of SLE patients admitted to the ICU in this study is high, and infections were the principal reason for death. Baseline low HDL and higher procalcitonin are potential biomarkers to identify critically ill SLE patients.PMID:37769791 | DOI:10.1177/09612033231204074 (Source: Lupus)
Source: Lupus - September 28, 2023 Category: Rheumatology Authors: Arvind Bhargav Venkateswaran Ramanathan Ramu Ramadoss Chengappa Kavadichanda Christina M Mariaselvam Vir S Negi Molly M Thabah Source Type: research
Identification of monocyte-associated biomarkers in systemic lupus erythematosus and their pan-cancer analysis
We examined the expression of hub genes in cancer and their interaction with monocytes using the GEPIA and TIMER databases to understand the significance of essential genes in tumorigenesis. In addition, we performed transcription factor identification. We discovered three biomarkers (IFI30, BLVRA, and RIN2) that are mostly involved in interferon-related signaling pathways and are associated with monocyte-mediated immune responses in SLE. The three important genes are also strongly expressed in a number of malignancies and have a relationship with monocytes. As a result, IFI30, BLVRA, and RIN2 may act as SLE-associated bio...
Source: Lupus - September 28, 2023 Category: Rheumatology Authors: Huiting Chen Jinxuan He Linwei Wang Yanbin Lin Zhixiang Mou Xiaoxuan Huang Lan Chen Source Type: research
Outcome of critically ill patients with systemic lupus erythematosus from a medical intensive care unit in Southern India
CONCLUSION: The mortality of SLE patients admitted to the ICU in this study is high, and infections were the principal reason for death. Baseline low HDL and higher procalcitonin are potential biomarkers to identify critically ill SLE patients.PMID:37769791 | DOI:10.1177/09612033231204074 (Source: Lupus)
Source: Lupus - September 28, 2023 Category: Rheumatology Authors: Arvind Bhargav Venkateswaran Ramanathan Ramu Ramadoss Chengappa Kavadichanda Christina M Mariaselvam Vir S Negi Molly M Thabah Source Type: research
Identification of monocyte-associated biomarkers in systemic lupus erythematosus and their pan-cancer analysis
We examined the expression of hub genes in cancer and their interaction with monocytes using the GEPIA and TIMER databases to understand the significance of essential genes in tumorigenesis. In addition, we performed transcription factor identification. We discovered three biomarkers (IFI30, BLVRA, and RIN2) that are mostly involved in interferon-related signaling pathways and are associated with monocyte-mediated immune responses in SLE. The three important genes are also strongly expressed in a number of malignancies and have a relationship with monocytes. As a result, IFI30, BLVRA, and RIN2 may act as SLE-associated bio...
Source: Lupus - September 28, 2023 Category: Rheumatology Authors: Huiting Chen Jinxuan He Linwei Wang Yanbin Lin Zhixiang Mou Xiaoxuan Huang Lan Chen Source Type: research
Outcome of critically ill patients with systemic lupus erythematosus from a medical intensive care unit in Southern India
CONCLUSION: The mortality of SLE patients admitted to the ICU in this study is high, and infections were the principal reason for death. Baseline low HDL and higher procalcitonin are potential biomarkers to identify critically ill SLE patients.PMID:37769791 | DOI:10.1177/09612033231204074 (Source: Lupus)
Source: Lupus - September 28, 2023 Category: Rheumatology Authors: Arvind Bhargav Venkateswaran Ramanathan Ramu Ramadoss Chengappa Kavadichanda Christina M Mariaselvam Vir S Negi Molly M Thabah Source Type: research
Repeat kidney biopsy findings of lupus nephritis patients in clinical remission treated with Mycophenolate associated with Belimumab or Mycophenolate plus standard of care therapy. A "post-hoc" analysis of participants in the BLISS-LN and open label extension study belonging to a single center
Conclusions: Although the number of patients is insufficient to be able to draw unquestionable conclusions, adding Belimumab to the standard of care treatment with MMF would seem to increase the possibility of achieving a CCR, CHR, and a lower rate of relapses during treatment and long follow-up.PMID:37754750 | DOI:10.1177/09612033231204070 (Source: Lupus)
Source: Lupus - September 27, 2023 Category: Rheumatology Authors: Ana Malvar Valeria Alberton Cecilia Recalde Ricardo Heguilen Source Type: research
