Primary antiphospholipid syndrome with and without limb ischemia: A retrospective observational study
CONCLUSION: PAPS and LI have a distinct clinical and laboratory spectra from those without LI and it is characterized by an increased frequency of protein C deficiency, and a lower frequency of venous events, deep venous thrombosis and IgM anticardiolipin.PMID:37852301 | DOI:10.1177/09612033231208347 (Source: Lupus)
Source: Lupus - October 18, 2023 Category: Rheumatology Authors: Joz élio Freire de Carvalho Rodrigo A Brand ão Neto Thelma Larocca Skare Yehuda Shoenfeld Source Type: research
Downregulation of circETS1 disrupts Th17/Treg homeostasis by inhibiting < em > FOXP3 < /em > transcription: A new potential biomarker in systemic lupus erythematosus
In this study, we measured the expression levels of circETS1 in peripheral blood mononuclear cells (PBMCs) and CD4+ T cells of patients with SLE by quantitative polymerase chain reaction. The impact of circETS1 expression on the Th17/Treg balance and underlying mechanism were evaluated using double-luciferase reporter, gain-/loss-of-function, and rescue assays. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic value of circETS1. Both circETS1 and FOXP3 expression were downregulated in the PBMCs and CD4+ T cells of patients with SLE (n = 28) compared with those in the cells of hea...
Source: Lupus - October 18, 2023 Category: Rheumatology Authors: Sha Ma Guofu Feng Li Li Zi Li Xiaoyu Zhou Yan Zhou Ruixian Zhang Source Type: research
Primary antiphospholipid syndrome with and without limb ischemia: A retrospective observational study
CONCLUSION: PAPS and LI have a distinct clinical and laboratory spectra from those without LI and it is characterized by an increased frequency of protein C deficiency, and a lower frequency of venous events, deep venous thrombosis and IgM anticardiolipin.PMID:37852301 | DOI:10.1177/09612033231208347 (Source: Lupus)
Source: Lupus - October 18, 2023 Category: Rheumatology Authors: Joz élio Freire de Carvalho Rodrigo A Brand ão Neto Thelma Larocca Skare Yehuda Shoenfeld Source Type: research
Identify the influences of systemic lupus erythematosus on acquired ADAMTS13-deficient thrombotic thrombocytopenic purpura using comprehensive bioinformatics analysis
CONCLUSIONS: Three core genes were linked to the molecular pathogenesis of SLE and aTTP, and two drugs may be viable treatments for both diseases.PMID:37846867 | DOI:10.1177/09612033231209109 (Source: Lupus)
Source: Lupus - October 17, 2023 Category: Rheumatology Authors: Jian Zhang Source Type: research
Identify the influences of systemic lupus erythematosus on acquired ADAMTS13-deficient thrombotic thrombocytopenic purpura using comprehensive bioinformatics analysis
CONCLUSIONS: Three core genes were linked to the molecular pathogenesis of SLE and aTTP, and two drugs may be viable treatments for both diseases.PMID:37846867 | DOI:10.1177/09612033231209109 (Source: Lupus)
Source: Lupus - October 17, 2023 Category: Rheumatology Authors: Jian Zhang Source Type: research
The prognostic value of neutrophile/lymphocyte ratio and serum chemerin to predict maternal-fetal complications in pregnant systemic lupus erythematosus patients
CONCLUSION: The NLR may help predict maternal-fetal complications in SLE pregnancy, constituting a marker of subclinical inflammation. Chemerin levels may be associated with preeclampsia. These biomarkers could improve the care of SLE patients with timely intervention of potential complications during pregnancy.PMID:37840528 | DOI:10.1177/09612033231206446 (Source: Lupus)
Source: Lupus - October 16, 2023 Category: Rheumatology Authors: Gabriela Medina Francisco R Gonz ález-Cortés Antonio S ánchez-González Juan G V ázquez-Rodríguez Irvin Ordo ñez-González Mar ía P Jiménez-Arellano Grettel Garc ía-Collinot Susana I Morales-Montalvo Oscar I Florez-Durante Mar ía P Cruz-Domíngu Source Type: research
Clinical disease activity index applicability in lupus arthropathy: Unraveling underdiagnosed joint activity
CONCLUSION: The CDAI was not directly associated with the presence of arthritis by the joint criteria of SLEDAI-2K and the presence of JA was significantly associated with the CDAI but not with arthritis at SLEDAI-2K.PMID:37844912 | DOI:10.1177/09612033231206454 (Source: Lupus)
Source: Lupus - October 16, 2023 Category: Rheumatology Authors: Carlos Antonio Moura Vanessa Fonseca Eneida M Alves Isabela Silva de Oliveira Mittermayer B Santiago Source Type: research
The prognostic value of neutrophile/lymphocyte ratio and serum chemerin to predict maternal-fetal complications in pregnant systemic lupus erythematosus patients
CONCLUSION: The NLR may help predict maternal-fetal complications in SLE pregnancy, constituting a marker of subclinical inflammation. Chemerin levels may be associated with preeclampsia. These biomarkers could improve the care of SLE patients with timely intervention of potential complications during pregnancy.PMID:37840528 | DOI:10.1177/09612033231206446 (Source: Lupus)
Source: Lupus - October 16, 2023 Category: Rheumatology Authors: Gabriela Medina Francisco R Gonz ález-Cortés Antonio S ánchez-González Juan G V ázquez-Rodríguez Irvin Ordo ñez-González Mar ía P Jiménez-Arellano Grettel Garc ía-Collinot Susana I Morales-Montalvo Oscar I Florez-Durante Mar ía P Cruz-Domíngu Source Type: research
Machine learning: Predicting hospital length of stay in patients admitted for lupus flares
CONCLUSION: Our results were consistent with the established literature and showed promise in ML over traditional methods of predictive analyses, even with rare rheumatic events such as lupus flare hospitalizations.PMID:37831499 | DOI:10.1177/09612033231206830 (Source: Lupus)
Source: Lupus - October 13, 2023 Category: Rheumatology Authors: Radu Grovu Yanran Huo Andrew Nguyen Omar Mourad Zihang Pan Khalil El-Gharib Chapman Wei Ahmad Mustafa Theodore Quan Anastasia Slobodnick Source Type: research
Machine learning: Predicting hospital length of stay in patients admitted for lupus flares
CONCLUSION: Our results were consistent with the established literature and showed promise in ML over traditional methods of predictive analyses, even with rare rheumatic events such as lupus flare hospitalizations.PMID:37831499 | DOI:10.1177/09612033231206830 (Source: Lupus)
Source: Lupus - October 13, 2023 Category: Rheumatology Authors: Radu Grovu Yanran Huo Andrew Nguyen Omar Mourad Zihang Pan Khalil El-Gharib Chapman Wei Ahmad Mustafa Theodore Quan Anastasia Slobodnick Source Type: research
A single-center model for implementation of SLEDAI documentation adherence in childhood-onset systemic lupus erythematosus (cSLE)
CONCLUSION: Our study demonstrates that monthly email reminders as well as EMR-mediated electronic in-basket reminders increased SLEDAI documentation rates at an academic center. Noted barriers to documentation were reported to be forgetfulness (67%) and lack of time (33%).PMID:37807814 | DOI:10.1177/09612033231206451 (Source: Lupus)
Source: Lupus - October 9, 2023 Category: Rheumatology Authors: Meghan Corrigan Nelson Colleen Mosley Tonya Bennett Evan Orenstein Kelly Rouster-Stevens Source Type: research
A single-center model for implementation of SLEDAI documentation adherence in childhood-onset systemic lupus erythematosus (cSLE)
CONCLUSION: Our study demonstrates that monthly email reminders as well as EMR-mediated electronic in-basket reminders increased SLEDAI documentation rates at an academic center. Noted barriers to documentation were reported to be forgetfulness (67%) and lack of time (33%).PMID:37807814 | DOI:10.1177/09612033231206451 (Source: Lupus)
Source: Lupus - October 9, 2023 Category: Rheumatology Authors: Meghan Corrigan Nelson Colleen Mosley Tonya Bennett Evan Orenstein Kelly Rouster-Stevens Source Type: research
A single-center model for implementation of SLEDAI documentation adherence in childhood-onset systemic lupus erythematosus (cSLE)
CONCLUSION: Our study demonstrates that monthly email reminders as well as EMR-mediated electronic in-basket reminders increased SLEDAI documentation rates at an academic center. Noted barriers to documentation were reported to be forgetfulness (67%) and lack of time (33%).PMID:37807814 | DOI:10.1177/09612033231206451 (Source: Lupus)
Source: Lupus - October 9, 2023 Category: Rheumatology Authors: Meghan Corrigan Nelson Colleen Mosley Tonya Bennett Evan Orenstein Kelly Rouster-Stevens Source Type: research
A single-center model for implementation of SLEDAI documentation adherence in childhood-onset systemic lupus erythematosus (cSLE)
CONCLUSION: Our study demonstrates that monthly email reminders as well as EMR-mediated electronic in-basket reminders increased SLEDAI documentation rates at an academic center. Noted barriers to documentation were reported to be forgetfulness (67%) and lack of time (33%).PMID:37807814 | DOI:10.1177/09612033231206451 (Source: Lupus)
Source: Lupus - October 9, 2023 Category: Rheumatology Authors: Meghan Corrigan Nelson Colleen Mosley Tonya Bennett Evan Orenstein Kelly Rouster-Stevens Source Type: research
Bioinformatics analysis of potential common pathogenic mechanisms for systemic lupus erythematosus and acute myocardial infarction
CONCLUSIONS: This study reveals a common pathogenesis of SLE and AMI and provides new perspectives for further mechanism research. The identified common pathways and hub genes may have important clinical implications for the prevention and treatment of AMI in SLE patients.PMID:37800460 | DOI:10.1177/09612033231202659 (Source: Lupus)
Source: Lupus - October 6, 2023 Category: Rheumatology Authors: Yang Gao Yunxia Wang Muwei Li Chuanyu Gao Source Type: research
