Spectrum of initial clinical presentations in Pakistani patients with systemic lupus erythematosus in the Arthritis Care Foundation lupus cohort
CONCLUSION: In our study, a majority of patients presented with mucocutaneous symptoms. It is therefore of paramount importance to suspect autoimmune diseases in patients with these system involvements.PMID:38078848 | DOI:10.1177/09612033231221909 (Source: Lupus)
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Madeeha Siddique Nighat Mir Ahmed Sumaira Farman Raja Muhammad Ahmed Saeed Sadaf Sarwar Source Type: research

Efficacy of Telitacicept in a systemic lupus erythematosus patient with suboptimal response to Belimumab: A case report
Lupus. 2023 Dec 11:9612033231221911. doi: 10.1177/09612033231221911. Online ahead of print.ABSTRACTAs a therapeutic treatment for systemic lupus erythematosus (SLE), Belimumab reduces disease relapses and minimizes organ damage. Clinical practice, however, shows that the treatment is ineffective for a number of patients. Treatments for such cases are still lacking. As a biologic agent that targets both BLys and APRIL, Telitacicept inhibits both B cells and plasma cells. This case report describes a 35-year-old female with lupus nephritis (LN) who had previously undergone 10 cycles of Belimumab treatment but remained poorly...
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Li Huang Gangzhen Qian Huhai Zhang Qixuan Li Liping Chen Xiaopeng Tang Hongwen Zhao Source Type: research

Impaired serotonin synthesis in hippocampus of murine lupus represents an early neuropsychiatric event
CONCLUSION: Impaired hippocampal serotonin synthesis in the hippocampus of lupus-prone mice represents an early neuropsychiatric event. These findings may have important implications for the use of symptomatic therapy in diffuse NPSLE.PMID:38073556 | DOI:10.1177/09612033231221651 (Source: Lupus)
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Dionysis Nikolopoulos Modestos Nakos-Bimpos Theodora Manolakou Alexia Polissidis Dimitrios T Boumpas Source Type: research

Spectrum of initial clinical presentations in Pakistani patients with systemic lupus erythematosus in the Arthritis Care Foundation lupus cohort
CONCLUSION: In our study, a majority of patients presented with mucocutaneous symptoms. It is therefore of paramount importance to suspect autoimmune diseases in patients with these system involvements.PMID:38078848 | DOI:10.1177/09612033231221909 (Source: Lupus)
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Madeeha Siddique Nighat Mir Ahmed Sumaira Farman Raja Muhammad Ahmed Saeed Sadaf Sarwar Source Type: research

Efficacy of Telitacicept in a systemic lupus erythematosus patient with suboptimal response to Belimumab: A case report
Lupus. 2023 Dec 11:9612033231221911. doi: 10.1177/09612033231221911. Online ahead of print.ABSTRACTAs a therapeutic treatment for systemic lupus erythematosus (SLE), Belimumab reduces disease relapses and minimizes organ damage. Clinical practice, however, shows that the treatment is ineffective for a number of patients. Treatments for such cases are still lacking. As a biologic agent that targets both BLys and APRIL, Telitacicept inhibits both B cells and plasma cells. This case report describes a 35-year-old female with lupus nephritis (LN) who had previously undergone 10 cycles of Belimumab treatment but remained poorly...
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Li Huang Gangzhen Qian Huhai Zhang Qixuan Li Liping Chen Xiaopeng Tang Hongwen Zhao Source Type: research

Impaired serotonin synthesis in hippocampus of murine lupus represents an early neuropsychiatric event
CONCLUSION: Impaired hippocampal serotonin synthesis in the hippocampus of lupus-prone mice represents an early neuropsychiatric event. These findings may have important implications for the use of symptomatic therapy in diffuse NPSLE.PMID:38073556 | DOI:10.1177/09612033231221651 (Source: Lupus)
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Dionysis Nikolopoulos Modestos Nakos-Bimpos Theodora Manolakou Alexia Polissidis Dimitrios T Boumpas Source Type: research

Spectrum of initial clinical presentations in Pakistani patients with systemic lupus erythematosus in the Arthritis Care Foundation lupus cohort
CONCLUSION: In our study, a majority of patients presented with mucocutaneous symptoms. It is therefore of paramount importance to suspect autoimmune diseases in patients with these system involvements.PMID:38078848 | DOI:10.1177/09612033231221909 (Source: Lupus)
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Madeeha Siddique Nighat Mir Ahmed Sumaira Farman Raja Muhammad Ahmed Saeed Sadaf Sarwar Source Type: research

Efficacy of Telitacicept in a systemic lupus erythematosus patient with suboptimal response to Belimumab: A case report
Lupus. 2023 Dec 11:9612033231221911. doi: 10.1177/09612033231221911. Online ahead of print.ABSTRACTAs a therapeutic treatment for systemic lupus erythematosus (SLE), Belimumab reduces disease relapses and minimizes organ damage. Clinical practice, however, shows that the treatment is ineffective for a number of patients. Treatments for such cases are still lacking. As a biologic agent that targets both BLys and APRIL, Telitacicept inhibits both B cells and plasma cells. This case report describes a 35-year-old female with lupus nephritis (LN) who had previously undergone 10 cycles of Belimumab treatment but remained poorly...
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Li Huang Gangzhen Qian Huhai Zhang Qixuan Li Liping Chen Xiaopeng Tang Hongwen Zhao Source Type: research

Impaired serotonin synthesis in hippocampus of murine lupus represents an early neuropsychiatric event
CONCLUSION: Impaired hippocampal serotonin synthesis in the hippocampus of lupus-prone mice represents an early neuropsychiatric event. These findings may have important implications for the use of symptomatic therapy in diffuse NPSLE.PMID:38073556 | DOI:10.1177/09612033231221651 (Source: Lupus)
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Dionysis Nikolopoulos Modestos Nakos-Bimpos Theodora Manolakou Alexia Polissidis Dimitrios T Boumpas Source Type: research

Spectrum of initial clinical presentations in Pakistani patients with systemic lupus erythematosus in the Arthritis Care Foundation lupus cohort
CONCLUSION: In our study, a majority of patients presented with mucocutaneous symptoms. It is therefore of paramount importance to suspect autoimmune diseases in patients with these system involvements.PMID:38078848 | DOI:10.1177/09612033231221909 (Source: Lupus)
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Madeeha Siddique Nighat Mir Ahmed Sumaira Farman Raja Muhammad Ahmed Saeed Sadaf Sarwar Source Type: research

Efficacy of Telitacicept in a systemic lupus erythematosus patient with suboptimal response to Belimumab: A case report
Lupus. 2023 Dec 11:9612033231221911. doi: 10.1177/09612033231221911. Online ahead of print.ABSTRACTAs a therapeutic treatment for systemic lupus erythematosus (SLE), Belimumab reduces disease relapses and minimizes organ damage. Clinical practice, however, shows that the treatment is ineffective for a number of patients. Treatments for such cases are still lacking. As a biologic agent that targets both BLys and APRIL, Telitacicept inhibits both B cells and plasma cells. This case report describes a 35-year-old female with lupus nephritis (LN) who had previously undergone 10 cycles of Belimumab treatment but remained poorly...
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Li Huang Gangzhen Qian Huhai Zhang Qixuan Li Liping Chen Xiaopeng Tang Hongwen Zhao Source Type: research

Impaired serotonin synthesis in hippocampus of murine lupus represents an early neuropsychiatric event
CONCLUSION: Impaired hippocampal serotonin synthesis in the hippocampus of lupus-prone mice represents an early neuropsychiatric event. These findings may have important implications for the use of symptomatic therapy in diffuse NPSLE.PMID:38073556 | DOI:10.1177/09612033231221651 (Source: Lupus)
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Dionysis Nikolopoulos Modestos Nakos-Bimpos Theodora Manolakou Alexia Polissidis Dimitrios T Boumpas Source Type: research

Spectrum of initial clinical presentations in Pakistani patients with systemic lupus erythematosus in the Arthritis Care Foundation lupus cohort
CONCLUSION: In our study, a majority of patients presented with mucocutaneous symptoms. It is therefore of paramount importance to suspect autoimmune diseases in patients with these system involvements.PMID:38078848 | DOI:10.1177/09612033231221909 (Source: Lupus)
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Madeeha Siddique Nighat Mir Ahmed Sumaira Farman Raja Muhammad Ahmed Saeed Sadaf Sarwar Source Type: research

Efficacy of Telitacicept in a systemic lupus erythematosus patient with suboptimal response to Belimumab: A case report
Lupus. 2023 Dec 11:9612033231221911. doi: 10.1177/09612033231221911. Online ahead of print.ABSTRACTAs a therapeutic treatment for systemic lupus erythematosus (SLE), Belimumab reduces disease relapses and minimizes organ damage. Clinical practice, however, shows that the treatment is ineffective for a number of patients. Treatments for such cases are still lacking. As a biologic agent that targets both BLys and APRIL, Telitacicept inhibits both B cells and plasma cells. This case report describes a 35-year-old female with lupus nephritis (LN) who had previously undergone 10 cycles of Belimumab treatment but remained poorly...
Source: Lupus - December 11, 2023 Category: Rheumatology Authors: Li Huang Gangzhen Qian Huhai Zhang Qixuan Li Liping Chen Xiaopeng Tang Hongwen Zhao Source Type: research

Immunohistochemical expression of perforin in adult systemic lupus erythematosus associated macrophage activation syndrome: Clinicohematological correlation and literature review
CONCLUSION: We noted a decrease in perforin mediated CD8 + T cell cytotoxicity in SLE. Immunohistochemical demonstration of the same along with histiocytic hemophagocytosis on BM biopsy may be useful adjunct in early diagnosis and management of MAS in SLE.PMID:38069452 | DOI:10.1177/09612033231221414 (Source: Lupus)
Source: Lupus - December 9, 2023 Category: Rheumatology Authors: Bakialakshmi Velayutham Somanath Padhi Sujata Devi Susama Patra Chinmayee Panigrahi Mathan Kumar Ramasubbu Rajesh Kumar Samiur Raheman Source Type: research