Journal of the Mechanical Behavior of Biomedical Materials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Micromechanical modelling of transverse fracture behaviour of lamellar bone using a phase-field damage model: The role of non-collagenous proteins and mineralised collagen fibrils
In this study, a two-dimensional micromechanics damage-based representative volume element (RVE) of lamellar bone was developed, which included a novel implementation of a phase-field damage model to describe the behaviour of non-collagenous proteins at mineral-mineral and mineral-fibril interface regions. It was found that, while the stiffness of the tissue was governed by the relative proportion of extra-fibrillar mineral and mineralised collagen fibrils, the strength and toughness of the tissue in transverse direction relied on the interactions occurring at mineral-mineral and mineral-fibril interfaces, highlighting the...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 3, 2024 Category: Materials Science Authors: Hamid Alijani Ted J Vaughan Source Type: research

A novel intraocular pressure predicting method based on hyperelastic mechanical model of cornea
In this study, a three-dimensional analytical model based on hyperelastic constitutive relationship to predict correlation between cornea vertex displacement and the IOP is proposed. The analytical model is validated by rigorous experiments. Rabbit corneas were selected for this study and their mechanical properties were obtained using uniaxial tensile tests. To mimic the environment in which the cornea exists, an artificial anterior chamber equipped with water-injection pipelines was constructed to study the relationship between the corneal vertex displacement with IOP value in practical situation. The experimental result...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 2, 2024 Category: Materials Science Authors: Shi Yan Xiaohui Song Xiaocheng Hu Ke Yao Shaoxing Qu Source Type: research

Effect of density grading on the mechanical behaviour of advanced functionally graded lattice structures
J Mech Behav Biomed Mater. 2024 Feb 27;153:106477. doi: 10.1016/j.jmbbm.2024.106477. Online ahead of print.ABSTRACTLattice structures have found significant applications in the biomedical field due to their interesting combination of mechanical and biological properties. Among these, functionally graded structures sparked interest because of their potential of varying their mechanical properties throughout the volume, allowing the design of biomedical devices able to match the characteristics of a graded structure like human bone. The aim of this works is the study of the effect of the density grading on the mechanical res...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 1, 2024 Category: Materials Science Authors: Fabio Distefano Gabriella Epasto Source Type: research

Cell adhesion affects the properties of interstitial fluid flow: A study using multiscale poroelastic composite modeling
In this study, we conduct a multiscale, multiphysics modeling of the brain gray matter as a poroelastic composite. We develop a customized representative volume element based on cytoarchitectural features that encompass important microscopic components of the tissue, namely the extracellular space, the capillaries, the pericapillary space, the interstitial fluid, cell-cell and cell-capillary junctions, and neuronal and glial cell bodies. Using asymptotic homogenization and direct numerical simulation, the effective properties at the tissue level are identified based on microscopic properties. To analyze the influence of va...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 1, 2024 Category: Materials Science Authors: Hamidreza Dehghani Gerhard A Holzapfel Michel Mittelbronn Andreas Zilian Source Type: research

Impact of prior axonal injury on subsequent injury during brain tissue stretching - A mesoscale computational approach
J Mech Behav Biomed Mater. 2024 Feb 27;153:106489. doi: 10.1016/j.jmbbm.2024.106489. Online ahead of print.ABSTRACTEpidemiology studies of traumatic brain injury (TBI) show individuals with a prior history of TBI experience an increased risk of future TBI with a significantly more detrimental outcome. But the mechanisms through which prior head injuries may affect risks of injury during future head insults have not been identified. In this work, we show that prior brain tissue injury in the form of mechanically induced axonal injury and glial scar formation can facilitate future mechanically induced tissue injury. To achie...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 1, 2024 Category: Materials Science Authors: Amirhamed Bakhtiarydavijani Tonya W Stone Source Type: research

Mechanical loading of ex vivo bovine trabecular bone in 3D printed bioreactor chambers
This study demonstrated that bone organ culture in 3D printed MED610TM bioreactors replicated Eapp trends found in previous studies with PC bioreactors. However, further studies are warranted with a larger sample size to increase statistical power and histology to assess cell viability and bone mineral apposition rate.PMID:38422872 | DOI:10.1016/j.jmbbm.2024.106470 (Source: Journal of the Mechanical Behavior of Biomedical Materials)
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 29, 2024 Category: Materials Science Authors: Brian A Kunath Kail Beloglowka Roshni Rainbow Heidi-Lynn Ploeg Source Type: research

Energetically stable curve fitting to hyperelastic models based on uniaxial and biaxial tensile tests
This study provides a procedure to determine stable strain energy functions in a biaxial strain space based on either uniaxial or biaxial tensile tests. Instead of conservative, strain-independent conditions, a stability region is defined in the strain space based on the sample's tensile tests, thus allowing optimisation within a wider parameter space, resulting in better approximations. An extension of the Levenberg-Marquardt algorithm incorporating user-defined stability constraints is proposed, and the constrained optimisation algorithm is applied to isotropic and anisotropic models. The uniqueness of solutions of the F...
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 28, 2024 Category: Materials Science Authors: Brigitta K T óth Andr ás Lengyel Source Type: research

Towards the mechanical characterisation of unruptured intracranial aneurysms: Numerical modelling of interactions between a deformation device and the aneurysm wall
J Mech Behav Biomed Mater. 2024 Feb 21;153:106469. doi: 10.1016/j.jmbbm.2024.106469. Online ahead of print.ABSTRACTIntracranial aneurysm is a critical pathology related to the arterial wall deterioration. This work is an essential aspect of a large scale project aimed at providing clinicians with a non-invasive patient-specific decision support tool regarding the rupture risk assessment. A machine learning algorithm links the aneurysm shape observed and a database of UIA clinical images associated with in vivo wall mechanical properties and rupture characterisation. The database constitution is derived from a device protot...
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 25, 2024 Category: Materials Science Authors: J Raviol G Plet R Hasegawa K Yu H Kosukegawa M Ohta H Magoariec C Pailler-Mattei Source Type: research