Evaluation of gelatin bloom strength on gelatin methacryloyl hydrogel properties
J Mech Behav Biomed Mater. 2024 Mar 18;154:106509. doi: 10.1016/j.jmbbm.2024.106509. Online ahead of print.ABSTRACTGelatin methacryloyl (GelMA) hydrogels are widely used for a variety of tissue engineering applications. The properties of gelatin can affect the mechanical properties of gelatin gels; however, the role of gelatin properties such as bloom strength on GelMA hydrogels has not yet been explored. Bloom strength is a food industry standard for describing the quality of gelatin, where higher bloom strength is associated with higher gelatin molecular weight. Here, we evaluate the role of bloom strength on GelMA hydro...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 22, 2024 Category: Materials Science Authors: Samantha G Zambuto Samyuktha S Kolluru Eya Ferchichi Hannah F Rudewick Daniella M Fodera Kristin M Myers Silviya P Zustiak Michelle L Oyen Source Type: research

Effect of mechanical fatigue on commercial bioprosthetic TAVR valve mechanical and microstructural properties
J Mech Behav Biomed Mater. 2024 Mar 7;154:106441. doi: 10.1016/j.jmbbm.2024.106441. Online ahead of print.ABSTRACTValvular structural deterioration is of particular concern for transcatheter aortic valve replacements due to their suspected shorter longevity and increasing use in younger patient populations. In this work we investigated the mechanical and microstructural changes in commercial TAVR valves composed of both glutaraldehyde fixed bovine and porcine pericardium (GLBP and GLPP) following accelerated wear testing (AWT) as outlined in ISO 5840 standards. This provided greater physiological relevance to the loading c...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 22, 2024 Category: Materials Science Authors: Christopher Noble Alexander Hooke Arush Rajotia David Morse Dan Dragomir-Daescu Jeffery Salisbury Melissa D Young Amir Lerman Source Type: research

Mechanical insights into jawbone characteristics under chronic kidney disease: A comprehensive nanoindentation approach
This study sought to evaluate the time-dependent viscoelastic behaviors of rat jawbones, particularly in the scenarios both with and without CKD. We hypothesized that CKD might compromise the bone's innate toughening mechanisms, potentially owing to the time-dependent viscoelasticity of the bone matrix proteins. The maxillary and mandibular bones of Wistar rats were subjected to nanoindentation and Raman micro-spectroscopy. Load-hold-displacement curves from the cortical regions were obtained via nanoindentation and were mathematically characterized using a suitable viscoelastic constitutive model. Raman micro-spectroscopy...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 22, 2024 Category: Materials Science Authors: Chie Watanabe Jingxiao Zhong Sotaro Yamashita Yusuke Kondo Chihiro Masaki Ryuji Hosokawa Yo Shibata Source Type: research

Nacre-like block lattice metamaterials with targeted phononic band gap and mechanical properties
J Mech Behav Biomed Mater. 2024 Mar 18;154:106511. doi: 10.1016/j.jmbbm.2024.106511. Online ahead of print.ABSTRACTThe extraordinary quasi-static mechanical properties of nacre-like composite metamaterials, such as high specific strength, stiffness, and toughness, are due to the periodic arrangement of two distinct phases in a "brick and mortar" structure. It is also theorized that the hierarchical periodic structure of nacre structures can provide wider band gaps at different frequency scales. However, the function of hierarchy in the dynamic behavior of metamaterials is largely unknown, and most current investigations ar...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 22, 2024 Category: Materials Science Authors: Ravi Kiran Bollineni Moustafa Sayed Ahmed Shima Shahab Reza Mirzaeifar Source Type: research

Evaluation of gelatin bloom strength on gelatin methacryloyl hydrogel properties
J Mech Behav Biomed Mater. 2024 Mar 18;154:106509. doi: 10.1016/j.jmbbm.2024.106509. Online ahead of print.ABSTRACTGelatin methacryloyl (GelMA) hydrogels are widely used for a variety of tissue engineering applications. The properties of gelatin can affect the mechanical properties of gelatin gels; however, the role of gelatin properties such as bloom strength on GelMA hydrogels has not yet been explored. Bloom strength is a food industry standard for describing the quality of gelatin, where higher bloom strength is associated with higher gelatin molecular weight. Here, we evaluate the role of bloom strength on GelMA hydro...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 22, 2024 Category: Materials Science Authors: Samantha G Zambuto Samyuktha S Kolluru Eya Ferchichi Hannah F Rudewick Daniella M Fodera Kristin M Myers Silviya P Zustiak Michelle L Oyen Source Type: research

Mechanical properties of clot made from human and bovine whole blood differ significantly
J Mech Behav Biomed Mater. 2024 Mar 15;154:106508. doi: 10.1016/j.jmbbm.2024.106508. Online ahead of print.ABSTRACTThromboembolism - that is, clot formation and the subsequent fragmentation of clot - is a leading cause of death worldwide. Clots' mechanical properties are critical determinants of both the embolization process and the pathophysiological consequences thereof. Thus, understanding and quantifying the mechanical properties of clots is important to our ability to treat and prevent thromboembolic disease. However, assessing these properties from in vivo clots is experimentally challenging. Therefore, we and others...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 21, 2024 Category: Materials Science Authors: Gabriella P Sugerman Grace N Bechtel Zuzanna Malinowska Sapun H Parekh Manuel K Rausch Source Type: research

Structural parameters defining distribution of collagen fiber directions in human carotid arteries
In this study, their orientation in human common carotid artery was investigated using polarized light microscopy and an automated algorithm giving more than 4·106 fiber angles per slice. In total 113 slices acquired from 18 arteries taken from 14 cadavers were used for fiber orientation in the circumferential-axial plane. All histograms were approximated with unimodal von Mises distribution to evaluate dominant direction of fibers and their concentration parameter. 10 specimens were analyzed also in circumferential-radial and axial-radial planes (2-4 slices per specimen in each plane); the portion of radially oriented fi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 20, 2024 Category: Materials Science Authors: Ji ří Fischer Aneta Heidrov á Mark éta Hermanová Zden ěk Bednařík Marek Joukal Ji ří Burša Source Type: research

Anisotropic plates with architected tendon network
J Mech Behav Biomed Mater. 2024 Mar 15;153:106505. doi: 10.1016/j.jmbbm.2024.106505. Online ahead of print.ABSTRACTWe synthesize geometrically tailorable anisotropic plates by combining button shaped fish-scale like features on soft substrates, then lacing them with high-stiffness strings. This creates a new type of biomimetic architectured structure with multiple broken symmetries. First, the tendons and substrate together break the symmetry of the bending response between the concave and convex curvature. Next, the weave pattern of the tendons further breaks symmetry along the two directors of plates. The anisotropy is c...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 20, 2024 Category: Materials Science Authors: Md Shahjahan Hossain Hossein Ebrahimi Ranajay Ghosh Source Type: research

Structural parameters defining distribution of collagen fiber directions in human carotid arteries
In this study, their orientation in human common carotid artery was investigated using polarized light microscopy and an automated algorithm giving more than 4·106 fiber angles per slice. In total 113 slices acquired from 18 arteries taken from 14 cadavers were used for fiber orientation in the circumferential-axial plane. All histograms were approximated with unimodal von Mises distribution to evaluate dominant direction of fibers and their concentration parameter. 10 specimens were analyzed also in circumferential-radial and axial-radial planes (2-4 slices per specimen in each plane); the portion of radially oriented fi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 20, 2024 Category: Materials Science Authors: Ji ří Fischer Aneta Heidrov á Mark éta Hermanová Zden ěk Bednařík Marek Joukal Ji ří Burša Source Type: research

Anisotropic plates with architected tendon network
J Mech Behav Biomed Mater. 2024 Mar 15;153:106505. doi: 10.1016/j.jmbbm.2024.106505. Online ahead of print.ABSTRACTWe synthesize geometrically tailorable anisotropic plates by combining button shaped fish-scale like features on soft substrates, then lacing them with high-stiffness strings. This creates a new type of biomimetic architectured structure with multiple broken symmetries. First, the tendons and substrate together break the symmetry of the bending response between the concave and convex curvature. Next, the weave pattern of the tendons further breaks symmetry along the two directors of plates. The anisotropy is c...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 20, 2024 Category: Materials Science Authors: Md Shahjahan Hossain Hossein Ebrahimi Ranajay Ghosh Source Type: research

Dimensional accuracy and simulation-based optimization of polyolefins and biocopolyesters for extrusion-based additive manufacturing and steam sterilization
J Mech Behav Biomed Mater. 2024 Mar 13;153:106507. doi: 10.1016/j.jmbbm.2024.106507. Online ahead of print.ABSTRACTPolyolefins exhibit robust mechanical and chemical properties and can be applied in the medical field, e.g. for the manufacturing of dentures. Despite their wide range of applications, they are rarely used in extrusion-based printing due to their warpage tendency. The aim of this study was to investigate and reduce the warpage of polyolefins compared to commonly used filaments after additive manufacturing (AM) and sterilization using finite element simulation. Three types of filaments were investigated: a medi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 19, 2024 Category: Materials Science Authors: Felix Burkhardt Carl G Schirmeister Christian Wesemann Lukas Baur Kirstin Vach Massimo Nutini Erik H Licht Marc C Metzger Rolf M ülhaupt Benedikt C Spies Source Type: research

Fracture load in double keyhole notch PLA-Cu < sub > 2 < /sub > O nanocomposites manufactured via compression molding and 3D printing: An experimental and numerical study
J Mech Behav Biomed Mater. 2024 Mar 12;153:106504. doi: 10.1016/j.jmbbm.2024.106504. Online ahead of print.ABSTRACTPolylactic acid (PLA) polymer has garnered significant attention due to its biocompatibility. The incorporation of copper oxide (Cu2O) nanoparticles into this polymer is expected to enhance its antibacterial, electrical, and thermal properties. This modification can potentially improve the performance of PLA in the fields of prosthetics manufacturing or printed circuit fabrication. However, the current research is rather focused on the mechanical properties of the PLA-Cu2O nanocomposites. This research is thus...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 19, 2024 Category: Materials Science Authors: Javad Khodadad Hatkeposhti Naser Kordani Mohammad Akbarzadeh Pasha Ahmad Barari Source Type: research

Dimensional accuracy and simulation-based optimization of polyolefins and biocopolyesters for extrusion-based additive manufacturing and steam sterilization
J Mech Behav Biomed Mater. 2024 Mar 13;153:106507. doi: 10.1016/j.jmbbm.2024.106507. Online ahead of print.ABSTRACTPolyolefins exhibit robust mechanical and chemical properties and can be applied in the medical field, e.g. for the manufacturing of dentures. Despite their wide range of applications, they are rarely used in extrusion-based printing due to their warpage tendency. The aim of this study was to investigate and reduce the warpage of polyolefins compared to commonly used filaments after additive manufacturing (AM) and sterilization using finite element simulation. Three types of filaments were investigated: a medi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 19, 2024 Category: Materials Science Authors: Felix Burkhardt Carl G Schirmeister Christian Wesemann Lukas Baur Kirstin Vach Massimo Nutini Erik H Licht Marc C Metzger Rolf M ülhaupt Benedikt C Spies Source Type: research

Fracture load in double keyhole notch PLA-Cu < sub > 2 < /sub > O nanocomposites manufactured via compression molding and 3D printing: An experimental and numerical study
J Mech Behav Biomed Mater. 2024 Mar 12;153:106504. doi: 10.1016/j.jmbbm.2024.106504. Online ahead of print.ABSTRACTPolylactic acid (PLA) polymer has garnered significant attention due to its biocompatibility. The incorporation of copper oxide (Cu2O) nanoparticles into this polymer is expected to enhance its antibacterial, electrical, and thermal properties. This modification can potentially improve the performance of PLA in the fields of prosthetics manufacturing or printed circuit fabrication. However, the current research is rather focused on the mechanical properties of the PLA-Cu2O nanocomposites. This research is thus...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 19, 2024 Category: Materials Science Authors: Javad Khodadad Hatkeposhti Naser Kordani Mohammad Akbarzadeh Pasha Ahmad Barari Source Type: research

A numerical study of dehydration induced fracture toughness degradation in human cortical bone
J Mech Behav Biomed Mater. 2024 Feb 16;153:106468. doi: 10.1016/j.jmbbm.2024.106468. Online ahead of print.ABSTRACTA 2D plane strain extended finite element method (XFEM) model was developed to simulate three-point bending fracture toughness tests for human bone conducted in hydrated and dehydrated conditions. Bone microstructures and crack paths observed by micro-CT imaging were simulated using an XFEM damage model. Critical damage strains for the osteons, matrix, and cement lines were deduced for both hydrated and dehydrated conditions and it was found that dehydration decreases the critical damage strains by about 50%. ...
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 17, 2024 Category: Materials Science Authors: Mihee Shin Penny J Martens Thomas Siegmund Jamie J Kruzic Bernd Gludovatz Source Type: research