Neuroinvasive potential of human coronavirus OC43: case report of fatal encephalitis in an immunocompromised host
AbstractNeurologic manifestations of COVID-19 include anosmia, ageusia, encephalopathy, agitation, confusion, ischemic strokes, Guillain –Barré syndrome, seizures, and hemorrhagic encephalitis. Although mechanisms of central nervous system (CNS) injury are likely diverse, direct viral invasion of the CNS has been demonstrated in case reports. Neurotropism of human coronaviruses (HCoVs) is therefore of great interest in the context of the COVID-19 pandemic. Here we present an autopsy-proven case of fatal human coronavirus (HCoV)-OC43 encephalitis in an infant with aplastic thymus and chronic T-cell lymphopenia. Clinician...
Source: Journal of NeuroVirology - January 6, 2021 Category: Neurology Source Type: research
Collateral damage: Impact of SARS-CoV-2 pandemic in people living with HIV
AbstractPeople living with HIV (PLWH) may be at higher risk for adverse outcomes indirectly associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2). When comparing responses to questionnaires administered when social distancing and quarantine guidelines were first implemented, we found that PLWH were more likely to have restricted access to medical care, increased financial stress, increased symptoms of anxiety and depression, and increased substance use compared to demographically-similar people without HIV. (Source: Journal of NeuroVirology)
Source: Journal of NeuroVirology - January 6, 2021 Category: Neurology Source Type: research
Meningoencephalitis associated with COVID-19: a systematic review
AbstractWith the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and radiological findings among patients with SARS-CoV-2-associated meningoencephalitis in the form of a systemic review. This review was carried out based on the existing PRISMA (Preferred Report for Systematic Review and Meta analyses) consensus statement. The data for this review was collected from four databases: Pubmed/Medline, NIH Litcovid, Embase, and Cochrane library and Preprint servers up til...
Source: Journal of NeuroVirology - December 26, 2020 Category: Neurology Source Type: research
Brain-derived neurotrophic factor (BDNF) is associated with depressive symptoms in older adults with HIV disease
This study examined the possible role of brain-derived neurotrophic factor (BDNF) in symptoms of depression and other aspects of mood in 109 PWH and 43 seronegative participants aged 50 and older. Participants completed the Profile of Mood States (POMS) which measured six dimensions of mood and was normatively adjusted for sex. A model controlling for medical comorbidities and substance use diagnoses among PWH showed a significant interaction between BDNF and POMS subscales. Planned post hoc analyses revealed that lower BDNF was only associated with higher scores on Depression-Dejection and Confusion-Bewilderment POMS subs...
Source: Journal of NeuroVirology - November 3, 2020 Category: Neurology Source Type: research
Encephalopathy associated with COVID-19 in a patient with multiple sclerosis
AbstractFrom the beginning of COVID-19 pandemics, the involvement of patient ’s nervous system with this virus is increasingly reporting. Although various reports are published on affliction of multiple sclerosis (MS) patients with SARS-CoV-2, no report has been published on brain involvement by this virus in MS patients so far. Herein, a 34-year-old patient with MS who ex perienced the decreased level of consciousness and encephalopathy following COVID-19 involvement has been reported. (Source: Journal of NeuroVirology)
Source: Journal of NeuroVirology - October 28, 2020 Category: Neurology Source Type: research
