Critical period of exposure to mercury and the diagnostic of autism spectrum disorder: A systematic review
Recent autism spectrum disorder (ASD) cases show a notable link to increased heavy metal exposure, particularly mercury (Hg), a recognized neurotoxin found in urban pollution. This review explores the connection between pre- and post-natal Hg exposure and ASD, analyzing 57 articles from databases like PubMed and Embase. Of these, 61.40% confirm a positive association between ASD and Hg. The biological samples most used to analyze Hg body burdens were hair (36.84%) and blood (36.84%), indicating heightened levels in polluted environments during the post-natal period. AbstractAutism spectrum disorder (ASD) is characterized b...
Source: Journal of Neurochemistry - February 12, 2024 Category: Neuroscience Authors: Bruna Bittencourt Netto,
Elica Pizzolo da Silva,
Maiara de Aguiar da Costa,
Victória Linden de Rezende,
Sofia Januário Bolan,
Luciane Bisognin Ceretta,
Michael Aschner,
Diogo Dominguini,
Cinara Ludvig Gonçalves Tags: REVIEW Source Type: research
Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke
In conclusion, our data provide the first evidence that TNFSF9 triggers microglia activation by activating the ferroptosis signalling pathway following ischaem ic stroke, leading to brain injury and neurological deficits. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - February 12, 2024 Category: Neuroscience Authors: Zifu Li,
Tianxiang Gao,
Jing Wang,
Xiaoxi Zhang,
Yongxin Zhang,
Lei Zhang,
Pengfei Yang,
Jianmin Liu Tags: ORIGINAL ARTICLE Source Type: research
Fundamental Neurochemistry Review: At the intersection between the brain and the immune system: Non ‐coding RNAs spanning learning, memory and adaptive immunity
We suggest that learning and the brain's adaptive immune system are functionally linked by a plethora of non-coding RNA. That is, the same ncRNA can be repurposed through temporary modifications to its flexible structure, and used to transmit and encode information throughout and between the two systems. This theory comes from a multitude of studies showing that the same ncRNA species function in both systems and affecting the cells of one system affects the other. Consequentially, future academic and clinical research involving these systems should consider their intertwined nature. AbstractNon-coding RNAs (ncRNAs) are hi...
Source: Journal of Neurochemistry - February 10, 2024 Category: Neuroscience Authors: Mason R. B. Musgrove,
Marina Mikhaylova,
Timothy W. Bredy Tags: REVIEW Source Type: research
The calcium –calmodulin‐dependent protein kinase kinase inhibitor, STO‐609, inhibits nicotine‐induced currents and intracellular calcium increase in insect neurosecretory cells
Dorsal unpaired median neurons are insect neurosecretory cells that express alpha-bungarotoxin ( α-Bgt)-sensitive and -insensitive nicotinic acetylcholine receptors (nAChRs) subtypes. We found that the calmodulin kinase kinase (CaMKK) selective inhibitor STO reduced nicotinic currents, and strongly when co-applied with α-Bgt. Interestingly, intracellular application of the AMPK activator, A-7 6, prevented the reduction in nicotine-induced currents observed in the presence of the AMPK inhibitor, DM. STO prevented the increase in intracellular calcium induced by nicotine. Moreover, currents induced by the benzamide compoun...
Source: Journal of Neurochemistry - February 10, 2024 Category: Neuroscience Authors: Maria Taha,
Jean ‐Noël Houchat,
Emiliane Taillebois,
Steeve H. Thany Tags: ORIGINAL ARTICLE Source Type: research
The sphingosine 1 ‐phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus
FTY720 is a synthetic analogue of sphingosine 1-phosphate. It is currently used to treat multiple sclerosis and has recently been approved for use in adolescents. The aim of this study was to investigate how FTY720 alters the lipid composition of the brain of adolescent mice. Three weeks of chronic FTY720 treatment caused an up-regulation of 99 lipid species in the mouse hippocampus, including several oxidised phosphatidylcholines, whereas only 3 lipid species of the phosphatidic acid class were down-regulated. Our study presents novel insight into FTY720's molecular mechanism of action in the central nervous system. FST, ...
Source: Journal of Neurochemistry - February 10, 2024 Category: Neuroscience Authors: Daniela M. Magalh ães,
Nicolas A. Stewart,
Myrthe Mampay,
Sara O. Rolle,
Chloe M. Hall,
Emad Moeendarbary,
Melanie S. Flint,
Ana M. Sebastião,
Cláudia A. Valente,
Marcus K. Dymond,
Graham K. Sheridan Tags: ORIGINAL ARTICLE Source Type: research
NMDA glutamate receptor antagonist MK ‐801 induces proteome changes in adult human brain slices which are partially counteracted by haloperidol and clozapine
Schizophrenia presents a complex molecular pathophysiology, and the hypofunction of the glutamatergic NMDA receptor is recognized as one of the primary mechanisms. Using adult human brain-derived slice cultures and proteomics, we have identified altered pathways in NMDA antagonist MK-801-treated slices, some of which are associated with schizophrenia in previous works. By co-treating the slices with MK-801 and antipsychotics, we showed that clozapine was more effective in attenuating the molecular alterations caused by NMDAr hypofunction than haloperidol. AbstractDeciphering the molecular pathways associated with N-methyl-...
Source: Journal of Neurochemistry - February 9, 2024 Category: Neuroscience Authors: Val éria de Almeida,
Niele Dias Mendes,
Giuliana S. Zuccoli,
Guilherme Reis‐de‐Oliveira,
Glaucia M. Almeida,
Guilherme Gozzoli Podolsky‐Gondim,
Luciano Neder,
Daniel Martins‐de‐Souza,
Adriano Sebollela Tags: ORIGINAL ARTICLE Source Type: research
Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma
We suggest intrathecal IgM synthesis as a novel and easily accessible biomarker in patients with suspected central nervous system lymphoma. Our systematic study of the biomarker revealed high specificity but limited sensitivity in patients with CNS lymphoma when compared to control groups of other neurological diseases with similar radiological patterns. Because of its low threshold availability, intrathecal IgM synthesis analysis has the potential to improve diagnostic accuracy for CNS lymphoma, particularly in resource-limited settings. AbstractFor CNS lymphomas (CNSL), there is a high need for minimally invasive and eas...
Source: Journal of Neurochemistry - February 9, 2024 Category: Neuroscience Authors: Raphael Reinecke,
Kolja Jahnke,
Martha Foltyn ‐Dumitru,
Karsten Lachner,
Moritz Armbrust,
Katharina J. Weber,
Pia S. Zeiner,
Marcus Czabanka,
Uta Brunnberg,
Sylvia Hartmann,
Joachim P. Steinbach,
Michael W. Ronellenfitsch Tags: ORIGINAL ARTICLE Source Type: research
Mapping the lipidome in mitochondria ‐associated membranes (MAMs) in an in vitro model of Alzheimer's disease
The accumulation of APP and A β that occurs in N2A APPswe cells (AD cell model), which is known to change the communication between the ER and mitochondria affecting interorganelle Ca2+ transfer and ATP production, also affects the lipid homeostasis in the ER, MAMs, and mitochondria. A differential phospholipids and fatty acids species profile is observed in the membranes of these organelles and subcellular inter-organelle structures, indicating the specificity of each lipidome. The AD-associated lipid changes can represent an attempt to adjust to stressful and pathological conditions. AbstractThe disruption of mitochondr...
Source: Journal of Neurochemistry - February 8, 2024 Category: Neuroscience Authors: T ânia Fernandes,
Tânia Melo,
Tiago Conde,
Bruna Neves,
Pedro Domingues,
Rosa Resende,
Cláudia F. Pereira,
Paula I. Moreira,
Maria Rosário Domingues Tags: ORIGINAL ARTICLE Source Type: research
Microdosing ketamine in Drosophila does not block serotonin reuptake, but causes complex behavioral changes mediated by glutamate and serotonin receptors
Microdosing ketamine is a novel depression treatment, but it is not clear how it changes serotonin.Drosophila melanogaster (fruit fly) is a good model to study depressive behaviors. We used fast-scan cyclic voltammetry, video tracking, and feeding assays to measure serotonin and behavior after feeding ketamine and SSRIs to larvae. At microdoses, ketamine did not affect serotonin, which was different from SSRIs. However, higher doses inhibited dSERT. Locomotion and feeding changes were also dose-dependent, and we saw separate effects with NMDA and serotonin receptor drugs in a dSERT mutant. This work facilitates future beha...
Source: Journal of Neurochemistry - February 7, 2024 Category: Neuroscience Authors: Kelly E. Dunham,
Kani H. Khaled,
Leah Weizman,
B. Jill Venton Tags: ORIGINAL ARTICLE Source Type: research
Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning
We examined the involvement of nucleus accumbens' D1- and D2-neurons in associative learning, by measuring calcium transients with fiber photometry in mice. We show that during appetitive Pavlovian learning, D1- and D2-neurons exhibit a general increase in activity in response to the conditioned stimuli (CS), and distinct changes in activity after un conditioned stimulus (US – sucrose) consumption that dynamically evolve throughout learning. In an aversive Pavlovian learning task, D1- and D2-neurons develop increases in activity in response to both CS and US (shock). Our data support a model of concurrent activation of...
Source: Journal of Neurochemistry - February 6, 2024 Category: Neuroscience Authors: Catarina Deseyve,
Ana Ver ónica Domingues,
Tawan T. A. Carvalho,
Gisela Armada,
Raquel Correia,
Natacha Vieitas‐Gaspar,
Marcelina Wezik,
Luísa Pinto,
Nuno Sousa,
Bárbara Coimbra,
Ana João Rodrigues,
Carina Soares‐Cunha Tags: ORIGINAL ARTICLE Source Type: research
Genetic deletion of hormone ‐sensitive lipase in mice reduces cerebral blood flow but does not aggravate the impact of diet‐induced obesity on memory
This study investigated mice with ablated hormone-sensitive lipase (HSL) activity. HSL −/−, HSL+/−, and HSL+/+ mice were exposed to high-fat or control diet for 8 weeks, and tested for behavior and metabolic phenotype. Brain perfusion was measured using MRI, immunofluorescence microscopy in brain slices was used to measure coverage of blood vessels, astrocytes, and microglia, and mass spectrometry was used to measure brain lipid profiles. Altogether, results from these experiments indicate that HSL deletion leads to reduced brain perfusion, without aggravating obesity-induced memory impairment. AbstractHormone-sens...
Source: Journal of Neurochemistry - February 6, 2024 Category: Neuroscience Authors: Cecilia Skoug,
Oksana Rogova,
Peter Sp égel,
Cecilia Holm,
João M. N. Duarte Tags: ORIGINAL ARTICLE Source Type: research
The effect of sevoflurane exposure on cell ‐type‐specific changes in the prefrontal cortex in young mice
This study focuses on investigating the impact of neonatal sevoflurane exposure on cell-type-specific alterations in the prefrontal cortex (PFC) of young mice. Neonatal mice were subjected to either control treatment (60% oxygen balanced with nitrogen) or sevoflurane anesthesia (3% sevoflurane in 60% oxygen balanced with nitrogen) for 2 hours on postnatal days (PNDs) 6, 8, and 10. Behavioral tests and single-nucleus RNA sequencing (snRNA-seq) of the PFC were conducted from PNDs 31 to 37. Mechanistic exploration included clustering analysis, identification of differentially expressed genes (DEGs), enrichment analyses, si...
Source: Journal of Neurochemistry - February 6, 2024 Category: Neuroscience Authors: Bao ‐Jian Zhao,
Shao‐Yong Song,
Wei‐Ming Zhao,
Han‐Bing Xu,
Ke Peng,
Xi‐Sheng Shan,
Qing‐Cai Chen,
Hong Liu,
Hua‐Yue Liu,
Fu‐Hai Ji Tags: ORIGINAL ARTICLE Source Type: research
Maternal history of Alzheimer's disease predisposes to altered serum cholesterol levels in adult offspring
The objective of this study is to examine the causal impact of maternal history of AD on changes in serum cholesterol levels in adult offspring. By retrieving genetic variants from summary statistics of large-scale genome-wide association study of maternal history of AD (European-based:Ncase = 27 696,Ncontrol = 260 980). The causal association between genetically predicted maternal history of AD and changes in serum cholesterol levels in adult offspring was examined using the two-sample Mendelian randomization (MR) method. Causal impact estimates were calculated using single-nucleotide polymorphis ms in both ...
Source: Journal of Neurochemistry - February 6, 2024 Category: Neuroscience Authors: Yuehui Liang,
Ming ‐Gang Deng,
Qinghong Jian,
Mingwei Liu,
Kui Fang,
Shuai Chen Tags: ORIGINAL ARTICLE Source Type: research
Free energy profile of the substrate ‐induced occlusion of the human serotonin transporter
We showed that the occlusion mechanism of the serotonin transporter (SERT) is an energetically downhill process which involves multiple intermediate conformations. We demonstrated that the transporter recognizes the presence of serotonin (5HT), which shifts the free energy equilibrium towards intermediate conformations that are stabilized by interactions between 5HT and conserved residues in TM1b and TM6a (D98 and F335). Increasing forces between 5HT and the bundle domain then pull SERT to fully occlude. This finding increases our understanding of the substrate recognition, the driving forces and the associated free energy...
Source: Journal of Neurochemistry - February 6, 2024 Category: Neuroscience Authors: Leticia Alves da Silva,
Erika Lazzarin,
Ralph Gradisch,
Amy Clarke,
Thomas Stockner Tags: ORIGINAL ARTICLE Source Type: research
Perineuronal net deglycosylation associates with tauopathy ‐induced gliosis and neurodegeneration
Brain perineuronal nets (PNNs) are vital for neurocircuit stability and changes in their abundance and composition have been linked to Alzheimer's disease (AD) progression. In this work, we investigated age-associated PNN changes in transgenic mice with tauopathy-related AD neuropathology. 9-month-old PS19 (P301S) mice exhibited changes in PNN chondroitin sulfate-glycosaminoglycan (CS-GAG) composition and abundance, but not the underlying CS proteoglycan (CSPG) core proteins, in association with pTau, gliosis, and neurodegeneration. In contrast, Tau4RTg2652 mice showed stable PNNs despite pTau accumulation, emphasizing the...
Source: Journal of Neurochemistry - February 5, 2024 Category: Neuroscience Authors: Aric F. Logsdon,
Brian Foresi,
Shannon J. Hu,
Emily Quah,
Cristiana J. Meuret,
Jaden P. Le,
Aarun S. Hendrickson,
Ingrid K. Redford,
Asmit Kumar,
Bao Anh Phan,
Tammy P. Doan,
Cassidy Noonan,
Nzinga E. Hendricks,
Jeanna M. Wheeler,
Brian C. K Tags: ORIGINAL ARTICLE Source Type: research
