BACE2 beyond β‐processing of APP, its neuroprotective role in cerebrovascular endothelium
In Alzheimer's disease, an imbalance between the β-site amyloid precursor protein cleaving enzyme 2 (BACE2) and 1 (BACE1), with a BACE2 decrease and a BACE1 increase of their functions in brain endothelial cells, could lead to failure in soluble non-amyloidogenic APP fragment (sAPPα)-mediated vasoprotective functions and the accumulation of cere brovascular amyloid beta (Aβ) deposits, respectively. This Editorial highlights a study by Katusic et al, who report that BACE2 plays a role in preservation of cerebral vascular endothelial nitric oxide synthase (eNOS) function, thus exerting protective functions mediated by sAP...
Source: Journal of Neurochemistry - August 17, 2023 Category: Neuroscience Authors: Javier S áez‐Valero,
Rocío Pérez‐González Tags: EDITORIAL Source Type: research
The causal role of circulating amino acids on neurodegenerative disorders: A two ‐sample Mendelian randomization study
The potential association between amino acids and neurodegenerative diseases was demonstrated by Mendelian randomization here. Higher circulating glutamine has a potential causal association with the lower risk of Alzheimer's disease, meanwhile, a possible relationship between leucine and Parkinson's disease was first proposed in this study. AbstractPotential associations between the risk of neurodegenerative diseases and circulating levels of amino acids have been implied in both experimental research and observational studies. However, because of the confounding and reverse causality, the findings could be biased. We aim...
Source: Journal of Neurochemistry - August 12, 2023 Category: Neuroscience Authors: Ji ‐Yun Cheng,
Yue‐Ting Deng,
Jin‐Tai Yu Tags: ORIGINAL ARTICLE Source Type: research
HCN1 epilepsy: From genetics and mechanisms to precision therapies
We describe how mouse models have furthered our understanding of the phenotype of, and efficacious treatment options for, HCN1 epilepsy, and we explore the next steps needed to advance our knowledge of this devastating disease. AbstractPathogenic variation inHCN1 is now an established cause of epilepsy and intellectual disability. Variation inHCN1 causes a spectrum of disease with a genotype –phenotype relationship emerging. De novo pathogenic variants that occur in the transmembrane domains of the channel typically cause a cation ‘leak’ that associates with severe developmental and epileptic encephalopathy (DEE). Ge...
Source: Journal of Neurochemistry - August 11, 2023 Category: Neuroscience Authors: Lauren E. Bleakley,
Christopher A. Reid Tags: REVIEW Source Type: research
The multifaceted roles of the brain glycogen
Glycogen is an essential carbohydrate storage molecule involved in multiple tissue-specific processes. This review provides a comprehensive summary of our understanding of brain glycogen and the multifaceted roles of glycogen proposed by recent articles. The roles are described in health and disease with a focus on current evidence linking glycogen and glycosylation. Finally, we highlight the therapeutic potential of targeting glycogen metabolism and potential avenues for future research. AbstractGlycogen is a biologically essential macromolecule that is directly involved in multiple human diseases. While its primary role ...
Source: Journal of Neurochemistry - August 9, 2023 Category: Neuroscience Authors: Kia H. Markussen,
Manuela Corti,
Barry J. Byrne,
Craig W. Vander Kooi,
Ramon C. Sun,
Matthew S. Gentry Tags: REVIEW Source Type: research
Phospholipid cofactor solubilization inhibits formation of native prions
The propagation of infectious mammalian prions in vitro requires cofactors, such as phospholipid or RNA molecules. Here, we report that the ability of phospholipids to act as prion cofactors for the conversion of GPI-anchored native prion protein substrate (PrPC) into its infectious conformation (PrPSc) is inhibited by phospholipid solubilization. These results suggest that bilayer membrane architecture may play an important role in prion formation. AbstractCofactor molecules are required to generate infectious mammalian prions in vitro. Mouse and hamster prions appear to have different cofactor preferences: Whereas both m...
Source: Journal of Neurochemistry - August 8, 2023 Category: Neuroscience Authors: Abigail M. Schwind,
Daniel J. Walsh,
Cassandra M. Burke,
Surachai Supattapone Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: ISSUE INFORMATION Source Type: research
Author Index
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: Author Index Source Type: research
Advanced school awardees
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: ABSTRACT Source Type: research
Esn ‐yms
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: ABSTRACT Source Type: research
Poster Sessions B
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: ABSTRACT Source Type: research
Poster Sessions A
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: ABSTRACT Source Type: research
Young_Members_Symposia
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: ABSTRACT Source Type: research
Emerging_Group_Leaders_Symposia
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: ABSTRACT Source Type: research
Mark_Smith_Award
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: ABSTRACT Source Type: research
Esn ‐ysla
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - August 7, 2023 Category: Neuroscience Tags: ABSTRACT Source Type: research
