Breaking the rules of SLC6 transporters: Export of the human creatine transporter ‐1 from the endoplasmic reticulum is supported by its N‐terminus
Point mutations in the human creatine transporter 1 (CRT1) trigger the creatine transporter deficiency syndrome manifested by intellectual disability and epilepsy. Such pathogenic variants frequently impair CRT1 protein folding and trafficking. By generating serial truncations and chimeric constructs, we identified the amino-terminus region as a key determinant of endoplasmic reticulum (ER)-exit mechanisms of CRT1. Surprisingly, mutations in the putative carboxyl-terminal ER-export motifs failed to impair the delivery of CRT1 to the plasma membrane. Thus, CRT1 is unique among its solute carrier 6 transporter relatives, sin...
Source: Journal of Neurochemistry - February 29, 2024 Category: Neuroscience Authors: Didem Ün,
Vasylyna Kovalchuk,
Ali El‐Kasaby,
Ameya Kasture,
Florian Koban,
Oliver Kudlacek,
Michael Freissmuth,
Sonja Sucic Tags: ORIGINAL ARTICLE Source Type: research
MicroRNA ‐29b‐3p degenerates terminally differentiated dopaminergic SH‐SY5Y cells by perturbation of mitochondrial functions
MicroRNA-29b-3p, previously implicated in neuronal differentiation and damage, was investigated for its role in neurotoxicant-induced disruption of mitochondrial homeostasis. Our study unveiled that miR-29b-3p over-expression adversely impacted cellular bioenergetics, dynamics, and redox regulation, thereby promoting mitochondrial dysfunction. This initiated a cascade involving SIRT-1/YY-1/PGC-1 α, culminating in the BNIP-3L-mediated caspase activation pathway in differentiated dopaminergic SH-SY5Y cells. These findings shed light on the previously unexplored dimension of miR-29b-3p, establishing its link to neurotoxicant...
Source: Journal of Neurochemistry - February 28, 2024 Category: Neuroscience Authors: Sana Sarkar,
Anuj Pandey,
Sanjeev Kumar Yadav,
Pragati Raghuwanshi,
Mohammed Haris Siddiqui,
Saripella Srikrishna,
Aditya Bhushan Pant,
Sanjay Yadav Tags: ORIGINAL ARTICLE Source Type: research
Toward understanding the neural mechanisms involved in early life stress ‐induced aggression
Early life stress is a major risk factor for the development of antisocial behavior. This Editorial highlights an article in the current issue of the Journal of Neurochemistry that demonstrates the involvement of the central nucleus of the amygdala (CeA) in the escalation of aggressive behavior in a rat model of maternal separation. Using optogenetics, the authors provide direct evidence that activation of CeA neurons increases intermale aggressive behavior and that bilateral CeA activation shifts behavioral patterns toward more qualitatively intense aggressive behavior than unilateral CeA activation, implicating the CeA r...
Source: Journal of Neurochemistry - February 28, 2024 Category: Neuroscience Authors: Aki Takahashi Tags: EDITORIAL Source Type: research
Brian Collier (1940 –2024)
Dr. Brian Collier, the former Editor-in-Chief of the Journal of Neurochemistry from 1996 to 2006, passed away January 4th, 2024. Brian's illustrious career spanned the fields of neurochemistry and pharmacology. He published his findings on mechanisms of acetylcholine synthesis and storage in the Journal of Neurochemistry, and his contributions remain landmarks in neurochemical research. Photo courtesy of the authors. AbstractDr. Brian Collier, the former Editor-in-Chief of the Journal of Neurochemistry from 1996 to 2006, passed away January 4th, 2024. Brian's illustrious career spanned the fields of neurochemistry and phar...
Source: Journal of Neurochemistry - February 24, 2024 Category: Neuroscience Authors: Marco A. M. Prado,
Anurag Tandon Tags: OBITUARY Source Type: research
miRNAs in cerebrospinal fluid associated with Alzheimer's disease: A systematic review and pathway analysis using a data mining and machine learning approach
An integrative review aimed to identify key miRNAs for distinguishing AD patients from cognitively healthy individuals. Notable miRNAs included miRNA-30a-3p, miRNA-193a-5p, miRNA-143-3p, miRNA-145-5p. Pathway enrichment analysis highlighted the significance of the MAPK pathway, which plays a vital role in AD-related events. These findings offer potential for AD diagnostic tests and monitoring disease progression. Furthermore, further exploration of these signalling pathways contributes to a deeper understanding of AD pathophysiology. AbstractAlzheimer's disease (AD) is the most common type and accounts for 60% –70% of th...
Source: Journal of Neurochemistry - February 23, 2024 Category: Neuroscience Authors: Jessica Diniz Pereira,
L ívia Cristina Ribeiro Teixeira,
Izabela Mamede,
Michelle Teodoro Alves,
Paulo Caramelli,
Marcelo Rizzatti Luizon,
Adriano Alonso Veloso,
Karina Braga Gomes Tags: SYSTEMATIC REVIEW Source Type: research
Issue Information
Front coverDespite the advent of combination anti-retroviral therapy (cART), nearly half of people infected with HIV (PWH) treated with cART still exhibit HIV-associated neurocognitive disorders (HAND). HAND can be worsened by comorbid opioid use disorder (OUD). The basal ganglia are particularly vulnerable to HIV-1. Evidence suggests that dopaminergic neurotransmission is disrupted by HIV exposure. We assessed in mice whether co-exposure to opioids may alter neurotransmitter levels in the striatum and if this in turn influences behavior. Our results provide novel insight into the unique effects of HIV-1 Tat and morphine o...
Source: Journal of Neurochemistry - February 23, 2024 Category: Neuroscience Tags: ISSUE INFORMATION Source Type: research
Milestone review: GABA, from chemistry, conformations, ionotropic receptors, modulators, epilepsy, flavonoids, and stress to neuro ‐nutraceuticals
GABA, a deceptively simple molecule, is shown in extreme conformations and analogues with selective actions on ionotropic GABA receptors, together with some GABA-enriched chocolates purchased in Japan, one of the very many publicly available GABA-enriched products. These studies arose out of a PhD project in the 1970s and illustrate the development of our knowledge of these receptors and their modulators in the areas of epilepsy, stress, and neuro-nutraceuticals. AbstractArising out of a PhD project more than 50 years ago to synthesise analogues of the neurotransmitter GABA, a series of new chemical entities were found ...
Source: Journal of Neurochemistry - February 22, 2024 Category: Neuroscience Authors: Graham A. R. Johnston,
Philip M. Beart Tags: REVIEW Source Type: research
Cell density impacts the susceptibility to ferroptosis by modulating IRP1 ‐mediated iron homeostasis
In this study, the authors pinpointed that increased cell seeding density leads to enhanced resistance to ferroptosis. Mechanistically, increased cell seeding density led to a decrease in iron-responsi ve protein 1 levels, which leads to reduction in intracellular iron levels by affecting the level of ferroportin or transferrin receptor. As a result, the reduced iron levels markedly boosted resistance against ferroptosis. AbstractFerroptosis has been implicated in several neurological disorders and may be therapeutically targeted. However, the susceptibility to ferroptosis varies in different cells, and inconsistent result...
Source: Journal of Neurochemistry - February 22, 2024 Category: Neuroscience Authors: Hong ‐fa Yan,
Qing‐zhang Tuo,
Peng Lei Tags: ORIGINAL ARTICLE Source Type: research
Mass spectrometry imaging highlights dynamic patterns of lipid co ‐expression with Aβ plaques in mouse and human brains
Using spatial massspectrometry imaging in conjunction with multiplex mass cytometry imaging andimmuno-histochemistry, disease related peri-amyloid- β plaque lipidomicdisruptions were captured in both mouse and human. These changes were subsequently colocalised with increased CD68 and LAMP1 upregulation. The focally elevated lipids include lysophospholipids (lysophosphatidylinositol (LPI), lysophosphatidylglycerol (LPG), lysophosphatidic Acid ( LPA), and lysophosphatidylcholine (LPC)), bis (monoacylglycerol) phosphates (BMP), and phosphatidylglycerolsm (PG). AbstractLipids play crucial roles in the susceptibility and brain...
Source: Journal of Neurochemistry - February 20, 2024 Category: Neuroscience Authors: Helen Xuexia Huang,
Paolo Inglese,
Jiabin Tang,
Riad Yagoubi,
Gon çalo D. S. Correia,
Verena M. Horneffer‐van der Sluis,
Stephane Camuzeaux,
Vincen Wu,
Maksym V. Kopanitsa,
Nanet Willumsen,
Johanna S. Jackson,
Anna M. Barron,
Takashi Sait Tags: ORIGINAL ARTICLE Source Type: research
Lipid imaging of Alzheimer's disease pathology
AbstractAlzheimer's disease (AD) affects one in eight individuals over 65 and poses an immense societal challenge. AD pathology is characterized by the formation of beta-amyloid plaques and Tau tangles in the brain. While some disease-modifying treatments targeting beta-amyloid are emerging, the exact chain of events underlying the pathogenesis of this disease remains unclear. Brain lipids have long been implicated in AD pathology, though their role in AD pathogenesis remains not fully resolved. Significant advancements in mass spectrometry imaging (MSI) allow to detail spatial lipid regulations in biological tissues at th...
Source: Journal of Neurochemistry - February 19, 2024 Category: Neuroscience Authors: J örg Hanrieder Tags: EDITORIAL Source Type: research
Increased levels of advanced oxidation protein products (AOPPs) were associated with nociceptive behavior and clinical scores in an experimental progressive autoimmune encephalomyelitis model (PMS ‐EAE)
Primary progressive multiple sclerosis (PPMS) is the most disabling clinical form of multiple sclerosis (MS). The involvement of advanced oxidation protein products (AOPPs) and their accumulation in plasma have been related to clinical disability in MS patients, but has not been evaluated yet in neuropathic pain- and anxiety-like symptoms. Here, we demonstrated an association of rising AOPPs levels with non-stimulus-induced painful perception, anxiety-like behavior, and central nervous system oxidative damage in an experimental autoimmune encephalomyelitis (PMS-EAE) model using female C57BL/6J mice. AbstractMultiple sclero...
Source: Journal of Neurochemistry - February 19, 2024 Category: Neuroscience Authors: Patr ícia Rodrigues,
Julia Maria Frare,
Diulle Spat Peres,
Fernanda Tibolla Viero,
Náthaly Andrighetto Ruviaro,
Carolina dos Santos Stein,
Evelyne da Silva Brum,
Rafael Noal Moresco,
Sara Marchesan Oliveira,
Guilherme Vargas Bochi,
Gabriela Tags: ORIGINAL ARTICLE Source Type: research
Profiling amyloid ‐β peptides as biomarkers for cerebral amyloid angiopathy
This study supports the potential use of this panel of CSF Aβ peptides to indicate presence of CAA pathology with high accuracy. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - February 17, 2024 Category: Neuroscience Authors: Emma van den Berg,
Iris Kersten,
Gunnar Brinkmalm,
Kjell Johansson,
Anna M. de Kort,
Catharina J. M. Klijn,
Floris H. B. M. Schreuder,
Johan Gobom,
Erik Stoops,
Erik Portelius,
Eleni Gkanatsiou,
Henrik Zetterberg,
Kaj Blennow,
Hinke B. Kuiper Tags: ORIGINAL ARTICLE Source Type: research
Truncated GPNMB, a microglial transmembrane protein, serves as a scavenger receptor for oligomeric β‐amyloid peptide1‐42 in primary type 1 microglia
In this study, we report that the truncated form of GPNMB, the antigen for 9F5, serves as a scavenger receptor for oligomeric Aβ1-42 (o-A β1-42) in rat primary type 1 MG.125I-labeled o-A β1-42 exhibited specific and saturable endosomal/lysosomal degradation in primary-cultured type 1 MG from GPNMB-expressing wild-type mice, whereas the degradation activity was markedly reduced in cells fromGpnmb-knockout mice. TheGpnmb-siRNA significantly inhibits the degradation of125I-o-A β1-42 by murine microglial MG5 cells. Therefore, GPNMB contributes to mouse MG's o-A β1-42 clearance. In rat primary type 1 MG, the cell surface e...
Source: Journal of Neurochemistry - February 16, 2024 Category: Neuroscience Authors: Kohichi Kawahara,
Takuya Hasegawa,
Noa Hasegawa,
Taisei Izumi,
Koji Sato,
Toshiyuki Sakamaki,
Masayuki Ando,
Takehiko Maeda Tags: ORIGINAL ARTICLE Source Type: research
Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy
In conclusion, our data revealed the existence of a cir c_lrrc49/Ist1/autophagy signaling axis contributing to the progression of orofacial neuropathic pain. These discoveries reveal the intricate molecular processes that drive orofacial neuropathic pain and identify circ_lrrc49 as a promising target for potential therapeutic interventions. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - February 13, 2024 Category: Neuroscience Authors: Qingfeng Tang,
Zhonghan Fang,
Honglin Liao,
Yanyan Zhang,
Chunjie Li,
Cheng Zhou,
Fei Liu,
Jiefei Shen Tags: ORIGINAL ARTICLE Source Type: research
Critical period of exposure to mercury and the diagnostic of autism spectrum disorder: A systematic review
Recent autism spectrum disorder (ASD) cases show a notable link to increased heavy metal exposure, particularly mercury (Hg), a recognized neurotoxin found in urban pollution. This review explores the connection between pre- and post-natal Hg exposure and ASD, analyzing 57 articles from databases like PubMed and Embase. Of these, 61.40% confirm a positive association between ASD and Hg. The biological samples most used to analyze Hg body burdens were hair (36.84%) and blood (36.84%), indicating heightened levels in polluted environments during the post-natal period. AbstractAutism spectrum disorder (ASD) is characterized b...
Source: Journal of Neurochemistry - February 12, 2024 Category: Neuroscience Authors: Bruna Bittencourt Netto,
Elica Pizzolo da Silva,
Maiara de Aguiar da Costa,
Victória Linden de Rezende,
Sofia Januário Bolan,
Luciane Bisognin Ceretta,
Michael Aschner,
Diogo Dominguini,
Cinara Ludvig Gonçalves Tags: REVIEW Source Type: research
