A tribute to Sebasti án Cerdán and his key contributions to brain metabolism
Sebasti án Cerdán, a wonderful colleague and brilliant and innovative NMR spectroscopist sadly passed away in May 2022. His studies using multinuclear magnetic resonance spectroscopy (MRS) techniques contributed greatly to the understanding of brain metabolism, including identification of the pyruvate rec ycling pathway in brain and determining metabolic changes in the brain related to appetite regulation and the development of obesity. He will be greatly missed. Photo of Sebastián Cerdán on the Great Wall of China at the 3rd International Society for Neurochemistry (ISN) Special. Conference/8th In ternational Conferen...
Source: Journal of Neurochemistry - May 12, 2023 Category: Neuroscience Authors: Jorgina Satrustegui,
Pilar L ópez Larrubia,
Tiago B. Rodrigues,
In‐Young Choi,
Mary C. McKenna Tags: OBITUARY Source Type: research
Peripheral and central neuroplasticity in a mouse model of endometriosis
AbstractChronic pelvic pain (CPP) is the most debilitating symptom of gynaecological disorders such as endometriosis. However, it remains unclear how sensory neurons from pelvic organs affected by endometriosis, such as the female reproductive tract, detect and transmit nociceptive events and how these signals are processed within the central nervous system (CNS) Using a previously characterised mouse model of endometriosis we investigated whether the increased pain sensitivity occurring in endometriosis could be attributed to i) changes in mechanosensory properties of sensory afferents innervating the reproductive tract, ...
Source: Journal of Neurochemistry - May 11, 2023 Category: Neuroscience Authors: Joel Castro,
Jessica Maddern,
Andelain Erickson,
Andrea. M. Harrington,
Stuart M. Brierley Tags: ORIGINAL ARTICLE Source Type: research
The polyphenol EGCG directly targets intracellular amyloid ‐β aggregates and promotes their lysosomal degradation
AbstractThe accumulation of amyloidogenic protein aggregates in neurons is a pathogenic hallmark of a large number of neurodegenerative diseases including Alzheimer's disease (AD). Small molecules targeting such structures and promoting their degradation may have therapeutic potential for the treatment of AD. Here, we searched for natural chemical compounds that decrease the abundance of stable, proteotoxic β-sheet-rich amyloid-β (Aβ) aggregates in cells. We found that the polyphenol (-)-epigallocatechin gallate (EGCG) functions as a potent chemical aggregate degrader (CAD) in SH-EP cells. We further demonstrate that a ...
Source: Journal of Neurochemistry - May 11, 2023 Category: Neuroscience Authors: Christopher Secker,
Angelika Y. Motzny,
Simona Kostova,
Alexander Buntru,
Lucas Helmecke,
Laura Reus,
Robert Steinfort,
Lydia Brusendorf,
Annett Boeddrich,
Nancy Neuendorf,
Lisa Diez,
Peter Schmieder,
Aline Schulz,
Constantin Czekelius,
Eric Tags: ORIGINAL ARTICLE Source Type: research
Real ‐time quaking‐induced conversion assay using a small‐scale substrate production workflow for the diagnosis of Creutzfeldt‐Jakob disease
This study aimed to evaluate the performance of RT-QuIC with recPrP produced in-house through a small-scale method – i.e. the application of reusable pre-packed chromatography columns and subsequent dialysis. Here, CSF specimens from patients suspected of having prion disease were consecutively collected and stored between October 2015 and January 2023. Electronic medical record data were reviewed to clinicall y classified participants as probable sCJD or non-sCJD. CSF RT-QuIC was performed using in-house recPrP. Its specificity and sensitivity for diagnosing probable sCJD were reported, along with details of other clini...
Source: Journal of Neurochemistry - May 10, 2023 Category: Neuroscience Authors: Poosanu Thanapornsangsuth,
Adipa Chongsuksantikul,
Abhinbhen W. Saraya,
Akarin Hiransuthikul,
Thiravat Hemachudha Tags: ORIGINAL ARTICLE Source Type: research
Fundamental Neurochemistry Review: Old brain stories ‐ Influence of age and sex on the neurodegeneration‐associated lipid changes
AbstractBrain aging is a naturally occurring process resulting in the decline of cognitive functions and increased vulnerability to develop age-associated disorders. Fluctuation in lipid species is crucial for normal brain development and function. However, impaired lipid metabolism and changes in lipid composition in the brain have been increasingly recognized to play a crucial role in physiological aging, as well as in several neurodegenerative diseases. In the last decades, the role of sexual dimorphism in the vulnerability to develop age-related neurodegeneration has increased. However, further studies are warranted fo...
Source: Journal of Neurochemistry - May 10, 2023 Category: Neuroscience Authors: Lorena Cuenca ‐Bermejo,
Alessandro Prinetti,
Karolina Kublickiene,
Valeria Raparelli,
Alexandra Kautzky‐Willer,
Colleen M. Norris,
Louise Pilote,
The GOING‐FWD Consortium,
M. T. Herrero Tags: REVIEW Source Type: research
