Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal cord. Using the ALS mouse model expressing the G93A mutant of Superoxide Dismutase 1 (SOD1G93A), we found that glycogen accumulates in the spinal cord during disease progression, and that increased glycogen is associated with reactive astrocytes. Genetic reduction of glycogen levels increases lifespan and alters inflammatory cytokines, while increasing glycogen levels leads to a more rapid disease progression. These results suggest that glycogen in reactive astrocytes contribut...
Source: Journal of Neurochemistry - July 4, 2023 Category: Neuroscience Authors: M. Kathryn Brewer,
Pascual Torres,
Vict òria Ayala,
Manuel Portero‐Otin,
Reinald Pamplona,
Pol Andrés‐Benito,
Isidro Ferrer,
Joan J. Guinovart,
Jordi Duran Tags: ORIGINAL ARTICLE Source Type: research
Clustering of CaV1.3 L ‐type calcium channels by Shank3
Clustering of L-type voltage-gated Ca2+ channels (LTCCs) in the plasma membrane is increasingly implicated in creating highly localized Ca2+ signaling nanodomains. Left panel: Our data support the clustering of multiple CaV1.3L L-type calcium channels by the neuronal scaffolding protein Shank3 via direct interaction of the Shank3 PDZ domain with the C-terminal domain of CaV1.3L under basal conditions. Right panel: Ca2+ influx via CaV1.3L causes disassociation of Shank3 from CaV1.3L, disrupting Shank3-mediated clustering of CaV1.3L channels. Shank3-mediated CaV1.3L clustering under basal conditions may have a key role in ...
Source: Journal of Neurochemistry - July 1, 2023 Category: Neuroscience Authors: Qian Yang,
Tyler L. Perfitt,
Juliana Quay,
Lan Hu,
Dorian Lawson ‐Qureshi,
Roger J. Colbran Tags: ORIGINAL ARTICLE Source Type: research
Obesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline
Midlife obesity doubles future Alzheimer's disease (AD) risk. We used a transcriptomic discovery approach in dorsal hippocampus of TgF344-AD and WT rats fed standard chow or a high-fat, high-sugar “Western” diet to examine interactions between obesity and AD during mild cognitive impairment (MCI). AD up-regulated cholesterol synthesis, whereas obesity during AD development additionally dysregulated lipid clearance, mitochondrial genes, and neurotransmission pathways, particularly involvin g norepinephrine. Cell-type deconvolution highlighted inflammatory microglial activation in AD development, with multiple additional...
Source: Journal of Neurochemistry - July 1, 2023 Category: Neuroscience Authors: Thea Anderson,
Sumeet Sharma,
Michael A. Kelberman,
Christopher Ware,
Nanxi Guo,
Zhaohui Qin,
David Weinshenker,
Marise B. Parent Tags: ORIGINAL ARTICLE Source Type: research
Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease
The receptor for advanced glycation end products (RAGE) is a multiligand protein that has been reported to be a critical modulator of neuroinflammation in Alzheimer's disease (AD), but it is also involved in nerve repair, transcytosis of proteins through the blood –brain barrier (including amyloid β peptide), modulation of neuronal apoptosis, and even in neuronal differentiation. A recent study showed that α-synuclein fibrils bind to RAGE, and we review the possible roles of this receptor in Parkinson's disease (PD). AbstractThe receptor for advanced glycation end products (RAGE) is a transmembrane receptor that belong...
Source: Journal of Neurochemistry - June 29, 2023 Category: Neuroscience Authors: Juciano Gasparotto,
Nauana Somensi,
Carolina Saibro Girardi,
Reykla Ramon Bittencourt,
Laura Martinewski Oliveira,
Laura Piloneto Hoefel,
Ingrid Matsubara Scheibel,
Daniel Oppermann Peixoto,
Jos é Claudio Fonseca Moreira,
Tiago Fleming Outeiro, Tags: REVIEW Source Type: research
Gene expression profiling in whole blood stimulated ex vivo with lipopolysaccharide as a tool to predict post ‐stroke depressive symptoms: Proof‐of‐concept study
We studied if blood gene expression could facilitate identification of persons who will develop depression 3 months after ischemic stroke. Venous blood samples were collected on day 3 after stroke. Obtained blood was stimulated in vitro with lipopolysaccharide, a powerful inducer of gene expression. After stimulation, RNA was isolated and sequenced. Expression of 510 genes differed between patients who developed depression and those who had not depression after stroke. Bioinformatic analysis revealed that expression of 6 genes (PKM, PRRC2C, NUP188, CHMP3, H2AC8, NOP10) accurately predicted a risk of depression. Our finding...
Source: Journal of Neurochemistry - June 27, 2023 Category: Neuroscience Authors: Marcin Piechota,
Dzesika Hoinkis,
Michal Korostynski,
Slawomir Golda,
Joanna Pera,
Tomasz Dziedzic Tags: ORIGINAL ARTICLE Source Type: research
Retraction: Cyclo(His ‐Pro) up‐regulates heme oxygenase 1 via activation of Nrf2‐ARE signalling
The above article, published online on 16th October 2009 in Wiley Online Library (wileyonlinelibrary.com) and corrected in 2014 with a Corrigendum (JNeurochem 128(6): 975, URL:https://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2011.07368.x) correcting Figure 3 of the original publication, has been retracted by agreement between the journal ’s Editor-in-Chief, Andrew Lawrence, the International Society for Neurochemistry and John Wiley& Sons Ltd. The retraction has been agreed due to concerns raised regarding possible image manipulation of Figure 5b. Corresponding author Alba Minelli as well as all other authors have...
Source: Journal of Neurochemistry - June 26, 2023 Category: Neuroscience Tags: RETRACTION Source Type: research
Retraction: Broad DNA repair responses in neural injury are associated with activation of the IL ‐6 pathway in cholesterol‐fed rabbits
The above article, published online on 16th October 2009, has been retracted by agreement between the journal ’s Editor-in-Chief, Andrew J. Lawrence, Deputy Editor-in-Chief, Marco A.M. Prado, and John Wiley and Sons Ltd. The retraction has been agreed due to identification of image manipulation and duplication in Figures 1A, 2A, 1C, 1D, 4C, 3A, 4A, 4E, 5A, and 5B. The corresponding author was unable to pr ovide the original unmodified blots and raw data to clarify the concerns upon request. The author's institution has been informed of the concerns, but no response was received. The article is retracted on the basis that...
Source: Journal of Neurochemistry - June 26, 2023 Category: Neuroscience Tags: RETRACTION Source Type: research
Biomarkers for predicting disease course in Sanfilippo syndrome: An urgent unmet need in childhood ‐onset dementia
Peripherally accessible biomarkers are urgently required to provide a prognosis for children with pre-symptomatic Sanfilippo syndrome, enabling early trial/treatment access and optimal outcomes. Furthermore, clinical trials require biomarkers to better stratify patients into treatment groups and measure neurocognitive outcomes. The development of biomarkers relies on the appropriate targeting of neuropathological pathways involved in each disease context, as addressed in this review. Extraction of brain-derived vesicle-encapsulated synaptic and mitochondrial proteins, as well as quantification of neuroinflammatory and neur...
Source: Journal of Neurochemistry - June 26, 2023 Category: Neuroscience Authors: Leanne K. Winner,
Mary ‐Louise Rogers,
Marten F. Snel,
Kim M. Hemsley Tags: REVIEW Source Type: research
Circadian rhythm alterations affecting the pathology of neurodegenerative diseases
Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), spinocerebellar ataxia (SCA), and multiple-system atrophy (MSA) dysregulate clock genes, which leads to sleep disturbances and can also exacerbate these diseases. In PD, the decrease in clock genes leads to oxidative stress. In AD, this disturbance leads to an increase in tau phosphorylation. In HD, it intensifies the accumulation of mutant huntingtin, and in MSA, it impairs dopaminergic signaling. These alterations act as a feedback loop, exacerbat...
Source: Journal of Neurochemistry - June 26, 2023 Category: Neuroscience Authors: Jaquelini Betta Canever,
Let ícia Yoshitome Queiroz,
Ericks Sousa Soares,
Núbia Carelli Pereira Avelar,
Helena Iturvides Cimarosti Tags: REVIEW Source Type: research
Whole ‐brain neural connectivity to cholinergic neurons in the nucleus basalis of Meynert
Nucleus basalis of Meynert (NBM) cholinergic neurons mainly received inputs from the caudate putamen and the posterior limb of the anterior commissure in the subcortex. Moreover, the majority of cholinergic terminals from the NBM were observed in the cortex mantle, especially the motor cortex, sensory cortex. Interestingly, although NBM cholinergic neurons received input projections from the caudate putamen (CPu), interstitial nucleus of the posterior limb of the anterior commissure (IPAC), central amygdaloid nucleus (CeA), and lateral globus pallidus (LGP), NBM cholinergic neurons sparsely sent axon projection to innervat...
Source: Journal of Neurochemistry - June 24, 2023 Category: Neuroscience Authors: Zhao ‐yi Chen,
Yao‐lian Yang,
Mai Li,
Lu Gao,
Wei‐min Qu,
Zhi‐li Huang,
Xiang‐shan Yuan Tags: ORIGINAL ARTICLE Source Type: research
Mitophagy suppresses motor neuron necroptotic mitochondrial damage and alleviates necroptosis that converges to SARM1 in acrylamide ‐induced dying‐back neuropathy
We propose upstream necroptotic mitochondrial damage initiates SARM1-dependent core axonal destruction program in acrylamide (ACR)-induced dying-back neuropathy. Rapamycin (RAPA) intervention enhanced mitophagic flux and timely removed damage-related molecules that gathered on mitochondria, for instance, phosphorylation-activated MLKL. Thus, mitophagy inhibited mitochondrial damage that was associated with multiple necroptotic pathways, alleviating ACR-induced neuropathy. AbstractAcrylamide (ACR), a common industrial ingredient that is also found in many foodstuffs, induces dying-back neuropathy in humans and animals. Howe...
Source: Journal of Neurochemistry - June 23, 2023 Category: Neuroscience Authors: Shuai Wang,
Yiyu Yang,
Zhigang Yu,
Mingxue Song,
Zhidan Liu,
Shulin Shan,
Hui Yong,
Wenting Ni,
Yalong Qiang,
Cuiqin Zhang,
Shu ’e Wang,
Xiulan Zhao,
Fuyong Song Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
Front coverThe traditional medicinal mushroom Hericium erinaceus, also known as lion ’s mane mushroom has bioactive compounds with neurotrophic activity. Here, we purified and identified biologically active molecules isolated from H. erinaceus, based on their ability to promote neurite extensive outgrowth in hippocampal neurons. We found that N-de phenylethyl isohericerin (NDPIH) and its hydrophobic derivative hericene A, were highly potent in inducing neurite outgrowth and branching in cultured hippocampal neurons. In addition, mice feed with hericene A showed both increased BDNF signaling and enhanced hippocampal memor...
Source: Journal of Neurochemistry - June 23, 2023 Category: Neuroscience Tags: ISSUE INFORMATION Source Type: research
Acknowledgement of reviewers
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 23, 2023 Category: Neuroscience Tags: ACKNOWLEDGEMENT OF REVIEWERS Source Type: research
Genetic ablation of Saposin ‐D in Krabbe disease eliminates psychosine accumulation but does not significantly improve demyelination
In this study, we generated Twi mice with a Sap-D deficiency (Twi/Sap-D KO), which are genetically deficient in both GALC and Sap-D and found that very little psychosine accumulated in the CNS or PNS of the mouse. As expected, demyelination with the infiltration of multinucleated macrophages (globoid cells) characteristic of Krabbe disease was milder in Twi/Sap-D KO mice than in Twi mice both in the CNS and PNS during the early disease stage. However, at the later disease stage, qualitatively and quantitatively comparable demyelination occurred in Twi/Sap-D KO mice, particularly in the PNS, and the lifespans of Twi/Sap-D K...
Source: Journal of Neurochemistry - June 20, 2023 Category: Neuroscience Authors: Takashi Watanabe,
Kazuhito Tsuboi,
Nobuaki Matsuda,
Yuta Ishizuka,
Shinji Go,
Etsuko Watanabe,
Ayaka Ono,
Yasuo Okamoto,
Junko Matsuda Tags: ORIGINAL ARTICLE Source Type: research
Cerebrospinal fluid, brain, and spinal cord levels of L ‐aspartate signal excitatory neurotransmission abnormalities in multiple sclerosis patients and experimental autoimmune encephalomyelitis mouse model
Multiple sclerosis (MS) is a chronic immune-mediated disease characterized by inflammation, demyelination, gliosis, and neurodegeneration in the central nervous system. Neuroinflammatory processes in MS are associated with a remarkable overactivation of glutamate receptors; however, the specific involvement of excitatory amino acid levels remains unclear. In a cohort of relapsing –remitting MS patients but not controls, we showed a marked correlation between the cerebrospinal fluid (CSF) levels of the endogenous NMDA receptor agonist, L-aspartate, and those of the cytokines G-CSF, IL-1ra, MIP-1β, and Eotaxin. These find...
Source: Journal of Neurochemistry - June 19, 2023 Category: Neuroscience Authors: Francesco Errico,
Luana Gilio,
Andrea Mancini,
Tommaso Nuzzo,
Mario Stampanoni Bassi,
Laura Bellingacci,
Fabio Buttari,
Ettore Dolcetti,
Antonio Bruno,
Giovanni Galifi,
Roberto Furlan,
Annamaria Finardi,
Anna Di Maio,
Massimiliano Di Filip Tags: ORIGINAL ARTICLE Source Type: research
