Letter to the Editor submitted in response to "psoriasis in pregnancy: case series and literature review of data concerning exposure during pregnancy to ustekinumab".
Letter to the Editor submitted in response to "psoriasis in pregnancy: case series and literature review of data concerning exposure during pregnancy to ustekinumab". J Dermatolog Treat. 2018 Aug 04;:1-5 Authors: Megna M, Villani A, Balato N, Balato A PMID: 30078336 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Access to Injectable Biologic Medications by Medicare Beneficiaries: Geographic Distribution of U.S. Dermatologist Prescribers.
CONCLUSIONS: There are disparities in the availability of IB-prescribing dermatologists across urban-rural geographic settings in the U.S. PMID: 30078341 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Comparing the short-term therapeutic effects and safety profiles of rituximab therapy in pemphigus vulgaris patients either early treated or later than six months.
This study aims to establish the optimal time for rituximab therapy in PV patients. METHODS: In this retrospective study patients who received rituximab within six months of diagnosis were classified as the early treatment group, and patients who have received it later than six months were classified as the delayed treatment group. RESULTS: ninety-five PV patients were reviewed. Fourteen (14.8%) and 81 (85.2%) patients received rituximab within the first six-months from diagnosis and after that, respectively. In the former group, seven patients have received rituximab as the first-line therapy. The rate of complete...
Source: Journal of Dermatological Treatment - August 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Ablative fractional Co2 laser aided delivery of long-acting glucocorticoid in the treatment of acral vitiligo: A multicenter, prospective, self- bilateral controlled study.
CONCLUSIONS: A triple method of ablative fractional CO2 laser, topical compound betamethasone solution plus NB-UVB provided an alternative choice for acral vitiligo with remarkable safety profile. PMID: 30081694 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Fractional carbon dioxide laser assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis.
Authors: Abd El-Aal EB, Abdou H, Ibrahim SM, Eldestawy MT Abstract BACKGROUND: Onychomycosis is a chronic fungal infection of the nails and the treatment has been proven to be a challenge to healthcare professionals. OBJECTIVE: To evaluate the efficacy of fractional carbon dioxide laser assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis. METHODS & MATERIALS: A total of 102 patients with onychomycosis were randomly assigned to groups A and B, both groups were treated with 4 sessions of fractional CO2 laser and followed by topical tazarotene 0.1% in group ...
Source: Journal of Dermatological Treatment - August 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Steroid phobia among general users of topical steroids: a cross-sectional nationwide survey.
Conclusions Steroid phobia among general users of topical steroids appears to be relatively high despite most of them being non-chronic topical steroid users. Healthcare professionals should not refrain from counselling patients, but instead actively address the issues leading to fears in patients. PMID: 30081700 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Rituximab and Low Dose Oral Immune Modulating Treatment to Maintain a Sustained Response in Severe Pemphigus Patients.
CONCLUSIONS: We propose an alternative treatment strategy utilizing RTX as a rescue agent in combination with long-term LRMD as a means to maintain a sustained long-term CR post-RTX therapy in severe pemphigus patients. This strategy could prevent disease flares and the need for additional RTX cycles and higher dosages of immunomodulatory therapies. PMID: 30086663 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

How to choose between IL-17 inhibitors and IL-23 inhibitors for psoriasis.
Authors: Amin M, Lee EB, Wu JJ PMID: 30086664 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The effect of Adalimumab on the vasculature in psoriatic skin lesions.
DISCUSSION: Adalimumab treatment of psoriasis causes an evident reduction in endothelial cell proliferation, vascular network size and vessel diameter, parallel to the clinical improvement. Vascular parameters do not capture early improvement to adalimumab treatment. However, (non-) invasive measurement of vascular function parallels the clinical improvement and may be a valuable marker for disease activity. PMID: 30074865 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 5, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The use of energy devices in the treatment of striae: a systematic literature review.
CONCLUSIONS: The therapeutic measures for striae are multiple and no current treatment offers consistent and complete resolution. However, energy devices are a safe and potentially effective modality in the treatment of striae. PMID: 30049244 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 29, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Development of a new synthetic xerogel nanoparticles of silver and zinc oxide against causative agents of Dermatophytoses.
CONCLUSION: Xerogel nanoparticles composed of Ag and ZnO were successfully prepared. They had antidermatophytic action in specific concentrations. PMID: 30051722 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 29, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

No need to change the drug class: ixekizumab- following secukinumab-therapy in psoriasis.
CONCLUSIONS: Ixekizumab proved to be an effective and safe therapeutic option for patients with prior systemic therapies, including biological treatments with the same mechanism of action. Thus, failure of secukinumab does not preclude future therapy success with a second IL-17 directed therapy. PMID: 30051725 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 29, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Hyperhidrosis Quality of Life Measures: Review and Patient Perspective.
CONCLUSIONS: There are several tools available for assessing quality of life in hyperhidrosis patients; disease specific measures are widely used and appear suitable. It is unclear which tool is the most reliable, although the HidroQoL© tool was preferred by a small group of patient advisors. Abstract. PMID: 30051732 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 29, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologic and small molecule medications in the management of pyoderma gangrenosum.
Authors: McKenzie F, Cash D, Gupta A, Cummings LW, Ortega-Loayza A Abstract Pyoderma gangrenosum (PG) is an uncommon inflammatory skin disorder characterized by neutrophil dysfunction. There are currently no FDA approved drugs for the treatment of this disease, and treatment has typically relied on traditional immunosuppressive medications such as prednisone or cyclosporine. The efficacy of biologics in the treatment of other pro-inflammatory conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease is well-documented in the literature. Therefore, the use of biologic medications for the tre...
Source: Journal of Dermatological Treatment - July 29, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Review of European registries for psoriasis.
CONCLUSIONS: Patient registries are routinely used in dermatology and psoriasis registries offer pertinent long-term safety information regarding conventional systemic therapies and biologic agents for psoriasis. PMID: 30051739 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 29, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patient Perceptions of Hidradenitis Suppurativa Stressors.
Authors: Senthilnathan A, Feldman SR, Pichardo RO PMID: 30028268 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 22, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Rituximab/IVIG in pemphigus - a 10 year study with a long follow-up.
CONCLUSION: Rituximab is an effective and safe treatment for pemphigus and should be considered earlier in the algorithm of pemphigus treatment. PMID: 29889591 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 12, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Retinoic Acid Receptor Agonist as Monotherapy for Early-Stage Mycosis Fungoides: Does it Work?
CONCLUSIONS: Early-stage MF patients may benefit from low dose RAR-agonist monotherapy, although the CR rate is low. PMID: 29889596 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 12, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Is maintenance treatment in adult acne important? Benefits from maintenance therapy with adapalene, and low doses of alpha and beta hydroxy acids.
In this study, 100 patients (aged 25-39 years of age) with mild and moderate adult acne were enrolled. RESULTS: The maintenance therapy (adapalene 0.1% three times a week and low doses of alpha and beta hydroxy acids) led to a significant decrease in the number of acne lesions (from 31.3 to 12.25; p 
Source: Journal of Dermatological Treatment - June 8, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A Feasibility Study of a Novel Low Level Light Therapy for Digital Ulcers in Systemic Sclerosis.
Authors: Hughes M, Moore T, Manning J, Wilkinson J, Watson S, Samraj P, Dinsdale G, Roberts C, Rhodes LE, Herrick AL, Murray A Abstract BACKGROUND: Locally acting, well-tolerated treatments for systemic sclerosis (SSc) digital ulcers (DUs) are needed. OBJECTIVES: Our primary aim was to investigate the safety, feasibility and tolerability of a novel low level light therapy (LTTT). A secondary aim was to tentatively assess efficacy. METHODS: A custom-built device comprising infrared (850nm), red (660nm) and violet (405nm) LEDs was utilised. DUs were irradiated with 10J/cm2 twice weekly for three weeks, with f...
Source: Journal of Dermatological Treatment - June 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Corrigendum.
Authors: PMID: 29862870 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Clinical and dermoscopic evaluation of combined (salicylic acid 20% and azelaic acid 20%) versus trichloroacetic acid 25% chemical peel in acne: a RCT.
CONCLUSION: Chemical peeling is effective in controlling mild-moderate acne in SPT III-IV. Combined SA 20% and AA 20% is recommended at early stage of treatment if patients have more inflammatory lesions, while TCA is recommended if patients have more non-inflammatory lesions. PMID: 29862871 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Is a single day patient friendly methyl aminolevulinate photodynamic therapy illumination scheme for superficial basal cell carcinoma feasible? A randomized multicenter pilot trial.
CONCLUSION: Single day protocol for MAL-PDT for sBCC is feasible and this study shows promising results. PMID: 29862877 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Gene Expression Profiling Analysis the Effect of Hydrocortisone on Keloid Fibroblasts by Bioinformatics.
CONCLUSIONS: VEGF and TNC were respectively involved in KHC and KNHC in the mechanism of focal adhesion. JUN might be a potential molecular marker related to normal scar. PMID: 29863417 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 6, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment of psoriasis with crisaborole.
Authors: Lee EB, Lebwohl MG, Wu JJ Abstract Crisaborole, a topical phosphodiesterase-4 (PDE4) inhibitor, is effective in patients with atopic dermatitis. As systemic PDE4 inhibition has also been used with success in psoriasis, clinical trials are underway to determine the utility of topical PDE4 inhibitors in these patients. However, there is no current literature documenting use of crisaborole for psoriasis. Here, we present two cases in which patients with psoriasis were treated successfully with crisaborole. PMID: 29812961 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 2, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Imaging the hidden in dermatology across history.
Authors: Cm van de Kerkhof P PMID: 29845897 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 2, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and Survival of Biologic Agents in psoriasis: A practical real-life 12-year experience in a French dermatology department.
CONCLUSIONS: In a long-term real-life setting, drug survival of ustekinumab is better than that of TNF-a inhibitors for both biologic-naive and biologic-experienced patients with psoriasis. PMID: 29848153 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 2, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Innovative nanocompounds for cutaneous administration of classical antifungal drugs: a systematic review.
Authors: Santos RS, Loureiro K, Rezende P, Nalone L, Barbosa RM, Santini A, Santos AC, da Silva CF, Souto EB, de Souza DP, Amaral RG, Severino P Abstract Nanomedicine manipulates materials at atomic, molecular, and supramolecular scale, with at least one dimension within the nanometer range, for biomedical applications. The resulting nanoparticles have been consistently shown beneficial effects for antifungal drugs delivery, overcoming the problems of low bioavailability and high toxicity of these drugs. Due to their unique features, namely the small mean particle size, nanoparticles contribute to the enhanced drug...
Source: Journal of Dermatological Treatment - June 2, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment patterns, adherence, and persistence among psoriasis patients treated with biologics in a real-world setting, overall and by disease severity.
CONCLUSIONS: Biologic-treated psoriasis patients had inadequate adherence (i.e., MPR
Source: Journal of Dermatological Treatment - May 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Do Sunscreen Prevent Recurrent Herpes Labialis in Summer?
CONCLUSION: HL recurrence rate can be reduced by using sunblock stick in summer. PMID: 29804485 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 30, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologics Monitoring: Incongruity between Recommendations and Clinician Monitoring Trends.
CONCLUSIONS: There are inconsistencies between current monitoring practices and guidelines. Clarifying biologics monitoring recommendations in psoriasis patients may reduce healthcare costs and provider workload. PMID: 29792371 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 26, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A Randomised Comparison of Efficacy and Safety of Intralesional Triamcinolone Injection and Clobetasol Propionate Ointment for Psoriatic Nails.
Authors: Boontaveeyuwat E, Silpa-Archa N, Danchaivichit N, Wongpraparut C Abstract BACKGROUND: Even though the traditional therapy for nail psoriasis has been used for decades, no randomised, controlled trial of such treatment has been conducted to date. OBJECTIVE: To evaluate the efficacy and safety of intralesional triamcinolone injections compared with 0.05% clobetasol ointment for psoriatic nails. MATERIALS AND METHODS: Psoriasis patients, each with three fingernails with similar degrees of severity, were randomly recruited for intralesional triamcinolone injection group, 0.05% clobetasol ointment group...
Source: Journal of Dermatological Treatment - May 25, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Detection and treatment of Staphylococcus aureus colonization in chronic hand eczema: a multicenter study.
CONCLUSIONS: Our study revealed the present situation of SA colonization in four cities of China using a new method and had reference significance in anti-SA using topical antibiotic. PMID: 29781315 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 25, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Poor medication adherence in patients with psoriasis and a successful intervention.
CONCLUSION: Medication adherence of the psoriasis patients is poor but can be improved by a health education intervention. PMID: 29790405 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 25, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The efficacy and safety of other cryotherapy compounds for the treatment of genital warts: A randomized controlled trial.
CONCLUSIONS: The Wartner compound is as effective as the conventional cryotherapy method for treating genital warts. It is particularly valuable when there are contraindications or no access to common treatment options. PMID: 29790804 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 25, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patients' preferences for different corticosteroid vehicles are highly variable.
DISCUSSION: There was wide variation in patient preference for topical medication vehicles used for treating psoriasis. Several vehicle characteristics were considered important to adherence. Given the marked variation in vehicle preference, topical treatment should be individualized according to patients' preferences. PMID: 29770722 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Randomized, double blind study on intralesional metronidazole vs intralesional sodium stibogluconate in L. donovani cutaneous leishmaniasis.
Authors: Somaratne VN, Ranawaka RR, Jayaruwan HM, Wipuladasa DM, de Silva SHP Abstract OBJECTIVES: Aim of our study was to assess the efficacy of intralesional metronidazole on L. donovani cutaneous leishmaniasis (CL). MATERIAL AND METHODS: 188 patients with CL were randomly allocated to intralesional sodium stibogluconate (SSG) and intralesional metronidazole. Cure was assessed after 1-10 injections. Cure rates were assessed for statistical significance using Chi square test at p = 0.05 level (SLCTR/2014/028). RESULTS: When the treatment cut off was taken at 100%, the rate of cure for SSG (n&...
Source: Journal of Dermatological Treatment - May 17, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Sebo-Pharmacokinetics: A Proposed Percutaneous Sebum Egression Method.
DISCUSSION: Here, we summarize the current available data on drug delivery via the sebaceous gland and suggest a practical method to directly document sebo-pharmacokinetics in man and animal. PMID: 29768083 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 17, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Educational level and job status are the most important factors affecting compliance to oral antihistamine therapy for patients with chronic urticaria.
CONCLUSION: Most CU patients had good compliance to OAs. Educational level and job status were significant predictors of MC to OAs in CU. The impact and long-term effects of education and job status should be evaluated in different patient groups. PMID: 29757034 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Pediatric patients with psoriasis and psychiatric disorders: Premorbidity and co-morbidity in a case-control study.
Authors: Kara T, Topkarcı Z, Yılmaz S, Akaltun İ, Erdoğan B Abstract Psychiatric disorders are thought to play an important role in the onset, exacerbation and course of several chronic dermatological diseases. We aimed to investigate psychiatric diagnoses in children with psoriasis before and during the disease and to examine potentially related factors.108 children aged 8-16 years, 54 with a diagnosis of psoriasis and 54 healthy subjects, were included in the study. Participants were assessed using dermatological and psychiatric examinations and scales. At least one psychiatric diagnosis was present in 70.3% ...
Source: Journal of Dermatological Treatment - May 16, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Comparison of NAPSI and N-NAIL for evaluation of fingernail psoriasis in patients with moderate-to-severe plaque psoriasis treated using ustekinumab.
CONCLUSIONS: When comparing the mean scores between week 0 and 52, the N-NAIL score (P = 0.04) better reflected a significant improvement of nail psoriasis than the NAPSI (P = 0.09), and ustekinumab treatment resulted in a more rapid and effective improvement of splinter hemorrhages. PMID: 29757042 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Comparison of Mental Health Outcomes Among Adults with Psoriasis on Biologic versus Oral Therapies: A Population-Based Study.
Authors: Salame N, Ehsani-Chimeh N, Armstrong AW Abstract PURPOSE: We sought to compare the impact of biologic versus oral therapies on mental health outcomes among adult U.S. residents with moderate-to-severe psoriasis. METHODS: We performed a nationwide, cross-sectional study comparing 2,303,534 (weighted) adults with moderate-to-severe psoriasis on biologic versus oral therapies and their associated mental health outcomes using the 2003-2015 Medical Expenditure Panel Survey (MEPS). Mental health outcomes were measured with the Kessler 6 (K6), a validated measure of psychological distress, and Patient Health ...
Source: Journal of Dermatological Treatment - May 16, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologic Treatment of Recalcitrant Pediatric Psoriasis: A Case Series from a Tertiary Medical Center.
CONCLUSION: Biologic therapy is effective and safe in recalcitrant pediatric psoriasis. PMID: 29757046 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 16, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment of Seborrheic Dermatitis: A Comprehensive Review.
Authors: Borda LJ, Perper M, Keri JE Abstract Seborrheic Dermatitis (SD) is a chronic, recurring inflammatory skin disorder that manifests as erythematous macules or plaques with varying levels of scaling associated with pruritus. The condition typically occurs as an inflammatory response to Malassezia species and tends to occur on seborrheic areas, such as the scalp, face, chest, back, axilla, and groin areas. SD treatment focuses on clearing signs of the disease; ameliorating associated symptoms, such as pruritus; and maintaining remission with long-term therapy. Since the primary underlying pathogenic mechanisms...
Source: Journal of Dermatological Treatment - May 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Systematic review of anti-drug antibodies of IL-17 inhibitors for psoriasis.
Authors: Thomas LW, Lee EB, Wu JJ Abstract Three main biologics target the IL-17 pathway; these include secukinmab, ixekizumab, brodalumab, all of which are approved for treatment of moderate-to-severe plaque psoriasis. We performed a systematic review of the literature to determine if IL-17 inhibitors are prone to developing ADA and how efficacy of treatment is influenced. A total of 14 papers were reviewed. Only one secukinmab trial detected treatment-emergent ADA in 4 out of 996 (0.41%) patients during the 52-week treatment period. Two of these patients (1 on 150-mg retreatment as needed and 1 on 150-mg fixed in...
Source: Journal of Dermatological Treatment - May 10, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Healthcare resource utilization, costs of care, and treatment of mycosis fungoides cutaneous T-cell lymphoma patterns in a large managed care population: a retrospective US claims-based analysis.
Authors: Tsang Y, Gu T, Sharma G, Raspa S, Drake B, Tan H Abstract PURPOSE: To evaluate health care utilization, treatment patterns and costs among patients with mycosis fungoides-cutaneous T-cell lymphoma (MF-CTCL). METHODS: This retrospective cohort study queried the HealthCore Integrated Research Database to identify patients ≥18 years with ≥2 diagnoses of MF-CTCL (ICD-9-CM code 202.1x, 202.2x) between 07 January 2006 and 07 January 2013. Index date was defined as first MF-CTCL diagnosis. Patients were continuously enrolled ≥6 months before and ≥12 months after index date. Se...
Source: Journal of Dermatological Treatment - May 9, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Drug survival of secukinumab for psoriasis in a real-world setting.
Authors: Lee EB, Amin M, Egeberg A, Wu JJ PMID: 29733240 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 9, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patient Perceptions of Antibiotic Use and Resistance at a Single University Dermatology Clinic.
Authors: Goettsche LS, Weig EA, Chung J, Hoff BM, Ince D, Wanat KA Abstract Antibiotic resistance is an important problem which requires continued patient education and important prescribing stewardship. Dermatologists prescribe the most antibiotics per provider in comparison to other specialties and have an important role to play in the campaign of mindful prescribing. Data on the dermatology patients' knowledge and perception regarding antibiotic resistance is lacking and could play a role in providers' continuation of medications. We conducted a single institution survey of 512 dermatology clinic patients to und...
Source: Journal of Dermatological Treatment - May 8, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Epigenetic Therapy and Dermatologic Disease: Moving Beyond CTCL.
This article provides an overview of current epigenetic therapies for CTCL and reviews the epigenetics of other dermatologic diseases, including melanoma, psoriasis, systemic lupus erythematosus, and systemic sclerosis, with attention toward potential epigenetic pharmacotherapies. PMID: 29726727 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 8, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Therapeutic Strategies for Pigmented Purpuric Dermatoses: A Systematic Literature Review.
CONCLUSION: To our knowledge, this is the first review focusing on the therapeutic strategies for pigmented purpuric dermatoses. This paper aims to raise awareness for the need to conduct larger systematic studies in order to adequately evaluate the effectiveness of the above mentioned therapeutic strategies. PMID: 29726735 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 8, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research