Anti-TNF biosimilars in psoriasis: from scientific evidence to real-world experience.
Authors: Barker J, Girolomoni G, Egeberg A, Goncalves J, Pieper B, Kang T Abstract Tumor necrosis factor (TNF) inhibitors account for a large proportion of drugs used to treat psoriasis and are indicated first-line options in certain settings. Several biosimilar drugs based on the anti-TNF agents adalimumab, infliximab, and etanercept are now available for use in patients with psoriasis. The favorable cost differential of biosimilars is expected to improve access to biologic therapy for biologic-naive psoriasis patients, who are often undertreated. Also, substantial cost savings can be made if patients are switched...
Source: Journal of Dermatological Treatment - May 17, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Calcific uremic arteriolopathy (calciphylaxis) calls into question the validity of guidelines of diagnosis and treatment.
Authors: Chiriac A, Grosu OM, Terinte C, Perţea M Abstract Calciphylaxis is associated with end-stage renal failure or kidney transplant, although, cases of non-uremic calciphylaxis have been reported. It is a rare disorder, with high mortality, characterized by vascular calcification within cutaneous vessels; vascular calcification can occur in other organs, besides skin, like heart, lung or pancreas, which is named visceral calciphylaxis. The diagnosis is based mainly on clinical features and histopathological findings. Here, we review current knowledge regarding diagnosis and therapeutic approach to cutaneous c...
Source: Journal of Dermatological Treatment - May 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Photodynamic therapy for actinic keratosis in vegan and omnivore patients: the role of diet on skin healing.
Authors: Fusano M, Zane C, Calzavara-Pinton P, Bencini PL Abstract BACKGROUND: Photodynamic therapy (PDT) is an approved and effective treatment for actinic keratosis (AK). The time of complete skin healing is estimated to range between 5-10 days, but the role of nutrition in influencing it has never been evaluated. OBJECTIVE: The aim of this study was to compare the time of skin healing and side effects in omnivores and vegans treated with PDT for AK. MATERIALS AND METHODS: Thirty omnivore and thirty vegan patients, treated with PDT for AK, were enrolled. Side effects, according to Local Skin Response (LSR...
Source: Journal of Dermatological Treatment - May 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Factors Affecting Adherence and Patient Satisfaction with Treatment: A Cross Sectional Study of 500 Patients with Acne Vulgaris.
Authors: Hayran Y, İncel Uysal P, Öktem A, Gür Aksoy G, Akdoğan N, Yalçın B Abstract BACKGROUND: Acne Vulgaris is a chronic inflammatory disease that requires long-term treatment. Adherence to treatment is a problem in chronic diseases and may affect treatment outcomes. OBJECTIVE: We aim to investigate treatment adherence and satisfaction of patients with acne and identify independent factors that affect them. METHODS: Five hundred patients with acne were included in this cross-sectional study. Demographic and clinical characteristics of the patients were recorded. Severity of acne was a...
Source: Journal of Dermatological Treatment - May 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and Safety of Biosimilar Rituximab in Patients with Pemphigus Vulgaris: A Prospective Observational Study.
Authors: Toosi R, Mahmoudi H, Balighi K, Teimourpour A, Alaeen H, Shaghaghi M, Abedini R, Daneshpazhooh M Abstract The optimal treatment for pemphigus vulgaris (PV) has not been clearly determined yet. Rituximab (RTX) was recently approved for moderate to severe PV. In this prospective study we evaluated the efficacy and safety of RTX by assessing the pemphigus disease area index (PDAI) score, clinical response and any adverse events during at least 12-month follow-up. We evaluated anti-desmoglein (Dsg) 1,3 level at baseline, 3 months and 12 months after RTX infusion. A total of 110 patients treated with biosimilar...
Source: Journal of Dermatological Treatment - May 12, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Hidradenitis suppurativa and risk of suicide - systematic review and meta-analysis.
Authors: Phan K, Loya A, Ramachandran V, Smith SD Abstract The painful and chronic nature of hidradenitis suppurativa (HS) and associated stigma leads to detrimental impact on patients' quality of life. There is increasing evidence that HS is associated with various psychiatric comorbidities including depression, anxiety disorders and psychoses. However, few studies have investigated the relationship between HS and suicide risk. We performed a systematic review and meta-analysis to determine whether HS patients are at elevated risk of suicide compared to controls. 1128 studies were identified from the systematic li...
Source: Journal of Dermatological Treatment - May 9, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Apremilast is efficacious in refractory alopecia areata.
Authors: Taneja N, Gupta S PMID: 31055978 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 7, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Smoothened receptor inhibitor vismodegib for the treatment of basal cell carcinoma: a retrospective analysis of efficacy and side effects.
CONCLUSIONS: Our results show that vismodegib therapy is effective in the treatment of BCC; however, side effects are often severe. Since the suspension of treatment can lead to therapy resistance, the management of side effects is of great importance. PMID: 31039644 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

US real-world effectiveness of secukinumab for the treatment of psoriasis: 6-month analysis from the Corrona Psoriasis Registry.
Authors: Strober BE, Germino R, Guana A, Greenberg JD, Litman HJ, Guo N, Lebwohl M Abstract OBJECTIVE: To examine the real-world effectiveness of secukinumab with regard to clinical and patient-reported outcomes (PROs) from enrollment to a 6-month follow-up visit in patients with psoriasis in the Corrona Psoriasis Registry. METHODS: Eligible patients aged ≥ 18 years who initiated secukinumab at enrollment in the Corrona Psoriasis Registry and had a 6-month follow-up visit (window: 5-9 months) as of December 31 2017, were included in the analysis. Measures of disease severity and PROs were assessed ...
Source: Journal of Dermatological Treatment - May 2, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evaluation of efficacy and safety of oral terbinafine and itraconazole combination therapy in the management of dermatophytosis.
CONCLUSION: The combination of systemic terbinafine and itraconazole therapy may be an effective and safe therapeutic strategy in the management of dermatophytosis. PMID: 31030594 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 30, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effective treatment of disseminated superficial actinic porokeratosis with chemical peels - customary treatment for a rare disease.
We report a series of five female patients with history of DSAP that were successfully treated with chemical peels. All patients suffered from the disease for 14.4 years on average and all were refractory to at least two therapeutic options, mostly imiquimod and topical tretinoin. Patients were treated with glycolic acid 50% and salicylic acid 25% in a two-layer-technique. After a mean of three cycles every six weeks a clear reduction in lesion was assessed by physicians. Patients were highly satisfied with outcome and rare occurrence of side effects as assessed by TSQM questionnaire. Chemical peels are safe and well toler...
Source: Journal of Dermatological Treatment - April 27, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

From intervention to maintenance treatment to true disease modification in every day treatment of patients with psoriasis.
Authors: van de Kerkhof PC PMID: 31023167 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 27, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Psoriatic arthritis for dermatologists.
Authors: Gottlieb A, Merola JF Abstract Psoriatic arthritis (PsA) affects up to one-third of patients with psoriasis and is the major comorbidity of psoriasis because of the likelihood that loss of function and permanent disability will develop if initiation of treatment is delayed. Dermatologists are uniquely positioned to recognize early signs of PsA and be the first-line healthcare practitioners to detect PsA in patients with psoriasis. PsA can affect 6 clinical domains: peripheral arthritis, dactylitis, enthesitis, psoriasis, psoriatic nail disease, and axial disease. However, not every patient will have involv...
Source: Journal of Dermatological Treatment - April 26, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: A randomized pilot study.
Authors: Wang GJ, Gao XY, Wu Y, He HQ, Yu Y, Qin HH, Shen WT Abstract OBJECTIVE: To assess the efficacy and safety of artemether emulsion in patients with papulopustular rosacea. METHODS: A total of 130 (randomized 1:1) were externally administered either artemether emulsion (1%) or metronidazole emulsion (3%) twice daily for 4 weeks with an open-label 8-week follow-up. The primary endpoints included the proportion of patients who achieved clinical effective responses, as well as erythema and papule and pustule score at week 4. RESULTS: Numerically more patients achieved an effective response at week 4 with...
Source: Journal of Dermatological Treatment - April 26, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Combination of pulsed dye laser and verapamil in comparison with verapamil alone in the treatment of keloid.
CONCLUSION: Combination therapy with PDL + intralesional verapamil was superior in efficacy when compared to intralesional verapamil alone, in the treatment of keloids. PMID: 31017496 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 26, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Clinical factors influencing the response to intravenous immunoglobulin treatment in cases of treatment-resistant pyoderma gangrenosum.
Authors: Haag CK, Ortega-Loayza AG, Latour E, Keller JJ, Fett NM Abstract BACKGROUND: Pyoderma gangrenosum (PG) is a neutrophilic disorder which classically presents as chronic, painful ulcers on the lower extremities. There is evidence supporting a potential role for intravenous immunoglobulin (IVIG) as adjuvant therapy for treatment-resistant cases; however, it is unclear which patients will most benefit from this modality of treatment - an especially important consideration given the cost per infusion ($5,000-$10,000). Thus, we sought to identify the clinical characteristics of patients with refractory PG lesion...
Source: Journal of Dermatological Treatment - April 20, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Dry skin management: Practical approach in light of latest research on skin structure and function.
Authors: Proksch E, Berardesca E, Misery L, Engblom J, Bouwstra J Abstract Dry skin is a common condition that is attributed to a lack of water in the stratum corneum. With the availability of new technologies, light has been shed on the pathophysiology of dry skin at the molecular level. With the aim to discuss implications of this latest research for the optimal formulation of emollients designed to treat dry skin, five specialists met in November 2017. Research on three topics thereby provided particularly detailed new insights on how to manage dry skin: research on the lipid composition and organization of the ...
Source: Journal of Dermatological Treatment - April 20, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Clinical assessment of topical erythromycin gel with and without zinc acetate for treating mild to moderate acne vulgaris.
Authors: Sayyafan MS, Ramzi M, Salmanpour R Abstract Erythromycin is an effective topical antibiotic for treating mild to moderate inflammatory acne vulgaris, especially papules acne during puberty as well as papules - pustular acne in adult women. Erythromycin is a macrolide antibiotic that has long been used as a topical dosage form to treat acne. It has favorable effects in resolving inflammatory acne lesions not only by reducing Propioni bacterium acnes density, but also by directly inhibiting neutrophil chemotactic factors and reactive oxygen species (ROS) production (1- 3). Zinc, a metallic element has bacter...
Source: Journal of Dermatological Treatment - April 20, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A case of Generalized Pustular Psoriasis and arthritis treated with ixekizumab.
Authors: Dattola A, Manfreda V, Esposito M, Bianchi L, Giunta A PMID: 30998424 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 20, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Lp- PLA2 as a promising predictor of comorbidities in patients with severe psoriasis.
CONCLUSION: Lp-PLA2 assay might be helpful in assessment of the risk of cardiometabolic comorbidities development especially in patients with severe psoriasis and obesity. PMID: 30998429 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 20, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Dead Sea Climatotherapy versus topical steroid treatment for Atopic Dermatitis children: long-term follow-up study.
Authors: Marsakova A, Kudish A, Gkalpakiotis S, Jahn I, Arenberger P, Harari M Abstract The aim of this study was to compare long-term results of 4 weeks Dead Sea Climatotherapy at the Deutsches Medizinisches Zentrum, Israel to those obtained by classical topical treatment for moderate-to-severe Atopic Dermatitis. Seventy-two children from the Czech Republic were divided into three groups of twenty-four and treated during 3 periods (March 2014, October 2014 and March 2015) with gradually increasing sun exposure during 28 consecutive days. Forty-four children were treated with steroid creams at the Department of Der...
Source: Journal of Dermatological Treatment - April 19, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Tissue lipocalin-2 in psoriasis: Is it a marker of metabolic disturbance or a possible marker of therapeutic efficacy after narrow band ultraviolet B?
CONCLUSION: Psoriatic patients were at higher risk of metabolic disorders. LCN2 was not related to metabolic disturbances in our patients. NBUVB might exert its therapeutic effect in psoriasis through reduction of tissue LCN2. PMID: 30995143 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 19, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The Effects of Isotretinoin on Affective and Cognitive Functions are Disparate in Adolescent Acne Vulgaris Patients.
CONCLUSIONS: In a vulnerable age group, our results demonstrate an improvement for neurocognitive functions in isotretinoin patients. The conflicting results suggest distinct mechanisms to be responsible for the effects on affective and cognitive functions. PMID: 30985218 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 17, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effectiveness of etanercept biosimilar SB4 in maintaining low disease activity in patients with psoriatic arthritis switched from etanercept originator: an open label one year study.
CONCLUSIONS: SB4 was effective in maintaining a state of low disease activity in the majority of patients switched from the reference etanercept. However, the proportion of patients (11 subjects) who failed to maintain a state of low disease activity at the end of the study was statistically significant. Loss of effectiveness in the above subjects was mainly due to subjective evaluations given by the patients, rather than an objectifiable exacerbation of disease. PMID: 30985223 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 17, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts.
CONCLUSION: The treatment with PDT is effective in reducing the high rate of recurrence for intra anal- rectal warts. Pain is still a great challenge for the therapy. PMID: 30990345 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 17, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Superficial radiotherapy for non-melanoma skin cancer of the lip: a 44-year Italian experience.
CONCLUSION: Our findings confirm that superficial radiotherapy is an effective treatment for early BCC or SCC of the vermilion lip, especially in the ageing population, in high-risk tumours, and even if poor cosmetic outcome is expected from surgical excision. PMID: 30973789 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Successful Treatment of Ulcerated Infantile Hemangioma with Brimonidine-Timolol Cream: 2 Cases Report and Review of the Literature.
In conclusion, brimonidine 0.2%-timolol 0.5% cream is a promising alternative in the topical treatment of ulcerated haemangiomas. PMID: 30973791 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Reconstruction of nasal supratip defect using vertical alar groove tissue.
CONCLUSION: Creating a tangential advancement flap using the vertical alar groove tissue is a simple, single-stage procedure with excellent surgical outcome. It may be useful in the reconstruction of supratip defects with a diameter of less than 2cm. PMID: 30957584 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Drug survival of guselkumab for psoriasis in a real-world setting: a single-center retrospective chart review.
Authors: Lee EB, Reynolds KA, Pithadia DJ, Egeberg A, Wu JJ PMID: 30957586 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Association of lymphopenia and eosinophilia with dimethylfumarate treatment efficacy and tolerability in psoriasis: A retrospective study.
Authors: van Hezik D, Bovenschen HJ Abstract Background Dimethylfumarate (DMF) is an effective treatment for psoriasis, which may cause side effects in a considerable group of patients. Alterations in white blood cell counts (WBC) may predict treatment success and the occurrence of side effects. Objectives To analyze WBC counts with respect to efficacy and the prevalence of side effects during DMF therapy for psoriasis. Methods and Materials Psoriasis patients were treated with DMF. Retrospective data (WBC counts, treatment results and side effects) were analyzed to assess correlations with respect to efficacy, tol...
Source: Journal of Dermatological Treatment - April 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy of Bleomycin Application on Periungual Warts after Treatment with Ablative Carbon Dioxide Fractional Laser: A Pilot Study.
CONCLUSION: Bleomycin solution after ablative fractional carbon dioxide laser is effective and safe to treat periungual warts. Further large controlled studies are necessary to validate effectiveness and find an optimal regimen. PMID: 30957690 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Long-term effects of biologic therapies on peripheral blood eosinophils in patients with psoriasis: A 3-year single-centre study.
Authors: Akdogan N, Dogan S, Atakan N Abstract BACKGROUND: Biologic therapies (BTs),etanercept, infliximab, adalimumab, ustekinumab, are generally well-tolerated and safe agents in psoriasis management. OBJECTIVES: To determine the overall effect of BTs on peripheral blood eosinophil count(PBEc) and percentage(PBEp), peripheral blood basophil count(PBBc) and percentage(PBBp), white blood cell count(WBCc),erythrocyte sedimentation rate(ESR),and serum C-reactive protein(s-CRP) level during a 3-year follow-up in patients with psoriasis. METHODS: This retrospective cohort study included 200 patients(116 men;84 ...
Source: Journal of Dermatological Treatment - April 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Ustekinumab treatment for moderate to severe psoriasis. Eight-year real-world follow-up of 61 cases in a tertiary level hospital.
Conclusions This real world-setting study shows maintenance of long-term efficacy and safety of ustekinumab treatment in moderate-severe plaque psoriasis in daily practice through 8 years. PMID: 30961404 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A cross-sectional study of YouTube videos as a source of patient information about phototherapy and excimer laser for psoriasis.
Authors: Pithadia DJ, Reynolds KA, Lee EB, Wu JJ Abstract YouTube is increasingly utilized by patients for health information. We aimed to assess the educational quality of YouTube videos about phototherapy and excimer laser for psoriasis. A cross-sectional analysis of YouTube videos was conducted using the search terms psoriasis phototherapy and psoriasis laser. Of the 200 videos screened, 124 met inclusion criteria. Sixty-eight (54.8%) were generated by device manufacturers advertising their product, 35 (28.2%) by healthcare professionals, and 8 (6.5%) by patients delivering testimonials from experiences receivin...
Source: Journal of Dermatological Treatment - April 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Safety and efficacy of Certolizumab Pegol in a real-life cohort of patients with Psoriasis and Psoriatic Arthritis.
CONCLUSIONS: CZP was safe and effective in a real-life cohort of patients affected by PsO and PsA, who have had an inadequate response to previous systemic treatments. PMID: 30963798 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 10, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The Contradictory Inefficacy of Methotrexate in Hidradenitis Suppurativa: A Need to Revise Pathogenesis or Acknowledge Disease Heterogeneity?
Authors: Frew JW Abstract The pathogenesis of Hidradenitis Suppurativa (HS) centers around Th17/Treg dysfunction illustrated by lesional elevation of IL-17A, IL-6, and other inflammatory mediators resulting in a chronic feed-forward inflammatory cascade. Similar inflammatory mechanisms have been identified in psoriasis and rheumatoid arthritis (RA) in which traditional immunosuppressants (including methotrexate) are routinely used with reasonable levels of disease control. Methotrexate's mechanism of action in these instances include downregulation of the Th17 axis via alterations in dendritic cell and T-cell activ...
Source: Journal of Dermatological Treatment - April 6, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Notalgia Paresthetica: Treatment Review and Algorithmic Approach.
CONCLUSIONS: Treatment should begin with topical agents or physical therapy, then systemic agents, and finally procedural modalities. We recommend combining treatment options with physical therapy for sustained treatment response. PMID: 30942103 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 4, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The use of phosphodiesterase inhibitors for the treatment of alopecia.
CONCLUSIONS: Preliminary results using topical caffeine for AGA or TE are promising with minimal adverse events. However, these studies are primarily single-center trials with few patients. Studies using topical or systemic PDEi for AA demonstrate limited success. Current research using PDEi for alopecia is limited, however new clinical trials are being conducted. PMID: 30935254 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patients opinion and adherence to antimalarials in lupus erythematosus and rheumatoid arthritis treatment.
CONCLUSIONS: Fear has been a factor that makes adherence to treatment difficult. Making patients aware of the importance of the treatment is strongly relevant because antimalarials are well tolerated. PMID: 30935255 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris: assessment of safety and tolerability in subgroups.
Authors: Harper JC, Roberts WE, Zeichner JA, Guenin E, Bhatt V, Pillai R Abstract BACKGROUND: Topical tretinoin's role in acne has been established through evidence-based guidelines. Cutaneous irritation and potential to cause or exacerbate postinflammatory hyperpigmentation (PIH) may limit use. OBJECTIVE: Evaluate safety and tolerability of novel polymeric formulation of tretinoin 0.05% lotion in moderate-to-severe acne. METHODS: One thousand six hundred and forty patients randomized to tretinoin 0.05% lotion or vehicle in two double-blind placebo-controlled 12-week studies. Investigator-evaluated cutaneou...
Source: Journal of Dermatological Treatment - April 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Can we consider silymarin as a treatment option for vitiligo? A double-blind controlled randomized clinical trial of phototherapy plus oral Silybum marianum product versus phototherapy alone.
This study examined the effect of Phototherapy plus oral Silybummarianum on the treatment of skin lesions of Vitiligo. MATERIALS AND METHODS: In this randomized controlled clinical trial, 34 patients with vitiligo who were referred to Dermatology Clinic of Shahid Faghihi Hospital, Shiraz, Iran, were randomly divided into two groups. The first group was treated with phototherapy plus Narrowband UVB plus oral silymarin and the other group was treated with phototherapy with placebo. The patients in both groups were evaluated with vitiligo area severity index (VASI) at the beginning and end of the study. SPSS software vers...
Source: Journal of Dermatological Treatment - April 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Off-label studies on apremilast in dermatology: a review.
CONCLUSION: The relatively safe adverse effect profile of apremilast and its broad immunomodulatory characteristics may make it a promising option in the future for patients with difficult to treat diseases in dermatology, refractory to first line therapies, but further studies will be necessary to clarify its role. PMID: 30935262 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Secukinumab treatment in psoriatic patients: Italian experiences.
Authors: Idolazzi L PMID: 30919722 [PubMed] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 31, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Secukinumab for the treatment of residual psoriasis: a case series.
Authors: Malagoli P Abstract Patients with plaque-type psoriasis persisting in limited and critical areas often require further treatment even after a PASI reduction has been obtained. Due to its alternative mechanism of action, secukinumab may be a therapeutic upgrade for patients who respond to anti-TNF-α drug but have persistent disease in limited and critical areas. This paper describes our experience in patients with residual psoriasis limited to critical areas, after anti-TNF-α treatment, who subsequently received secukinumab. Specifically, before secukinumab, 4 patients were treated with acitreti...
Source: Journal of Dermatological Treatment - March 31, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Improved Effectiveness from Individualized Dosing of Self-Administered Biologics for the Treatment of Moderate-to-Severe Psoriasis: A 5-Year Retrospective Chart Review from a Spanish University Hospital.
Authors: Sanz-Gil R, Pellicer A, Montesinos MC, Valcuende-Cavero F Abstract BACKGROUND: Biologics for moderate-to-severe psoriasis are expensive and treatment substitutions may vastly increase cost. Moreover, administration regimens in routine practice may differ from recommended guidelines. OBJECTIVES: To evaluate long-term effectiveness, regimen, drug-survival, and efficiency of self-administered biologics in clinical practice. METHODS: We performed a five-year retrospective study in 72 patients (44 ± 14 years old) with moderate-to-severe psoriasis at the University Hospital La Plana ...
Source: Journal of Dermatological Treatment - March 31, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Choice Overload in Systemic Psoriasis Therapy.
Authors: Whitman PA, Cline AE, Feldman SR PMID: 30919721 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 30, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Correction.
Authors: PMID: 30909761 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 28, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Risk of herpes zoster with IL-17 inhibitor therapy for psoriasis and other inflammatory conditions.
Authors: Wu KK, Lee MP, Lee EB, Wu JJ Abstract Psoriasis is a chronic inflammatory skin disease that has been associated with a significantly higher risk of herpes zoster (HZ). Several newer biologics such as secukinumab, ixekizumab, and brodalumab inhibit IL-17 and have been highly effective for treatment of psoriasis. However, adverse events related to the immunosuppressive properties of these biologics have been observed. This review aims to synthesize and evaluate the literature investigating the risk of HZ in patients treated with IL-17 inhibitors, with a focus on psoriasis patients. Clinical trials, cohort st...
Source: Journal of Dermatological Treatment - March 24, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Aloe Polysaccharide Protects Skin Cells from UVB Irradiation through Keap1/Nrf2/ARE Signal Pathway.
Authors: Yuan L, Duan X, Zhang R, Zhang Y, Qu M Abstract The aim of this study was to investigate if aloe polysaccharide (AP) has the repairing effect on ultraviolet b (UVB) injured nerve cells. The study applied BALB/c female mice as animal model, and NFG activated PC12 cells as cell model of skin nerve. The cell viability was detected by MTT assay, and cell apoptosis was detected by TUNEL (TdT-mediated dUTP nick-end labeling) and Annexin-/PI assay, and cell cycle status in different groups were observed via flow cytometry (FCM). Enzyme-linked immunosorbent assay (ELISA) was applied to analyze oxidative stress and...
Source: Journal of Dermatological Treatment - March 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Finasteride and Androgenic Alopecia; from Therapeutic Options to Medical Implications.
Authors: Motofei IG, Rowland DL, Tampa M, Sarbu MI, Mitran MI, Mitran CI, Stoian AP, Diaconu CC, Paunica S, Georgescu SR Abstract Androgenic alopecia (AGA) is an aesthetic condition with varying psycho-social implications, easily accepted by some patients and tolerated only with difficulty by others. Modern therapeutic options such as 5α-reductase inhibitors have significant outcomes, but also exert significant side effects in a subset of patients. The literature describes three distinct situations regarding finasteride administration, a compound largely used for AGA. Some studies show finasteride to be very ...
Source: Journal of Dermatological Treatment - March 23, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research