Long-term drug survival and predictor analysis of the whole psoriatic patient population on biological therapy in Hungary.
Authors: Pogácsás L, Borsi A, Takács P, Remenyik É, Kemény L, Kárpáti S, Holló P, Wikonkál N, Gyulai R, Károlyi Z, Rakonczai P, Balázs T, Szegedi A Abstract Persistence is an important component of therapeutic success, which depends on a variety of factors. Persistence measured under optimal conditions during clinical trials does not necessarily coincide with persistence observed in the real-world settings. The aim of the present study was to compare persistence rate of TNF-alpha inhibitors and interleukin 12/23 inhibitor in all psoriasis ...
Source: Journal of Dermatological Treatment - August 11, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Improvements in psoriasis within different body regions vary over time following treatment with ixekizumab.
Authors: Blauvelt A, Muram TM, See K, Mallinckrodt CH, Crowley JJ, van de Kerkhof P Abstract BACKGROUND: Ixekizumab is a high-affinity monoclonal antibody that selectively targets interleukin-17A. OBJECTIVE: Examine the efficacy of ixekizumab in clearing psoriasis within different body regions. METHODS: Data from 3 placebo- (PBO) or PBO- and etanercept (ETN)-controlled trials were integrated. Patients with moderate-to-severe psoriasis were randomized to 12 weeks of PBO (UNCOVER-1, -2, -3, N = 792; UNCOVER-2, -3, N = 361), 50 mg ETN twice weekly (N = 740), or ...
Source: Journal of Dermatological Treatment - August 11, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Prospects of topical protection from ultraviolet radiation exposure: a critical review on the juxtaposition of the benefits and risks involved with the use of chemoprotective agents.
Authors: Bora NS, Mazumder B, Chattopadhyay P Abstract Solar ultraviolet (UV) radiation exposure is known to cause inevitable damage to human skin via different mechanisms which include disruption of genetic material and generation of free radicals. In the ever emerging field of photoprotective agents, there have been constant endeavors to uphold the standards for optimum protection from solar UV induced damages which include alarming conditions ranging from severe keratosis to malignant transformation of skin cells. Out of the various methods available for photoprotection, chemical photoprotective agents are most ...
Source: Journal of Dermatological Treatment - August 9, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effectiveness of etanercept in children with plaque psoriasis in real practice: a one-year multicentre retrospective study.
Conclusions Etanercept was an effective and well tolerated treatment in this real-life cohort of patients. PMID: 28783991 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 9, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Secukinumab is the most efficient treatment for achieving clear skin in psoriatic patients: a cost-consequence study from the Spanish National Health Service.
Authors: Puig L, Notario J, Jiménez-Morales A, David MR, Lopez-Ferrer A, Gozalbo I, Prades M, Lizán L, Blanch C Abstract OBJECTIVE: To compare the cost-consequence of biologic drugs for moderate-severe psoriasis from the perspective of the Spanish National Health System. METHODS: We built a decision tree with a 2-year time horizon. Efficacy data for biologics (etanercept, infliximab, adalimumab, ustekinumab and secukinumab) was drawn from published meta-analyses: PASI75 for the induction phase and PASI90 for the rest of follow-up. Patients with PASI 
Source: Journal of Dermatological Treatment - August 9, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Wide range of age of onset and low referral rates to psychiatry in a large cohort of acne excori ée at a Swiss tertiary hospital.
DISCUSSION: Our study shows that dermatologists focus on treating acne-like lesions in SPD, but rarely refer to psychiatry. Possible reasons include considerations of patients' reactions who often reject the idea of a psychological origin of the disease. Our results suggest that new treatment strategies should be created to address SPD correctly, i.e. by combined consultations with psychiatrists or specific training of dermatologists in psychiatric therapy and diagnostics. PMID: 28784003 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 9, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Skin microneedling plus Platelet-Rich Plasma versus skin microneedling alone in the treatment of atrophic post acne scars: a split face comparative study.
CONCLUSION: Both microneedling and microneedling in combined with PRP showed satisfactory results. PMID: 28782384 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 8, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The Effect of Phototherapy on Progression to Tumors in Patients with Patch and Plaque Stage of Mycosis Fungoides.
CONCLUSIONS: The therapeutic effects of phototherapy, with longer times to tumor progression and increased overall survival, appear to outweigh its potential adverse effects. PMID: 28782389 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 8, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Use of moisturizers among Danish atopic dermatitis patients- which perceived product characteristics associate with long-term adherence?
CONCLUSION: AD patients state that the most important factor when choosing a product is out of personal experience followed by high lipid content and recommended by GP/dermatologist. As secondary reasons 'consistency', 'absorbs fast' and 'nice to wear' were important. Respondents generally use more than one product and are aware of additives. Evidence-based guidance on the choice of emollients is needed. The role of the professionals supporting the patient in navigating this market of emollients is therefore particularly important. PMID: 28782438 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 8, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Prescription-level factors associated with primary nonadherence to dermatologic medications.
CONCLUSIONS: Medication class or administration route may be associated with increased risk of nonadherence, and identifying these factors is important in considering ways to reduce primary nonadherence rates in dermatology. PMID: 28783420 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 8, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Is weekly dose of adalimumab a simple approach for resistant psoriasis?
Authors: Mazzilli S, Zangrilli A, Bavetta M, Bianchi L Abstract Backgroud: In real life, dose escalation can be a good approach for increasing efficacy in a subgroup of patients with an insufficient response to biologic therapy, reducing the signs and symptoms of psoriasis and improving the quality of life (QOL). OBJECTIVE: To determine the effectiveness of escalating adalimumab dosage from 40 mg eow to 40 mg weekly in a patient affected by psoriasis (PsO) and psoriatic arthritis (PsA) with 
Source: Journal of Dermatological Treatment - August 5, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Long term management of distinct facial flushing and persistent erythema of rosacea by treatment with carvedilol.
CONCLUSIONS: These findings demonstrate facial flushing and persistent erythema can be effectively treated by carvedilol long-term with a fast onset of improvement in a dose well tolerated. PMID: 28748731 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 29, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The increasing relevance of biofilms in common dermatological conditions.
CONCLUSIONS: Biofilms are a significant cause of disease with wide implications in the field of dermatology. Several novel treatments have been found to be effective against biofilms, depending on the underlying microbes and type of disease. PMID: 28749746 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 29, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The association of isoconazole - diflucortolone in the treatment of paediatric tinea corporis.
CONCLUSIONS: Our study in atopic children with tinea corporis superinfected by S. aureus confirms that a topical therapy with the association isoconazole-diflucortolone is useful and safe. PMID: 28753055 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 29, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Mometasone furoate in the treatment of vulvar lichen sclerosus: could its formulation influence efficacy, tolerability and adherence to treatment?
CONCLUSIONS: MMF in ointment formulation seems to be more effective in treating active VLS in comparison with MMF cream. Both formulations are well tolerated and there is no difference in patient adherence and satisfaction. PMID: 28753097 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 29, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Clinical correlates and prognostic value of different metastatic sites in patients with malignant melanoma of the skin; a SEER database analysis.
Authors: Abdel-Rahman O Abstract BACKGROUND: Population-based data on the clinical correlates and prognostic value of the pattern of metastases among patients with cutaneous melanoma are needed. METHODS: Surveillance, Epidemiology and End Results (SEER) database (2010-2013) has been explored through SEER*Stat program. For each of six distant metastatic sites (bone, brain, liver, lung, distant lymph nodes, skin/subcutaneous), relevant correlation with baseline characteristics were reported. Survival analysis has been conducted through Kaplan-Meier analysis and multivariate analysis has been conducted through a C...
Source: Journal of Dermatological Treatment - July 28, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Secukinumab improves scalp pain, itching, scaling, and quality of life in patients with moderate-to-severe scalp psoriasis.
Authors: Feldman SR, Green L, Kimball AB, Siu K, Zhao Y, Herrera V, Nyirady J, Alexis AF Abstract INTRODUCTION: Scalp psoriasis adversely affects patients' lives and is often resistant to treatment however it has not been a major focus of a clinical study. This analysis assessed the effect of secukinumab on patient-reported outcomes (PRO) of scalp psoriasis. METHODS: A randomized, double-blind, placebo-controlled, multicenter study was conducted in 102 adult patients with moderate-to-severe scalp psoriasis. Patients were randomized 1:1 to secukinumab 300mg or placebo. Patients rated their scalp-related pain, it...
Source: Journal of Dermatological Treatment - July 26, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Perspectives.
Authors: Feldman SR PMID: 28730945 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 23, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet B phototherapy.
Authors: Wacewicz M, Socha K, Soroczyńska J, Niczyporuk M, Aleksiejczuk P, Ostrowska J, Borawska MH Abstract BACKGROUND: Vitiligo is a chronic, depigmenting skin disorder, which pathogenesis is still unknown. Narrow band ultraviolet-B is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. PURPOSE: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo. METHODS: We assessed fifty patient...
Source: Journal of Dermatological Treatment - July 20, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: A randomized double blind placebo controlled study.
CONCLUSION: Cysteamine cream showed significant efficacy in decreasing melanin content of the lesions, as established by Dermacatch(®) as a new measuring method. PMID: 28678558 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 6, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Combination of benzoyl peroxide 5% gel with liquid cleanser and moisturizer SPF 30 in acne treatment results in high levels of subject satisfaction, good adherence and favorable tolerability.
CONCLUSIONS: The combination of BPO 5% gel with liquid cleanser and moisturizer SPF 30 resulted in high levels of subject satisfaction, good tolerability and treatment adherence. PMID: 28678647 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 6, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

High rates of secondary non-adherence causes decreased efficacy of 0.1% topical tacrolimus in adult eczema patients: results from a multicenter clinical trial.
CONCLUSION: Application amount of topical agent is important in increasing treatment efficacy in adult patients with atopic dermatitis. PMID: 28670943 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 5, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Morgellons Disease; experiences of an integrated multidisciplinary dermatology team to achieve positive outcomes.
CONCLUSIONS: Morgellons disease is a condition which is widely discussed on the internet and patients often self-diagnose. The course of the disease can be chronic and debilitating. For a positive outcome, it is important that a strong physican-patient relationship is cultivated. As demonstrated in this case series, managing patients holistically in an integrated multidisciplinary dermatology setting helps achieve positive outcomes. PMID: 28665169 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 2, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patient-reported outcomes in topical field treatment of actinic keratosis in Swedish and Danish patients.
The objective of this study was to analyze patient-reported treatment adherence, treatment satisfaction and health-related quality of life (HRQoL) with topical treatments of actinic keratosis (AK) in routine clinical practice in Denmark and Sweden. Adult patients prescribed field-directed topical AK treatments with diclofenac gel, imiquimod or ingenol mebutate per routine clinical practice were eligible for the observational RAPID-ACT study. Data were collected through physician and patient questionnaires that included validated instruments to measure treatment satisfaction (TSQM-9), treatment adherence (MMAS) and HRQoL (E...
Source: Journal of Dermatological Treatment - June 30, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Patients with male gender or greater body weight use smaller amounts of topical therapy in psoriasis.
CONCLUSIONS: We look forward to seeing whether the current pressure to improve psoriasis treatment leads to more patients receiving systemic therapies or to better adherence to, and persistence with, topical therapies. PMID: 28660780 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 30, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Complete resolution of mycosis fungoides tumors with imiquimod 5% cream: a case series.
CONCLUSIONS: Our case series is only the second report in the literature demonstrating complete resolution of MF tumors with topical imiquimod. An additional therapeutic option for tumor-stage MF, imiquimod may represent an effective alternative to localized radiation for isolated MF tumors and warrants further investigation in the treatment of various stages of MF. PMID: 28635518 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 23, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Methotrexate for the Treatment of Pediatric Alopecia Areata.
This study present a case series reviewing the efficacy of methotrexate in our pediatric patients with alopecia areata, making use of a retrospective chart review design from 2011-2016. In this data set, 8/14 subjects (57%) experienced good regrowth with methotrexate, while 3/14 (21%) had a response that could not be assessed due to loss to follow-up or premature discontinuation of the medication. No cases discontinued the medication due to recognized methotrexate side effects. This review suggests methotrexate is a generally safe and often effective medication in pediatric alopecia areata. PMID: 28627278 [PubMed - as ...
Source: Journal of Dermatological Treatment - June 20, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effect of psoriasis activity and topical treatment on plasma epidermal growth factor (EGF) and its soluble receptor (sEGFR).
Authors: Szterling-Jaworowska M, Baran A, Myśliwiec H, Flisiak I Abstract BACKGROUND: Pathogenesis of psoriasis involves epidermal growth factor (EGF) which participates in keratinocyte proliferation, angiogenesis and cell differentiation through binding to soluble epidermal growth factor receptor (sEGFR). It is synthesised by, among others, keratinocytes, especially within psoriatic skin. OBJECTIVE: To evaluate EGF and sEGFR plasma concentrations during topical psoriatic treatment. METHODS: Blood samples were collected from 51 patients with plaque psoriasis. EGF and sEGFR plasma concentrations were examin...
Source: Journal of Dermatological Treatment - June 19, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Defining treatment success in rosacea as 'clear' may provide multiple patient benefits: Results of a pooled analysis.
Authors: Webster G, Schaller M, Tan J, Jackson JM, Kerrouche N, Schäfer G Abstract Background Rosacea treatment success is usually defined as a score of 1 ("almost clear") or 0 ("clear") on the 5-point Investigator Global Assessment (IGA) scale. Objective To evaluate whether after successful treatment, "clear" subjects had better outcomes than "almost clear" subjects. Methods A pooled analysis was performed on 1366 rosacea subjects from 4 randomized controlled trials with IGA before and after treatment (ivermectin, metronidazole or vehicle). Assessments included the Derm...
Source: Journal of Dermatological Treatment - June 16, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Development and initial psychometric evaluation of patient-reported outcome questionnaires to evaluate the symptoms and impact of hidradenitis suppurativa.
CONCLUSION: The HSSA and HSIA are content-valid, HS-specific, PRO questionnaires with demonstrated ability to generate reliable, valid scores when administered to patients with HS in a research setting. PMID: 28608738 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 15, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Number needed to treat and costs per responder among biologic treatments for moderate-to-severe plaque psoriasis in Japan.
CONCLUSION: Adalimumab 40mg/80mg and secukinumab 150mg/300mg were the most efficacious and cost-efficient for patients with psoriasis in Japan. PMID: 28608740 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 15, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Optimal Wound Care Management in Hidradenitis Suppurativa.
Authors: Kazemi A, Carnaggio K, Clark M, Shephard C, Okoye GA Abstract Hidradenitis suppurativa (HS) presents the problem of a chronic, relapsing, painful, draining wound. There is a myriad of HS wound care management strategies implemented by clinicians and patients that is centered around which dressings to use. Many factors affect which HS wound care dressing is the most appropriate to use such as the type of HS wound, cost, ease of application, patient comfort, absorbency, and odor management among many others. In this work, the authors prepare a set of guidelines for optimal HS wound care dressing use based on...
Source: Journal of Dermatological Treatment - June 15, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The efficacy of short term clobetasol lotion in the treatment of scalp psoriasis.
CONCLUSION: Psoriasis is a long-term disease, and improving adherence in the short time could improve patient's adherence to treatment in long time. PMID: 28609161 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 15, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Atopic dermatitis 2017: where we were 10-15 years ago in psoriasis.
Authors: No DJ, Amin M, Egeberg A, Thyssen JP, Wu JJ Abstract Novel and innovative treatment options for atopic dermatitis are underway. The recent advancements in understanding atopic dermatitis are reminiscent of the progress made in psoriasis research over a decade ago. PMID: 28604121 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Home self-administration of omalizumab.
Authors: Ghazanfar MN, Thomsen SF PMID: 28604125 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Correlation between trough serum levels of Adalimumab and absolute PASI score in a series of patients with psoriasis.
CONCLUSIONS: We found an adequate correlation between drug serum levels and PASI scores. Monitoring of absolute PASI and serum levels can provide a personalized and cost-effective evaluation. PMID: 28604127 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The efficacy of methotrexate in the treatment of En coup de sabre (linear morphea subtype).
CONCLUSION: Methotrexate appeared to be an effective and safe therapy for en coup de sabre patients. PMID: 28604132 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia.
Authors: Rossi A, Campo D, Fortuna MC, Garelli V, Pranteda G, Di Nunno D, Carlesimo M Abstract Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18-40 years old. Several molecules are commonly used for the treatment of AGA, acting on different steps of its pathogenesis (Minoxidil, Finasteride, Serenoa repens) and show some side effects. In literature, on the basis of hypertrichosis observed in patients treated with analogues of prostaglandin PGF2α, was supposed that prostaglandins would have an important role in the hair growth: PGE and PGF2α play a ...
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

eHealth Technologies as an Intervention to Improve Adherence to Topical Antipsoriatics: A Systematic Review.
CONCLUSION: There is a critical need for high-quality RCTs testing if the ubiquitous eHealth technologies, e.g. some of the numerous apps, can improve psoriasis patients' rates of adherence to topical antipsoriatics. PMID: 28604138 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Review: the re-emergence of brachytherapy as treatment for non-melanoma skin cancer.
Authors: Ota K, Adar T, Dover L, Khachemoune A Abstract Electronic Brachytherapy (EBT) has seen a significant rise in use over the past few years in treating non-melanoma skin cancer (NMSC). However, the current literature in EBT remains scarce. Existing data on high dose rate brachytherapy (HDR-BT) with surface applicators is often used to justify its efficacy and safety. In this review we study the two treatment modalities on their efficacy in treating NMSC and we explore the reasons behind the recent uprise in EBT. A literature review using PubMed was performed for articles published until January 2017 studying ...
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Primary cutaneous post liver transplant lymphoproliferative disorder (PTLD) successfully treated with radiotherapy.
Authors: Murad A, Sheahan K, Kirby B Abstract A post liver transplant patient developed lesions with the clinical features suggestive of SCC-in-situ on his face and chest which occurred simultaneously since six months prior to his presentation. Skin histopathology confirmed the diagnosis of SCC-in-situ with additional plasmalymphocytic infiltrate in the dermis. Immunohistochemistry with his clinical presentation were in keeping with primary cutaneous post-transplant lymphoproliferative disorder (PTLD). He did not have any systemic involvement. Lesions were treated with radiotherapy with good response. This rare pre...
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Importance of Light in the Treatment of Vitiligo with JAK-inhibitors.
Authors: Joshipura D, Plotnikova N, Goldminz A, Deverapalli S, Turkowski Y, Gottlieb A, Rosmarin D Abstract Vitiligo is an autoimmune pigmentary disorder characterized by depigmented patches of skin with a selective loss of melanocytes. Recent advances describe vitiligo as a T-helper (Th1) cell-mediated disease with elevated levels of IFN-γ and its associated chemokines CXCL9 and CXCL10 responsible for depigmentation. The Janus kinase (JAK) inhibitors have shown promise for the treatment of vitiligo with improved response in the sun-exposed areas. We propose viewing the treatment of vitiligo as a two-step pro...
Source: Journal of Dermatological Treatment - June 8, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologics for psoriasis : maintenance treatment and true disease modification.
Authors: van de Kerkhof PC PMID: 28566054 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 3, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Letter to the Editor submitted in response to "The Extinction of Topical Erythromycin Therapy for Acne Vulgaris and Concern for the Future of Topical Clindamycin."
Letter to the Editor submitted in response to "The Extinction of Topical Erythromycin Therapy for Acne Vulgaris and Concern for the Future of Topical Clindamycin." J Dermatolog Treat. 2017 May 26;:1-9 Authors: Gupta T, Sardana K, Kumar B, Gautam HK PMID: 28545314 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 27, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evaluation of the Efficacy and Safety of Tavaborole Topical Solution, 5%, in the Treatment of Onychomycosis of the Toenail in Adults: A Pooled Analysis of an 8-Week, Poststudy Follow-Up From Two Randomized Phase 3 Studies.
Authors: Gupta AK, Hall S, Zane LT, Lipner SR, Rich P Abstract PURPOSE: The role of topical antifungal agents in the long-term management of toenail onychomycosis is not well established. The current study evaluated durability of clinical benefit of tavaborole topical solution, 5%, for the treatment of toenail onychomycosis. METHODS: We conducted a pooled analysis of 8-week, poststudy follow-up (PSFU) data from two phase 3, randomized controlled trials in a subset of patients who experienced complete or almost clear nail at the end of treatment (week 52); 48 weeks of treatment with once-daily tavaborole compare...
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy of Topical Latanoprost Versus Minoxidil and Betamethasone Valerate on The Treatment of Alopecia Areata.
CONCLUSION: Latanoprost, minoxidil and betamethasone valerate are effective and safe in the treatment of patchy AA. The use of latanoprost added to the therapeutic efficacy of topical betamethasone valerate in the treatment of AA and could be an effective adjunctive topical therapy for AA. PMID: 28521549 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Interleukin-17 Inhibition: Role in Psoriasis and Inflammatory Bowel Disease.
DISCUSSION: Anti-IL-17 medications are associated with IBD exacerbation. Caution should be used in prescribing these medications in patients with diagnosed IBD or personal history suggestive of IBD. PMID: 28521565 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment of recurrent pilonidal cysts with Nd-YAG laser: report of our experience.
Conclusions Nd-YAG laser is an effective treatment for pilonidal cysts, providing excellent results with quick healing and no risk of serious adverse side-effects. It could be a very attractive alternative to open surgery, enabling patients to prevent the frequent and severe postoperative issues associated with surgery. PMID: 28521574 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Pharmacokinetics of ingenol mebutate gel under maximum use conditions in large treatment areas.
CONCLUSION: Subnanomolar systemic exposure to ingenol mebutate was measured after application of the gel to approximately 250 cm(2) on the full face, scalp, or arm under maximum use conditions. No clinically relevant systemic adverse reactions were observed, and local skin responses were manageable. PMID: 28524709 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and safety of etanercept in psoriasis and psoriatic arthritis in the PRESTA study: Analysis in patients from Central and Eastern Europe.
The objective of this analysis was to evaluate the efficacy of etanercept (ETN) in PsA patients from CEE. METHODS: In PRESTA, patients were randomised to receive ETN 50 mg BIW or 50 mg QW for 12 weeks (double-blind phase), and ETN 50 mg QW for 12 additional weeks (open-label). In this analysis only patients from Czech Republic, Hungary, Poland, and Serbia were included. The primary efficacy variable was the proportion of subjects achieving a physician global assessment (PGA) of psoriasis status: 'clear' or 'almost clear' at week 12. RESULTS: In the 307 patients, 54% BIW/QW compared with 40% (QW...
Source: Journal of Dermatological Treatment - May 18, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research