Variation of topical application to skin under good clinical practice (GCP): A "best performance" scenario.
CONCLUSION: There was a major variation of test ointment application studied under GCP conditions with adherent participants. In dermatological practice, the variation is assumed to be even higher. This should be taken into account in clinical trials, especially dose-finding studies typically operating with 3-5-fold increments. PMID: 26758402 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Lycopene reduces mortality in people with systemic lupus erythematosus: A pilot study based on the third national health and nutrition examination survey.
CONCLUSIONS: These findings from nationally representative samples indicate that higher serum lycopene has the protective effect on mortality in SLE. Further studies with large sample size are needed to confirm these primary results. PMID: 26762689 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis.
CONCLUSION: INCB039110 produced significant improvements in sPGA, demonstrating proof of concept in chronic plaque psoriasis. PMID: 26769332 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Percutaneous penetration and pharmacodynamics: Wash-in and wash-off of sunscreen and insect repellent.
Authors: Rodriguez J, Maibach HI Abstract Increased awareness of skin cancer and mosquito-transmitted diseases has increased use of insect repellents and sunscreens. The challenge in setting recommendations for use and reapplication, especially when used concomitantly, lies in finding the balance between applying a durable product effective in withstanding natural and physical factors such as water, sweat, temperature and abrasion, while limiting percutaneous absorption and decreasing risk of potential dermal and systemic toxicity. Inorganic sunscreens show no or little percutaneous absorption or toxic effects in c...
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Rosacea patients seeking advice: Qualitative analysis of patients' posts on a rosacea support forum.
CONCLUSION: Proactively providing reliable resources and comprehensive explanations on treatments, triggers, diet and skin care could be helpful in reducing patients' confusion about rosacea and enhancing rosacea patient-physician relationships. PMID: 26815357 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Melanoma and non-melanoma skin cancer in psoriatic patients treated with high-dose phototherapy.
CONCLUSIONS: A noteworthy number of NMSC were diagnosed in this Mediterranean population of patients exposed to high-dose UV treatment. A thorough risk-benefit evaluation should always be done before UV treatment and patients should be carefully monitored for skin cancer during and after treatment discontinuation. PMID: 26822468 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Role of cleansers in the management of acne: Results of an Italian survey in 786 patients.
CONCLUSION: The results of this survey cannot be compared with other studies because of the lack of similar studies about this topic. These results suggest that a sample of Italian acne patients consider cleansers as an important adjuvant treatment in acne. PMID: 26822550 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Retrospective analysis of the effectiveness and costs of traditional treatments for moderate-to-severe psoriasis: A single-center, Italian study.
Authors: Carpentieri A, Pacello L, De Marco IM, Loiacono A, Picconi O, Loconsole F Abstract BACKGROUND: Current guidelines recommend the use of systemic therapy and phototherapy for the treatment of moderate-to-severe plaque psoriasis. OBJECTIVES: To evaluate the effectiveness, impact on health status perception, and costs of traditional systemic therapies and phototherapy in real-life patients with moderate-to-severe psoriasis. METHODS: Retrospective analysis of data from 100 psoriatic patients referring to a dermatology clinic in Italy and treated with traditional therapies. RESULTS: Patients were pre...
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Focus on five patients treated with cyclosporine up to 62 months.
CONCLUSION: Cyclosporine is an acceptable monotherapy for psoriasis in selected patients. The prompt discontinuation of treatment usually results in resolution of any eventual toxicity. PMID: 26822802 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Localized topical steroid use and central serous retinopathy.
CONCLUSION: It is critical that dermatologists are aware of this association, and refer patients who develop ocular symptoms after using topical steroids to ophthalmology. PMID: 26822912 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Demyelinating disorders secondary to TNF-inhibitor therapy for the treatment of psoriasis: A review.
CONCLUSION: Although there is potential for TNF blockade to lead to demyelination of the central and peripheral nervous systems, the results of the present review suggest that demyelinating diseases associated with TNFi are extremely rare. TNFi are not recommended for use in patients with a personal history of demyelinating disease. However, with clinical vigilance and individualized treatment regimen, TNFi may be safe for use in other patients. PMID: 26837667 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Emollient efficacy and acceptability in the treatment of eczematous dry skin: A double-blind, randomised comparison of two UK-marketed products.
Authors: Djokic-Gallagher J, Rosher P, Walker J, Sykes K, Hart V Abstract OBJECTIVE: The aim of this study was to compare the moisturising efficacy and acceptability of physical characteristics of two commonly prescribed emollients licenced in the UK, Doublebase Dayleve gel (DELP) and Diprobase cream (DIPC). METHODS: The study was a double-blind, concurrent bi-lateral comparison in female eczema subjects with dry skin. RESULTS: In Part 1, comparing the area under the curve (AUC) change from baseline corneometer readings over 24 h following single applications of the emollients to the volar forearms of 34 su...
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Interleukin-1 receptor antagonist (anakinra) for Schnitzler syndrome.
We report on a 68-year-old female patient with a 10-year medical history of chronic urticaria, recurrent fever, severe arthralgia and increased CRP. Over the years, multiple diagnostic investigations were performed without conclusive findings, and therapeutic attempts with anti-histamines and several immunosuppressive agents had failed. The decision to initiate monotherapy with interleukin-1 (IL-1) receptor antagonist was based on immunohistochemical detection of the abundance of IL-1β positive cells in the patient's skin biopsy. After starting treatment with anakinra, disappearance of symptoms could be observed withi...
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Combination of non-ablative fractional photothermolysis and 0.1% tacrolimus ointment is efficacious for treating idiopathic guttate hypomelanosis.
CONCLUSION: Fractional 1550-nm ytterbium/erbium fiber laser combined with topical 0.1% tacrolimus ointment was effective for IGH. PMID: 26864301 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The future of lasers in onychomycosis
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 13, 2015 Category: Dermatology Tags: article Source Type: research

Efficacy of sodium hypochlorite (bleach) baths to reduce Staphylococcus aureus colonization in childhood onset moderate-to-severe eczema: A randomized, placebo-controlled cross-over trial
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 13, 2015 Category: Dermatology Tags: article Source Type: research

Blister roof grafting, cultured melanocytes transplantation and non-cultured epidermal cell suspension transplantation in treating stable vitiligo: A mutual self-control study
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 7, 2015 Category: Dermatology Tags: article Source Type: research

Desired Improvement Tool (DIT): A tool to assess desire for improvement in psoriasis patients
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - August 6, 2015 Category: Dermatology Tags: article Source Type: research

An observational study of the real-life management of psoriasis patients treated with etanercept according to the new reimbursement criteria (in Belgium)
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 28, 2015 Category: Dermatology Tags: article Source Type: research

Effects of Kyunghee Facial Resistance Program (KFRP) on mechanical and elastic properties of skin
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 28, 2015 Category: Dermatology Tags: article Source Type: research

Cutaneous cryosurgery in the United States
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 25, 2015 Category: Dermatology Tags: article Source Type: research

Risk factors, psychological impacts and current treatments of acne in Shanghai area of China
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 22, 2015 Category: Dermatology Tags: article Source Type: research

The effect of volatility on percutaneous absorption
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 16, 2015 Category: Dermatology Tags: article Source Type: research

A multicenter, non-interventional study to evaluate patient-reported experiences of living with psoriasis
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 3, 2015 Category: Dermatology Tags: article Source Type: research

A retrospective analysis of pediatric patients with lichen sclerosus treated with a standard protocol of class I topical corticosteroid and topical calcineurin inhibitor
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 3, 2015 Category: Dermatology Tags: article Source Type: research

Practical guidance on immunogenicity to biologic agents used in the treatment of psoriasis: What can be learnt from other diseases?
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 26, 2015 Category: Dermatology Tags: article Source Type: research

Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 25, 2015 Category: Dermatology Tags: article Source Type: research

Clinical features of Behçet’s disease: A retrospective chart review of 26 patients
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 25, 2015 Category: Dermatology Tags: article Source Type: research

Successful treatment of severe psoriasis with ustekinumab in a 13-year old girl
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 25, 2015 Category: Dermatology Tags: article Source Type: research

Meglumine antimoniate is more effective than sodium stibogluconate in the treatment of cutaneous leishmaniasis
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 24, 2015 Category: Dermatology Tags: article Source Type: research

Biologics and biosimilars
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 24, 2015 Category: Dermatology Tags: article Source Type: research

Squamous cell carcinoma originating from cutaneous cysts: The Henry Ford Experience and review of the literature
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 24, 2015 Category: Dermatology Tags: article Source Type: research

Patient reported health outcomes and non-adherence in psoriasis patients receiving adalimumab or ustekinumab for moderate to severe plaque psoriasis
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 20, 2015 Category: Dermatology Tags: article Source Type: research

Long-term safety and effectiveness of high-dose dimethylfumarate in the treatment of moderate to severe psoriasis: a prospective single-blinded follow-up study
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 19, 2015 Category: Dermatology Tags: article Source Type: research

Efficacy and cost of etanercept in long-term psoriasis: Rational use in clinical practice
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 18, 2015 Category: Dermatology Tags: article Source Type: research

Improvement of inflammatory dermatoses severity and quality of life in patients treated with a betamethasone valerate plaster (LIBERE study)
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 16, 2015 Category: Dermatology Tags: article Source Type: research

Routes of drug delivery into the nail apparatus: Implications for the efficacy of topical nail solutions in onychomycosis
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 19, 2015 Category: Dermatology Tags: article Source Type: research

Psoriasis patients’ willingness to accept side-effect risks for improved treatment efficacy
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 7, 2015 Category: Dermatology Tags: article Source Type: research

Long-term effect of early-life supplementation with probiotics on preventing atopic dermatitis: A meta-analysis
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 5, 2015 Category: Dermatology Tags: article Source Type: research

Combination therapy of methotrexate plus NBUVB phototherapy is more effective than methotrexate monotherapy in the treatment of chronic plaque psoriasis
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 24, 2015 Category: Dermatology Tags: article Source Type: research

A massive neglected giant basal cell carcinoma in a schizophrenic patient treated successfully with vismodegib
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 24, 2015 Category: Dermatology Tags: article Source Type: research

Certolizumab pegol – A new therapeutic option for refractory disseminated pyoderma gangrenosum associated with Crohn’s disease
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 24, 2015 Category: Dermatology Tags: article Source Type: research

Long-term use of a 4% sodium cromoglicate cutaneous emulsion in the treatment of moderate to severe atopic dermatitis in children
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 24, 2015 Category: Dermatology Tags: article Source Type: research

Successful reconstruction after resection of malignant skin tumor on triangular fossa using anterior auricular bilobed flap
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 21, 2015 Category: Dermatology Tags: article Source Type: research

Treatment of atopic dermatitis with KAM-3008, a barrier-based, non-steroidal topical cream
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 20, 2015 Category: Dermatology Tags: article Source Type: research

Triterpenes with healing activity: A systematic review
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 20, 2015 Category: Dermatology Tags: article Source Type: research

Correlations among steroid fear, acceptability, usage frequency, quality of life and disease severity in childhood eczema
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 20, 2015 Category: Dermatology Tags: article Source Type: research

Safety and efficacy of cetirizine versus cetirizine plus ranitidine in chronic urticaria: Double-blind randomized placebo-controlled study
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 18, 2015 Category: Dermatology Tags: article Source Type: research

Use of off-label doses is frequent in biologic therapy for moderate to severe psoriasis: A cross-sectional study in clinical practice
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 17, 2015 Category: Dermatology Tags: article Source Type: research

Clinical symptoms and self-reported disease severity among patients with psoriasis – Implications for psoriasis management
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 17, 2015 Category: Dermatology Tags: article Source Type: research