Atopic dermatitis 2017: where we were 10-15 years ago in psoriasis.
Authors: No DJ, Amin M, Egeberg A, Thyssen JP, Wu JJ Abstract Novel and innovative treatment options for atopic dermatitis are underway. The recent advancements in understanding atopic dermatitis are reminiscent of the progress made in psoriasis research over a decade ago. PMID: 28604121 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Home self-administration of omalizumab.
Authors: Ghazanfar MN, Thomsen SF PMID: 28604125 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Correlation between trough serum levels of Adalimumab and absolute PASI score in a series of patients with psoriasis.
CONCLUSIONS: We found an adequate correlation between drug serum levels and PASI scores. Monitoring of absolute PASI and serum levels can provide a personalized and cost-effective evaluation. PMID: 28604127 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The efficacy of methotrexate in the treatment of En coup de sabre (linear morphea subtype).
CONCLUSION: Methotrexate appeared to be an effective and safe therapy for en coup de sabre patients. PMID: 28604132 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia.
Authors: Rossi A, Campo D, Fortuna MC, Garelli V, Pranteda G, Di Nunno D, Carlesimo M Abstract Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18-40 years old. Several molecules are commonly used for the treatment of AGA, acting on different steps of its pathogenesis (Minoxidil, Finasteride, Serenoa repens) and show some side effects. In literature, on the basis of hypertrichosis observed in patients treated with analogues of prostaglandin PGF2α, was supposed that prostaglandins would have an important role in the hair growth: PGE and PGF2α play a ...
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

eHealth Technologies as an Intervention to Improve Adherence to Topical Antipsoriatics: A Systematic Review.
CONCLUSION: There is a critical need for high-quality RCTs testing if the ubiquitous eHealth technologies, e.g. some of the numerous apps, can improve psoriasis patients' rates of adherence to topical antipsoriatics. PMID: 28604138 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Review: the re-emergence of brachytherapy as treatment for non-melanoma skin cancer.
Authors: Ota K, Adar T, Dover L, Khachemoune A Abstract Electronic Brachytherapy (EBT) has seen a significant rise in use over the past few years in treating non-melanoma skin cancer (NMSC). However, the current literature in EBT remains scarce. Existing data on high dose rate brachytherapy (HDR-BT) with surface applicators is often used to justify its efficacy and safety. In this review we study the two treatment modalities on their efficacy in treating NMSC and we explore the reasons behind the recent uprise in EBT. A literature review using PubMed was performed for articles published until January 2017 studying ...
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Primary cutaneous post liver transplant lymphoproliferative disorder (PTLD) successfully treated with radiotherapy.
Authors: Murad A, Sheahan K, Kirby B Abstract A post liver transplant patient developed lesions with the clinical features suggestive of SCC-in-situ on his face and chest which occurred simultaneously since six months prior to his presentation. Skin histopathology confirmed the diagnosis of SCC-in-situ with additional plasmalymphocytic infiltrate in the dermis. Immunohistochemistry with his clinical presentation were in keeping with primary cutaneous post-transplant lymphoproliferative disorder (PTLD). He did not have any systemic involvement. Lesions were treated with radiotherapy with good response. This rare pre...
Source: Journal of Dermatological Treatment - June 13, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Importance of Light in the Treatment of Vitiligo with JAK-inhibitors.
Authors: Joshipura D, Plotnikova N, Goldminz A, Deverapalli S, Turkowski Y, Gottlieb A, Rosmarin D Abstract Vitiligo is an autoimmune pigmentary disorder characterized by depigmented patches of skin with a selective loss of melanocytes. Recent advances describe vitiligo as a T-helper (Th1) cell-mediated disease with elevated levels of IFN-γ and its associated chemokines CXCL9 and CXCL10 responsible for depigmentation. The Janus kinase (JAK) inhibitors have shown promise for the treatment of vitiligo with improved response in the sun-exposed areas. We propose viewing the treatment of vitiligo as a two-step pro...
Source: Journal of Dermatological Treatment - June 8, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Biologics for psoriasis : maintenance treatment and true disease modification.
Authors: van de Kerkhof PC PMID: 28566054 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 3, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Letter to the Editor submitted in response to "The Extinction of Topical Erythromycin Therapy for Acne Vulgaris and Concern for the Future of Topical Clindamycin."
Letter to the Editor submitted in response to "The Extinction of Topical Erythromycin Therapy for Acne Vulgaris and Concern for the Future of Topical Clindamycin." J Dermatolog Treat. 2017 May 26;:1-9 Authors: Gupta T, Sardana K, Kumar B, Gautam HK PMID: 28545314 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 27, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evaluation of the Efficacy and Safety of Tavaborole Topical Solution, 5%, in the Treatment of Onychomycosis of the Toenail in Adults: A Pooled Analysis of an 8-Week, Poststudy Follow-Up From Two Randomized Phase 3 Studies.
Authors: Gupta AK, Hall S, Zane LT, Lipner SR, Rich P Abstract PURPOSE: The role of topical antifungal agents in the long-term management of toenail onychomycosis is not well established. The current study evaluated durability of clinical benefit of tavaborole topical solution, 5%, for the treatment of toenail onychomycosis. METHODS: We conducted a pooled analysis of 8-week, poststudy follow-up (PSFU) data from two phase 3, randomized controlled trials in a subset of patients who experienced complete or almost clear nail at the end of treatment (week 52); 48 weeks of treatment with once-daily tavaborole compare...
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy of Topical Latanoprost Versus Minoxidil and Betamethasone Valerate on The Treatment of Alopecia Areata.
CONCLUSION: Latanoprost, minoxidil and betamethasone valerate are effective and safe in the treatment of patchy AA. The use of latanoprost added to the therapeutic efficacy of topical betamethasone valerate in the treatment of AA and could be an effective adjunctive topical therapy for AA. PMID: 28521549 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Interleukin-17 Inhibition: Role in Psoriasis and Inflammatory Bowel Disease.
DISCUSSION: Anti-IL-17 medications are associated with IBD exacerbation. Caution should be used in prescribing these medications in patients with diagnosed IBD or personal history suggestive of IBD. PMID: 28521565 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Treatment of recurrent pilonidal cysts with Nd-YAG laser: report of our experience.
Conclusions Nd-YAG laser is an effective treatment for pilonidal cysts, providing excellent results with quick healing and no risk of serious adverse side-effects. It could be a very attractive alternative to open surgery, enabling patients to prevent the frequent and severe postoperative issues associated with surgery. PMID: 28521574 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Pharmacokinetics of ingenol mebutate gel under maximum use conditions in large treatment areas.
CONCLUSION: Subnanomolar systemic exposure to ingenol mebutate was measured after application of the gel to approximately 250 cm(2) on the full face, scalp, or arm under maximum use conditions. No clinically relevant systemic adverse reactions were observed, and local skin responses were manageable. PMID: 28524709 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and safety of etanercept in psoriasis and psoriatic arthritis in the PRESTA study: Analysis in patients from Central and Eastern Europe.
The objective of this analysis was to evaluate the efficacy of etanercept (ETN) in PsA patients from CEE. METHODS: In PRESTA, patients were randomised to receive ETN 50 mg BIW or 50 mg QW for 12 weeks (double-blind phase), and ETN 50 mg QW for 12 additional weeks (open-label). In this analysis only patients from Czech Republic, Hungary, Poland, and Serbia were included. The primary efficacy variable was the proportion of subjects achieving a physician global assessment (PGA) of psoriasis status: 'clear' or 'almost clear' at week 12. RESULTS: In the 307 patients, 54% BIW/QW compared with 40% (QW...
Source: Journal of Dermatological Treatment - May 18, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A new topical panthenol-containing emollient for maintenance treatment of childhood atopic dermatitis: Results from a multicenter prospective study.
Authors: Stettler H, Kurka P, Kandzora J, Pavel V, Breuer M, Macura-Biegun A Abstract PURPOSE: A study was conducted with a new topical panthenol-containing emollient (NTP-CE) to investigate the efficacy and safety of a 3-month maintenance treatment in infants and children with stabilized mild atopic dermatitis (AD). METHODS: After the stabilization phase (up to 2 months) using a corticosteroid-free topical medical device, 108 subjects (aged 2-49 months) with a SCORing AD (SCORAD) on the target area of
Source: Journal of Dermatological Treatment - May 18, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Use of non-biologic treatments in antihistamine-refractory chronic urticaria: a review of published evidence.
CONCLUSION: The treatment options reviewed should be seen as potential alternatives in treatment-resistant chronic urticaria where guideline-based selections have failed. However, larger controlled trials are warranted to advance the level of evidence, possibly supporting some treatments' future recommendation in selected patients. PMID: 28513247 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 18, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Topical use of dexpanthenol: a 70th anniversary article.
Authors: Proksch E, de Bony R, Trapp S, Boudon S Abstract Approximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen™ Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the field of dermatology and skin care. Various studies confirmed dexpanthenol's moisturizing and skin barrier enhancing potential. It prevents skin irritation, stimulates skin regeneration and promotes wound healing. Two main directions in the use of topi...
Source: Journal of Dermatological Treatment - May 17, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Topical 0.25% Desoximetasone Spray Efficacy for Moderate to Severe Plaque Psoriasis: A Randomized Clinical Trial.
Authors: Saleem MD, Negus D, Feldman SR Abstract BACKGROUND: Traditionally, ointments were the vehicle of choice for psoriasis. Poor adherence of traditional vehicles limits the use of topical corticosteroids. Alternative formulations have gained popularity due to their ease of application, improved adherence, and efficacy. OBJECTIVE: To evaluate the efficacy of topical desoximetasone 0.25% spray formulation in extensive psoriasis. METHODS: This multicenter, double-blinded, randomized trial compared twice daily topical 0.25% desoximetasone spray to placebo in subjects ≥18 with moderate to severe plaque p...
Source: Journal of Dermatological Treatment - May 17, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Combination Therapy of BRAF Inhibitors for Advanced Melanoma with BRAF V600 Mutation: A Systematic Review and Meta-Analysis.
CONCLUSIONS: Combination therapy with BRAF inhibitors and MEK inhibitors significantly improved OS, PFS, and ORR in patients with advanced melanoma with BRAF mutation. PMID: 28504036 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 17, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Desoximetasone 0.25% spray, adrenal suppression and efficacy, in extensive plaque psoriasis.
CONCLUSIONS: Considerable improvement can be achieved with short term potent topical corticosteroid treatment even in patients with severe, extensive psoriasis. For such use, topical desoximetasone has less risk of HPA-suppression than does topical clobetasol. PMID: 28494626 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 14, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

What Is Clearance Worth? Patients' Stated Risk Tolerance for Psoriasis Treatments.
CONCLUSIONS: Most patients placed greater value on eliminating even very small plaques compared to avoiding treatment-related risks. The perceived importance of complete versus near-complete clearance was stronger than previously documented. PMID: 28494683 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 14, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evolution in psoriasis management.
Authors: Feldman SR PMID: 28494688 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 14, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Serum YKL-40 as a potential biomarker of inflammation in psoriasis.
Authors: Baran A, Myśliwiec H, Szterling-Jaworowska M, Kiluk P, Świderska M, Flisiak I Abstract OBJECTIVE: YKL-40 is an inflammatory glycoprotein associated with atherosclerosis, cardiovascular disease, diabetes or metabolic syndrome which are common comorbidities in psoriasis. The aim of the study was to assess serum YKL-40 level in psoriasis and elucidate possible associations with disease activity, inflammatory or metabolic parameters and treatment. METHODS: A total of 37 individuals with active plaque-type psoriasis and 15 healthy controls were enrolled. Blood samples were collected before and after two w...
Source: Journal of Dermatological Treatment - May 14, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Beyond Monotherapy: Creative Strategies in Topical Therapy of Psoriasis.
This article reviews five types of strategies for improved efficacy from topical agents beyond monotherapy. These strategies include proactive use, rotational therapy, sequential therapy, using topical agents to shorten the onset of therapeutic action for slower internal agents or phototherapy, and combination use for added efficacy. Each of these are reviewed in detail. PMID: 28481664 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 11, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Review of U.S. Registries for Psoriasis.
CONCLUSIONS: Patient registries are frequently used for psoriasis in the U.S. and provide important information about the safety, efficacy, and long-term effects of systemic therapies. PMID: 28481671 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 11, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A case series of Imatinib induced generalized hypopigmentation and progression of existing acquired dermal melanocytosis.
We report a case series of three Asian Chinese females with pre-existing acquired dermal melanocytosis that progressed after initiation of imatinib treatment, and concurrently developed generalized hypopigmentation of the skin. All three patients had similar histological findings on skin biopsy. It is postulated that the KIT-SCF pathway has a central role in the pathogenetic mechanism. Therefore, it is important for physicians to be aware of this potential side effect of paradoxical pigmentation in patients treated with imatinib. PMID: 28481685 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 11, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Small cryotherapy devices for the treatment of skin warts.
CONCLUSIONS: Both cryotherapy devices produced sufficient tissue damage, at least in the potatoes, to a depth of 0.5-1.2 mm when applied for 40" (commercially proposed time). PMID: 28475390 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 8, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Efficacy and safety of an over-the-counter 1% colloidal oatmeal cream in the management of mild to moderate atopic dermatitis in children: a double-blind, randomized, active-controlled study.
CONCLUSION: OTC 1% oatmeal cream was equally effective and safe as the prescription barrier cream for the symptomatic treatment of mild-to-moderate AD in children. TRIAL REGISTRATION NUMBER: NCT01326910. PMID: 28366039 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 4, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Atopic dermatitis management with tacrolimus ointment (Protopic ®).
Atopic dermatitis management with tacrolimus ointment (Protopic®). J Dermatolog Treat. 2003 Oct;14(sup1):5-16 Authors: Kapp A, Allen BR, Reitamo S Abstract Tacrolimus ointment is the first of a new class of non-steroidal topical immunomodulators indicated for the treatment of atopic dermatitis. Topical tacrolimushas been subject to an extensive clinical development program involving more than 16,000 patients. A clinical trial program, including vehicle-controlled studies, short- and long-term comparative studies and long-term safety studies, has investigated tacrolimus 0.1%and 0.03%ointment for the...
Source: Journal of Dermatological Treatment - April 1, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Evaluation of the influence of family and friends, and the Internet on patient perceptions of long-term topical corticosteroid use.
Authors: Smith SD, Farrugia LL, Harris V, Lee A, Blaszczynski A, Fischer G Abstract BACKGROUND: Topical corticosteroids (TCS) are key to managing chronic inflammatory dermatoses (CID). Parents/patients cite TCS phobia as an impediment to treatment adherence. Family/friends and the Internet are a source of misinformation on TCS which can negatively impact perceptions of TCS safety. PURPOSE: To assess information from family/friends and the Internet, as related to and reported by patients/parents using long term TCS. METHODS: A multicenter cross-sectional survey of patients (aged 18+) and parents of patients (aged
Source: Journal of Dermatological Treatment - March 31, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Rethinking costs of psoriasis: 10% of patients account for nearly 40% of healthcare expenditures among enrollees with psoriasis in a U.S. health plan.
Authors: Armstrong AW, Zhao Y, Herrera V, Li Y, Bancroft T, Hull M, Altan A Abstract OBJECTIVE: To examine characteristics, healthcare utilization and costs among patients with psoriasis who have high medical costs. METHODS: This is a retrospective study of patients with psoriasis with continuous enrollment from 1 January 2011 to 31 December 2013 in a large US health plan. Total paid 2012 healthcare costs excluding biologics (to identify costliest not due to biologic costs) were used to create cohorts representing the top 10% (T10) and bottom 90% (B90) of expenditures. Demographics, comorbidities, prescriptions...
Source: Journal of Dermatological Treatment - March 24, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Correction to: Psoriasis patients with psoriasis Area and Severity Index (PASI) 90 response achieve greater health-related quality-of-life improvements than those with PASI 75-89 response: results from two phase 3 studies of secukinumab.
Authors: PMID: 28320215 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 24, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A combination of Yiqiqubai granule and 308-nm excimer laser in treatment of segmental vitiligo: a prospective study of 233 patients.
Authors: Zhang C, Zhou L, Huang J, Shi W Abstract OBJECTIVE: To study the effect of Yiqiqubai granule combined with 308-nm excimer laser treatment for segmental vitiligo (SV). METHODS: A prospective research was performed in 233 patients with SV treated in Shanghai General Hospital from 11 February 2015 to 25 August 2016, they were divided into group A (n = 75), group B (n = 78) and group C (n = 80) according to the random number table. Group A was treated with Yiqiqubai granule, group B treated with 308-nm excimer laser and group C treated with combined treatments. The...
Source: Journal of Dermatological Treatment - March 24, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Sublingual immunotherapy in patients with latex allergy: systematic review and meta-analysis of randomized controlled trials.
Authors: Sridharan K, Sivaramakrishnan G Abstract Latex allergy (LA) is a commonly observed entity for which sublingual immunotherapy (SLIT) has been shown to be effective in many small randomized clinical trials. The present study was conducted with an aim of systematically reviewing the existing literature on the efficacy and safety of SLIT in patients with LA and to apply the principles of meta-analysis. A search for randomized controlled trials with appropriate search strategy in PubMed and CENTRAL was conducted. Studies with documented clinical history of LA and SLIT administered in any dose, duration and regi...
Source: Journal of Dermatological Treatment - March 24, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Enhancing clinical communication in dermatologists: a personalized educational intervention.
CONCLUSION: The one-to-one coaching is a convenient and well-received personalized means of enhancing clinical communication in dermatologists, leading to more patient-centered medical encounters with better treatment outcomes. PMID: 28322070 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 24, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Value in innovative dermatological treatments.
Authors: van de Kerkhof PC PMID: 28322080 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 24, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Is photodynamic therapy a relevant therapeutic option in refractory benign familial pemphigus (hailey hailey disease)? a series of 8 patients.
CONCLUSION: Our series, although limited in size, emphasizes the interest of PDT in this difficult condition even though results may be incomplete. Treatment-related pain can be adequately managed by prior analgesics, cooling with sprayed water and local tumescent anesthesia. Overall, PDT appears as a relevant option in refractory HHD management with a favorable benefit/risk ratio. PMID: 28301978 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Retinoids: A Journey from the Molecular Structures and Mechanisms of Action to Clinical Uses in Dermatology and Adverse Effects.
Authors: Khalil S, Bardawil T, Stephan C, Darwiche N, Abbas O, Kibbi AG, Nemer G, Kurban M Abstract Retinoids are a class of compounds derived from vitamin A or have structural and/or functional similarity with vitamin A. They are classified into three generations based on their molecular structures. Inside the body, retinoids bind to several classes of proteins including retinoid-binding proteins and retinoid nuclear receptors. This eventually leads to the activation of specific regulatory regions of DNA - called the retinoic acid response elements - involved in regulating cell growth, differentiation and apoptosi...
Source: Journal of Dermatological Treatment - March 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Axillary Hyperhidrosis: A Focused Review.
The objective of this paper is to review the epidemiology, clinical presentation, pathophysiology, histology, and genetics, and management and treatment of axillary hyperhidrosis. PMID: 28318360 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 21, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Prospective pilot study on combined use of pulsed dye laser and 1% topical rapamycin for treatment of non-facial cutaneous capillary malformation.
CONCLUSION: 1% topical rapamycin does not seem to be effective as a treatment modality for cutaneous CM of trunk or extremities. PMID: 28285560 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 14, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Impact of immunogenicity on response to anti-TNF therapy in moderate-to-severe plaque psoriasis: results of the PREDIR study.
This study was conducted to examine the relationship between loss of clinical response to anti-tumor necrosis factor (TNF) therapy and the production of anti-drug antibodies (ADAs) and the potential effects of biologic immunogenicity. MATERIALS AND METHODS: This observational, non-interventional, cross-sectional study included patients with moderate-to-severe plaque psoriasis and secondary failure of adalimumab, etanercept and infliximab who were seen in the clinical practice setting. Clinical data and blood samples were collected after patient enrollment at the time that next doses of anti-TNF therapy were scheduled. ...
Source: Journal of Dermatological Treatment - March 11, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Platelet rich plasma for treatment of nonscarring hair loss: systematic review of literature.
CONCLUSION: Most of the available evidence has shown low quality and controversial results about the efficacy of PRP in treating non cicatricial alopecias, including androgenetic alopecia and alopecia areata. Further randomized controlled studies with more sample size and standard protocols regarding the number and interval of treatment sessions, number of platelets, method of activation, etc, are required to investigate the efficacy and safety of PRP in treating hair loss. PMID: 28271918 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 10, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

A dose finding trial with a novel ingenol derivative (ingenol disoxate; LEO 43204) for field treatment of actinic keratosis on full face or 250cm(2) on the chest.
Authors: Bourcier M, Stein Gold L, Guenther L, Andreassen CM, Selmer J, Goldenberg G Abstract PURPOSE: Actinic keratoses (AKs) may progress to squamous cell carcinoma and can occur in cancerized fields as sub-clinical and clinically visible lesions. Ingenol disoxate gel is a topical field therapy for AK. This Phase I/II trial aimed to assess the safety and efficacy of ingenol disoxate on full face or chest in patients with AKs. MATERIALS AND METHODS: Part 1 was a phase-I, open-label, dose-escalation trial investigating the maximum tolerated dose of ingenol disoxate. Part 2 was a phase-II, randomized, double-bli...
Source: Journal of Dermatological Treatment - March 9, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Psoriasis patients with psoriasis Area and Severity Index (PASI) 90 response achieve greater health-related quality-of-life improvements than those with PASI 75-89 response: results from two phase 3 studies of secukinumab.
Authors: Elewski BE, Puig L, Mordin M, Gilloteau I, Sherif B, Fox T, Gnanasakthy A, Papavassilis C, Strober BE Abstract BACKGROUND: The emergence of new biological therapies showing high and sustained level of Psoriasis Area and Severity Index (PASI) 90 response has provided the possibility of both greater skin clearance and increased quality of life (QOL). OBJECTIVE: To evaluate the association of greater response in skin clearance with improvements in skin-related QOL up to 52 weeks. METHODS: Subjects achieving various levels of skin clearance (PASI 90-100 or PASI 75-89) and Dermatology Life Quality Index...
Source: Journal of Dermatological Treatment - March 9, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

High grade follicular lymphoma in a patient receiving adalimumab and methotrexate for pityriasis rubra pilaris.
Authors: Nic Dhonncha E, Fadalla K, Moriarty B, Gibbons D, Collins CD, Fabre A, Collins P PMID: 28266882 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 9, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Correction to: Early clinical response to tofacitinib treatment as a predictor of subsequent efficacy: Results from two phase 3 studies of patients with moderate-to-severe plaque psoriasis.
Authors: PMID: 28201942 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 22, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Risk versus benefit or risk versus risk: Risk aversion in the medical decision making process.
Authors: Oussedik E, Anderson MS, Feldman SR PMID: 28201943 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 22, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research