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Patients' preferences for systemic treatment of atopic dermatitis: safety and efficacy count the most
CONCLUSIONS: Participants attached great importance to safety and symptom control. However, preferences were also dependent on individual characteristics, underscoring the importance of personal counseling. Conjoined with medical considerations, patients' preferences have fundamental impact on shared decisions for treatment of AD.PMID:38297480 | DOI:10.1080/09546634.2024.2308682 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 1, 2024 Category: Dermatology Authors: Marthe-Lisa Schaarschmidt Daniel Kromer Phoebe Wellmann Wiebke K Peitsch Christian Kromer Source Type: research

Leptin induces altered differentiation of keratinocytes by inducing insulin resistance: implications for metabolic syndrome-induced resistance of psoriatic therapy
Conclusions: Leptin induces insulin resistance by upregulating SOCS3 and give rise to differentiation disorder of keratinocyte. Insulin resistance may serve as a target for anti-psoriatic therapies.PMID:38297481 | DOI:10.1080/09546634.2024.2309305 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 1, 2024 Category: Dermatology Authors: Rui Wang Chongli Yu Zijie Tang Jie Sun Youlin Wang Zhenkai Zhao Biwen Lin Chengxin Li Source Type: research

Ruxolitinib cream monotherapy demonstrates rapid improvement in the extent and signs of mild to moderate atopic dermatitis across head and neck and other anatomic regions in adolescents and adults: pooled results from 2 phase 3 studies
Conclusions: These results support the use of ruxolitinib cream for AD treatment across all anatomic regions, including HN.PMID:38297490 | DOI:10.1080/09546634.2024.2310633 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 1, 2024 Category: Dermatology Authors: Eric L Simpson Robert Bissonnette Zelma C Chiesa Fuxench Howard Kallender Daniel Sturm Haobo Ren Linda F Stein Gold Source Type: research

Predictive factors for responders to upadacitinib treatment in patients with atopic dermatitis
CONCLUSIONS: Lower total EASI and higher age may predict responders to upadacitinib 15 mg while lower IgE and lower LDH may predict responders to 30 mg.PMID:38297496 | DOI:10.1080/09546634.2024.2310643 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 1, 2024 Category: Dermatology Authors: Teppei Hagino Mai Yoshida Risa Hamada Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research

Expression of mast cell tryptase and immunoglobulin E is increased in cutaneous photodamage: implications for carcinogenesis
Conclusions: Therefore, IgE+ mast cells participate in photodamage and carcinogenesis, though it is unclear whether they are tumor-protective or -causative.PMID:38291602 | DOI:10.1080/09546634.2024.2307488 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 31, 2024 Category: Dermatology Authors: Jenni Korhonen Hanna Siiskonen Salla Haimakainen Rauno J Harvima Ilkka T Harvima Source Type: research

Upadacitinib for the management of bullous pemphigoid coexisting with psoriasis vulgaris: a case report and literature review
J Dermatolog Treat. 2024 Dec;35(1):2302394. doi: 10.1080/09546634.2024.2302394. Epub 2024 Jan 23.ABSTRACTBoth bullous pemphigoid (BP) and psoriasis are common immune-related dermatological conditions in clinical practice, but the co-occurrence of these two diseases is rare. Currently, there is no consensus on the long-term safe and effective treatment for patients with both BP and psoriasis. JAK inhibitors are emerging as targeted therapeutic drugs that act by inhibiting Janus kinase activity, regulating the JAK/STAT pathway, blocking the transduction pathway of key proinflammatory cytokines, and influencing T-cell differe...
Source: Journal of Dermatological Treatment - January 24, 2024 Category: Dermatology Authors: Fangying Su Tai Wang Qunshi Qin Zhi Xie Source Type: research

The expression of CD200 and CD23 on B lymphocytes in the pollen season and outside the pollen season in atopic dermatitis patients with and without dupilumab therapy
J Dermatolog Treat. 2024 Dec;35(1):2305832. doi: 10.1080/09546634.2024.2305832. Epub 2024 Jan 23.NO ABSTRACTPMID:38263709 | DOI:10.1080/09546634.2024.2305832 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 24, 2024 Category: Dermatology Authors: Jarmila Čelakovská Eva Čermáková Ctirad Andr ýs Petra Boudkova Jan Krejsek Source Type: research

Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry
Conclusion: Patients with psoriasis using biologicals are less likely to have work-for-pay. Treatment improves the work productivity of employed patients, but we were unable to detect changes in ADL performance.PMID:38263716 | DOI:10.1080/09546634.2024.2304025 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 24, 2024 Category: Dermatology Authors: Tamara W van Hal Juul M P A van den Reek Mark H Wenink Marisol E Otero Paul M Ossenkoppele Marcellus D Njoo Annet Oostveen Bas Peters Milan Tjioe Else N Kop John E M K örver Sharon R P Dodemont Marloes M Kleinpenning Maartje A M Berends Wendelien R Veldk Source Type: research

A therapeutic challenge: managing severe atopic dermatitis with concurrent alpha-1-antitrypsin deficiency
J Dermatolog Treat. 2024 Dec;35(1):2307495. doi: 10.1080/09546634.2024.2307495. Epub 2024 Jan 23.NO ABSTRACTPMID:38258513 | DOI:10.1080/09546634.2024.2307495 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 23, 2024 Category: Dermatology Authors: M Cebolla-Verdugo C Llamas-Segura L Linares-Gonz ález R Ruiz-Villaverde F J Navarro-Trivi ño Source Type: research

The efficacy and safety of low-dose rituximab in the treatment of pemphigus vulgaris: a cohort study
CONCLUSIONS: This study indicated that low-dose RTX may be a beneficial and secure therapy option for patients with moderate to severe PV.PMID:38247364 | DOI:10.1080/09546634.2024.2302071 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 22, 2024 Category: Dermatology Authors: Xingli Zhou Tongying Zhan Xiaoxi Xu Tianjiao Lan Hongxiang Hu Yuxi Zhou Dengmei Xia Jinqiu Wang Yiyi Wang Yue Xiao Wei Li Source Type: research

Monitoring adherence to vulvar lichen sclerosus treatment - a prospective study
Conclusion: Poor adherence to both twice daily application and prescribed medication quantity occurred frequently. Factors related to self-reported non-adherence included perceived greater efficacy, inconvenience, and time-constraints. Patient adherence to recommended treatment and clinical outcomes are areas for improvement in patients with vulvar lichen sclerosus.PMID:38240095 | DOI:10.1080/09546634.2023.2285725 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 19, 2024 Category: Dermatology Authors: Mallory L Zaino Jessica N Pixley Vani Mangalam Subramanian Deepak Sirdeshmukh Steven R Feldman Rita O Pichardo Source Type: research

Complete response of extensive alopecia areata refractory to baricitinib after five months of treatment with upadacitinib
J Dermatolog Treat. 2024 Dec;35(1):2304630. doi: 10.1080/09546634.2024.2304630. Epub 2024 Jan 19.NO ABSTRACTPMID:38240097 | DOI:10.1080/09546634.2024.2304630 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 19, 2024 Category: Dermatology Authors: Francisco Javier De la Torre-Gomar Juan Pablo Velasco-Amador Álvaro Prados-Carmona Ricardo Ruiz-Villaverde Source Type: research

Injection site reactions after dupilumab or tralokinumab for atopic dermatitis
J Dermatolog Treat. 2024 Dec;35(1):2304027. doi: 10.1080/09546634.2024.2304027. Epub 2024 Jan 19.ABSTRACTBackground: Injection site reaction (ISR) is a local phenomenon defined as a constellation of symptoms, including swelling, erythema, pruritus, and pain around the site of injection.Objective: ISR is reported as a frequent adverse event after subcutaneous injection (SCI) of several biologics.Methods: We performed an observational real-life study to compare dupilumab and tralokinumab as regards ISR, analysing frequency, duration and intensity of symptoms related to SCI. From January 2023 to June 2023, we enrolled adult p...
Source: Journal of Dermatological Treatment - January 19, 2024 Category: Dermatology Authors: Fabrizio Martora Cataldo Patruno Silvia D'Ascenzo Maddalena Napolitano Source Type: research

Correction
J Dermatolog Treat. 2024 Dec;35(1):2302710. doi: 10.1080/09546634.2024.2302710. Epub 2024 Jan 19.NO ABSTRACTPMID:38240290 | DOI:10.1080/09546634.2024.2302710 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 19, 2024 Category: Dermatology Source Type: research

Is apremilast a treatment for SAPHO syndrome?
J Dermatolog Treat. 2024 Dec;35(1):2300743. doi: 10.1080/09546634.2023.2300743. Epub 2024 Jan 17.NO ABSTRACTPMID:38230420 | DOI:10.1080/09546634.2023.2300743 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - January 17, 2024 Category: Dermatology Authors: Ju Zhang Yixuan Li Jing Wang Huan Jiang Jiaping Qi Chen Li Zhenhua Ying Source Type: research